Magnificent Vistas of Ignorance | Alejandro Sánchez Alvarado | TEDxKC

Life on this planet is the history of rule breakers – species that didn't get the memo about how they were supposed to behave. So if we are studying rule breakers, then shouldn't how we study them break the rules, too?

This fascinating talk poses the question: is the way science approaches life’s biggest mysteries restricting our ability to solve them?

Alejandro Sánchez Alvarado is a researcher at the Stowers Institute for Medical Research and the Howard Hughes Medical Institute and Fellow of the American Academy of Arts and Sciences.

Dr. Sánchez Alvarado's current research efforts are aimed at understanding the molecular and cellular basis of animal regeneration.

This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at http://ted.com/tedx

I've been spending my summers
in the marine biological laboratory

in Woods Hole, Massachusetts.

And there, what I've been doing
is essentially renting a boat.

What I would like to do is ask you

to come on a boat ride with me tonight.

So, we ride off from Eel Pond
into Vineyard Sound,

right off the coast of Martha's Vineyard,

equipped with a drone
to identify potential spots

from which to peer into the Atlantic.

Earlier, I was going to say
into the depths of the Atlantic,

but we don't have to go too deep
to reach the unknown.

Here, barely two miles away

from what is arguably the greatest
marine biology lab in the world,

we lower a simple
plankton net into the water

and bring up to the surface

things that humanity rarely
pays any attention to,

and oftentimes has never seen before.

Here's one of the organisms
that we caught in our net.

This is a jellyfish.

But look closely,

and living inside of this animal
is another organism

that is very likely
entirely new to science.

A complete new species.

Or how about this other transparent beauty

with a beating heart,

asexually growing on top of its head,

progeny that will move on
to reproduce sexually.

Let me say that again:

this animal is growing asexually
on top of its head,

progeny that is going to reproduce
sexually in the next generation.

A weird jellyfish?

Not quite.

This is an ascidian.

This is a group of animals

that now we know we share
extensive genomic ancestry with,

and it is perhaps the closest
invertebrate species to our own.

Meet your cousin,

Thalia democratica.

(Laughter)

I'm pretty sure you didn't save a spot
at your last family reunion

for Thalia,

but let me tell you,

these animals are profoundly related to us

in ways that we're just
beginning to understand.

So, next time you hear anybody
derisively telling you

that this type of research
is a simple fishing expedition,

I hope that you'll remember
the trip that we just took.

Today, many of the biological
sciences only see value

in studying deeper what we already know --

in mapping already-discovered continents.

But some of us are much more
interested in the unknown.

We want to discover
completely new continents,

and gaze at magnificent
vistas of ignorance.

We crave the experience
of being completely baffled

by something we've never seen before.

And yes, I agree

there's a lot of little ego satisfaction
in being able to say,

"Hey, I was the first one
to discover that."

But this is not
a self-aggrandizing enterprise,

because in this type
of discovery research,

if you don't feel like a complete
idiot most of the time,

you're just not sciencing hard enough.

(Laughter)

So every summer I bring onto the deck
of this little boat of ours

more and more things
that we know very little about.

I would like tonight
to tell you a story about life

that rarely gets told
in an environment like this.

From the vantage point of our 21st-century
biological laboratories,

we have begun to illuminate
many mysteries of life with knowledge.

We sense that after centuries
of scientific research,

we're beginning to make
significant inroads

into understanding some of the most
fundamental principles of life.

Our collective optimism is reflected
by the growth of biotechnology

across the globe,

striving to utilize scientific knowledge
to cure human diseases.

Things like cancer, aging,
degenerative diseases;

these are but some
of the undesirables we wish to tame.

I often wonder:

Why is it that we are having
so much trouble

trying to solve the problem of cancer?

Is it that we're trying to solve
the problem of cancer,

and not trying to understand life?

Life on this planet
shares a common origin,

and I can summarize 3.5 billion years
of the history of life on this planet

in a single slide.

What you see here are representatives
of all known species in our planet.

In this immensity of life
and biodiversity,

we occupy a rather unremarkable position.

(Laughter)

Homo sapiens.

The last of our kind.

And though I don't really want
to disparage at all

the accomplishments of our species,

as much as we wish it to be so
and often pretend that it is,

we are not the measure of all things.

We are, however,
the measurers of many things.

We relentlessly quantify,
analyze and compare,

and some of this is absolutely invaluable
and indeed necessary.

But this emphasis today on forcing
biological research to specialize

and to produce practical outcomes

is actually restricting our ability
to interrogate life

to unacceptably narrow confines
and unsatisfying depths.

We are measuring an astonishingly
narrow sliver of life,

and hoping that those numbers
will save all of our lives.

How narrow do you ask?

Well, let me give you a number.

The National Oceanic and Atmospheric
Administration recently estimated

that about 95 percent of our oceans
remain unexplored.

Now let that sink in for a second.

95 percent of our oceans
remain unexplored.

I think it's very safe to say

that we don't even know
how much about life we do not know.

So, it's not surprising
that every week in my field

we begin to see the addition
of more and more new species

to this amazing tree of life.

This one for example --

discovered earlier this summer,

new to science,

and now occupying its lonely branch
in our family tree.

What is even more tragic

is that we know about a bunch
of other species of animals out there,

but their biology remains
sorely under-studied.

I'm sure some of you
have heard about the fact

that a starfish can actually
regenerate its arm after it's lost.

But some of you might not know

that the arm itself can actually
regenerate a complete starfish.

And there are animals out there
that do truly astounding things.

I'm almost willing to bet

that many of you have never heard
of the flatworm, Schmidtea mediterranea.

This little guy right here

does things that essentially
just blow my mind.

You can grab one of these animals
and cut it into 18 different fragments,

and each and every one of those fragments
will go on to regenerate

a complete animal

in under two weeks.

18 heads, 18 bodies, 18 mysteries.

For the past decade and a half or so,

I've been trying to figure out
how these little dudes do what they do,

and how they pull this magic trick off.

But like all good magicians,

they're not really releasing
their secrets readily to me.

(Laughter)

So here we are,

after 20 years of essentially
studying these animals,

genome mapping, chin scratching,

and thousands of amputations
and thousands of regenerations,

we still don't fully understand
how these animals do what they do.

Each planarian an ocean unto itself,

full of unknowns.

One of the common characteristics

of all of these animals
I've been talking to you about

is that they did not appear
to have received the memo

that they need to behave
according to the rules

that we have derived from a handful
of randomly selected animals

that currently populate the vast majority

of biomedical laboratories
across the world.

Meet our Nobel Prize winners.

Seven species, essentially,

that have produced for us the brunt
of our understanding

of biological behavior today.

This little guy right here --

three Nobel Prizes in 12 years.

And yet, after all the attention
they have garnered,

and all the knowledge they have generated,

as well as the lion's share
of the funding,

here we are standing [before] the same
litany of intractable problems

and many new challenges.

And that's because, unfortunately,

these seven animals essentially correspond

to 0.0009 percent of all of the species
that inhabit the planet.

So I'm beginning to suspect

that our specialization is beginning
to impede our progress at best,

and at worst, is leading us astray.

That's because life
on this planet and its history

is the history of rule breakers.

Life started on the face of this planet
as single-cell organisms,

swimming for millions
of years in the ocean,

until one of those creatures decided,

"I'm going to do things differently today;

today I would like to invent
something called multicellularity,

and I'm going to do this."

And I'm sure it wasn't a popular
decision at the time --

(Laughter)

but somehow, it managed to do it.

And then, multicellular
organisms began to populate

all these ancestral oceans,

and they thrived.

And we have them here today.

Land masses began to emerge
from the surface of the oceans,

and another creature thought,

"Hey, that looks like a really nice
piece of real estate.

I'd like to move there."

"Are you crazy?

You're going to desiccate out there.
Nothing can live out of water."

But life found a way,

and there are organisms
now that live on land.

Once on land, they may have
looked up into the sky

and said, "It would be nice
to go to the clouds,

I'm going to fly."

"You can't break the law of gravity,
there's no way you can fly."

And yet, nature has invented --

multiple and independent times --

ways to fly.

I love to study these animals
that break the rules,

because every time they break a rule,
they invent something new

that made it possible for us
to be able to here today.

These animals did not get the memo.

They break the rules.

So if we're going to study animals
that break the rules,

shouldn't how we study them
also break the rules?

I think we need to renew
our spirit of exploration.

Rather than bring nature
into our laboratories

and interrogate it there,

we need to bring our science

into the majestic laboratory
that is nature,

and there, with our modern
technological armamentarium,

interrogate every new form
of life we find,

and any new biological attribute
that we may find.

We actually need to bring
all of our intelligence

to becoming stupid again --

clueless [before] the immensity
of the unknown.

Because after all,

science is not really about knowledge.

Science is about ignorance.

That's what we do.

So if we're serious about this,

we are going to have to start
seriously supporting

those institutions that make it possible
for discovery research to take place.

Institutions like our own,

the Stowers Institute for Medical Research
in Kansas City, Missouri,

or the National Institute of General
Medical Sciences in Bethesda, Maryland,

and of course,
our gateway to biodiversity,

the Marine Biological Laboratory
in Woods Hole, Massachusetts.

I have been very fortunate to be able
to do some of this training myself,

and it is a pleasure for me

to actually grab students
out of the confines of their laboratories

away from their computers
and their catalogs,

and throw them into the world
of discovery and exploration.

It is an immense pleasure,
a real pleasure to actually see

to see how these bright, young minds'
curiosity spreads its wings

and flies away when faced
with the unknown.

This is how we become real scientists.

So we need these people
to actually go out there

and ask the better questions
that will bring us closer

to the answers that we seek.

Once, Antoine de Saint-Exupéry wrote,

"If you want to build a ship,

don't drum up people to collect wood

and don't assign them tasks and work,

but rather teach them to long
for the endless immensity of the sea ..."

As a scientist and a teacher,

I like to paraphrase this to read

that we scientists need
to teach our students

to long for the endless
immensity of the sea

that is our ignorance.

We Homo sapiens are the only
species we know of

that is driven to scientific inquiry.

We, like all other species on this planet,

are inextricably woven
into the history of life on this planet.

And I think I'm a little wrong
when I say that life is a mystery,

because I think that life
is actually an open secret

that has been beckoning our species
for millennia to understand it.

So I ask you:

Aren't we the best chance
that life has to know itself?

And if so,

what the heck are we waiting for?

We need to do things differently.

Tonight, I'm going to ask you
to please help us build

the greatest discovery research vessel
in the history of humankind.

Call your legislators,

ask them to fund basic discovery research,

support and give what you can
to institutions such as these

that are dedicated to discovery research,

and hop on board with us
on a grand expedition

to radically transform
our understanding of life.

And along the way,

change the way we do
biomedical research, forever.

Thank you.

(Applause)