A new weapon in the fight against superbugs
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0:02 - 0:06So ... we're in a real live war
at the moment, -
0:06 - 0:08and it's a war that we're truly losing.
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0:09 - 0:11It's a war on superbugs.
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0:14 - 0:16So you might wonder,
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0:16 - 0:18if I'm going to talk about superbugs,
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0:18 - 0:22why I'm showing you a photograph
of some soccer fans -- -
0:22 - 0:25Liverpool soccer fans
celebrating a famous victory -
0:25 - 0:27in Istanbul, a decade ago.
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0:28 - 0:30In the back, in the red shirt,
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0:30 - 0:32well, that's me,
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0:32 - 0:37and next to me in the red hat,
that's my friend Paul Rice. -
0:37 - 0:41So a couple of years
after this picture was taken, -
0:41 - 0:44Paul went into hospital
for some minor surgery, -
0:44 - 0:49and he developed
a superbug-related infection, -
0:49 - 0:50and he died.
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0:50 - 0:53And I was truly shocked.
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0:53 - 0:56He was a healthy guy in the prime of life.
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0:57 - 0:58So there and then,
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0:58 - 1:01and actually with a lot of encouragement
from a couple of TEDsters, -
1:02 - 1:05I declared my own
personal war on superbugs. -
1:06 - 1:09So let's talk about superbugs
for a moment. -
1:09 - 1:12The story actually starts in the 1940s
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1:12 - 1:15with the widespread
introduction of antibiotics. -
1:16 - 1:17And since then,
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1:17 - 1:22drug-resistant bacteria
have continued to emerge, -
1:22 - 1:25and so we've been forced to develop
newer and newer drugs -
1:25 - 1:27to fight these new bacteria.
-
1:28 - 1:34And this vicious cycle
actually is the origin of superbugs, -
1:34 - 1:38which is simply bacteria
for which we don't have effective drugs. -
1:39 - 1:43I'm sure you'll recognize
at least some of these superbugs. -
1:43 - 1:45These are the more
common ones around today. -
1:46 - 1:51Last year, around 700,000 people died
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1:51 - 1:53from superbug-related diseases.
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1:54 - 1:57Looking to the future,
-
1:57 - 2:00if we carry on on the path we're going,
-
2:00 - 2:04which is basically a drugs-based
approach to the problem, -
2:04 - 2:07the best estimate
by the middle of this century -
2:07 - 2:12is that the worldwide death toll
from superbugs will be 10 million. -
2:12 - 2:1410 million.
-
2:14 - 2:17Just to put that in context,
that's actually more -
2:17 - 2:20than the number of people
that died of cancer worldwide last year. -
2:21 - 2:25So it seems pretty clear
that we're not on a good road, -
2:25 - 2:29and the drugs-based approach
to this problem is not working. -
2:30 - 2:33I'm a physicist,
-
2:33 - 2:37and so I wondered, could we take
a physics-based approach -- -
2:37 - 2:39a different approach to this problem.
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2:40 - 2:41And in that context,
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2:41 - 2:44the first thing we know for sure,
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2:44 - 2:47is that we actually know how to kill
every kind of microbe, -
2:47 - 2:49every kind of virus,
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2:49 - 2:50every kind of bacteria.
-
2:51 - 2:53And that's with ultraviolet light.
-
2:54 - 2:56We've actually known this
for more than 100 years. -
2:57 - 3:00I think you all know
what ultraviolet light is. -
3:00 - 3:03It's part of a spectrum
that includes infrared, -
3:03 - 3:04it includes visible light,
-
3:04 - 3:08and the short-wavelength part
of this group is ultraviolet light. -
3:10 - 3:13The key thing from our perspective here
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3:13 - 3:18is that ultraviolet light kills bacteria
by a completely different mechanism -
3:18 - 3:20from the way drugs kill bacteria.
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3:21 - 3:26So ultraviolet light is just as capable
of killing a drug-resistant bacteria -
3:26 - 3:29as any other bacteria,
-
3:29 - 3:33and because ultraviolet light
is so good at killing all bugs, -
3:33 - 3:36it's actually used a lot these days
to sterilize rooms, -
3:36 - 3:39sterilize working surfaces.
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3:39 - 3:42What you see here is a surgical theater
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3:42 - 3:47being sterilized with germicidal
ultraviolet light. -
3:48 - 3:50But what you don't see
in this picture, actually, -
3:50 - 3:52is any people,
-
3:52 - 3:54and there's a very good reason for that.
-
3:54 - 3:58Ultraviolet light
is actually a health hazard, -
3:58 - 4:00so it can damage cells in our skin,
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4:00 - 4:01cause skin cancer,
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4:01 - 4:03it can damage cells in our eye,
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4:03 - 4:06cause eye diseases like cataract.
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4:06 - 4:10So you can't use conventional,
germicidal, ultraviolet light -
4:10 - 4:12when there are people are around.
-
4:12 - 4:13And of course,
-
4:13 - 4:16we want to sterilize mostly
when there are people around. -
4:17 - 4:20So the ideal ultraviolet light
-
4:20 - 4:23would actually be able
to kill all bacteria, -
4:23 - 4:25including superbugs,
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4:25 - 4:27but would be safe for human exposure.
-
4:28 - 4:33And actually that's where my physics
background kicked into this story. -
4:33 - 4:35Together with my physics colleagues,
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4:36 - 4:42we realized there actually is a particular
wavelength of ultraviolet light -
4:42 - 4:44that should kill all bacteria,
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4:44 - 4:46but should be safe for human exposure.
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4:47 - 4:50That wavelength is called far-UVC light,
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4:50 - 4:55and it's just the short-wavelength part
of the ultraviolet spectrum. -
4:55 - 4:58So let's see how that would work.
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4:58 - 5:02What you're seeing here
is the surface of our skin, -
5:02 - 5:07and I'm going to superimpose on that
some bacteria in the air above the skin. -
5:08 - 5:09Now we're going to see what happens
-
5:09 - 5:14when conventional, germicidal,
ultraviolet light impinges on this. -
5:16 - 5:17So what you see is,
-
5:17 - 5:22as we know, germicidal light
is really good at killing bacteria, -
5:22 - 5:23but what you also see
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5:23 - 5:27is that it penetrates
into the upper layers of our skin, -
5:27 - 5:29and it can damage
those key cells in our skin -
5:29 - 5:33which ultimately, when damaged,
can lead to skin cancer. -
5:34 - 5:37So let's compare now with far-UVC light --
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5:37 - 5:38same situation,
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5:38 - 5:41skin and some bacteria
in the air above them. -
5:42 - 5:44So what you're seeing now
-
5:44 - 5:48is that again, far-UVC light's
perfectly fine at killing bacteria, -
5:48 - 5:53but what far-UVC light can't do
is penetrate into our skin. -
5:53 - 5:56And there's a good,
solid physics reason for that: -
5:56 - 6:01far-UVC light is incredibly, strongly
absorbed by all biological materials, -
6:01 - 6:03so it simply can't go very far.
-
6:05 - 6:09Now, viruses and bacteria
are really, really, really small, -
6:09 - 6:14so the far-UVC light can certainly
penetrate them and kill them, -
6:14 - 6:17but what it can't do
is penetrate into skin, -
6:17 - 6:19and it can't even penetrate
the dead-cell area -
6:19 - 6:21right at the very surface of our skin.
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6:22 - 6:28So far-UVC light
should be able to kill bacteria, -
6:28 - 6:29but kill them safely.
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6:31 - 6:33So that's the theory.
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6:33 - 6:35It should work, should be safe.
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6:36 - 6:38What about in practice?
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6:38 - 6:39Does it really work?
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6:39 - 6:40Is it really safe?
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6:41 - 6:43So that's actually what our lab
has been working on -
6:43 - 6:45the past five or six years,
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6:45 - 6:48and I'm delighted to say the answer
to both these questions -
6:48 - 6:49is an emphatic yes.
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6:49 - 6:51Yes, it does work,
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6:51 - 6:52but yes, it is safe.
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6:52 - 6:54So I'm delighted to say that,
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6:54 - 6:56but actually I'm not very
surprised to say that, -
6:57 - 6:59because it's purely the laws
of physics at work. -
7:02 - 7:04So let's look to the future.
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7:04 - 7:10I'm thrilled that we now have
a completely new weapon, -
7:10 - 7:13and I should say an inexpensive weapon,
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7:13 - 7:16in our fight against superbugs.
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7:16 - 7:18For example,
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7:18 - 7:21I see far-UVC lights in surgical theaters.
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7:22 - 7:25I see far-UVC lights
in food preparation areas. -
7:26 - 7:29And in terms of preventing
the spread of viruses, -
7:29 - 7:32I see far-UVC lights in schools,
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7:32 - 7:35preventing the spread of influenza,
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7:35 - 7:37preventing the spread of measles,
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7:37 - 7:41and I see far-UVC lights
in airports or airplanes, -
7:41 - 7:45preventing the global spread
of viruses like H1N1 virus. -
7:46 - 7:48So back to my friend Paul Rice.
-
7:48 - 7:52He was actually a well-known
and well-loved local politician -
7:52 - 7:55in his and my hometown of Liverpool,
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7:55 - 7:59and they put up a statue in his memory
in the center of Liverpool, -
7:59 - 8:00and there it is.
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8:00 - 8:03But me,
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8:03 - 8:07I want Paul's legacy to be a major advance
in this war against superbugs. -
8:08 - 8:10Armed with the power of light,
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8:10 - 8:12that's actually within our grasp.
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8:13 - 8:14Thank you.
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8:14 - 8:19(Applause)
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8:19 - 8:23Chris Anderson: Stay up here, David,
I've got a question for you. -
8:23 - 8:24(Applause)
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8:25 - 8:30David, tell us where you're up to
in developing this, -
8:30 - 8:33and what are the remaining obstacles
to trying to roll out -
8:33 - 8:34and realize this dream?
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8:35 - 8:38David Brenner: Well, I think we now know
that it kills all bacteria, -
8:38 - 8:40but we sort of knew
that before we started, -
8:40 - 8:42but we certainly tested that.
-
8:42 - 8:45So we have to do lots and lots
of tests about safety, -
8:45 - 8:48and so it's more about safety
than it is about efficacy. -
8:49 - 8:51And we need to do short-term tests,
-
8:51 - 8:53and we need to do long-term tests
-
8:53 - 8:57to make sure you can't develop
melanoma many years on. -
8:57 - 9:01So those studies
are pretty well done at this point. -
9:02 - 9:07The FDA of course is something
we have to deal with, -
9:07 - 9:09and rightly so,
-
9:09 - 9:12because we certainly can't use this
in the real world without FDA approval. -
9:13 - 9:16CA: Are you trying
to launch first in the US, -
9:16 - 9:17or somewhere else?
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9:18 - 9:20DB: Actually, in a couple of countries.
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9:20 - 9:23In Japan and in the US, both.
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9:24 - 9:28CA: Have you been able to persuade
biologists, doctors, -
9:29 - 9:30that this is a safe approach?
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9:31 - 9:34DB: Well, as you can imagine,
there is a certain skepticism -
9:34 - 9:37because everybody knows
that UV light is not safe. -
9:38 - 9:40So when somebody comes along and says,
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9:40 - 9:43"Well, this particular UV light is safe,"
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9:43 - 9:45there is a barrier to be crossed,
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9:45 - 9:47but the data are there,
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9:47 - 9:50and I think that's what
we're going to be standing on. -
9:50 - 9:52CA: Well, we wish you well.
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9:52 - 9:54This is potentially such important work.
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9:54 - 9:56Thank you so much
for sharing this with us. -
9:56 - 9:57Thank you, David.
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9:57 - 10:01(Applause)
- Title:
- A new weapon in the fight against superbugs
- Speaker:
- David Brenner
- Description:
-
Since the widespread use of antibiotics began in the 1940s, we've tried to develop new drugs faster than bacteria can evolve -- but this strategy isn't working. Drug-resistant bacteria known as superbugs killed nearly 700,000 people last year, and by 2050 that number could be 10 million -- more than cancer kills each year. Can physics help? In a talk from the frontiers of science, radiation scientist David Brenner shares his work studying a potentially life-saving weapon: a wavelength of ultraviolet light known as far-UVC, which can kill superbugs safely, without penetrating our skin. Followed by a Q&A with TED Curator Chris Anderson.
- Video Language:
- English
- Team:
- closed TED
- Project:
- TEDTalks
- Duration:
- 10:13
Brian Greene edited English subtitles for A new weapon in the fight against superbugs | ||
Brian Greene edited English subtitles for A new weapon in the fight against superbugs | ||
Brian Greene edited English subtitles for A new weapon in the fight against superbugs | ||
Brian Greene edited English subtitles for A new weapon in the fight against superbugs | ||
Brian Greene approved English subtitles for A new weapon in the fight against superbugs | ||
Brian Greene edited English subtitles for A new weapon in the fight against superbugs | ||
Krystian Aparta accepted English subtitles for A new weapon in the fight against superbugs | ||
Krystian Aparta edited English subtitles for A new weapon in the fight against superbugs |