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One simple vitamin can reduce your risk of heart disease.
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Eating chocolate reduces stress in students.
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New drug prolongs lives of patients with rare disease.
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Health headlines like these are published
every day,
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sometimes making opposite claims
from each other.
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There can be a disconnect between broad,
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attention-grabbing headlines
and the often specific,
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incremental results of the medical
research they cover.
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So how can you avoid being
misled by grabby headlines?
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The best way to assess a headline’s
credibility
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is to look at the original
research it reports on.
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We’ve come up with a hypothetical research
scenario
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for each of these three headlines.
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Keep watching for the explanation
of the first example;
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then pause at the headline to
answer the question.
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These are simplified scenarios.
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A real study would detail many more
factors and how it accounted for them,
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but for the purposes of this exercise,
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assume all the information
you need is included.
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Let’s start by considering the
cardiovascular effects
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of a certain vitamin, Healthium.
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The study finds that participants taking
Healthium
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had a higher level of healthy cholesterol
than those taking a placebo.
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Their levels became similar to those of
people with naturally high levels
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of this kind of cholesterol.
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Previous research has shown that people
with naturally high levels
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of healthy cholesterol have lower
rates of heart disease.
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So what makes this headline misleading:
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Healthium reduces risk of heart disease.
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The problem with this headline is that the
research didn’t actually investigate
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whether Healthium reduces heart disease.
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It only measured Healthium’s impact
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on levels of a particular
kind of cholesterol.
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The fact that people with naturally high
levels of that cholesterol
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have lower risk of heart attacks
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doesn’t mean that the same will be true
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of people who elevate their cholesterol
levels using Healthium.
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Now that you’ve cracked the
case of Healthium,
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try your hand at a particularly alluring
mystery:
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the relationship between eating chocolate
and stress.
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This hypothetical study
recruits ten students.
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Half begin consuming a
daily dose of chocolate,
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while half abstain.
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As classmates, they all follow
the same schedule.
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By the end of the study, the chocolate
eaters are less stressed
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than their chocolate-free counterparts.
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What’s wrong with this headline:
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Eating chocolate reduces
stress in students
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It’s a stretch to draw a conclusion about
students in general from a sample of ten.
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That’s because the fewer participants are
in a random sample,
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the less likely it is that the sample will
closely represent
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the target population as a whole.
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For example, if the broader population of
students is half male and half female,
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the chance of drawing a sample of 10
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that’s skewed 70% male and
30% is about 12%.
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In a sample of 100 that would be less than
a .0025% chance,
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and for a sample of 1000,
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the odds are less than 6 x 10^-36.
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Similarly, with fewer participants,
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each individual’s outcome has a larger
impact on the overall results—
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and can therefore skew big-picture trends.
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Still, there are a lot of good reasons for
scientists run small studies.
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By starting with a small sample,
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they can evaluate whether the results are
promising enough
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to run a more comprehensive,
expensive study.
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And some research requires very specific
participants
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that may be impossible to
recruit in large numbers.
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The key is reproducibility—
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if an article draws a conclusion
from one small study,
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that conclusion may be suspect—
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but if it’s based on many studies
that have found similar results,
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it’s more credible.
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We’ve still got one more puzzle.
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In this scenario, a study tests a new drug
for a rare, fatal disease.
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In a sample of 2,000 patients,
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the ones who start taking the drug upon
diagnosis live longer
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than those who take the placebo.
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This time, the question
is slightly different.
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What’s one more thing you’d like to know
before deciding if the headline,
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New drug prolongs lives of patients
with rare disease, is justified?
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Before making this call,
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you’d want to know how much the drug
prolonged the patients’ lives.
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Sometimes, a study can have results that,
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while scientifically valid, don’t have
much bearing on real world outcomes.
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For example, one real-life clinical trial
of a pancreatic cancer drug
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found an increase in life expectancy—
of ten days.
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The next time you see a surprising medical
headline,
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take a look at the science
it’s reporting on.
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Even when full papers aren’t
available without a fee,
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you can often find summaries of
experimental design
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and results in freely available abstracts,
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or even within the text
of a news articles.
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It’s exciting to see scientific research
covered in the news,
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and important to understand
the studies’ findings.