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Dr. Riess has devoted her career to research on the neuroscience and art of the patient-doctor relationship and teaching psychiatry residents and medical students. Her research team conducts translational research based on the neuroscience of emotions. The effectiveness of Dr. Riess's empathy training approach has been demonstrated in several studies including a randomized controlled trial. She has developed faculty curricula for "Teaching the Teachers" of Psychotherapy that is used by faculty psychiatrists. Dr. Riess's empathy training curricula are implemented internationally in healthcare as well as in business.

Dr. Riess is an Associate Professor of Psychiatry at Harvard Medical School. She directs the Empathy & Relational Science Program, conducting research on the neuroscience of emotions and empathy, and is Co-Founder, Chief Scientist and Chairman of Empathetics, LLC. She is also a core member of the Research Consortium for Emotional Intelligence and is a faculty member of the Harvard Macy Institute for Physician Leaders.