0:00:11.872,0:00:15.281 If you've got a cold, [br]mucus is hard to miss. 0:00:15.281,0:00:19.364 But what is it, and what does it do[br]besides making you miserable? 0:00:19.364,0:00:23.539 Your body produces more than a liter[br]of mucus every day, 0:00:23.539,0:00:27.234 and all the wet surfaces of your body[br]that are not covered by skin, 0:00:27.234,0:00:28.524 like your eyes, 0:00:28.524,0:00:29.352 nose, 0:00:29.352,0:00:30.255 mouth, 0:00:30.255,0:00:31.054 lungs, 0:00:31.054,0:00:33.369 and stomach get a liberal coating. 0:00:33.369,0:00:36.386 That's why they're known [br]as mucus membranes. 0:00:36.386,0:00:38.928 Mucus plays lots of roles[br]in your body. 0:00:38.928,0:00:41.947 It keeps delicate tissues [br]from drying out and cracking, 0:00:41.947,0:00:44.355 which would expose them to infection. 0:00:44.355,0:00:46.762 It lubricates your eyes so you can blink. 0:00:46.762,0:00:49.365 It protects your stomach lining[br]from acid. 0:00:49.365,0:00:53.236 It neutralizes threats by removing[br]or trapping substances 0:00:53.236,0:00:55.227 that could make you sick. 0:00:55.227,0:01:01.366 And finally, it houses and keeps your[br]body's trillions of bacterial inhabitants, 0:01:01.366,0:01:04.720 your microbiota, under control. 0:01:04.720,0:01:07.083 Mucus contains lots [br]of different compounds, 0:01:07.083,0:01:10.168 including proteins, fats, and salts. 0:01:10.168,0:01:15.851 But a key component of mucus versatility[br]is a set of proteins called mucins. 0:01:15.851,0:01:19.412 Mucins are the primary [br]large molecules in mucus 0:01:19.412,0:01:23.054 and are essential [br]for giving mucus its slippery feel. 0:01:23.054,0:01:26.903 They belong to a class of proteins[br]called glycoproteins 0:01:26.903,0:01:30.465 which are built out of both amino acids[br]and sugars. 0:01:30.465,0:01:35.768 In mucin, long chains of sugars[br]are attached to specific amino acids 0:01:35.768,0:01:37.564 in the protein backbone. 0:01:37.564,0:01:43.031 The hydrophilic sugar chains help mucin[br]dissolve in your body's watery fluids. 0:01:43.031,0:01:45.909 Mucus, which is up to 90% water, 0:01:45.909,0:01:48.831 stays hydrated thanks [br]to these sugar chains. 0:01:48.831,0:01:52.003 Some of these mucins can interact[br]with other mucin molecules 0:01:52.003,0:01:55.602 to create a complex network[br]that establishes a barrier 0:01:55.602,0:01:58.786 against pathogens and other invaders. 0:01:58.786,0:02:03.148 That's why mucus is the body's first line[br]of defense against foreign objects, 0:02:03.148,0:02:05.455 like bacteria and dust. 0:02:05.455,0:02:09.314 It's continuously produced to clear them[br]from the respiratory tract, 0:02:09.314,0:02:11.532 like a slimy conveyor belt. 0:02:11.532,0:02:15.807 This keeps bacteria from getting[br]a solid purchase on delicate lung tissue, 0:02:15.807,0:02:20.302 or making it to the blood stream,[br]where they could cause a major infection. 0:02:20.302,0:02:23.929 Many of those harmful bacteria[br]also cause diseases 0:02:23.929,0:02:27.783 when they cluster into slimy growths[br]called biofilms. 0:02:27.783,0:02:29.325 But mucus contains mucins, 0:02:29.325,0:02:31.609 antimicrobial peptides, 0:02:31.609,0:02:32.899 antibodies, 0:02:32.899,0:02:36.839 and even bacteria-hungry viruses[br]called bacteriophages 0:02:36.839,0:02:40.786 that all work together to prevent[br]biofilms from forming. 0:02:40.786,0:02:43.518 If microbes do become harmful [br]and you get sick, 0:02:43.518,0:02:48.590 the body ramps up mucus production[br]to try to quickly flush out the offenders, 0:02:48.590,0:02:53.573 and the immune system floods your mucus[br]with extra white blood cells. 0:02:53.573,0:02:57.290 In fact, the greenish mucus often[br]associated with infections 0:02:57.290,0:03:01.265 gets its color from an enzyme[br]produced by those white blood cells. 0:03:01.265,0:03:04.348 This multi-pronged approach [br]to bacterial management 0:03:04.348,0:03:07.918 is one of the main reasons [br]why we're not sick all the time. 0:03:07.918,0:03:11.769 Even though mucus protects against[br]the infectious bacteria, 0:03:11.769,0:03:16.134 the vast majority of your body's bacterial[br]tenants are not harmful, 0:03:16.134,0:03:18.282 and many are actually beneficial. 0:03:18.282,0:03:21.368 That's particularly true [br]when they live in mucus, 0:03:21.368,0:03:23.335 where they can perform [br]important functions, 0:03:23.335,0:03:25.053 like synthesizing vitamins, 0:03:25.053,0:03:27.235 suppressing harmful inflammation, 0:03:27.235,0:03:30.867 and controlling the growth [br]of more harmful species. 0:03:30.867,0:03:34.333 So even though you probably associate[br]mucus with being ill, 0:03:34.333,0:03:36.585 it's really helping you stay healthy. 0:03:36.585,0:03:38.246 Sure, it might seem gross, 0:03:38.246,0:03:42.393 but can you think of any other substance[br]that can lubricate, 0:03:42.393,0:03:43.802 keep your body clean, 0:03:43.802,0:03:45.153 fight infection, 0:03:45.153,0:03:48.585 and domesticate a teeming [br]bacterial population? 0:03:48.585,0:03:51.504 Nope, just mucus.