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The major side-effects of Metformin
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are related to the gastrointestinal tract.
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There may be some cramp-y abdominal pain,
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some diarrhea, loose bowel movements;
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Some people get a little bit anorectic
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they lose their appetite on Metformin.
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They might even get a metallic taste in their mouth
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that is associated with the administration of Metformin.
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About 10% of people are unable to tolerate Metformin
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because of these gastrointestinal side-effects
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and Metformin is not to be used in people
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who have impaired kidney function
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and all patients should
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check with their doctor
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what their level of kidney function is
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to make sure that metformin is
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not contraindicated for them.
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But Metformin has a long track record
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of efficacy in safety and it is
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the number one drug that's recommended
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by the American Diabetes Association,
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the European Diabetes Association, and the
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American Association of Clinical Endocrinologists
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to initiate treatment in patients
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with type 2 diabetes.