WEBVTT 00:00:04.662 --> 00:00:06.465 The next time you look in the mirror. 00:00:06.465 --> 00:00:07.585 think about this. 00:00:07.585 --> 00:00:08.432 In many ways, 00:00:08.432 --> 00:00:10.661 you're more microbe than human. 00:00:10.661 --> 00:00:12.283 There are ten times more cells 00:00:12.283 --> 00:00:13.753 from microorganisms - 00:00:13.753 --> 00:00:15.483 bacteria, viruses, fungi- 00:00:15.483 --> 00:00:18.651 than human cells in and on our bodies. 00:00:18.991 --> 00:00:20.391 And our genes are outnumbered 00:00:20.391 --> 00:00:23.742 a hundred to one by microbial genes. 00:00:23.742 --> 00:00:25.214 Scientists even have a name 00:00:25.214 --> 00:00:27.243 for all these microbial genes: 00:00:27.243 --> 00:00:29.386 the human microbiome. 00:00:30.484 --> 00:00:32.323 Now, this might make a lot of people 00:00:32.323 --> 00:00:34.355 rush for the hand sanitizer, 00:00:34.355 --> 00:00:36.035 but it turns out most 00:00:36.035 --> 00:00:38.172 of these microorganisms aren't bad, 00:00:38.172 --> 00:00:40.124 germs that will make us sick, 00:00:40.124 --> 00:00:41.702 most are good. 00:00:41.702 --> 00:00:43.410 And without these good microbes 00:00:43.410 --> 00:00:45.405 our bodies don't seem to do as well. 00:00:45.405 --> 00:00:47.272 We don't seem to be as healthy, 00:00:47.272 --> 00:00:49.166 and we actually might get sick 00:00:49.166 --> 00:00:50.165 more often. 00:00:52.205 --> 00:00:53.272 So one question is: 00:00:53.272 --> 00:00:54.621 where do our microbiomes 00:00:54.621 --> 00:00:56.564 come from in the first place? 00:00:56.564 --> 00:00:57.894 Well, like a lot of things, 00:00:57.894 --> 00:00:59.425 it starts with our mothers. 00:00:59.710 --> 00:01:02.031 As the infant passes through the birth cannal, 00:01:02.031 --> 00:01:04.970 it gets coded with microbes from the mom. 00:01:04.970 --> 00:01:06.822 These microbes may kind of 00:01:06.822 --> 00:01:08.705 seed the baby with just the right mix. 00:01:09.315 --> 00:01:11.205 Combined with bacteria in breast milk 00:01:11.205 --> 00:01:13.405 and other microbes we encounter early on, 00:01:13.405 --> 00:01:15.551 they seem to slowly take shape 00:01:15.551 --> 00:01:18.082 in our first few years of life. 00:01:19.223 --> 00:01:20.933 The overall mix of our microbes 00:01:20.933 --> 00:01:22.693 becomes very personal, 00:01:22.693 --> 00:01:25.674 sort of like a fingerprint, or maybe a blood type. 00:01:25.674 --> 00:01:27.346 But our microbes tend to resemble 00:01:27.346 --> 00:01:29.331 those of our parents and siblings. 00:01:29.331 --> 00:01:32.552 And may stay with us for much of our lives. 00:01:35.714 --> 00:01:38.173 They may also be doing all sorts of things, 00:01:38.173 --> 00:01:40.993 such as educating our immune cells, 00:01:40.993 --> 00:01:41.970 like this one. 00:01:41.970 --> 00:01:43.352 Teaching them the difference 00:01:43.352 --> 00:01:45.232 between things they should fight off 00:01:45.232 --> 00:01:46.903 –bad bugs that might make us sick- 00:01:46.903 --> 00:01:48.704 And things that aren't a threat, 00:01:48.704 --> 00:01:50.603 like our good microbes. 00:01:54.176 --> 00:01:55.455 When we are adults, 00:01:55.455 --> 00:01:57.730 microbes become our first line of defense, 00:01:57.730 --> 00:01:59.700 fighting off germs that try to invade our 00:01:59.700 --> 00:02:01.084 bodies, protecting their 00:02:01.084 --> 00:02:03.012 turf, while protecting our health. 00:02:05.591 --> 00:02:07.325 Scientists have discovered they can 00:02:07.325 --> 00:02:09.752 even spew out their own antibiotics. 00:02:16.172 --> 00:02:18.055 The types of microbes in your body 00:02:18.055 --> 00:02:20.443 vary depending exactly where they live, 00:02:20.443 --> 00:02:23.055 like different ecosystems in nature. 00:02:23.900 --> 00:02:28.192 There are wet places, like our mouths, noses and armpits. 00:02:28.192 --> 00:02:31.014 Oily places, like our scalps and backs. 00:02:31.014 --> 00:02:33.604 And dry places, like our forearms. 00:02:33.604 --> 00:02:35.211 Different species of microbes 00:02:35.211 --> 00:02:38.306 have adapted to each of these habitats. 00:02:40.503 --> 00:02:43.181 The biggest, most important microbial habitat 00:02:43.181 --> 00:02:45.533 seems to be in the gut. 00:02:45.533 --> 00:02:47.855 It's the most complex, the most diverse, 00:02:47.855 --> 00:02:49.732 and everything microbes are doing 00:02:49.732 --> 00:02:51.552 everywhere else in our bodies: 00:02:51.552 --> 00:02:52.854 fighting off infections, 00:02:52.854 --> 00:02:55.856 revving up and dampening down our immune systems, 00:02:55.856 --> 00:02:57.284 signaling cells... 00:02:57.284 --> 00:03:00.083 That's all happening in the gut in spades. 00:03:00.083 --> 00:03:03.782 They even seem to help regulate our metabolisms. 00:03:03.782 --> 00:03:05.344 How much energy we burn, 00:03:05.344 --> 00:03:07.165 and how much fat we store. 00:03:07.303 --> 00:03:09.852 So, if it's not functioning properly for some reason 00:03:09.852 --> 00:03:12.686 because of what we eat, antibiotics we take, 00:03:12.686 --> 00:03:15.945 that may actually lead to all kinds of diseases. 00:03:15.945 --> 00:03:18.521 Diseases like colon cancer, colitis, 00:03:18.521 --> 00:03:21.550 maybe even diabetes and obesity. 00:03:24.954 --> 00:03:26.583 Some scientists think one reason 00:03:26.583 --> 00:03:28.282 a lot of diseases are increasing 00:03:28.282 --> 00:03:31.394 is because we've lost key gut microbes. 00:03:31.394 --> 00:03:34.694 Our microbiomes look far less diverse compared to those 00:03:34.694 --> 00:03:36.034 compared to those of people 00:03:36.034 --> 00:03:38.794 in less developed countries and earlier generations. 00:03:38.794 --> 00:03:40.124 And remember how we get 00:03:40.124 --> 00:03:41.882 our microbiomes in the first place? 00:03:41.882 --> 00:03:43.683 From our mothers when we are born, 00:03:43.683 --> 00:03:45.060 and from breast milk? 00:03:45.060 --> 00:03:46.821 Well, some scientists think that 00:03:46.821 --> 00:03:48.914 too many babies aren't getting that, 00:03:48.914 --> 00:03:50.475 because of all the C-sections, 00:03:50.475 --> 00:03:52.297 and not enough breast feeding, 00:03:52.297 --> 00:03:55.112 plus all the antibiotics kids get these days, 00:03:55.112 --> 00:03:58.055 and our obsession with cleanliness. 00:03:58.055 --> 00:03:59.994 All this may help explain why problems 00:03:59.994 --> 00:04:02.315 like asthma and allergies, have been soaring 00:04:02.315 --> 00:04:04.784 Maybe because our microbiomes 00:04:04.784 --> 00:04:06.314 never taught our immune systems 00:04:06.314 --> 00:04:08.694 how to work the right way. 00:04:12.245 --> 00:04:14.216 Maybe swallowing good microbes probiotics 00:04:15.213 --> 00:04:17.473 could prevent and treat some diseases. 00:04:17.745 --> 00:04:19.682 So could taking prebiotics 00:04:19.682 --> 00:04:22.033 essentially food that good microbes love. 00:04:29.083 --> 00:04:30.951 We end our story with a reminder. 00:04:30.951 --> 00:04:32.984 This research is really new, 00:04:32.984 --> 00:04:34.541 we still have a lot to learn 00:04:34.541 --> 00:04:36.101 about what many of our microbes 00:04:36.101 --> 00:04:37.355 are really doing. 00:04:37.355 --> 00:04:38.563 But scientists say that 00:04:38.563 --> 00:04:40.471 it's getting clearer and clearer that 00:04:40.471 --> 00:04:43.504 the tiny organisms all over our bodies 00:04:43.504 --> 00:04:47.143 are essential to our health and happiness.