0:00:14.739,0:00:16.717 These days scientists know how you inherit 0:00:16.717,0:00:18.468 characteristics from your parents. 0:00:18.468,0:00:19.969 They are able to calculate probabilities 0:00:19.969,0:00:21.187 of having a specific trait 0:00:21.187,0:00:22.479 or getting a genetic disease 0:00:22.479,0:00:23.711 according to the information they have 0:00:23.711,0:00:25.767 from the parents and the family history. 0:00:25.767,0:00:27.791 But how is this possible? 0:00:27.791,0:00:29.114 To understand how traits pass 0:00:29.114,0:00:31.345 from one living being to its descendants, 0:00:31.345,0:00:33.512 we need to go back in time to the 19th century 0:00:33.512,0:00:35.764 and a man named Gregor Mendel. 0:00:35.764,0:00:37.893 Mendel was an Austrian monk and biologist 0:00:37.893,0:00:39.559 who loved to work with plants. 0:00:39.559,0:00:40.507 By breeding the pea plants 0:00:40.507,0:00:42.143 he was growing in the monastery's garden, 0:00:42.143,0:00:44.844 he discovered the principals that rule heredity. 0:00:44.844,0:00:46.317 In one of most classic examples, 0:00:46.317,0:00:48.694 Mendel combined a pure-bred, yellow-seeded plant 0:00:48.694,0:00:50.698 with a pure-bred, green-seeded plant, 0:00:50.698,0:00:52.783 and he got only yellow seeds. 0:00:52.783,0:00:55.151 He called the yellow-colored trait the dominant one 0:00:55.151,0:00:57.507 because it was expressed in all the new seeds. 0:00:57.507,0:01:01.310 Then he let the new yellow-seeded hybrid plants self-fertilize. 0:01:01.310,0:01:02.543 And in this second generation, 0:01:02.543,0:01:04.427 he got both yellow and green seeds, 0:01:04.427,0:01:06.088 which meant that the green trait had been hidden 0:01:06.088,0:01:07.470 by the dominant yellow. 0:01:07.470,0:01:10.014 He called this hidden trait the recessive trait. 0:01:10.014,0:01:11.424 From those results, Mendel inferred 0:01:11.424,0:01:13.927 that each trait depends on a pair of factors, 0:01:13.927,0:01:15.096 one of them coming from the mother 0:01:15.096,0:01:17.105 and the other from the father. 0:01:17.105,0:01:19.064 Now we know that these factors are called alleles 0:01:19.064,0:01:21.525 and represent the different variations of a gene. 0:01:21.525,0:01:23.021 Depending on which type of allele 0:01:23.021,0:01:24.439 Mendel found in each seed, 0:01:24.439,0:01:26.274 we can have what we call a homozygous pea, 0:01:26.274,0:01:27.982 where both alleles are identical, 0:01:27.982,0:01:29.616 and what we call a heterozygous pea, 0:01:29.616,0:01:31.529 when the two alleles are different. 0:01:31.529,0:01:34.340 This combination of alleles is known as genotype 0:01:34.340,0:01:36.367 and its result, being yellow or green, 0:01:36.367,0:01:38.026 is called phenotype. 0:01:38.026,0:01:39.927 To clearly visualize how alleles are distributed 0:01:39.927,0:01:41.014 among its descendants, 0:01:41.014,0:01:43.477 we can use a diagram called the Punnett Square. 0:01:43.477,0:01:45.150 You just place the different alleles on both axes 0:01:45.150,0:01:47.599 and then you figure out the possible combinations. 0:01:47.599,0:01:49.491 Let's look at Mendel's peas, for example. 0:01:49.491,0:01:52.818 Let's write the dominate yellow allele as an upper-case "Y" 0:01:52.818,0:01:55.187 and the recessive green allele as a lower-case "y". 0:01:55.187,0:01:58.193 The upper-case Y always overpowers his lower-case friend, 0:01:58.193,0:01:59.608 so the only time you get green babies 0:01:59.608,0:02:01.985 is if you have lower-case y's. 0:02:01.985,0:02:03.325 In Mendel's first generation, 0:02:03.325,0:02:04.824 the yellow, homozygous pea mom 0:02:04.824,0:02:07.241 will give each pea kid a yellow, dominant allele, 0:02:07.241,0:02:08.952 and the green, homozygous pea dad 0:02:08.952,0:02:10.505 will give a green, recessive allele. 0:02:10.505,0:02:13.206 So, all the pea kids will be yellow, heterozygous. 0:02:13.206,0:02:14.923 Then, in the second generation, 0:02:14.923,0:02:16.742 where the two heterozygous kids marry, 0:02:16.742,0:02:19.949 their babies could have any of the three possible genotypes, 0:02:19.949,0:02:21.199 showing the two possible phenotypes 0:02:21.199,0:02:23.785 in a three-to-one proportion. 0:02:23.785,0:02:25.914 But even peas have a lot of characteristics. 0:02:25.914,0:02:27.583 For example, besides for being yellow or green, 0:02:27.583,0:02:29.468 peas can be round or wrinkled, 0:02:29.468,0:02:31.326 so we could have all these possible combinations: 0:02:31.326,0:02:32.243 round yellow peas, 0:02:32.243,0:02:32.996 round green peas, 0:02:32.996,0:02:33.824 wrinkled yellow peas, 0:02:33.824,0:02:35.467 and wrinkled green peas. 0:02:35.467,0:02:38.059 To calculate the proportions of each genotype and phenotype, 0:02:38.059,0:02:39.601 you can use a Pennett Square too. 0:02:39.601,0:02:42.080 Of course, this will make it a little more complex. 0:02:42.080,0:02:44.600 And lots of things are more complicated than peas, 0:02:44.600,0:02:46.328 like, say, people. 0:02:46.328,0:02:48.109 These days scientists know a lot more 0:02:48.109,0:02:49.578 about genetics and heredity. 0:02:49.578,0:02:50.623 And, there are many other ways 0:02:50.623,0:02:52.532 in which some characteristics are inherited. 0:02:52.532,0:02:54.566 But, it all started with Mendel and his peas.