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59 year old Karen Sonneberg
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grew up on the north shore
of Long Island,
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just an hour's drive
from New York City.
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Her parents survived
the Holocaust,
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but rarely mentioned it.
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All I knew was that
we were different,
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that I was different.
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I didn't exactly know why.
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Her parents were Jewish,
born in Germany.
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After Hitler came to power,
their families fled.
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Sonneberg's parents
were just children,
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but carried the traumas
of Nazi oppression
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throughout their lives.
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My mother,
from the time she was 3, on.
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My father,
from the time he was 5 or 6 years old.
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He was...
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subjected to...
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the painful existence
in Germany.
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Despite her own
comfortable upbringing
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here in the U. S.,
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Sonneberg privately
struggled for years
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with anxiety and stress.
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While she couldn't prove it,
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she believed it was
somehow linked
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to her parents'
traumatic childhoods.
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Having discussed this
with many of my friends,
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who come from
similar backgrounds,
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it seems to be
consistent in most of us.
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There were definitely
challenges, that
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"American kids"
didn't seem to have experienced.
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Even though you weren't there.
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Exactly.
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That's the amazing
part of it.
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Now, a new study
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published this month
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in the scientific journal
"Biological Psychiatry"
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bolsters Sonneberg's belief
that she experienced
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the after-effects
of her parents' trauma.
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Dr. Rachel Yehuda,
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director of Mt. Sinai's
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Traumatic Stress
Studies division,
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led the study.
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Her team interviewed,
and drew blood,
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from 32 sets of survivors
and their children,
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focusing on a gene
called FKBP5.
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We already know
that this is a gene
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that contributes to risk
for depression
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and Post Traumatic
Stress Disorder.
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Yehuda noticed a pattern
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among the Holocaust survivors
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called an "epigenetic change."
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Not a change in the gene itself,
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but rather, a change
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in a chemical marker
attached to it.
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When we looked at
their own children,
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their children also
had an epigenetic change,
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in the same spot,
on the stress-related gene.
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What does that suggest?
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Well, in the first generation,
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in a Holocaust survivor,
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it suggests that there has been
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an adaptation or a response
to a horrendous environmental event.
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in the second generation,
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it suggests that there
has also been
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a response, of the offspring,
to this parental trauma.
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Which means, children
of Holocaust survivors,
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like Sonneberg,
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could be more likely to
develop stress or anxiety disorders.
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Though their study was small,
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Yehuda and her team
controlled for any early trauma
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the survivors' children
may have experienced, themselves.
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How is it that a parent,
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who was subjected to
the trauma of the Holocaust,
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is able to somehow
transmit that to a child
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who wasn't there?
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Well that's a really good question.
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The study that we did
doesn't address the "hows."
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The study that we did
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just provides the proof of concept.
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We might be able to identify the "how,"
if we do more research.
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DNA is passed from parents to children.
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Research like Yehuda's suggests
parental life experiences
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can modify their
body chemistry,
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and those modifications
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can be transmitted
to children, as well.
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Scientists have examined
this idea before.
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After a famine in Holland
during 1944 and 1945,
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children were born
with the effects of malnutrition,
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two generations
after the food shortage ended.
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Previously, Yehuda herself
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studied stress hormone levels
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in children born to women
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who survived the September 11th
terrorist attacks.
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She's been examining the link
between trauma experienced
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by Holocaust survivors
and their children,
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for more than twenty years.
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A trauma is an event
that changes you.
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It doesn't have to change you
for the negative.
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Trauma changes you
in lots of different ways.
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Most people who experience
extreme trauma
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learn a great deal
from that experience.
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Some of those lessons
may be lessons
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that are transmitted
to the child.
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That's not a bad thing.
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Yehuda says
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the implications aren't limited
to Holocaust survivors,
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but this dwindling population
provides insight
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into how clinicians
understand and treat
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stress disorders.
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If you are at risk
for heart disease,
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a lot of times the doctor
can separate out,
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"Well this is your weight,
that's not good."
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"This is your diet,
these are your genetic risks."
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And things like that.
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It would be very nice,
if we could develop
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a similar risk profile
in the mental health arena,
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where we would be able
to understand
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where the risk factors come from
for depression and anxiety.
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We're on the 10th anniversary
of Hurricane Katrina.
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There were children who were born
after that trauma.
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There are children born
in the trauma of war in Syria
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and other crises around the world.
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If you are the child
of a parent who experienced trauma,
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are you doomed
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to be depressed or stressed
for the rest of your life?
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I don't think you are doomed.
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But, I think many children
of traumatized parents
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have struggled with
depression and anxiety.
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I can tell you that
many of them have felt relieved
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that, um...
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there might be
a contributing factor
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that has been based on
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how they are responding
to their parental trauma.
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I think that it has helped people
work through
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a lot of that
depression and anxiety.
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Relief is exactly
what Karen Sonneberg,
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the child of Holocaust survivors,
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felt, after she participated
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in one of Dr. Yehuda's
trauma survivor studies.
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She lost her mother
thirty years ago,
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but looks forward to
her father's 90th birthday
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next year.
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I've learned to cope
in my life.
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I've learned to move on,
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and get over all of this.
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Had I known, at the time,
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how my reactions
could impact future children,
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my children's reactions,
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I might have dealt with things
differently.
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Um, or, gotten them
some sort of treatment,
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that maybe would help them
in the future.