1 00:00:04,662 --> 00:00:06,465 The next time you look in the mirror. 2 00:00:06,465 --> 00:00:07,585 think about this. 3 00:00:07,585 --> 00:00:08,432 In many ways, 4 00:00:08,432 --> 00:00:10,661 you're more microbe than human. 5 00:00:10,661 --> 00:00:12,283 There are ten times more cells 6 00:00:12,283 --> 00:00:13,753 from microorganisms - 7 00:00:13,753 --> 00:00:15,483 bacteria, viruses, fungi- 8 00:00:15,483 --> 00:00:18,651 than human cells in and on our bodies. 9 00:00:18,991 --> 00:00:20,391 And our genes are outnumbered 10 00:00:20,391 --> 00:00:23,742 a hundred to one by microbial genes. 11 00:00:23,742 --> 00:00:25,214 Scientists even have a name 12 00:00:25,214 --> 00:00:27,243 for all these microbial genes: 13 00:00:27,243 --> 00:00:29,386 the human microbiome. 14 00:00:30,484 --> 00:00:32,323 Now, this might make a lot of people 15 00:00:32,323 --> 00:00:34,355 rush for the hand sanitizer, 16 00:00:34,355 --> 00:00:36,035 but it turns out most 17 00:00:36,035 --> 00:00:38,172 of these microorganisms aren't bad, 18 00:00:38,172 --> 00:00:40,124 germs that will make us sick, 19 00:00:40,124 --> 00:00:41,702 most are good. 20 00:00:41,702 --> 00:00:43,410 And without these good microbes 21 00:00:43,410 --> 00:00:45,405 our bodies don't seem to do as well. 22 00:00:45,405 --> 00:00:47,272 We don't seem to be as healthy, 23 00:00:47,272 --> 00:00:49,166 and we actually might get sick 24 00:00:49,166 --> 00:00:50,165 more often. 25 00:00:52,205 --> 00:00:53,272 So one question is: 26 00:00:53,272 --> 00:00:54,621 where do our microbiomes 27 00:00:54,621 --> 00:00:56,564 come from in the first place? 28 00:00:56,564 --> 00:00:57,894 Well, like a lot of things, 29 00:00:57,894 --> 00:00:59,425 it starts with our mothers. 30 00:00:59,710 --> 00:01:02,031 As the infant passes through the birth cannal, 31 00:01:02,031 --> 00:01:04,970 it gets coded with microbes from the mom. 32 00:01:04,970 --> 00:01:06,822 These microbes may kind of 33 00:01:06,822 --> 00:01:08,705 seed the baby with just the right mix. 34 00:01:09,315 --> 00:01:11,205 Combined with bacteria in breast milk 35 00:01:11,205 --> 00:01:13,405 and other microbes we encounter early on, 36 00:01:13,405 --> 00:01:15,551 they seem to slowly take shape 37 00:01:15,551 --> 00:01:18,082 in our first few years of life. 38 00:01:19,223 --> 00:01:20,933 The overall mix of our microbes 39 00:01:20,933 --> 00:01:22,693 becomes very personal, 40 00:01:22,693 --> 00:01:25,674 sort of like a fingerprint, or maybe a blood type. 41 00:01:25,674 --> 00:01:27,346 But our microbes tend to resemble 42 00:01:27,346 --> 00:01:29,331 those of our parents and siblings. 43 00:01:29,331 --> 00:01:32,552 And may stay with us for much of our lives. 44 00:01:35,714 --> 00:01:38,173 They may also be doing all sorts of things, 45 00:01:38,173 --> 00:01:40,993 such as educating our immune cells, 46 00:01:40,993 --> 00:01:41,970 like this one. 47 00:01:41,970 --> 00:01:43,352 Teaching them the difference 48 00:01:43,352 --> 00:01:45,232 between things they should fight off 49 00:01:45,232 --> 00:01:46,903 –bad bugs that might make us sick- 50 00:01:46,903 --> 00:01:48,704 And things that aren't a threat, 51 00:01:48,704 --> 00:01:50,603 like our good microbes. 52 00:01:54,176 --> 00:01:55,455 When we are adults, 53 00:01:55,455 --> 00:01:57,730 microbes become our first line of defense, 54 00:01:57,730 --> 00:01:59,700 fighting off germs that try to invade our 55 00:01:59,700 --> 00:02:01,084 bodies, protecting their 56 00:02:01,084 --> 00:02:03,012 turf, while protecting our health. 57 00:02:05,591 --> 00:02:07,325 Scientists have discovered they can 58 00:02:07,325 --> 00:02:09,752 even spew out their own antibiotics. 59 00:02:16,172 --> 00:02:18,055 The types of microbes in your body 60 00:02:18,055 --> 00:02:20,443 vary depending exactly where they live, 61 00:02:20,443 --> 00:02:23,055 like different ecosystems in nature. 62 00:02:23,900 --> 00:02:28,192 There are wet places, like our mouths, noses and armpits. 63 00:02:28,192 --> 00:02:31,014 Oily places, like our scalps and backs. 64 00:02:31,014 --> 00:02:33,604 And dry places, like our forearms. 65 00:02:33,604 --> 00:02:35,211 Different species of microbes 66 00:02:35,211 --> 00:02:38,306 have adapted to each of these habitats. 67 00:02:40,503 --> 00:02:43,181 The biggest, most important microbial habitat 68 00:02:43,181 --> 00:02:45,533 seems to be in the gut. 69 00:02:45,533 --> 00:02:47,855 It's the most complex, the most diverse, 70 00:02:47,855 --> 00:02:49,732 and everything microbes are doing 71 00:02:49,732 --> 00:02:51,552 everywhere else in our bodies: 72 00:02:51,552 --> 00:02:52,854 fighting off infections, 73 00:02:52,854 --> 00:02:55,856 revving up and dampening down our immune systems, 74 00:02:55,856 --> 00:02:57,284 signaling cells... 75 00:02:57,284 --> 00:03:00,083 That's all happening in the gut in spades. 76 00:03:00,083 --> 00:03:03,782 They even seem to help regulate our metabolisms. 77 00:03:03,782 --> 00:03:05,344 How much energy we burn, 78 00:03:05,344 --> 00:03:07,165 and how much fat we store. 79 00:03:07,303 --> 00:03:09,852 So, if it's not functioning properly for some reason 80 00:03:09,852 --> 00:03:12,686 because of what we eat, antibiotics we take, 81 00:03:12,686 --> 00:03:15,945 that may actually lead to all kinds of diseases. 82 00:03:15,945 --> 00:03:18,521 Diseases like colon cancer, colitis, 83 00:03:18,521 --> 00:03:21,550 maybe even diabetes and obesity. 84 00:03:24,954 --> 00:03:26,583 Some scientists think one reason 85 00:03:26,583 --> 00:03:28,282 a lot of diseases are increasing 86 00:03:28,282 --> 00:03:31,394 is because we've lost key gut microbes. 87 00:03:31,394 --> 00:03:34,694 Our microbiomes look far less diverse compared to those 88 00:03:34,694 --> 00:03:36,034 compared to those of people 89 00:03:36,034 --> 00:03:38,794 in less developed countries and earlier generations. 90 00:03:38,794 --> 00:03:40,124 And remember how we get 91 00:03:40,124 --> 00:03:41,882 our microbiomes in the first place? 92 00:03:41,882 --> 00:03:43,683 From our mothers when we are born, 93 00:03:43,683 --> 00:03:45,060 and from breast milk? 94 00:03:45,060 --> 00:03:46,821 Well, some scientists think that 95 00:03:46,821 --> 00:03:48,914 too many babies aren't getting that, 96 00:03:48,914 --> 00:03:50,475 because of all the C-sections, 97 00:03:50,475 --> 00:03:52,297 and not enough breast feeding, 98 00:03:52,297 --> 00:03:55,112 plus all the antibiotics kids get these days, 99 00:03:55,112 --> 00:03:58,055 and our obsession with cleanliness. 100 00:03:58,055 --> 00:03:59,994 All this may help explain why problems 101 00:03:59,994 --> 00:04:02,315 like asthma and allergies, have been soaring 102 00:04:02,315 --> 00:04:04,784 Maybe because our microbiomes 103 00:04:04,784 --> 00:04:06,314 never taught our immune systems 104 00:04:06,314 --> 00:04:08,694 how to work the right way. 105 00:04:12,245 --> 00:04:14,216 Maybe swallowing good microbes probiotics 106 00:04:15,213 --> 00:04:17,473 could prevent and treat some diseases. 107 00:04:17,745 --> 00:04:19,682 So could taking prebiotics 108 00:04:19,682 --> 00:04:22,033 essentially food that good microbes love. 109 00:04:29,083 --> 00:04:30,951 We end our story with a reminder. 110 00:04:30,951 --> 00:04:32,984 This research is really new, 111 00:04:32,984 --> 00:04:34,541 we still have a lot to learn 112 00:04:34,541 --> 00:04:36,101 about what many of our microbes 113 00:04:36,101 --> 00:04:37,355 are really doing. 114 00:04:37,355 --> 00:04:38,563 But scientists say that 115 00:04:38,563 --> 00:04:40,471 it's getting clearer and clearer that 116 00:04:40,471 --> 00:04:43,504 the tiny organisms all over our bodies 117 00:04:43,504 --> 00:04:47,143 are essential to our health and happiness.