1 00:00:14,756 --> 00:00:16,217 These days scientists know 2 00:00:16,241 --> 00:00:18,661 how you inherit characteristics from your parents. 3 00:00:18,685 --> 00:00:21,791 They're able to calculate probabilities of having a specific trait 4 00:00:21,815 --> 00:00:23,156 or getting a genetic disease 5 00:00:23,180 --> 00:00:26,430 according to the information from the parents and the family history. 6 00:00:26,454 --> 00:00:27,913 But how is this possible? 7 00:00:27,937 --> 00:00:31,321 To understand how traits pass from one living being to its descendants, 8 00:00:31,345 --> 00:00:33,536 we need to go back in time to the 19th century 9 00:00:33,560 --> 00:00:35,286 and a man named Gregor Mendel. 10 00:00:35,849 --> 00:00:37,869 Mendel was an Austrian monk and biologist 11 00:00:37,893 --> 00:00:39,591 who loved to work with plants. 12 00:00:39,615 --> 00:00:42,837 By breeding the pea plants he was growing in the monastery's garden, 13 00:00:42,861 --> 00:00:45,108 he discovered the principles that rule heredity. 14 00:00:45,132 --> 00:00:46,668 In one of most classic examples, 15 00:00:46,692 --> 00:00:48,875 Mendel combined a purebred yellow-seeded plant 16 00:00:48,899 --> 00:00:50,944 with a purebred green-seeded plant, 17 00:00:50,968 --> 00:00:52,897 and he got only yellow seeds. 18 00:00:52,921 --> 00:00:55,357 He called the yellow-colored trait the dominant one, 19 00:00:55,381 --> 00:00:57,554 because it was expressed in all the new seeds. 20 00:00:58,011 --> 00:01:01,356 Then he let the new yellow-seeded hybrid plants self-fertilize. 21 00:01:01,380 --> 00:01:04,500 And in this second generation, he got both yellow and green seeds, 22 00:01:04,524 --> 00:01:07,683 which meant the green trait had been hidden by the dominant yellow. 23 00:01:07,707 --> 00:01:09,989 He called this hidden trait the recessive trait. 24 00:01:10,013 --> 00:01:11,691 From those results, Mendel inferred 25 00:01:11,715 --> 00:01:13,903 that each trait depends on a pair of factors, 26 00:01:13,927 --> 00:01:15,562 one of them coming from the mother 27 00:01:15,586 --> 00:01:17,081 and the other from the father. 28 00:01:17,105 --> 00:01:19,416 Now we know that these factors are called alleles 29 00:01:19,440 --> 00:01:21,780 and represent the different variations of a gene. 30 00:01:21,804 --> 00:01:24,633 Depending on which type of allele Mendel found in each seed, 31 00:01:24,657 --> 00:01:28,231 we can have what we call a homozygous pea, where both alleles are identical, 32 00:01:28,255 --> 00:01:29,986 and what we call a heterozygous pea, 33 00:01:30,010 --> 00:01:31,732 when the two alleles are different. 34 00:01:31,756 --> 00:01:34,470 This combination of alleles is known as genotype 35 00:01:34,494 --> 00:01:36,446 and its result, being yellow or green, 36 00:01:36,470 --> 00:01:38,184 is called phenotype. 37 00:01:38,208 --> 00:01:41,483 To clearly visualize how alleles are distributed amongst descendants, 38 00:01:41,507 --> 00:01:43,526 we can a diagram called the Punnett square. 39 00:01:43,550 --> 00:01:45,631 You place the different alleles on both axes 40 00:01:45,655 --> 00:01:47,806 and then figure out the possible combinations. 41 00:01:47,830 --> 00:01:49,813 Let's look at Mendel's peas, for example. 42 00:01:49,837 --> 00:01:52,883 Let's write the dominant yellow allele as an uppercase "Y" 43 00:01:52,907 --> 00:01:55,471 and the recessive green allele as a lowercase "y." 44 00:01:55,495 --> 00:01:58,143 The uppercase Y always overpowers his lowercase friend, 45 00:01:58,167 --> 00:01:59,955 so the only time you get green babies 46 00:01:59,979 --> 00:02:01,731 is if you have lowercase Y's. 47 00:02:02,207 --> 00:02:05,004 In Mendel's first generation, the yellow homozygous pea mom 48 00:02:05,028 --> 00:02:07,422 will give each pea kid a yellow-dominant allele, 49 00:02:07,446 --> 00:02:10,667 and the green homozygous pea dad will give a green-recessive allele. 50 00:02:10,691 --> 00:02:13,090 So all the pea kids will be yellow heterozygous. 51 00:02:13,637 --> 00:02:15,232 Then, in the second generation, 52 00:02:15,256 --> 00:02:17,067 where the two heterozygous kids marry, 53 00:02:17,091 --> 00:02:20,001 their babies could have any of the three possible genotypes, 54 00:02:20,025 --> 00:02:21,728 showing the two possible phenotypes 55 00:02:21,752 --> 00:02:23,401 in a three-to-one proportion. 56 00:02:23,838 --> 00:02:25,891 But even peas have a lot of characteristics. 57 00:02:25,915 --> 00:02:27,931 For example, besides being yellow or green, 58 00:02:27,955 --> 00:02:29,517 peas may be round or wrinkled. 59 00:02:29,541 --> 00:02:31,835 So we could have all these possible combinations: 60 00:02:31,859 --> 00:02:33,590 round yellow peas, round green peas, 61 00:02:33,614 --> 00:02:35,632 wrinkled yellow peas, wrinkled green peas. 62 00:02:35,656 --> 00:02:38,538 To calculate the proportions for each genotype and phenotype, 63 00:02:38,562 --> 00:02:40,105 we can use a Punnett square too. 64 00:02:40,129 --> 00:02:42,514 Of course, this will make it a little more complex. 65 00:02:42,538 --> 00:02:44,885 And lots of things are more complicated than peas, 66 00:02:44,909 --> 00:02:46,304 like, say, people. 67 00:02:46,790 --> 00:02:49,980 These days, scientists know a lot more about genetics and heredity. 68 00:02:50,004 --> 00:02:53,534 And there are many other ways in which some characteristics are inherited. 69 00:02:53,558 --> 00:02:55,730 But, it all started with Mendel and his peas.