This documentary primarily covers the psychological profiles and exploits of three particular serial killers (Albert Fish, Andrei Chikatilo, and Jeffrey Dahmer), and features various psychologists, authors, pioneering FBI profiler Robert Ressler, and the prosecuting and defense attorneys of the Jeffrey Dahmer trial discussing their thoughts on the events. Also given a look are the factors, conditions, and motivations that might lead someone to become a serial killer. And, as suggested by the show's title, the most infamous fictional serial killer Hannibal "The Cannibal" Lecter is discussed, compared and contrasted to his real-life counterparts.