[Script Info] Title: [Events] Format: Layer, Start, End, Style, Name, MarginL, MarginR, MarginV, Effect, Text Dialogue: 0,0:00:07.09,0:00:10.30,Default,,0000,0000,0000,,zero waa Dialogue: 0,0:00:10.30,0:00:12.24,Default,,0000,0000,0000,,resolved Dialogue: 0,0:00:12.24,0:00:13.00,Default,,0000,0000,0000,,monday we'd Dialogue: 0,0:00:13.00,0:00:15.76,Default,,0000,0000,0000,,uh... laid out for you Dialogue: 0,0:00:15.76,0:00:20.50,Default,,0000,0000,0000,,many of the general concepts about meal\Nplaces Dialogue: 0,0:00:20.50,0:00:22.03,Default,,0000,0000,0000,,and malignant Dialogue: 0,0:00:22.03,0:00:23.02,Default,,0000,0000,0000,,and vote today Dialogue: 0,0:00:23.02,0:00:26.62,Default,,0000,0000,0000,,uh... were a lot of them for the most\Npart of his finish up here in a Dialogue: 0,0:00:26.62,0:00:28.90,Default,,0000,0000,0000,,direction the neoplasms Dialogue: 0,0:00:28.90,0:00:31.62,Default,,0000,0000,0000,,fighting the look of a lack of once\Ntopic Dialogue: 0,0:00:31.62,0:00:32.10,Default,,0000,0000,0000,,pictures show Dialogue: 0,0:00:32.10,0:00:36.05,Default,,0000,0000,0000,,of a variety of not a man woman and\Nstuff Dialogue: 0,0:00:36.05,0:00:39.06,Default,,0000,0000,0000,,tumors so that you can appreciate the Dialogue: 0,0:00:39.06,0:00:42.08,Default,,0000,0000,0000,,polyimide president clinton please Dialogue: 0,0:00:42.08,0:00:44.04,Default,,0000,0000,0000,,attorneys are really Dialogue: 0,0:00:44.04,0:00:46.16,Default,,0000,0000,0000,,and kind of the uh... Dialogue: 0,0:00:46.16,0:00:49.06,Default,,0000,0000,0000,,broad array of things that can happen Dialogue: 0,0:00:49.06,0:00:54.09,Default,,0000,0000,0000,,to give you an beginning him along the\Nlancaster neoplasms lasted goal for Dialogue: 0,0:00:54.09,0:00:55.59,Default,,0000,0000,0000,,today Dialogue: 0,0:00:55.59,0:00:57.02,Default,,0000,0000,0000,,as the florida Dialogue: 0,0:00:57.02,0:01:00.15,Default,,0000,0000,0000,,begin until and i think we we are told Dialogue: 0,0:01:00.15,0:01:01.10,Default,,0000,0000,0000,,asked that question Dialogue: 0,0:01:01.10,0:01:03.07,Default,,0000,0000,0000,,so it doesn't get lost Dialogue: 0,0:01:03.07,0:01:06.07,Default,,0000,0000,0000,,is ok we got all the cells Dialogue: 0,0:01:06.07,0:01:08.01,Default,,0000,0000,0000,,benign or malignant Dialogue: 0,0:01:08.01,0:01:12.06,Default,,0000,0000,0000,,what differences that make to the host\Nin other words what is the impact of Dialogue: 0,0:01:12.06,0:01:15.03,Default,,0000,0000,0000,,bridge america is taking what is the\Nimpact Dialogue: 0,0:01:15.03,0:01:16.09,Default,,0000,0000,0000,,of uh... Dialogue: 0,0:01:16.09,0:01:19.09,Default,,0000,0000,0000,,neoplasm anomalous Dialogue: 0,0:01:19.09,0:01:21.01,Default,,0000,0000,0000,,this outline Dialogue: 0,0:01:21.01,0:01:24.00,Default,,0000,0000,0000,,is a good way to go out at the Dialogue: 0,0:01:24.00,0:01:27.72,Default,,0000,0000,0000,,let's take perfectly benign neoplasms\Nthey're not Dialogue: 0,0:01:27.72,0:01:29.06,Default,,0000,0000,0000,,invasive Dialogue: 0,0:01:29.06,0:01:31.02,Default,,0000,0000,0000,,metastatic Dialogue: 0,0:01:31.02,0:01:32.01,Default,,0000,0000,0000,,questionnaires Dialogue: 0,0:01:32.01,0:01:35.37,Default,,0000,0000,0000,,raghavan i neoplasm what going to do the\Nhost Dialogue: 0,0:01:35.37,0:01:38.08,Default,,0000,0000,0000,,for most of the facts are going to be\Nlocal Dialogue: 0,0:01:38.08,0:01:41.04,Default,,0000,0000,0000,,if you receive the cartoon that i sure\Ndo Dialogue: 0,0:01:41.04,0:01:45.62,Default,,0000,0000,0000,,it's just a next like an expanding\Nballoon locally in some areas Dialogue: 0,0:01:45.62,0:01:47.01,Default,,0000,0000,0000,,then you would predict that Dialogue: 0,0:01:47.01,0:01:52.00,Default,,0000,0000,0000,,there are the first thing at a benign\Nneoplasm lewis's produce some local Dialogue: 0,0:01:52.00,0:01:53.04,Default,,0000,0000,0000,,mechanical effects Dialogue: 0,0:01:53.04,0:01:57.55,Default,,0000,0000,0000,,now these very from trivial to lethal Dialogue: 0,0:01:57.55,0:01:58.08,Default,,0000,0000,0000,,if you had a Dialogue: 0,0:01:58.08,0:02:01.01,Default,,0000,0000,0000,,a marble sized Dialogue: 0,0:02:01.01,0:02:04.05,Default,,0000,0000,0000,,benign neoplasm one-year love handles\Nhere Dialogue: 0,0:02:04.05,0:02:08.00,Default,,0000,0000,0000,,there'd be a couple of you in the world\Ni would know about it Dialogue: 0,0:02:08.00,0:02:11.01,Default,,0000,0000,0000,,maybe two more than that but Dialogue: 0,0:02:11.01,0:02:13.26,Default,,0000,0000,0000,,ferrier area where it would be trivial Dialogue: 0,0:02:13.26,0:02:18.18,Default,,0000,0000,0000,,uh... i and the other hand it could be\Nother cosmetic importance you wouldn't Dialogue: 0,0:02:18.18,0:02:23.19,Default,,0000,0000,0000,,want to benign neoplasms sizable walnut\Nthan the tip of your nose Dialogue: 0,0:02:23.19,0:02:26.02,Default,,0000,0000,0000,,biologically not terribly threatening\Nbut uh... Dialogue: 0,0:02:26.02,0:02:27.14,Default,,0000,0000,0000,,bad anyway Dialogue: 0,0:02:27.14,0:02:28.72,Default,,0000,0000,0000,,uh... Dialogue: 0,0:02:28.72,0:02:30.03,Default,,0000,0000,0000,,i mentioned result Dialogue: 0,0:02:30.03,0:02:35.00,Default,,0000,0000,0000,,this is something to keep your eye and\Nyou can buy of a benign neoplasm sounds Dialogue: 0,0:02:35.00,0:02:36.46,Default,,0000,0000,0000,,like a black see more Dialogue: 0,0:02:36.46,0:02:41.84,Default,,0000,0000,0000,,but think of an expanding the nine-year\Nplasma confines of the cranial Dialogue: 0,0:02:41.84,0:02:43.04,Default,,0000,0000,0000,,there's no room in there Dialogue: 0,0:02:43.04,0:02:45.32,Default,,0000,0000,0000,,as it starts growing as consumers Dialogue: 0,0:02:45.32,0:02:49.06,Default,,0000,0000,0000,,related press on something vital in the\Nbrain and you could produce if it's not Dialogue: 0,0:02:49.06,0:02:51.50,Default,,0000,0000,0000,,interrupted could produce death Dialogue: 0,0:02:51.50,0:02:55.07,Default,,0000,0000,0000,,so benign neoplasms can kill generally Dialogue: 0,0:02:55.07,0:02:58.01,Default,,0000,0000,0000,,by something going on Dialogue: 0,0:02:58.01,0:02:59.71,Default,,0000,0000,0000,,mechanically Dialogue: 0,0:02:59.71,0:03:01.47,Default,,0000,0000,0000,,ka Dialogue: 0,0:03:01.47,0:03:02.89,Default,,0000,0000,0000,,nine-year plasmids Dialogue: 0,0:03:02.89,0:03:06.92,Default,,0000,0000,0000,,as it's expanding locally again you\Nthink just about cartoon Dialogue: 0,0:03:06.92,0:03:10.47,Default,,0000,0000,0000,,it's going to press on adjacent\Nstructures Dialogue: 0,0:03:10.47,0:03:14.02,Default,,0000,0000,0000,,as it expands in that made the strongly Dialogue: 0,0:03:14.02,0:03:18.00,Default,,0000,0000,0000,,adjacent structures just by sitting on\Nit Dialogue: 0,0:03:18.00,0:03:21.82,Default,,0000,0000,0000,,knock off the function of over one\Ntissue or another selection b Dialogue: 0,0:03:21.82,0:03:25.35,Default,,0000,0000,0000,,uh... quite significant and that's all Dialogue: 0,0:03:25.35,0:03:26.64,Default,,0000,0000,0000,,based on our Dialogue: 0,0:03:26.64,0:03:29.03,Default,,0000,0000,0000,,adjust the expansion of the benign\Nneoplasm Dialogue: 0,0:03:29.03,0:03:32.85,Default,,0000,0000,0000,,now i have mentioned local complications\Nhere Dialogue: 0,0:03:32.85,0:03:34.02,Default,,0000,0000,0000,,these are sort of Dialogue: 0,0:03:34.02,0:03:37.24,Default,,0000,0000,0000,,secondary things that may occur and they\Nmay be very important Dialogue: 0,0:03:37.24,0:03:41.35,Default,,0000,0000,0000,,a benign neoplasm growing under a\Nsurface may expand to the point where Dialogue: 0,0:03:41.35,0:03:43.89,Default,,0000,0000,0000,,the surface all straight silver Dialogue: 0,0:03:43.89,0:03:45.86,Default,,0000,0000,0000,,then there may be hemorrhage Dialogue: 0,0:03:45.86,0:03:48.65,Default,,0000,0000,0000,,could be trivial could really thought\Nthat they could be hemorrhage from such Dialogue: 0,0:03:48.65,0:03:49.10,Default,,0000,0000,0000,,an australian area Dialogue: 0,0:03:49.10,0:03:51.98,Default,,0000,0000,0000,,or there might be infection Dialogue: 0,0:03:51.98,0:03:54.01,Default,,0000,0000,0000,,these are sort of secondary Dialogue: 0,0:03:54.01,0:03:58.86,Default,,0000,0000,0000,,uh... complications of of the local\Nmechanical situation Dialogue: 0,0:03:58.86,0:04:01.85,Default,,0000,0000,0000,,uh... or the other thing is the Dialogue: 0,0:04:01.85,0:04:04.82,Default,,0000,0000,0000,,uh... benign you pleasant unplug the\Nplumbing Dialogue: 0,0:04:04.82,0:04:08.71,Default,,0000,0000,0000,,so the wall of a doctor pressing on a\Nvessel or something of that sort it can Dialogue: 0,0:04:08.71,0:04:11.30,Default,,0000,0000,0000,,produce obstruction is very significant Dialogue: 0,0:04:11.30,0:04:13.95,Default,,0000,0000,0000,,these are all sort of local effects Dialogue: 0,0:04:13.95,0:04:18.98,Default,,0000,0000,0000,,there's one x sort of exception to this\Nand i've listed systemic and the crying Dialogue: 0,0:04:18.98,0:04:20.21,Default,,0000,0000,0000,,effects Dialogue: 0,0:04:20.21,0:04:22.59,Default,,0000,0000,0000,,their runs something like this Dialogue: 0,0:04:22.59,0:04:27.01,Default,,0000,0000,0000,,you had a good remember i told you the\Nbenign neoplasms are Dialogue: 0,0:04:27.01,0:04:29.39,Default,,0000,0000,0000,,almost invariably very well\Ndifferentiated Dialogue: 0,0:04:29.39,0:04:32.28,Default,,0000,0000,0000,,mhm means they resemble a parental\Ntissue Dialogue: 0,0:04:32.28,0:04:36.73,Default,,0000,0000,0000,,you have a benign neoplasms arising from\Nan end to the crime that is from the Dialogue: 0,0:04:36.73,0:04:37.06,Default,,0000,0000,0000,,hormone Dialogue: 0,0:04:37.06,0:04:39.79,Default,,0000,0000,0000,,secreting tissue Dialogue: 0,0:04:39.79,0:04:44.64,Default,,0000,0000,0000,,it may well be so well differentiated\Nthat it mimics the adult issued by Dialogue: 0,0:04:44.64,0:04:45.04,Default,,0000,0000,0000,,secreting Dialogue: 0,0:04:45.04,0:04:47.07,Default,,0000,0000,0000,,a particular hormone Dialogue: 0,0:04:47.07,0:04:50.06,Default,,0000,0000,0000,,that ordinarily comes from that issue Dialogue: 0,0:04:50.06,0:04:53.00,Default,,0000,0000,0000,,the difference though is Dialogue: 0,0:04:53.00,0:04:55.39,Default,,0000,0000,0000,,being autonomous Dialogue: 0,0:04:55.39,0:04:57.04,Default,,0000,0000,0000,,and out of control of the body Dialogue: 0,0:04:57.04,0:05:01.03,Default,,0000,0000,0000,,this tumor will produce gobs of that\Nhormone Dialogue: 0,0:05:01.03,0:05:04.00,Default,,0000,0000,0000,,and then the patient may present Dialogue: 0,0:05:04.00,0:05:07.01,Default,,0000,0000,0000,,little really tiny tumor somewhere may\Npresent Dialogue: 0,0:05:07.01,0:05:12.64,Default,,0000,0000,0000,,tremendous number of signs and symptoms\Ndue in excess of a particular hormone Dialogue: 0,0:05:12.64,0:05:17.69,Default,,0000,0000,0000,,so in that regard even a local benign\Nneoplasm could produce Dialogue: 0,0:05:17.69,0:05:18.71,Default,,0000,0000,0000,,systemic Dialogue: 0,0:05:18.71,0:05:22.07,Default,,0000,0000,0000,,and the crime effects Dialogue: 0,0:05:22.07,0:05:24.00,Default,,0000,0000,0000,,now Dialogue: 0,0:05:24.00,0:05:28.02,Default,,0000,0000,0000,,when we go over to the to the other side\Nand we say what to malignant neoplasms Dialogue: 0,0:05:28.02,0:05:29.01,Default,,0000,0000,0000,,do Dialogue: 0,0:05:29.01,0:05:33.99,Default,,0000,0000,0000,,the first answer is very loudly all of\Nthe above Dialogue: 0,0:05:33.99,0:05:34.10,Default,,0000,0000,0000,,except now Dialogue: 0,0:05:34.10,0:05:36.56,Default,,0000,0000,0000,,instead of just Dialogue: 0,0:05:36.56,0:05:40.88,Default,,0000,0000,0000,,serb pressing the adjacent tissue\Nmalignant neoplasm which is cable Dialogue: 0,0:05:40.88,0:05:41.06,Default,,0000,0000,0000,,invasion can Dialogue: 0,0:05:41.06,0:05:44.80,Default,,0000,0000,0000,,can destroy the reputation by invading n Dialogue: 0,0:05:44.80,0:05:50.07,Default,,0000,0000,0000,,and compress it can can violate ducks\Nand other structures by invading Dialogue: 0,0:05:50.07,0:05:55.00,Default,,0000,0000,0000,,many malignant neoplasms grow much more\Nrapidly this is not rulebook grow more Dialogue: 0,0:05:55.00,0:05:56.08,Default,,0000,0000,0000,,rapidly than benign ones Dialogue: 0,0:05:56.08,0:05:58.01,Default,,0000,0000,0000,,so it really does Dialogue: 0,0:05:58.01,0:06:01.05,Default,,0000,0000,0000,,all of the above with a vengeance Dialogue: 0,0:06:01.05,0:06:05.00,Default,,0000,0000,0000,,and also any given much castesystem\Nthere could be dozens or hundreds of the Dialogue: 0,0:06:05.00,0:06:08.07,Default,,0000,0000,0000,,past the seized in any given the task\Nforces can raise Dialogue: 0,0:06:08.07,0:06:09.06,Default,,0000,0000,0000,,local health Dialogue: 0,0:06:09.06,0:06:11.06,Default,,0000,0000,0000,,wherever it happens to be Dialogue: 0,0:06:11.06,0:06:13.20,Default,,0000,0000,0000,,so you can see that ah... Dialogue: 0,0:06:13.20,0:06:15.08,Default,,0000,0000,0000,,that all of the above is where the real Dialogue: 0,0:06:15.08,0:06:17.00,Default,,0000,0000,0000,,exclamation point Dialogue: 0,0:06:17.00,0:06:18.67,Default,,0000,0000,0000,,um... Dialogue: 0,0:06:18.67,0:06:20.25,Default,,0000,0000,0000,,and crime Dialogue: 0,0:06:20.25,0:06:20.92,Default,,0000,0000,0000,,cancers Dialogue: 0,0:06:20.92,0:06:25.20,Default,,0000,0000,0000,,can also secrete excess hormone just\Nlike the nine and the crime Dialogue: 0,0:06:25.20,0:06:26.07,Default,,0000,0000,0000,,so any of those things Dialogue: 0,0:06:26.07,0:06:28.73,Default,,0000,0000,0000,,that are listed up here you can see Dialogue: 0,0:06:28.73,0:06:32.38,Default,,0000,0000,0000,,now there is there a couple of other\Nthings uh... Dialogue: 0,0:06:32.38,0:06:36.32,Default,,0000,0000,0000,,unless i want to go understandably said\Na conceptual level Dialogue: 0,0:06:36.32,0:06:37.05,Default,,0000,0000,0000,,that uh... Dialogue: 0,0:06:37.05,0:06:42.01,Default,,0000,0000,0000,,malignant neoplasms may be associated\Nwith some very very significant systemic Dialogue: 0,0:06:42.01,0:06:44.00,Default,,0000,0000,0000,,changes Dialogue: 0,0:06:44.00,0:06:47.90,Default,,0000,0000,0000,,and uh... one of them that you may be\Nfamiliar with from Dialogue: 0,0:06:47.90,0:06:51.62,Default,,0000,0000,0000,,for milliliter answer or friends of\Nfriends of friends Dialogue: 0,0:06:51.62,0:06:52.09,Default,,0000,0000,0000,,these are the Dialogue: 0,0:06:52.09,0:06:54.54,Default,,0000,0000,0000,,buff Dialogue: 0,0:06:54.54,0:06:56.06,Default,,0000,0000,0000,,twinkly cancer patients Dialogue: 0,0:06:56.06,0:06:58.62,Default,,0000,0000,0000,,will answer phase of disease Dialogue: 0,0:06:58.62,0:07:00.76,Default,,0000,0000,0000,,where they lose their appetites Dialogue: 0,0:07:00.76,0:07:02.06,Default,,0000,0000,0000,,we begin to lose weight Dialogue: 0,0:07:02.06,0:07:05.10,Default,,0000,0000,0000,,the weight comes highly awesome Dialogue: 0,0:07:05.10,0:07:08.94,Default,,0000,0000,0000,,and they get weaker and weaker and\Nweaker and just Dialogue: 0,0:07:08.94,0:07:10.41,Default,,0000,0000,0000,,do windows Dialogue: 0,0:07:10.41,0:07:13.08,Default,,0000,0000,0000,,and very often Dialogue: 0,0:07:13.08,0:07:17.99,Default,,0000,0000,0000,,so we could their beds have some in the\Nfinal event in their lives is nemo near Dialogue: 0,0:07:17.99,0:07:22.42,Default,,0000,0000,0000,,which overtakes typically will only take\Na belfast patient like that Dialogue: 0,0:07:22.42,0:07:26.54,Default,,0000,0000,0000,,we refer to their way sort of wasting\Nsyndrome Dialogue: 0,0:07:26.54,0:07:28.100,Default,,0000,0000,0000,,as cake x_-ers Dialogue: 0,0:07:28.100,0:07:30.54,Default,,0000,0000,0000,,there's the spelling for it Dialogue: 0,0:07:30.54,0:07:34.09,Default,,0000,0000,0000,,as a general term but here we're talking\Nabout cancer coq xy and other words are Dialogue: 0,0:07:34.09,0:07:39.26,Default,,0000,0000,0000,,talking about a patient becoming a\Nnation and wasted because of the cancer Dialogue: 0,0:07:39.26,0:07:40.10,Default,,0000,0000,0000,,being there Dialogue: 0,0:07:40.10,0:07:45.06,Default,,0000,0000,0000,,when i was a kid in pathologies that\Nteach that this is simply a caloric Dialogue: 0,0:07:45.06,0:07:49.39,Default,,0000,0000,0000,,matter we had a rapidly growing tumor\Nwhich isn't enough calories competing Dialogue: 0,0:07:49.39,0:07:53.13,Default,,0000,0000,0000,,with the host the host lost appetite\Nalong the way Dialogue: 0,0:07:53.13,0:07:54.08,Default,,0000,0000,0000,,and that was that Dialogue: 0,0:07:54.08,0:07:58.00,Default,,0000,0000,0000,,we just lost weight on behalf of the\Njury Dialogue: 0,0:07:58.00,0:08:02.01,Default,,0000,0000,0000,,we now know that that's the only a small\Npart of the story Dialogue: 0,0:08:02.01,0:08:06.60,Default,,0000,0000,0000,,how this is a rather complex business\Nrelated and i would lead to a cytochrome Dialogue: 0,0:08:06.60,0:08:09.54,Default,,0000,0000,0000,,site a kind secretion on the part of the Dialogue: 0,0:08:09.54,0:08:11.17,Default,,0000,0000,0000,,as a gross Dialogue: 0,0:08:11.17,0:08:15.78,Default,,0000,0000,0000,,but be aware that very often in patients\Nwith cancer you see this as syndrome of Dialogue: 0,0:08:15.78,0:08:18.51,Default,,0000,0000,0000,,cake axia Dialogue: 0,0:08:18.51,0:08:19.01,Default,,0000,0000,0000,,there are Dialogue: 0,0:08:19.01,0:08:23.07,Default,,0000,0000,0000,,also in this is an important general\Nconcept that i want to get lost in the Dialogue: 0,0:08:23.07,0:08:25.82,Default,,0000,0000,0000,,specifics but there are other Dialogue: 0,0:08:25.82,0:08:28.08,Default,,0000,0000,0000,,symptom complex is that is a syndromes Dialogue: 0,0:08:28.08,0:08:30.73,Default,,0000,0000,0000,,in patients with cancer Dialogue: 0,0:08:30.73,0:08:32.06,Default,,0000,0000,0000,,that you cannot explain Dialogue: 0,0:08:32.06,0:08:35.08,Default,,0000,0000,0000,,uh... by local effects Dialogue: 0,0:08:35.08,0:08:36.08,Default,,0000,0000,0000,,mechanical effects Dialogue: 0,0:08:36.08,0:08:40.05,Default,,0000,0000,0000,,that you can't that they're not\Nexplainable on the basis of a Dialogue: 0,0:08:40.05,0:08:44.02,Default,,0000,0000,0000,,predictable and the crying secretion in\Nother words it's not that this is a Dialogue: 0,0:08:44.02,0:08:45.01,Default,,0000,0000,0000,,cancer that's Dialogue: 0,0:08:45.01,0:08:49.07,Default,,0000,0000,0000,,we know is making insulin and therefore\Nbeginning insulin sometimes it's not Dialogue: 0,0:08:49.07,0:08:50.00,Default,,0000,0000,0000,,that Dialogue: 0,0:08:50.00,0:08:51.05,Default,,0000,0000,0000,,uh... Dialogue: 0,0:08:51.05,0:08:54.40,Default,,0000,0000,0000,,we find some very weird Dialogue: 0,0:08:54.40,0:08:57.04,Default,,0000,0000,0000,,syndromes affecting a variety of organ\Nsystems Dialogue: 0,0:08:57.04,0:08:59.07,Default,,0000,0000,0000,,that are june should be Dialogue: 0,0:08:59.07,0:09:02.05,Default,,0000,0000,0000,,presence of the cancer's not\Nmechanically but the president cancer in Dialogue: 0,0:09:02.05,0:09:04.10,Default,,0000,0000,0000,,the body and these are referred to is Dialogue: 0,0:09:04.10,0:09:07.05,Default,,0000,0000,0000,,para neil plastic syndromes Dialogue: 0,0:09:07.05,0:09:12.02,Default,,0000,0000,0000,,and i want you to to get an idea that\Nconcept not the details of the various Dialogue: 0,0:09:12.02,0:09:13.09,Default,,0000,0000,0000,,syndromes Dialogue: 0,0:09:13.09,0:09:17.03,Default,,0000,0000,0000,,they're important because first of all\Nthey may be a greater problem to the Dialogue: 0,0:09:17.03,0:09:18.04,Default,,0000,0000,0000,,patient Dialogue: 0,0:09:18.04,0:09:22.02,Default,,0000,0000,0000,,than the mechanical aspect of the tumor\Nitself Dialogue: 0,0:09:22.02,0:09:27.02,Default,,0000,0000,0000,,and another thing is that the patient\Nmay present Dialogue: 0,0:09:27.02,0:09:31.06,Default,,0000,0000,0000,,the manifestations of a particular\Nperinatal plastic syndrome Dialogue: 0,0:09:31.06,0:09:35.02,Default,,0000,0000,0000,,at the time the cancer is still are cold Dialogue: 0,0:09:35.02,0:09:39.02,Default,,0000,0000,0000,,behooves you to be able to recognize\Nthat all my goodness this mixture Dialogue: 0,0:09:39.02,0:09:42.01,Default,,0000,0000,0000,,symptoms may mean Dialogue: 0,0:09:42.01,0:09:46.07,Default,,0000,0000,0000,,getty just a couple of examples along\Nwith the rest of your skimming reading Dialogue: 0,0:09:46.07,0:09:49.01,Default,,0000,0000,0000,,don't try to memorize any of this stuff\Nbut one economist Dialogue: 0,0:09:49.01,0:09:50.09,Default,,0000,0000,0000,,uh... Dialogue: 0,0:09:50.09,0:09:55.04,Default,,0000,0000,0000,,para neoplastic syndromes is hyper cal\Nsenior elevation in blood Dialogue: 0,0:09:55.04,0:09:58.05,Default,,0000,0000,0000,,calcium Dialogue: 0,0:09:58.05,0:10:02.09,Default,,0000,0000,0000,,you might think if you think he\Nmechanically think well cancer spreading Dialogue: 0,0:10:02.09,0:10:06.02,Default,,0000,0000,0000,,to the bone will destroy both liberate\Ncalcium Dialogue: 0,0:10:06.02,0:10:07.00,Default,,0000,0000,0000,,that happens Dialogue: 0,0:10:07.00,0:10:11.00,Default,,0000,0000,0000,,that's not apparently plastics into\Nlesson mechanical thanks Dialogue: 0,0:10:11.00,0:10:17.04,Default,,0000,0000,0000,,but some tumors will secreted\Nparathyroid like hormone Dialogue: 0,0:10:17.04,0:10:20.03,Default,,0000,0000,0000,,in other words are not related to\Nparathyroid glands of tumor of this Dialogue: 0,0:10:20.03,0:10:21.03,Default,,0000,0000,0000,,error that Dialogue: 0,0:10:21.03,0:10:25.03,Default,,0000,0000,0000,,but it's a create something that has a\Nparis i read hormone like activity in a Dialogue: 0,0:10:25.03,0:10:28.00,Default,,0000,0000,0000,,race is the serum calcium Dialogue: 0,0:10:28.00,0:10:30.05,Default,,0000,0000,0000,,that's not at all uncommon Dialogue: 0,0:10:30.05,0:10:33.07,Default,,0000,0000,0000,,uh... Dialogue: 0,0:10:33.07,0:10:37.04,Default,,0000,0000,0000,,other examples of parent neoplastic\Nsyndromes are from Dialogue: 0,0:10:37.04,0:10:39.01,Default,,0000,0000,0000,,what we call ext topic Dialogue: 0,0:10:39.01,0:10:42.06,Default,,0000,0000,0000,,hormone production where particular\Ntumor Dialogue: 0,0:10:42.06,0:10:46.00,Default,,0000,0000,0000,,is producing a hormone that has no\Nbusiness coming from there we see for Dialogue: 0,0:10:46.00,0:10:47.01,Default,,0000,0000,0000,,instance Dialogue: 0,0:10:47.01,0:10:49.02,Default,,0000,0000,0000,,lung tumors Dialogue: 0,0:10:49.02,0:10:50.07,Default,,0000,0000,0000,,that produce Dialogue: 0,0:10:50.07,0:10:55.03,Default,,0000,0000,0000,,cortical trochmann and other ways that a\Npituitary hormone that drives the Dialogue: 0,0:10:55.03,0:10:56.06,Default,,0000,0000,0000,,adrenal gland Dialogue: 0,0:10:56.06,0:10:58.07,Default,,0000,0000,0000,,this may produce all kinds of hell Dialogue: 0,0:10:58.07,0:11:02.06,Default,,0000,0000,0000,,because it real is overactive because of\Nthe that topic Dialogue: 0,0:11:02.06,0:11:04.08,Default,,0000,0000,0000,,hormone production Dialogue: 0,0:11:04.08,0:11:07.03,Default,,0000,0000,0000,,some tumors Dialogue: 0,0:11:07.03,0:11:08.00,Default,,0000,0000,0000,,provoke Dialogue: 0,0:11:08.00,0:11:11.03,Default,,0000,0000,0000,,hyper coagulate ability in other words\Nmake the flood Dialogue: 0,0:11:11.03,0:11:12.09,Default,,0000,0000,0000,,more likely to plop Dialogue: 0,0:11:12.09,0:11:16.00,Default,,0000,0000,0000,,when the study that in december but Dialogue: 0,0:11:16.00,0:11:20.06,Default,,0000,0000,0000,,suffice it to say i have seen patients\Nthat present with Dialogue: 0,0:11:20.06,0:11:22.06,Default,,0000,0000,0000,,delay saying collapsed Dialogue: 0,0:11:22.06,0:11:26.03,Default,,0000,0000,0000,,not spontaneously as unusual ambulatory\Npatients with a comment Dialogue: 0,0:11:26.03,0:11:28.10,Default,,0000,0000,0000,,uh... clocks in their leg means Dialogue: 0,0:11:28.10,0:11:33.00,Default,,0000,0000,0000,,and after all the dust settles it turns\Nout they've got an internal cancer Dialogue: 0,0:11:33.00,0:11:35.32,Default,,0000,0000,0000,,pancreatic cancer ovarian cancer Dialogue: 0,0:11:35.32,0:11:37.04,Default,,0000,0000,0000,,what have you Dialogue: 0,0:11:37.04,0:11:40.02,Default,,0000,0000,0000,,it's doing too Dialogue: 0,0:11:40.02,0:11:44.06,Default,,0000,0000,0000,,pro quo ideal in substances associated\Nwith the tumor Dialogue: 0,0:11:44.06,0:11:46.02,Default,,0000,0000,0000,,now i'll Dialogue: 0,0:11:46.02,0:11:48.04,Default,,0000,0000,0000,,drop-dead at this Dialogue: 0,0:11:48.04,0:11:52.02,Default,,0000,0000,0000,,and i'd suggest that you take a look at\Nthe uh... the appropriate pages in the Dialogue: 0,0:11:52.02,0:11:52.07,Default,,0000,0000,0000,,book Dialogue: 0,0:11:52.07,0:11:57.00,Default,,0000,0000,0000,,and just to see the variety apparently\Nisp neoplastic syndrome stop tryin Dialogue: 0,0:11:57.00,0:11:58.71,Default,,0000,0000,0000,,memorized just be aware Dialogue: 0,0:11:58.71,0:12:00.06,Default,,0000,0000,0000,,that general concept Dialogue: 0,0:12:00.06,0:12:03.05,Default,,0000,0000,0000,,affair neoplastic syndrome Dialogue: 0,0:12:03.05,0:12:06.06,Default,,0000,0000,0000,,part one more matter Dialogue: 0,0:12:06.06,0:12:07.100,Default,,0000,0000,0000,,quick pictures show Dialogue: 0,0:12:07.100,0:12:11.01,Default,,0000,0000,0000,,as a matter of moments sure Dialogue: 0,0:12:11.01,0:12:15.06,Default,,0000,0000,0000,,neoplasms and i want to emphasize that\Nthis is not a trivial matter it may seem Dialogue: 0,0:12:15.06,0:12:18.05,Default,,0000,0000,0000,,trivial to you know namely tumor so what Dialogue: 0,0:12:18.05,0:12:19.10,Default,,0000,0000,0000,,uh... Dialogue: 0,0:12:19.10,0:12:22.05,Default,,0000,0000,0000,,this is very very important Dialogue: 0,0:12:22.05,0:12:23.02,Default,,0000,0000,0000,,because Dialogue: 0,0:12:23.02,0:12:25.10,Default,,0000,0000,0000,,um... Dialogue: 0,0:12:25.10,0:12:27.06,Default,,0000,0000,0000,,if we Dialogue: 0,0:12:27.06,0:12:28.95,Default,,0000,0000,0000,,name the tumor Dialogue: 0,0:12:28.95,0:12:30.08,Default,,0000,0000,0000,,precisely and accurately Dialogue: 0,0:12:30.08,0:12:32.76,Default,,0000,0000,0000,,it transmits a lot of Dialogue: 0,0:12:32.76,0:12:36.46,Default,,0000,0000,0000,,information i was away as you worry more\Nabout on college if someone says it's Dialogue: 0,0:12:36.46,0:12:38.06,Default,,0000,0000,0000,,such and such kind of tumor this'll Dialogue: 0,0:12:38.06,0:12:42.03,Default,,0000,0000,0000,,bring up a a little rolodex card have a\Nwhole bunch of information Dialogue: 0,0:12:42.03,0:12:45.01,Default,,0000,0000,0000,,so it's important to be precise Dialogue: 0,0:12:45.01,0:12:46.07,Default,,0000,0000,0000,,in the terminology Dialogue: 0,0:12:46.07,0:12:51.27,Default,,0000,0000,0000,,and you've got to become familiar with\Nthis has got to be just reflex with u Dialogue: 0,0:12:51.27,0:12:53.02,Default,,0000,0000,0000,,you'll use it throughout your career Dialogue: 0,0:12:53.02,0:12:56.07,Default,,0000,0000,0000,,in the time to learn is right now\Nbecause of the on your exam Dialogue: 0,0:12:56.07,0:12:58.07,Default,,0000,0000,0000,,this weekend Dialogue: 0,0:12:58.07,0:13:03.00,Default,,0000,0000,0000,,i'd promised you upstairs is that\Nimportant and look what i want to be Dialogue: 0,0:13:03.00,0:13:06.01,Default,,0000,0000,0000,,able to do is take Dialogue: 0,0:13:06.01,0:13:07.07,Default,,0000,0000,0000,,the description Dialogue: 0,0:13:07.07,0:13:09.08,Default,,0000,0000,0000,,of a neoplasm Dialogue: 0,0:13:09.08,0:13:14.28,Default,,0000,0000,0000,,and only new picture taken description\Nother and say okay with those elements Dialogue: 0,0:13:14.28,0:13:18.02,Default,,0000,0000,0000,,this is exactly how i'm going to name it Dialogue: 0,0:13:18.02,0:13:21.00,Default,,0000,0000,0000,,you've should be able to use after you\Nleave the room today Dialogue: 0,0:13:21.00,0:13:22.04,Default,,0000,0000,0000,,but uh... Dialogue: 0,0:13:22.04,0:13:26.05,Default,,0000,0000,0000,,certainly by this weekend and it's it's\Nvery important to you throughout your Dialogue: 0,0:13:26.05,0:13:28.01,Default,,0000,0000,0000,,career Dialogue: 0,0:13:28.01,0:13:28.09,Default,,0000,0000,0000,,resilient Dialogue: 0,0:13:28.09,0:13:33.01,Default,,0000,0000,0000,,table in your book i think that page two\Nseventy three of them are wrong Dialogue: 0,0:13:33.01,0:13:37.06,Default,,0000,0000,0000,,that shows you benign this anomaly the\Ncounterpart of the nine this animal Dialogue: 0,0:13:37.06,0:13:39.00,Default,,0000,0000,0000,,wouldn't come apart and so forth Dialogue: 0,0:13:39.00,0:13:42.04,Default,,0000,0000,0000,,i want to memorize that Dialogue: 0,0:13:42.04,0:13:43.88,Default,,0000,0000,0000,,you know thirty seconds Dialogue: 0,0:13:43.88,0:13:45.04,Default,,0000,0000,0000,,without doing that chart Dialogue: 0,0:13:45.04,0:13:51.00,Default,,0000,0000,0000,,and it will give you an idea of how we\Ngo about naming things Dialogue: 0,0:13:51.00,0:13:51.07,Default,,0000,0000,0000,,basically Dialogue: 0,0:13:51.07,0:13:54.03,Default,,0000,0000,0000,,it's it's not rocket science Dialogue: 0,0:13:54.03,0:13:57.01,Default,,0000,0000,0000,,we name tumors on the on the basis of\Ntwo things Dialogue: 0,0:13:57.01,0:13:59.01,Default,,0000,0000,0000,,the tissue are joan Dialogue: 0,0:13:59.01,0:14:01.10,Default,,0000,0000,0000,,words benign or malignant Dialogue: 0,0:14:01.10,0:14:03.10,Default,,0000,0000,0000,,in other words uh... Dialogue: 0,0:14:03.10,0:14:07.03,Default,,0000,0000,0000,,try and looking at the neoplasm and\Nyou'll be able to do this this coming Dialogue: 0,0:14:07.03,0:14:08.09,Default,,0000,0000,0000,,spring Dialogue: 0,0:14:08.09,0:14:10.05,Default,,0000,0000,0000,,you'll be able to decide Dialogue: 0,0:14:10.05,0:14:12.08,Default,,0000,0000,0000,,its historic genesis white Dialogue: 0,0:14:12.08,0:14:16.03,Default,,0000,0000,0000,,tissue is springs from Dialogue: 0,0:14:16.03,0:14:18.10,Default,,0000,0000,0000,,an important part of the name Dialogue: 0,0:14:18.10,0:14:22.05,Default,,0000,0000,0000,,you'll see is in just a moment Dialogue: 0,0:14:22.05,0:14:27.01,Default,,0000,0000,0000,,depending on whether it's been nine or\Nmalignant we tack on a different suffix Dialogue: 0,0:14:27.01,0:14:29.08,Default,,0000,0000,0000,,in the kind of make a compound word Dialogue: 0,0:14:29.08,0:14:31.10,Default,,0000,0000,0000,,transmits an awful lot of information Dialogue: 0,0:14:31.10,0:14:33.09,Default,,0000,0000,0000,,so learn Dialogue: 0,0:14:33.09,0:14:35.07,Default,,0000,0000,0000,,to do this Dialogue: 0,0:14:35.07,0:14:38.03,Default,,0000,0000,0000,,now let's Dialogue: 0,0:14:38.03,0:14:40.00,Default,,0000,0000,0000,,dive right in Dialogue: 0,0:14:40.00,0:14:44.04,Default,,0000,0000,0000,,and and talk about first of all efforts\Nthe lil neoplasm Dialogue: 0,0:14:44.04,0:14:46.07,Default,,0000,0000,0000,,now the end of the net a c liam Dialogue: 0,0:14:46.07,0:14:49.06,Default,,0000,0000,0000,,you have become very familiar with this\Nis a sort of tissue Dialogue: 0,0:14:49.06,0:14:52.08,Default,,0000,0000,0000,,that covers a surface like the epidermis Dialogue: 0,0:14:52.08,0:14:53.05,Default,,0000,0000,0000,,deadlines Dialogue: 0,0:14:53.05,0:14:56.02,Default,,0000,0000,0000,,them out for the g{\u1}i{\u0} tract Dialogue: 0,0:14:56.02,0:14:58.02,Default,,0000,0000,0000,,lines cavities Dialogue: 0,0:14:58.02,0:14:59.57,Default,,0000,0000,0000,,by convention Dialogue: 0,0:14:59.57,0:15:01.06,Default,,0000,0000,0000,,we considered Dialogue: 0,0:15:01.06,0:15:04.10,Default,,0000,0000,0000,,liver tissue to be epithelium Dialogue: 0,0:15:04.10,0:15:09.04,Default,,0000,0000,0000,,kenny tissue of the two meals in\Nparticular to be to be at the funeral Dialogue: 0,0:15:09.04,0:15:15.02,Default,,0000,0000,0000,,and so forth so we're talking about the\Nserial neoplasms Dialogue: 0,0:15:15.02,0:15:18.06,Default,,0000,0000,0000,,the plot seconds a little bit Dialogue: 0,0:15:18.06,0:15:21.07,Default,,0000,0000,0000,,different kinds of epithelia as you will\Nlearn Dialogue: 0,0:15:21.07,0:15:25.05,Default,,0000,0000,0000,,their glandular epithelium they're not\Nglandular epithelium there is something Dialogue: 0,0:15:25.05,0:15:28.09,Default,,0000,0000,0000,,we call transitional epithelium etcetera Dialogue: 0,0:15:28.09,0:15:30.04,Default,,0000,0000,0000,,don't worry about it Dialogue: 0,0:15:30.04,0:15:34.02,Default,,0000,0000,0000,,but concentrate first-time glandular\Nepithelia Dialogue: 0,0:15:34.02,0:15:37.04,Default,,0000,0000,0000,,in other words uh... this is these are\Nfrom structures Dialogue: 0,0:15:37.04,0:15:38.09,Default,,0000,0000,0000,,we're talking about tumors Dialogue: 0,0:15:38.09,0:15:44.05,Default,,0000,0000,0000,,that arise from epithelia lhs structures\Nthat are glandular or to be more ductile Dialogue: 0,0:15:44.05,0:15:47.07,Default,,0000,0000,0000,,those are those of the call glandular\Ntype Dialogue: 0,0:15:47.07,0:15:49.01,Default,,0000,0000,0000,,the rooms Dialogue: 0,0:15:49.01,0:15:51.06,Default,,0000,0000,0000,,and unknown Dialogue: 0,0:15:51.06,0:15:53.07,Default,,0000,0000,0000,,means gland Dialogue: 0,0:15:53.07,0:15:56.03,Default,,0000,0000,0000,,and the suffix beaumont Dialogue: 0,0:15:56.03,0:15:58.10,Default,,0000,0000,0000,,refers to uh... to amass Dialogue: 0,0:15:58.10,0:16:03.09,Default,,0000,0000,0000,,and by convention if we have a benign Dialogue: 0,0:16:03.09,0:16:04.00,Default,,0000,0000,0000,,neoplasm Dialogue: 0,0:16:04.00,0:16:06.09,Default,,0000,0000,0000,,of glandular epithelium Dialogue: 0,0:16:06.09,0:16:12.00,Default,,0000,0000,0000,,it is an adenoma Dialogue: 0,0:16:12.00,0:16:15.07,Default,,0000,0000,0000,,that along transmits a lot of\Ninformation that says to your listener Dialogue: 0,0:16:15.07,0:16:19.08,Default,,0000,0000,0000,,if his name something that no one says\Nwell asap cereal Dialogue: 0,0:16:19.08,0:16:22.42,Default,,0000,0000,0000,,it is in the connective tissue tumors in\Nthe field Dialogue: 0,0:16:22.42,0:16:27.05,Default,,0000,0000,0000,,and it's glandular and it's benign Dialogue: 0,0:16:27.05,0:16:30.05,Default,,0000,0000,0000,,choice and adenomas Dialogue: 0,0:16:30.05,0:16:31.05,Default,,0000,0000,0000,,this is uh... Dialogue: 0,0:16:31.05,0:16:32.06,Default,,0000,0000,0000,,a cut Dialogue: 0,0:16:32.06,0:16:34.04,Default,,0000,0000,0000,,through the adrenal gland Dialogue: 0,0:16:34.04,0:16:38.07,Default,,0000,0000,0000,,managerial glance its deep enough at\Nabove the kidney waiting here Dialogue: 0,0:16:38.07,0:16:40.02,Default,,0000,0000,0000,,few inches in here Dialogue: 0,0:16:40.02,0:16:42.05,Default,,0000,0000,0000,,it's about about that big Dialogue: 0,0:16:42.05,0:16:43.03,Default,,0000,0000,0000,,normally Dialogue: 0,0:16:43.03,0:16:45.09,Default,,0000,0000,0000,,not done here is cut through the adrenal\Ngland Dialogue: 0,0:16:45.09,0:16:48.09,Default,,0000,0000,0000,,this is a cut through the normal plan Dialogue: 0,0:16:48.09,0:16:50.04,Default,,0000,0000,0000,,the yellow Dialogue: 0,0:16:50.04,0:16:52.08,Default,,0000,0000,0000,,part of the sandwiches the cortex Dialogue: 0,0:16:52.08,0:16:55.05,Default,,0000,0000,0000,,that makes various steroid hormones Dialogue: 0,0:16:55.05,0:16:56.10,Default,,0000,0000,0000,,and this is the mud all over Dialogue: 0,0:16:56.10,0:16:59.00,Default,,0000,0000,0000,,that makes catecholamines Dialogue: 0,0:16:59.00,0:17:00.08,Default,,0000,0000,0000,,i've got an effort and so forth Dialogue: 0,0:17:00.08,0:17:02.09,Default,,0000,0000,0000,,right in that dark spot Dialogue: 0,0:17:02.09,0:17:04.03,Default,,0000,0000,0000,,here we have Dialogue: 0,0:17:04.03,0:17:06.04,Default,,0000,0000,0000,,india plaza Dialogue: 0,0:17:06.04,0:17:11.06,Default,,0000,0000,0000,,first of all is very well circumscribed\Njust shout louder there Dialogue: 0,0:17:11.06,0:17:14.04,Default,,0000,0000,0000,,clearance sale of probably benign\Ndoesn't look invasive Dialogue: 0,0:17:14.04,0:17:17.09,Default,,0000,0000,0000,,i can tell you that under the microscope\Nthis was Dialogue: 0,0:17:17.09,0:17:21.06,Default,,0000,0000,0000,,perfectly differentiating himself\Nherself all their arranged a little Dialogue: 0,0:17:21.06,0:17:22.01,Default,,0000,0000,0000,,differently Dialogue: 0,0:17:22.01,0:17:24.19,Default,,0000,0000,0000,,they look like the cells here Dialogue: 0,0:17:24.19,0:17:27.84,Default,,0000,0000,0000,,you came to get a hint of that and that\Nit's the same a yellow Dialogue: 0,0:17:27.84,0:17:29.03,Default,,0000,0000,0000,,sort of stuff Dialogue: 0,0:17:29.03,0:17:30.09,Default,,0000,0000,0000,,comprising then at that Dialogue: 0,0:17:30.09,0:17:33.05,Default,,0000,0000,0000,,of which this is made Dialogue: 0,0:17:33.05,0:17:37.09,Default,,0000,0000,0000,,so this is an added no ma Dialogue: 0,0:17:37.09,0:17:42.30,Default,,0000,0000,0000,,arising from the adrenal cortex so we\Ncall it a bit and give it the whole in Dialogue: 0,0:17:42.30,0:17:45.04,Default,,0000,0000,0000,,adrenal cortical adenoma Dialogue: 0,0:17:45.04,0:17:46.06,Default,,0000,0000,0000,,now the question Dialogue: 0,0:17:46.06,0:17:49.09,Default,,0000,0000,0000,,is well how did that patient coming in\Nthis a doc Dialogue: 0,0:17:49.09,0:17:51.00,Default,,0000,0000,0000,,i've got a Dialogue: 0,0:17:51.00,0:17:53.80,Default,,0000,0000,0000,,walnut sized mass in my super arenal Dialogue: 0,0:17:53.80,0:17:56.02,Default,,0000,0000,0000,,uh... fat pad Dialogue: 0,0:17:56.02,0:17:59.05,Default,,0000,0000,0000,,then is obviously buried in there and\Nyou know when you feel that Dialogue: 0,0:17:59.05,0:18:00.09,Default,,0000,0000,0000,,uh... Dialogue: 0,0:18:00.09,0:18:06.03,Default,,0000,0000,0000,,the way this presented was because it\Nwas making an access of hormone Dialogue: 0,0:18:06.03,0:18:10.05,Default,,0000,0000,0000,,knows this is a patient belonged to his\Nor her life Dialogue: 0,0:18:10.05,0:18:14.04,Default,,0000,0000,0000,,developed a series of symptoms in this\Nparticular case i can tell from looking Dialogue: 0,0:18:14.04,0:18:16.04,Default,,0000,0000,0000,,at this and other history Dialogue: 0,0:18:16.04,0:18:18.00,Default,,0000,0000,0000,,this tumor was making Dialogue: 0,0:18:18.00,0:18:20.09,Default,,0000,0000,0000,,gobs and gobs of a vast room Dialogue: 0,0:18:20.09,0:18:25.00,Default,,0000,0000,0000,,and the patient came in with i'd will\Nbore you with a bit of syndrome Dialogue: 0,0:18:25.00,0:18:29.14,Default,,0000,0000,0000,,relating to blood pressure and changes\Nin certain cervelo delights and so forth Dialogue: 0,0:18:29.14,0:18:31.03,Default,,0000,0000,0000,,and the Dialogue: 0,0:18:31.03,0:18:32.09,Default,,0000,0000,0000,,smart physicians seven Dialogue: 0,0:18:32.09,0:18:36.42,Default,,0000,0000,0000,,flipping see these things together\Nsomething is making too much Dialogue: 0,0:18:36.42,0:18:39.02,Default,,0000,0000,0000,,oven adrenal cortical hormone Dialogue: 0,0:18:39.02,0:18:41.08,Default,,0000,0000,0000,,simply a matter of imaging finding out\Nwhich side Dialogue: 0,0:18:41.08,0:18:44.04,Default,,0000,0000,0000,,out icons and you got a cure Dialogue: 0,0:18:44.04,0:18:48.01,Default,,0000,0000,0000,,because that's perfectly benign very\Nwell differentiated Dialogue: 0,0:18:48.01,0:18:49.04,Default,,0000,0000,0000,,here's one for you Dialogue: 0,0:18:49.04,0:18:50.10,Default,,0000,0000,0000,,have to explain us a little bit like Dialogue: 0,0:18:50.10,0:18:53.08,Default,,0000,0000,0000,,this is a pancreas has been sliced Dialogue: 0,0:18:53.08,0:18:57.10,Default,,0000,0000,0000,,in the two has a look at matching this\Nis what the normal pancreas Dialogue: 0,0:18:57.10,0:19:01.06,Default,,0000,0000,0000,,pancreas pratama looks like it's a lobby\Nlocal angular tissue Dialogue: 0,0:19:01.06,0:19:04.03,Default,,0000,0000,0000,,and has a marble Dialogue: 0,0:19:04.03,0:19:06.01,Default,,0000,0000,0000,,very well circumscribed marble Dialogue: 0,0:19:06.01,0:19:07.09,Default,,0000,0000,0000,,in the middle of it Dialogue: 0,0:19:07.09,0:19:09.05,Default,,0000,0000,0000,,this was benign Dialogue: 0,0:19:09.05,0:19:13.01,Default,,0000,0000,0000,,can tell that by looking at exactly but\Nit's it's benign Dialogue: 0,0:19:13.01,0:19:14.05,Default,,0000,0000,0000,,it arose Dialogue: 0,0:19:14.05,0:19:19.00,Default,,0000,0000,0000,,from the island salon their hands Dialogue: 0,0:19:19.00,0:19:20.05,Default,,0000,0000,0000,,with that in mind Dialogue: 0,0:19:20.05,0:19:22.64,Default,,0000,0000,0000,,how do you suppose is patient presented Dialogue: 0,0:19:22.64,0:19:26.89,Default,,0000,0000,0000,,again that's a that's a little marble\Nmilitary christening lately in their Dialogue: 0,0:19:26.89,0:19:31.01,Default,,0000,0000,0000,,representation presenter y Dialogue: 0,0:19:31.01,0:19:33.05,Default,,0000,0000,0000,,removed Dialogue: 0,0:19:33.05,0:19:35.04,Default,,0000,0000,0000,,hypoglycaemia Dialogue: 0,0:19:35.04,0:19:39.02,Default,,0000,0000,0000,,another words that tumor was producing\Ninsulin without regard Dialogue: 0,0:19:39.02,0:19:41.06,Default,,0000,0000,0000,,to the needs of the body Dialogue: 0,0:19:41.06,0:19:44.01,Default,,0000,0000,0000,,lose patience though there are\Nvariations on this end of the basically Dialogue: 0,0:19:44.01,0:19:47.07,Default,,0000,0000,0000,,if they did not just beaten Dialogue: 0,0:19:47.07,0:19:52.00,Default,,0000,0000,0000,,insulin levels high and there's the\Nserum glucose goes down Dialogue: 0,0:19:52.00,0:19:57.04,Default,,0000,0000,0000,,you get a variety of symptoms all the\Nway to convulsions and coma Dialogue: 0,0:19:57.04,0:20:00.04,Default,,0000,0000,0000,,units that's the most dramatic part of\Nthis and Dialogue: 0,0:20:00.04,0:20:01.01,Default,,0000,0000,0000,,sexual Dialogue: 0,0:20:01.01,0:20:03.81,Default,,0000,0000,0000,,has effected by removing Dialogue: 0,0:20:03.81,0:20:06.02,Default,,0000,0000,0000,,sort of thing Dialogue: 0,0:20:06.02,0:20:09.08,Default,,0000,0000,0000,,all right here's another sort of that no\None want to talk about this in detail Dialogue: 0,0:20:09.08,0:20:12.07,Default,,0000,0000,0000,,this afternoon so i'm not going to be a\Nlabor it now Dialogue: 0,0:20:12.07,0:20:14.08,Default,,0000,0000,0000,,but this is a melanoma Dialogue: 0,0:20:14.08,0:20:15.08,Default,,0000,0000,0000,,arising Dialogue: 0,0:20:15.08,0:20:18.03,Default,,0000,0000,0000,,from the lining of the colon Dialogue: 0,0:20:18.03,0:20:20.00,Default,,0000,0000,0000,,which is a glandular lining Dialogue: 0,0:20:20.00,0:20:24.03,Default,,0000,0000,0000,,so an isbn nine so well circumscribed Dialogue: 0,0:20:24.03,0:20:25.01,Default,,0000,0000,0000,,non-invasive thing Dialogue: 0,0:20:25.01,0:20:27.06,Default,,0000,0000,0000,,so this is a calm on iq Dialogue: 0,0:20:27.06,0:20:30.09,Default,,0000,0000,0000,,adenoma Dialogue: 0,0:20:30.09,0:20:34.00,Default,,0000,0000,0000,,sort of growing on the stand here this\Nis normal Dialogue: 0,0:20:34.00,0:20:36.01,Default,,0000,0000,0000,,collage mucosa sort of pulled out Dialogue: 0,0:20:36.01,0:20:40.04,Default,,0000,0000,0000,,uh... won't be another name for that\Nengland and idea Dialogue: 0,0:20:40.04,0:20:42.04,Default,,0000,0000,0000,,right pollock Dialogue: 0,0:20:42.04,0:20:44.06,Default,,0000,0000,0000,,but i warn you Dialogue: 0,0:20:44.06,0:20:49.04,Default,,0000,0000,0000,,you got to be taken precise because the\Nterm pollack is just a topographical Dialogue: 0,0:20:49.04,0:20:50.05,Default,,0000,0000,0000,,term Dialogue: 0,0:20:50.05,0:20:54.06,Default,,0000,0000,0000,,anything that hangs like a dingell barry\Noff of Dialogue: 0,0:20:54.06,0:20:57.01,Default,,0000,0000,0000,,him you coastal services apollo Dialogue: 0,0:20:57.01,0:21:01.01,Default,,0000,0000,0000,,now some polyps are in fact neoplasms\Nlike this one Dialogue: 0,0:21:01.01,0:21:05.04,Default,,0000,0000,0000,,but summer simply inflammatory masses\Nsome of you who have nasal allergies may Dialogue: 0,0:21:05.04,0:21:09.04,Default,,0000,0000,0000,,have been told that you have nasal\Npolyps Dialogue: 0,0:21:09.04,0:21:12.08,Default,,0000,0000,0000,,is things that says sorta look like that\Nup there Dialogue: 0,0:21:12.08,0:21:17.06,Default,,0000,0000,0000,,but they're not neoplasms urges bags\Ninto gmail fluid in the few inflammatory Dialogue: 0,0:21:17.06,0:21:18.04,Default,,0000,0000,0000,,cells Dialogue: 0,0:21:18.04,0:21:20.00,Default,,0000,0000,0000,,so anything else Dialogue: 0,0:21:20.00,0:21:23.01,Default,,0000,0000,0000,,off on the surface you call a polyp\Nalone while you know that's a pollack Dialogue: 0,0:21:23.01,0:21:25.04,Default,,0000,0000,0000,,with their other kinds of politics and\Nthe colon Dialogue: 0,0:21:25.04,0:21:27.00,Default,,0000,0000,0000,,they're not all at a moment's Dialogue: 0,0:21:27.00,0:21:31.00,Default,,0000,0000,0000,,so if you want to be precise you could\Nsay this is an ad anomalous pollock Dialogue: 0,0:21:31.00,0:21:34.31,Default,,0000,0000,0000,,or simply Dialogue: 0,0:21:34.31,0:21:36.04,Default,,0000,0000,0000,,some of them ron stems like that Dialogue: 0,0:21:36.04,0:21:39.10,Default,,0000,0000,0000,,we call that eight people insulated Dialogue: 0,0:21:39.10,0:21:42.00,Default,,0000,0000,0000,,adenoma Dialogue: 0,0:21:42.00,0:21:43.01,Default,,0000,0000,0000,,some of them are Dialogue: 0,0:21:43.01,0:21:46.06,Default,,0000,0000,0000,,sort of attached to the surface without\Nmuch of his family are a couple of Dialogue: 0,0:21:46.06,0:21:47.03,Default,,0000,0000,0000,,little Dialogue: 0,0:21:47.03,0:21:50.04,Default,,0000,0000,0000,,an anomalous just doesn't budding right\Noff Dialogue: 0,0:21:50.04,0:21:52.08,Default,,0000,0000,0000,,the surface Dialogue: 0,0:21:52.08,0:21:56.08,Default,,0000,0000,0000,,these things are generally a symptomatic Dialogue: 0,0:21:56.08,0:21:59.08,Default,,0000,0000,0000,,it would take a helluva lot Dialogue: 0,0:21:59.08,0:22:02.00,Default,,0000,0000,0000,,adenoma to produce any symptoms Dialogue: 0,0:22:02.00,0:22:05.02,Default,,0000,0000,0000,,usually associate with a little a cold\Nleading Dialogue: 0,0:22:05.02,0:22:07.01,Default,,0000,0000,0000,,but basically they're they're hidden\Nthere Dialogue: 0,0:22:07.01,0:22:10.04,Default,,0000,0000,0000,,the significance is Dialogue: 0,0:22:10.04,0:22:12.01,Default,,0000,0000,0000,,some of these Dialogue: 0,0:22:12.01,0:22:13.02,Default,,0000,0000,0000,,dilemmas time Dialogue: 0,0:22:13.02,0:22:17.18,Default,,0000,0000,0000,,turn of the cancer and that's the news\Nthat the other theme of our Dialogue: 0,0:22:17.18,0:22:21.08,Default,,0000,0000,0000,,presentation this afternoon so i won't\Nbelabor it at this point Dialogue: 0,0:22:21.08,0:22:23.18,Default,,0000,0000,0000,,try and what about it Dialogue: 0,0:22:23.18,0:22:25.43,Default,,0000,0000,0000,,and you can go back on that chart i gave\Nyou Dialogue: 0,0:22:25.43,0:22:29.04,Default,,0000,0000,0000,,the next step down on my cell on the\Nleft side of the nine Dialogue: 0,0:22:29.04,0:22:31.00,Default,,0000,0000,0000,,man glandular epithelia Dialogue: 0,0:22:31.00,0:22:32.07,Default,,0000,0000,0000,,this is a cartoon Dialogue: 0,0:22:32.07,0:22:34.05,Default,,0000,0000,0000,,of a benign neoplasm Dialogue: 0,0:22:34.05,0:22:39.10,Default,,0000,0000,0000,,of the lining of the bladder happens to\Nbe what we call transitional epithelium Dialogue: 0,0:22:39.10,0:22:43.01,Default,,0000,0000,0000,,very often these sorts of things grow\Nout Dialogue: 0,0:22:43.01,0:22:44.09,Default,,0000,0000,0000,,and i think they Dialogue: 0,0:22:44.09,0:22:50.01,Default,,0000,0000,0000,,this does a good job as a series of\Nfinger like projections Dialogue: 0,0:22:50.01,0:22:52.02,Default,,0000,0000,0000,,pointing at you Dialogue: 0,0:22:52.02,0:22:56.01,Default,,0000,0000,0000,,in each one of these is that it is a bit\Nof stromal covered by a layer of Dialogue: 0,0:22:56.01,0:22:59.02,Default,,0000,0000,0000,,neoplastic transitional epithelium Dialogue: 0,0:22:59.02,0:23:03.06,Default,,0000,0000,0000,,and we refer to his finger like\Nprojections is painfully Dialogue: 0,0:23:03.06,0:23:05.08,Default,,0000,0000,0000,,so this becomes a Dialogue: 0,0:23:05.08,0:23:07.09,Default,,0000,0000,0000,,papilloma Dialogue: 0,0:23:07.09,0:23:11.39,Default,,0000,0000,0000,,this is a transition hands because it's\Na transitional epithelium Dialogue: 0,0:23:11.39,0:23:13.00,Default,,0000,0000,0000,,the transitional cell Dialogue: 0,0:23:13.00,0:23:16.00,Default,,0000,0000,0000,,papilloma Dialogue: 0,0:23:16.00,0:23:20.03,Default,,0000,0000,0000,,lala just mentioned passing that these\Ncan be a symptomatic or these peculiar Dialogue: 0,0:23:20.03,0:23:26.04,Default,,0000,0000,0000,,break off a little bit and then you get\Nsome blood in the year in you materia Dialogue: 0,0:23:26.04,0:23:29.06,Default,,0000,0000,0000,,i'll show you a real like real life Dialogue: 0,0:23:29.06,0:23:30.03,Default,,0000,0000,0000,,papilloma Dialogue: 0,0:23:30.03,0:23:31.05,Default,,0000,0000,0000,,uh... Dialogue: 0,0:23:31.05,0:23:36.01,Default,,0000,0000,0000,,these these little thing that these\Nthings presenters so little tiny bulbs Dialogue: 0,0:23:36.01,0:23:42.00,Default,,0000,0000,0000,,very often in the oral mucosa or the the\Nback of the throat the oral pharynx Dialogue: 0,0:23:42.00,0:23:46.09,Default,,0000,0000,0000,,this was one of those about the size of\Npeace Dialogue: 0,0:23:46.09,0:23:51.10,Default,,0000,0000,0000,,this is the normal swimmers epithelium\Nlining the aural pharynx Dialogue: 0,0:23:51.10,0:23:56.07,Default,,0000,0000,0000,,and what this says is a series of these\Nfinger like projections Dialogue: 0,0:23:56.07,0:23:58.02,Default,,0000,0000,0000,,growing Dialogue: 0,0:23:58.02,0:24:01.06,Default,,0000,0000,0000,,out of this epithelium we don't see the\Nprecise point attachment in each one of Dialogue: 0,0:24:01.06,0:24:05.02,Default,,0000,0000,0000,,these is a little finger cutting\Ncross-section Dialogue: 0,0:24:05.02,0:24:07.64,Default,,0000,0000,0000,,covered by this swing this epithelium Dialogue: 0,0:24:07.64,0:24:08.08,Default,,0000,0000,0000,,perfectly benign Dialogue: 0,0:24:08.08,0:24:12.02,Default,,0000,0000,0000,,so this would be called a swimmers\Nitself Dialogue: 0,0:24:12.02,0:24:14.01,Default,,0000,0000,0000,,papilloma Dialogue: 0,0:24:14.01,0:24:15.05,Default,,0000,0000,0000,,these are Dialogue: 0,0:24:15.05,0:24:19.07,Default,,0000,0000,0000,,well the variety of variation in this\Nteam i'm not on the skin surface is a is Dialogue: 0,0:24:19.07,0:24:21.08,Default,,0000,0000,0000,,a common wart Dialogue: 0,0:24:21.08,0:24:24.04,Default,,0000,0000,0000,,and they're all sorts of variations in\Nthis Dialogue: 0,0:24:24.04,0:24:28.08,Default,,0000,0000,0000,,generally caused by one or another\Nstring of the human papilloma virus h{\u1}p{\u0} Dialogue: 0,0:24:28.08,0:24:30.05,Default,,0000,0000,0000,,deal here about this Dialogue: 0,0:24:30.05,0:24:31.04,Default,,0000,0000,0000,,constantly Dialogue: 0,0:24:31.04,0:24:33.28,Default,,0000,0000,0000,,but uh... there is a Dialogue: 0,0:24:33.28,0:24:35.06,Default,,0000,0000,0000,,they'd have a little more Dialogue: 0,0:24:35.06,0:24:42.03,Default,,0000,0000,0000,,now one other variation on this team Dialogue: 0,0:24:42.03,0:24:44.06,Default,,0000,0000,0000,,sometimes it comes to pass Dialogue: 0,0:24:44.06,0:24:46.08,Default,,0000,0000,0000,,for a few days Dialogue: 0,0:24:46.08,0:24:49.00,Default,,0000,0000,0000,,neoplasm of glandular epithelium Dialogue: 0,0:24:49.00,0:24:51.56,Default,,0000,0000,0000,,that grows Dialogue: 0,0:24:51.56,0:24:52.10,Default,,0000,0000,0000,,in bubbles Dialogue: 0,0:24:52.10,0:24:56.04,Default,,0000,0000,0000,,in other words the neoplastic epithelium\Nlines Dialogue: 0,0:24:56.04,0:24:59.03,Default,,0000,0000,0000,,the inner aspect of the holes Dialogue: 0,0:24:59.03,0:25:04.02,Default,,0000,0000,0000,,which we call status technically a cyst\Nis a whole space filled with fluid Dialogue: 0,0:25:04.02,0:25:04.06,Default,,0000,0000,0000,,blinded Dialogue: 0,0:25:04.06,0:25:06.08,Default,,0000,0000,0000,,within epithelium Dialogue: 0,0:25:06.08,0:25:11.84,Default,,0000,0000,0000,,there are some neoplasms that growth has\Ncollections of multiple bottles vs Dialogue: 0,0:25:11.84,0:25:13.80,Default,,0000,0000,0000,,line by this Dialogue: 0,0:25:13.80,0:25:16.00,Default,,0000,0000,0000,,neoplastic glandular epithelium Dialogue: 0,0:25:16.00,0:25:18.08,Default,,0000,0000,0000,,in a good example of this is a Dialogue: 0,0:25:18.08,0:25:20.06,Default,,0000,0000,0000,,but i think fairly common Dialogue: 0,0:25:20.06,0:25:24.07,Default,,0000,0000,0000,,seven nine neoplasm we've seen over it Dialogue: 0,0:25:24.07,0:25:28.08,Default,,0000,0000,0000,,we call these things because they are\Nmultiple cysts Dialogue: 0,0:25:28.08,0:25:31.18,Default,,0000,0000,0000,,we call these cyst Dialogue: 0,0:25:31.18,0:25:34.02,Default,,0000,0000,0000,,one-word system adenoma Dialogue: 0,0:25:34.02,0:25:37.08,Default,,0000,0000,0000,,and here's what it would look like Dialogue: 0,0:25:37.08,0:25:39.06,Default,,0000,0000,0000,,don't have a scale on there Dialogue: 0,0:25:39.06,0:25:42.00,Default,,0000,0000,0000,,normal ovaries about the size of a Dialogue: 0,0:25:42.00,0:25:43.03,Default,,0000,0000,0000,,well you know Dialogue: 0,0:25:43.03,0:25:45.03,Default,,0000,0000,0000,,small not Dialogue: 0,0:25:45.03,0:25:48.04,Default,,0000,0000,0000,,this thing was about the size of a\Nfootball Dialogue: 0,0:25:48.04,0:25:50.05,Default,,0000,0000,0000,,they can they can get big Dialogue: 0,0:25:50.05,0:25:52.02,Default,,0000,0000,0000,,uh... Dialogue: 0,0:25:52.02,0:25:56.66,Default,,0000,0000,0000,,levy banana thier this it would be\Nsuggested by the fact that the surface Dialogue: 0,0:25:56.66,0:25:59.07,Default,,0000,0000,0000,,is perfectly smooth and whatever there\Nis Dialogue: 0,0:25:59.07,0:26:01.04,Default,,0000,0000,0000,,there's orderly Dialogue: 0,0:26:01.04,0:26:04.06,Default,,0000,0000,0000,,anesth one minute that surfaces\Nperfectly smooth Dialogue: 0,0:26:04.06,0:26:06.68,Default,,0000,0000,0000,,cut into the thing Dialogue: 0,0:26:06.68,0:26:10.01,Default,,0000,0000,0000,,you see assist the character Dialogue: 0,0:26:10.01,0:26:13.07,Default,,0000,0000,0000,,these were these were filled with a\Nmusician is material Dialogue: 0,0:26:13.07,0:26:15.08,Default,,0000,0000,0000,,which we washed away Dialogue: 0,0:26:15.08,0:26:20.07,Default,,0000,0000,0000,,of there's a system that's lined by Dialogue: 0,0:26:20.07,0:26:24.06,Default,,0000,0000,0000,,benign glandular epithelium there there\Nthere are so far Dialogue: 0,0:26:24.06,0:26:26.03,Default,,0000,0000,0000,,many little daughter cysts Dialogue: 0,0:26:26.03,0:26:29.03,Default,,0000,0000,0000,,so that is an ovarian Dialogue: 0,0:26:29.03,0:26:33.06,Default,,0000,0000,0000,,sister adenoma see how we built the\Nnames Dialogue: 0,0:26:33.06,0:26:35.01,Default,,0000,0000,0000,,without much in mind Dialogue: 0,0:26:35.01,0:26:38.10,Default,,0000,0000,0000,,we got a next step and say what about Dialogue: 0,0:26:38.10,0:26:39.09,Default,,0000,0000,0000,,malignancy Dialogue: 0,0:26:39.09,0:26:40.10,Default,,0000,0000,0000,,counterparts Dialogue: 0,0:26:40.10,0:26:46.00,Default,,0000,0000,0000,,now the role here is if you have been at\Nthe same feel neoplasm Dialogue: 0,0:26:46.00,0:26:48.04,Default,,0000,0000,0000,,of any sort Dialogue: 0,0:26:48.04,0:26:50.01,Default,,0000,0000,0000,,and it has malignant Dialogue: 0,0:26:50.01,0:26:52.05,Default,,0000,0000,0000,,it is a carcinoma Dialogue: 0,0:26:52.05,0:26:54.08,Default,,0000,0000,0000,,so it's the word Dialogue: 0,0:26:54.08,0:26:57.00,Default,,0000,0000,0000,,carcinoma appears as any part of the\Nnamed Dialogue: 0,0:26:57.00,0:26:58.08,Default,,0000,0000,0000,,you say to yourself Dialogue: 0,0:26:58.08,0:27:01.05,Default,,0000,0000,0000,,jake this is at it's a little Dialogue: 0,0:27:01.05,0:27:03.01,Default,,0000,0000,0000,,and there is no limit Dialogue: 0,0:27:03.01,0:27:05.07,Default,,0000,0000,0000,,transmit a lot of information with that Dialogue: 0,0:27:05.07,0:27:07.07,Default,,0000,0000,0000,,then you add Dialogue: 0,0:27:07.07,0:27:09.03,Default,,0000,0000,0000,,compound Dialogue: 0,0:27:09.03,0:27:10.46,Default,,0000,0000,0000,,the parts of the Dialogue: 0,0:27:10.46,0:27:11.93,Default,,0000,0000,0000,,gets its day Dialogue: 0,0:27:11.93,0:27:13.06,Default,,0000,0000,0000,,glandular Dialogue: 0,0:27:13.06,0:27:16.02,Default,,0000,0000,0000,,malignancy what do you suppose you call\Nit Dialogue: 0,0:27:16.02,0:27:17.08,Default,,0000,0000,0000,,adamo Dialogue: 0,0:27:17.08,0:27:18.05,Default,,0000,0000,0000,,carcinoma Dialogue: 0,0:27:18.05,0:27:21.01,Default,,0000,0000,0000,,if this is cuevas malignancy Dialogue: 0,0:27:21.01,0:27:24.50,Default,,0000,0000,0000,,square myself carcinoma et cetera only Dialogue: 0,0:27:24.50,0:27:26.27,Default,,0000,0000,0000,,and then you can't rely on Dialogue: 0,0:27:26.27,0:27:29.55,Default,,0000,0000,0000,,you'll see in our reports all sorts of\Nthings Dialogue: 0,0:27:29.55,0:27:31.86,Default,,0000,0000,0000,,moderately well differentiation did Dialogue: 0,0:27:31.86,0:27:35.45,Default,,0000,0000,0000,,moderately well differentiated nuisance\Nsecreting Dialogue: 0,0:27:35.45,0:27:36.09,Default,,0000,0000,0000,,adenocarcinoma lacz Dialogue: 0,0:27:36.09,0:27:39.10,Default,,0000,0000,0000,,put on some frosting on the cake the\Nfood Dialogue: 0,0:27:39.10,0:27:40.10,Default,,0000,0000,0000,,the basic thing is that tells you Dialogue: 0,0:27:40.10,0:27:44.04,Default,,0000,0000,0000,,that is glandular that it is Dialogue: 0,0:27:44.04,0:27:46.00,Default,,0000,0000,0000,,malignant Dialogue: 0,0:27:46.00,0:27:50.00,Default,,0000,0000,0000,,so i'll show you some carcinomas quickly Dialogue: 0,0:27:50.00,0:27:53.04,Default,,0000,0000,0000,,that'll make about half of you cringe Dialogue: 0,0:27:53.04,0:27:56.02,Default,,0000,0000,0000,,uh... that's just what the label says Dialogue: 0,0:27:56.02,0:27:59.08,Default,,0000,0000,0000,,of the glands of the penises largely\Nreplaced Dialogue: 0,0:27:59.08,0:28:00.08,Default,,0000,0000,0000,,by this Dialogue: 0,0:28:00.08,0:28:02.02,Default,,0000,0000,0000,,uh... Dialogue: 0,0:28:02.02,0:28:05.09,Default,,0000,0000,0000,,i'll give you another few words these\Nare all words you learn to live with we Dialogue: 0,0:28:05.09,0:28:09.06,Default,,0000,0000,0000,,would refer to a neoplasm has grown out\Nwhat how much room here Dialogue: 0,0:28:09.06,0:28:12.04,Default,,0000,0000,0000,,we talk about it is fun game Dialogue: 0,0:28:12.04,0:28:13.01,Default,,0000,0000,0000,,fungus funding Dialogue: 0,0:28:13.01,0:28:24.09,Default,,0000,0000,0000,,so this is Dialogue: 0,0:28:24.09,0:28:29.08,Default,,0000,0000,0000,,well some some sisterhood military\Ngeneric answer some sis Dialogue: 0,0:28:29.08,0:28:33.03,Default,,0000,0000,0000,,are not nearly fast Dialogue: 0,0:28:33.03,0:28:37.02,Default,,0000,0000,0000,,that you get if you obstructed for\Ninstance ductile structure Dialogue: 0,0:28:37.02,0:28:39.06,Default,,0000,0000,0000,,and something is secreting into it Dialogue: 0,0:28:39.06,0:28:43.01,Default,,0000,0000,0000,,it's obstructed here it'll become\Nsystemically dilated before missus Dialogue: 0,0:28:43.01,0:28:45.04,Default,,0000,0000,0000,,others just happen to be Dialogue: 0,0:28:45.04,0:28:50.06,Default,,0000,0000,0000,,the way they are because they're they're\Nneoplasms Dialogue: 0,0:28:50.06,0:28:54.10,Default,,0000,0000,0000,,well at any rate getting medicine is so\Nthis is a fun gating Dialogue: 0,0:28:54.10,0:28:56.03,Default,,0000,0000,0000,,neoplasm Dialogue: 0,0:28:56.03,0:29:01.05,Default,,0000,0000,0000,,another word we use is exo finicky excel\Nmeaning outward ph wide ta cee growing Dialogue: 0,0:29:01.05,0:29:02.04,Default,,0000,0000,0000,,outward Dialogue: 0,0:29:02.04,0:29:06.03,Default,,0000,0000,0000,,well this is partly funding but this was\Ninfiltrating deeply Dialogue: 0,0:29:06.03,0:29:09.15,Default,,0000,0000,0000,,this is a highly malignant neoplasm even\Nthough it's Dialogue: 0,0:29:09.15,0:29:10.08,Default,,0000,0000,0000,,pretty well differentiated Dialogue: 0,0:29:10.08,0:29:13.10,Default,,0000,0000,0000,,and this is presently mona lymph nodes\Nat the time Dialogue: 0,0:29:13.10,0:29:15.10,Default,,0000,0000,0000,,now this happened Dialogue: 0,0:29:15.10,0:29:19.08,Default,,0000,0000,0000,,they the covering of the glances cuevas Dialogue: 0,0:29:19.08,0:29:22.03,Default,,0000,0000,0000,,epithelium this was a swimmers cell Dialogue: 0,0:29:22.03,0:29:23.08,Default,,0000,0000,0000,,carcinoma Dialogue: 0,0:29:23.08,0:29:26.74,Default,,0000,0000,0000,,this illustrates a something you'll\Nlearn Dialogue: 0,0:29:26.74,0:29:30.02,Default,,0000,0000,0000,,it is not uncommon says people have a\Ngreat sense of the miles Dialogue: 0,0:29:30.02,0:29:34.05,Default,,0000,0000,0000,,this thing didn't show up the thursday\Nnight before he came into the doctor Dialogue: 0,0:29:34.05,0:29:37.02,Default,,0000,0000,0000,,this has been there many many months Dialogue: 0,0:29:37.02,0:29:40.09,Default,,0000,0000,0000,,and people have all sorts of ways of\Nexplaining these things away in the Dialogue: 0,0:29:40.09,0:29:43.02,Default,,0000,0000,0000,,nineteen hoping they're not there\Ntomorrow morning Dialogue: 0,0:29:43.02,0:29:44.25,Default,,0000,0000,0000,,when a shower Dialogue: 0,0:29:44.25,0:29:45.04,Default,,0000,0000,0000,,and so forth Dialogue: 0,0:29:45.04,0:29:48.05,Default,,0000,0000,0000,,but that's a highly advanced lesion Dialogue: 0,0:29:48.05,0:29:51.00,Default,,0000,0000,0000,,yours for the other half Dialogue: 0,0:29:51.00,0:29:53.09,Default,,0000,0000,0000,,now this one Dialogue: 0,0:29:53.09,0:29:58.10,Default,,0000,0000,0000,,is also basically my cell carcinoma\Nreveal a b errol covered by squamous Dialogue: 0,0:29:58.10,0:29:59.10,Default,,0000,0000,0000,,epithelium Dialogue: 0,0:29:59.10,0:30:00.07,Default,,0000,0000,0000,,scenarios Dialogue: 0,0:30:00.07,0:30:03.01,Default,,0000,0000,0000,,now that was sensed by the patient Dialogue: 0,0:30:03.01,0:30:06.05,Default,,0000,0000,0000,,as a sore store there that didn't heal Dialogue: 0,0:30:06.05,0:30:08.54,Default,,0000,0000,0000,,it was in the master was acts of faith Dialogue: 0,0:30:08.54,0:30:11.03,Default,,0000,0000,0000,,but this thing penetrated in Dialogue: 0,0:30:11.03,0:30:13.00,Default,,0000,0000,0000,,about a centimeter or two Dialogue: 0,0:30:13.00,0:30:17.04,Default,,0000,0000,0000,,not hand it was also present in the imo\Nlymph nodes Dialogue: 0,0:30:17.04,0:30:19.07,Default,,0000,0000,0000,,on that side Dialogue: 0,0:30:19.07,0:30:21.07,Default,,0000,0000,0000,,when the cell carcinoma Dialogue: 0,0:30:21.07,0:30:24.10,Default,,0000,0000,0000,,here's one that we don't see much\Nanymore and i hope you never see one Dialogue: 0,0:30:24.10,0:30:26.03,Default,,0000,0000,0000,,like this Dialogue: 0,0:30:26.03,0:30:28.02,Default,,0000,0000,0000,,and this is a cervix Dialogue: 0,0:30:28.02,0:30:30.00,Default,,0000,0000,0000,,to observe ovaries over here Dialogue: 0,0:30:30.00,0:30:32.01,Default,,0000,0000,0000,,and vagina Dialogue: 0,0:30:32.01,0:30:37.04,Default,,0000,0000,0000,,and what should have been a nice cervix\Nhere is completely destroyed Dialogue: 0,0:30:37.04,0:30:40.00,Default,,0000,0000,0000,,by this very very advanced Dialogue: 0,0:30:40.00,0:30:41.78,Default,,0000,0000,0000,,square was still Dialogue: 0,0:30:41.78,0:30:43.07,Default,,0000,0000,0000,,carcinoma Dialogue: 0,0:30:43.07,0:30:45.87,Default,,0000,0000,0000,,the face of the cervix that Dialogue: 0,0:30:45.87,0:30:49.06,Default,,0000,0000,0000,,juts into the giant is covered by square\Nwas that the feelings of many of these Dialogue: 0,0:30:49.06,0:30:51.10,Default,,0000,0000,0000,,cancers are swimmers Dialogue: 0,0:30:51.10,0:30:55.01,Default,,0000,0000,0000,,number i showed you beyond the cervix\Nthe other day that also has glandular Dialogue: 0,0:30:55.01,0:30:58.08,Default,,0000,0000,0000,,line so we do see some admin carcinomas\Nthere Dialogue: 0,0:30:58.08,0:30:59.08,Default,,0000,0000,0000,,these are Dialogue: 0,0:30:59.08,0:31:02.01,Default,,0000,0000,0000,,uh... basically provoked by Dialogue: 0,0:31:02.01,0:31:07.05,Default,,0000,0000,0000,,a number of strains of the human\Npapillomavirus Dialogue: 0,0:31:07.05,0:31:09.00,Default,,0000,0000,0000,,it's it's uh... Dialogue: 0,0:31:09.00,0:31:10.01,Default,,0000,0000,0000,,transmissible Dialogue: 0,0:31:10.01,0:31:12.05,Default,,0000,0000,0000,,virus and uh... this is Dialogue: 0,0:31:12.05,0:31:13.43,Default,,0000,0000,0000,,one of the Dialogue: 0,0:31:13.43,0:31:14.01,Default,,0000,0000,0000,,bad outcomes Dialogue: 0,0:31:14.01,0:31:19.02,Default,,0000,0000,0000,,now i say that i hope you'll never\Nsenior probably never see one quite Dialogue: 0,0:31:19.02,0:31:21.02,Default,,0000,0000,0000,,disadvantage of practice in this country Dialogue: 0,0:31:21.02,0:31:24.10,Default,,0000,0000,0000,,because of the widespread use of pap\Nsmears we discussed that last time you Dialogue: 0,0:31:24.10,0:31:25.63,Default,,0000,0000,0000,,can Dialogue: 0,0:31:25.63,0:31:29.38,Default,,0000,0000,0000,,even apprehend this sort of thing one is\Nstill in the insight tuesday jury even Dialogue: 0,0:31:29.38,0:31:31.07,Default,,0000,0000,0000,,earlier with displeasure Dialogue: 0,0:31:31.07,0:31:34.09,Default,,0000,0000,0000,,you don't have to wait for this when\Nthis woman already had a follow bloody Dialogue: 0,0:31:34.09,0:31:38.39,Default,,0000,0000,0000,,discharge because of this Dialogue: 0,0:31:38.39,0:31:40.09,Default,,0000,0000,0000,,neoplasm Dialogue: 0,0:31:40.09,0:31:44.05,Default,,0000,0000,0000,,well let's go back to him and g{\u1}i{\u0} tract Dialogue: 0,0:31:44.05,0:31:45.04,Default,,0000,0000,0000,,uni Dialogue: 0,0:31:45.04,0:31:50.00,Default,,0000,0000,0000,,upper aerodynamicists tracked into the\Ntongue the line-item all of the back of Dialogue: 0,0:31:50.00,0:31:51.09,Default,,0000,0000,0000,,the throat banks and so forth Dialogue: 0,0:31:51.09,0:31:57.05,Default,,0000,0000,0000,,we commonly see squeamish cell\Ncarcinomas Dialogue: 0,0:31:57.05,0:31:59.04,Default,,0000,0000,0000,,and this is a ton Dialogue: 0,0:31:59.04,0:32:01.10,Default,,0000,0000,0000,,that's been amputated Dialogue: 0,0:32:01.10,0:32:03.04,Default,,0000,0000,0000,,cuts actually Dialogue: 0,0:32:03.04,0:32:08.02,Default,,0000,0000,0000,,and you can see this very deeply\Ninvasive mass this was a squamous cell Dialogue: 0,0:32:08.02,0:32:09.03,Default,,0000,0000,0000,,carcinoma Dialogue: 0,0:32:09.03,0:32:09.06,Default,,0000,0000,0000,,rising Dialogue: 0,0:32:09.06,0:32:11.05,Default,,0000,0000,0000,,out here Dialogue: 0,0:32:11.05,0:32:12.09,Default,,0000,0000,0000,,these or older Dialogue: 0,0:32:12.09,0:32:14.08,Default,,0000,0000,0000,,uh... Dialogue: 0,0:32:14.08,0:32:20.01,Default,,0000,0000,0000,,for racial cancers are mostly related to\Nsmoking and drinking Dialogue: 0,0:32:20.01,0:32:22.03,Default,,0000,0000,0000,,and Dialogue: 0,0:32:22.03,0:32:26.01,Default,,0000,0000,0000,,histologically this might look identical\Nto living in the cervix but it's got a Dialogue: 0,0:32:26.01,0:32:28.01,Default,,0000,0000,0000,,different etiology Dialogue: 0,0:32:28.01,0:32:32.56,Default,,0000,0000,0000,,and different different behavior but\Nthis was a very deeply invasive Dialogue: 0,0:32:32.56,0:32:34.08,Default,,0000,0000,0000,,square missile carcinoma Dialogue: 0,0:32:34.08,0:32:38.03,Default,,0000,0000,0000,,here's another one mister heavy smoker Dialogue: 0,0:32:38.03,0:32:40.02,Default,,0000,0000,0000,,this is a larynx Dialogue: 0,0:32:40.02,0:32:41.05,Default,,0000,0000,0000,,opened in the back Dialogue: 0,0:32:41.05,0:32:44.06,Default,,0000,0000,0000,,so the adam's apple store the front my\Nspread open Dialogue: 0,0:32:44.06,0:32:47.06,Default,,0000,0000,0000,,there's a deeply ulcerative tumor there Dialogue: 0,0:32:47.06,0:32:48.09,Default,,0000,0000,0000,,uh... Dialogue: 0,0:32:48.09,0:32:53.06,Default,,0000,0000,0000,,this may have been around for months and\Nmonths and months and months Dialogue: 0,0:32:53.06,0:32:54.09,Default,,0000,0000,0000,,head-first Dialogue: 0,0:32:54.09,0:32:56.09,Default,,0000,0000,0000,,classes don't necessarily cause pain Dialogue: 0,0:32:56.09,0:33:00.04,Default,,0000,0000,0000,,you know i must say infiltrate nerves\Nare not going to cause much pain Dialogue: 0,0:33:00.04,0:33:04.07,Default,,0000,0000,0000,,this guy had inherited of cough in his\Nvoice changed as you can imagine the Dialogue: 0,0:33:04.07,0:33:07.05,Default,,0000,0000,0000,,vocal cord gradually being destroyed Dialogue: 0,0:33:07.05,0:33:10.06,Default,,0000,0000,0000,,you know a heavy smokers are used to\Nbeing a horse and coughing and so forth Dialogue: 0,0:33:10.06,0:33:13.08,Default,,0000,0000,0000,,and again the denial kicks in Dialogue: 0,0:33:13.08,0:33:16.51,Default,,0000,0000,0000,,this was a along the collected Dialogue: 0,0:33:16.51,0:33:19.00,Default,,0000,0000,0000,,square was still carcinoma Dialogue: 0,0:33:19.00,0:33:21.00,Default,,0000,0000,0000,,larynx Dialogue: 0,0:33:21.00,0:33:24.28,Default,,0000,0000,0000,,take it down the esophagus nam two miles\Nis up there Dialogue: 0,0:33:24.28,0:33:28.01,Default,,0000,0000,0000,,this is the sound is coming down the\Nsummit here and you can see we we've Dialogue: 0,0:33:28.01,0:33:30.01,Default,,0000,0000,0000,,opened an office is rough in the area Dialogue: 0,0:33:30.01,0:33:34.04,Default,,0000,0000,0000,,and the cut surface area to see at the\Nwall a second Dialogue: 0,0:33:34.04,0:33:37.17,Default,,0000,0000,0000,,this is a very advanced Dialogue: 0,0:33:37.17,0:33:38.02,Default,,0000,0000,0000,,carcinoma Dialogue: 0,0:33:38.02,0:33:43.00,Default,,0000,0000,0000,,aligning of the esophagus disclaimers in\Nthis was a square must sell Dialogue: 0,0:33:43.00,0:33:45.05,Default,,0000,0000,0000,,carcinoma Dialogue: 0,0:33:45.05,0:33:48.09,Default,,0000,0000,0000,,desert you can imagine will produce a\Nmechanical problems patients will have Dialogue: 0,0:33:48.09,0:33:50.01,Default,,0000,0000,0000,,trouble swallowing Dialogue: 0,0:33:50.01,0:33:51.07,Default,,0000,0000,0000,,and there again Dialogue: 0,0:33:51.07,0:33:53.24,Default,,0000,0000,0000,,i've seen patients come in Dialogue: 0,0:33:53.24,0:33:56.08,Default,,0000,0000,0000,,and strain baby food before they finally\Nsay oncall Dialogue: 0,0:33:56.08,0:33:59.06,Default,,0000,0000,0000,,and decide that something might be wrong Dialogue: 0,0:33:59.06,0:34:02.10,Default,,0000,0000,0000,,and these are very hard to cure because\Nof the fact that they are advancing Dialogue: 0,0:34:02.10,0:34:07.00,Default,,0000,0000,0000,,their local my pastor sees it's not just\Nin the past the seas Dialogue: 0,0:34:07.00,0:34:08.69,Default,,0000,0000,0000,,we can also see Dialogue: 0,0:34:08.69,0:34:11.35,Default,,0000,0000,0000,,adamo carcinomas nearsightedness Dialogue: 0,0:34:11.35,0:34:17.83,Default,,0000,0000,0000,,because there are some glandular\Nepithelium there that can also give rise Dialogue: 0,0:34:17.83,0:34:21.06,Default,,0000,0000,0000,,now if you look at that i tell you this\Nis a stomach has been opened in Dialogue: 0,0:34:21.06,0:34:23.10,Default,,0000,0000,0000,,washington is the esophagus up there is\Nthis Dialogue: 0,0:34:23.10,0:34:25.96,Default,,0000,0000,0000,,do indian coming off over here Dialogue: 0,0:34:25.96,0:34:31.05,Default,,0000,0000,0000,,if you look at that for a while at first\Nyou might say well nothing wrong on that Dialogue: 0,0:34:31.05,0:34:34.99,Default,,0000,0000,0000,,but you'll notice that the normal full\Npattern Dialogue: 0,0:34:34.99,0:34:37.29,Default,,0000,0000,0000,,desire note here Dialogue: 0,0:34:37.29,0:34:40.13,Default,,0000,0000,0000,,it doesn't look so awful that at first\Nblush Dialogue: 0,0:34:40.13,0:34:45.70,Default,,0000,0000,0000,,but that is a diffuse lee infiltrated\Ncarcinoma Dialogue: 0,0:34:45.70,0:34:49.41,Default,,0000,0000,0000,,what kind is suppose it is given up his\Nstomach is a Dialogue: 0,0:34:49.41,0:34:52.83,Default,,0000,0000,0000,,glandular lying Dialogue: 0,0:34:52.83,0:34:54.40,Default,,0000,0000,0000,,adenocarcinoma Dialogue: 0,0:34:54.40,0:34:56.96,Default,,0000,0000,0000,,and uh... these things are Dialogue: 0,0:34:56.96,0:35:01.27,Default,,0000,0000,0000,,very subtle and a symptomatic until\Ntheir advance this was very advances as Dialogue: 0,0:35:01.27,0:35:03.30,Default,,0000,0000,0000,,medicine at ican liver already Dialogue: 0,0:35:03.30,0:35:04.86,Default,,0000,0000,0000,,at the time it came Dialogue: 0,0:35:04.86,0:35:07.06,Default,,0000,0000,0000,,uh... Dialogue: 0,0:35:07.06,0:35:11.09,Default,,0000,0000,0000,,so they may have traditionally symptoms\Nat all and interesting wrinkle here is Dialogue: 0,0:35:11.09,0:35:15.05,Default,,0000,0000,0000,,uh... the incidence of this kind of\Ntumor is very high in japan Dialogue: 0,0:35:15.05,0:35:16.48,Default,,0000,0000,0000,,much higher than here Dialogue: 0,0:35:16.48,0:35:20.37,Default,,0000,0000,0000,,and it's largely in environmental thing\Nbecause the descendants of japanese who Dialogue: 0,0:35:20.37,0:35:21.02,Default,,0000,0000,0000,,come here Dialogue: 0,0:35:21.02,0:35:22.86,Default,,0000,0000,0000,,or pick up our other Dialogue: 0,0:35:22.86,0:35:23.10,Default,,0000,0000,0000,,yankee problems Dialogue: 0,0:35:23.10,0:35:28.83,Default,,0000,0000,0000,,but uh... this incident changes but it's\Nsuch a public health problem Dialogue: 0,0:35:28.83,0:35:30.10,Default,,0000,0000,0000,,that they will screen Dialogue: 0,0:35:30.10,0:35:34.24,Default,,0000,0000,0000,,for this sort of thing because there's\Nnothing like this could produce symptoms Dialogue: 0,0:35:34.24,0:35:34.10,Default,,0000,0000,0000,,early on Dialogue: 0,0:35:34.10,0:35:38.07,Default,,0000,0000,0000,,so the only hope of getting it earlier\Nis played by population screening and Dialogue: 0,0:35:38.07,0:35:40.60,Default,,0000,0000,0000,,that's that's another matter Dialogue: 0,0:35:40.60,0:35:42.04,Default,,0000,0000,0000,,for another time Dialogue: 0,0:35:42.04,0:35:46.09,Default,,0000,0000,0000,,here's one that will anticipate uh...\Nthis afternoon Dialogue: 0,0:35:46.09,0:35:48.32,Default,,0000,0000,0000,,getting down to a large intestine Dialogue: 0,0:35:48.32,0:35:51.35,Default,,0000,0000,0000,,this is actually in the first part of a\Nlarge intestine over here right where Dialogue: 0,0:35:51.35,0:35:56.29,Default,,0000,0000,0000,,the small intestine answers for the\Nappendix comes offices so called safe Dialogue: 0,0:35:56.29,0:35:57.82,Default,,0000,0000,0000,,this about Dialogue: 0,0:35:57.82,0:36:00.23,Default,,0000,0000,0000,,poultry four inches in diameter Dialogue: 0,0:36:00.23,0:36:01.01,Default,,0000,0000,0000,,and there's a huge Dialogue: 0,0:36:01.01,0:36:05.89,Default,,0000,0000,0000,,fung gaining neoplasm there Dialogue: 0,0:36:05.89,0:36:09.46,Default,,0000,0000,0000,,anissa grown glandular lining so it's an\Nadamo Dialogue: 0,0:36:09.46,0:36:10.79,Default,,0000,0000,0000,,carcinoma Dialogue: 0,0:36:10.79,0:36:11.51,Default,,0000,0000,0000,,now Dialogue: 0,0:36:11.51,0:36:13.10,Default,,0000,0000,0000,,in terms of our clinical present asian Dialogue: 0,0:36:13.10,0:36:17.08,Default,,0000,0000,0000,,uh... this thing isn't going to his big\Nis that there is a good person that's Dialogue: 0,0:36:17.08,0:36:19.74,Default,,0000,0000,0000,,trucked something bad big so that Dialogue: 0,0:36:19.74,0:36:22.07,Default,,0000,0000,0000,,the first confiscate passing by Dialogue: 0,0:36:22.07,0:36:25.60,Default,,0000,0000,0000,,doesn't cause any pain Dialogue: 0,0:36:25.60,0:36:27.100,Default,,0000,0000,0000,,at least at this stage Dialogue: 0,0:36:27.100,0:36:31.16,Default,,0000,0000,0000,,one things that happens with these as\Nthey believe Dialogue: 0,0:36:31.16,0:36:35.17,Default,,0000,0000,0000,,you know the passing traffic will will\Nerode the surface and they'll believe Dialogue: 0,0:36:35.17,0:36:37.89,Default,,0000,0000,0000,,they'll lose blood Dialogue: 0,0:36:37.89,0:36:39.06,Default,,0000,0000,0000,,this is all borrow Dialogue: 0,0:36:39.06,0:36:41.99,Default,,0000,0000,0000,,three feet from the i{\u1}n{\u0}s_ Dialogue: 0,0:36:41.99,0:36:46.45,Default,,0000,0000,0000,,colin goes up here cross here down here\Nthere's a little blue goes out Dialogue: 0,0:36:46.45,0:36:49.64,Default,,0000,0000,0000,,in the fact is five times the blood Dialogue: 0,0:36:49.64,0:36:54.73,Default,,0000,0000,0000,,goes from there to meet a nice it's no\Nlonger rat its black Dialogue: 0,0:36:54.73,0:36:58.98,Default,,0000,0000,0000,,the patient will be passing schools that\Ni mean if he's losing enough blood Dialogue: 0,0:36:58.98,0:37:00.68,Default,,0000,0000,0000,,we passing stools Dialogue: 0,0:37:00.68,0:37:02.03,Default,,0000,0000,0000,,that perhaps look Dialogue: 0,0:37:02.03,0:37:04.01,Default,,0000,0000,0000,,tari that's the efforts that given to\Nthem Dialogue: 0,0:37:04.01,0:37:07.06,Default,,0000,0000,0000,,something we called mellon up learn\Nad-aware Dialogue: 0,0:37:07.06,0:37:12.94,Default,,0000,0000,0000,,you don't know if m{\u1}e{\u0}l_ d{\u1}n{\u0}a_ means\Nblackberry stole Dialogue: 0,0:37:12.94,0:37:14.74,Default,,0000,0000,0000,,and patience will comment Dialogue: 0,0:37:14.74,0:37:17.07,Default,,0000,0000,0000,,and a couple of ways with this they may\Nsay Dialogue: 0,0:37:17.07,0:37:21.01,Default,,0000,0000,0000,,if their particular instrument look in\Nthe bolded for a flash Dialogue: 0,0:37:21.01,0:37:23.05,Default,,0000,0000,0000,,uh... dr Dialogue: 0,0:37:23.05,0:37:25.31,Default,,0000,0000,0000,,harry schools was wrong Dialogue: 0,0:37:25.31,0:37:29.07,Default,,0000,0000,0000,,more unlikely in this is something you\Nmust always remember middle-aged or Dialogue: 0,0:37:29.07,0:37:31.17,Default,,0000,0000,0000,,elderly patient comes an incentive Dialogue: 0,0:37:31.17,0:37:33.41,Default,,0000,0000,0000,,i'm just proved all the time Dialogue: 0,0:37:33.41,0:37:37.50,Default,,0000,0000,0000,,you know describes being he's easily\Nfatigued and weak and so forth you take Dialogue: 0,0:37:37.50,0:37:39.06,Default,,0000,0000,0000,,a look and they were kind of payal Dialogue: 0,0:37:39.06,0:37:41.23,Default,,0000,0000,0000,,are you doing a glowing Dialogue: 0,0:37:41.23,0:37:43.51,Default,,0000,0000,0000,,you find it terribly anemic Dialogue: 0,0:37:43.51,0:37:44.40,Default,,0000,0000,0000,,it's from chronic Dialogue: 0,0:37:44.40,0:37:48.04,Default,,0000,0000,0000,,i called blood loss like this Dialogue: 0,0:37:48.04,0:37:54.16,Default,,0000,0000,0000,,climate chances on the right side in the\Nkorea's Dialogue: 0,0:37:54.16,0:37:55.68,Default,,0000,0000,0000,,jess's all through the colon Dialogue: 0,0:37:55.68,0:37:59.20,Default,,0000,0000,0000,,uh... this is one very closely nis Dialogue: 0,0:37:59.20,0:38:02.00,Default,,0000,0000,0000,,wishes in circles the whole by all\Naround Dialogue: 0,0:38:02.00,0:38:04.19,Default,,0000,0000,0000,,like a napkin rings Dialogue: 0,0:38:04.19,0:38:08.56,Default,,0000,0000,0000,,you know who actually produce narrowing\Nbelow min obviously is infiltrated the Dialogue: 0,0:38:08.56,0:38:13.12,Default,,0000,0000,0000,,muscle of the wall that would produce a\Nchange in bal habits Dialogue: 0,0:38:13.12,0:38:15.83,Default,,0000,0000,0000,,it will produce frank Dialogue: 0,0:38:15.83,0:38:20.25,Default,,0000,0000,0000,,in the schools is close enough to the\Nunicef if it bleeds can come out blood Dialogue: 0,0:38:20.25,0:38:21.80,Default,,0000,0000,0000,,that's referred to Dialogue: 0,0:38:21.80,0:38:23.57,Default,,0000,0000,0000,,he met okie xia Dialogue: 0,0:38:23.57,0:38:25.75,Default,,0000,0000,0000,,ichi ohmae tito Dialogue: 0,0:38:25.75,0:38:30.74,Default,,0000,0000,0000,,c{\u1}d{\u0}h_ lindsayolives came at a meaning\Nblood his ears a wonderful greek word Dialogue: 0,0:38:30.74,0:38:33.00,Default,,0000,0000,0000,,for me to go potty Dialogue: 0,0:38:33.00,0:38:36.10,Default,,0000,0000,0000,,over Dialogue: 0,0:38:36.10,0:38:39.34,Default,,0000,0000,0000,,the american uses frank blood Dialogue: 0,0:38:39.34,0:38:41.88,Default,,0000,0000,0000,,unit in the school which may be that in Dialogue: 0,0:38:41.88,0:38:45.71,Default,,0000,0000,0000,,again people deny this is a law that\Nhemorrhoids and thereby preparation h Dialogue: 0,0:38:45.71,0:38:48.32,Default,,0000,0000,0000,,and stick it up there for Dialogue: 0,0:38:48.32,0:38:51.10,Default,,0000,0000,0000,,however long before they finally come in Dialogue: 0,0:38:51.10,0:38:55.34,Default,,0000,0000,0000,,the important thing is is will also\Npoint out this afternoon is be the Dialogue: 0,0:38:55.34,0:39:00.07,Default,,0000,0000,0000,,survival of the prognosis is stage\Nrelated Dialogue: 0,0:39:00.07,0:39:03.83,Default,,0000,0000,0000,,farzad penetrate through the ball wall\Nis it in the regional lymph nodes and so Dialogue: 0,0:39:03.83,0:39:04.51,Default,,0000,0000,0000,,forth Dialogue: 0,0:39:04.51,0:39:08.30,Default,,0000,0000,0000,,uh... these are the important factors Dialogue: 0,0:39:08.30,0:39:09.02,Default,,0000,0000,0000,,all right Dialogue: 0,0:39:09.02,0:39:11.15,Default,,0000,0000,0000,,couple of smokers things Dialogue: 0,0:39:11.15,0:39:14.73,Default,,0000,0000,0000,,you can see about fifty packages of Dialogue: 0,0:39:14.73,0:39:17.14,Default,,0000,0000,0000,,and that long Dialogue: 0,0:39:17.14,0:39:20.33,Default,,0000,0000,0000,,here is a massive obstructing Dialogue: 0,0:39:20.33,0:39:24.09,Default,,0000,0000,0000,,bronchus here this is the dilated\Nbronchus Dialogue: 0,0:39:24.09,0:39:25.01,Default,,0000,0000,0000,,and full of Dialogue: 0,0:39:25.01,0:39:28.72,Default,,0000,0000,0000,,newco kurland exudate Dialogue: 0,0:39:28.72,0:39:30.07,Default,,0000,0000,0000,,that's the tumor right there Dialogue: 0,0:39:30.07,0:39:32.45,Default,,0000,0000,0000,,and this patient presented Dialogue: 0,0:39:32.45,0:39:35.41,Default,,0000,0000,0000,,or we probably had a cough but all\Nsmoker's cough Dialogue: 0,0:39:35.41,0:39:38.30,Default,,0000,0000,0000,,uh... presented with repeated pneumonia Dialogue: 0,0:39:38.30,0:39:39.95,Default,,0000,0000,0000,,kept coming with episodes of pneumonia Dialogue: 0,0:39:39.95,0:39:42.29,Default,,0000,0000,0000,,who's always in the same place Dialogue: 0,0:39:42.29,0:39:45.66,Default,,0000,0000,0000,,and they finally tumbled to the fact\Nthat we always have obstruct must have Dialogue: 0,0:39:45.66,0:39:47.30,Default,,0000,0000,0000,,obstructive lesion there Dialogue: 0,0:39:47.30,0:39:49.49,Default,,0000,0000,0000,,and there it was Dialogue: 0,0:39:49.49,0:39:50.09,Default,,0000,0000,0000,,not leave Dialogue: 0,0:39:50.09,0:39:55.08,Default,,0000,0000,0000,,bronchus is line by a glandular type of\Nepithelium so there are adamo carcinomas Dialogue: 0,0:39:55.08,0:39:58.61,Default,,0000,0000,0000,,and one Dialogue: 0,0:39:58.61,0:40:02.88,Default,,0000,0000,0000,,notoriously there can be metalplaza xia\Nof the broncos that goes on to display Dialogue: 0,0:40:02.88,0:40:07.68,Default,,0000,0000,0000,,not only not a place of the displays\Nhuman cancer and many of these parts qua Dialogue: 0,0:40:07.68,0:40:09.02,Default,,0000,0000,0000,,must sell Dialogue: 0,0:40:09.02,0:40:10.67,Default,,0000,0000,0000,,carcinomas Dialogue: 0,0:40:10.67,0:40:13.05,Default,,0000,0000,0000,,so there is a relatively small one that\Nproduced Dialogue: 0,0:40:13.05,0:40:14.04,Default,,0000,0000,0000,,repeated bouts Dialogue: 0,0:40:14.04,0:40:16.04,Default,,0000,0000,0000,,of pneumonia Dialogue: 0,0:40:16.04,0:40:19.02,Default,,0000,0000,0000,,there's a larger one just to show you\Nwhat they could look like when they Dialogue: 0,0:40:19.02,0:40:21.08,Default,,0000,0000,0000,,really get out of hand Dialogue: 0,0:40:21.08,0:40:22.55,Default,,0000,0000,0000,,here's an interesting one Dialogue: 0,0:40:22.55,0:40:27.02,Default,,0000,0000,0000,,uh... close up here trachea coming down\Nhere bronchus hier bronchus here you see Dialogue: 0,0:40:27.02,0:40:28.04,Default,,0000,0000,0000,,this little thing Dialogue: 0,0:40:28.04,0:40:29.01,Default,,0000,0000,0000,,this was a Dialogue: 0,0:40:29.01,0:40:31.51,Default,,0000,0000,0000,,sway with cell carcinoma Dialogue: 0,0:40:31.51,0:40:33.05,Default,,0000,0000,0000,,and you say well why didn't they Dialogue: 0,0:40:33.05,0:40:37.86,Default,,0000,0000,0000,,uh... simply doing norman actually take\Noff the bronchus here you can live with Dialogue: 0,0:40:37.86,0:40:40.31,Default,,0000,0000,0000,,one long Dialogue: 0,0:40:40.31,0:40:43.11,Default,,0000,0000,0000,,doing it right here this is an autopsy\Nspecimens Dialogue: 0,0:40:43.11,0:40:44.05,Default,,0000,0000,0000,,and actually this Dialogue: 0,0:40:44.05,0:40:47.05,Default,,0000,0000,0000,,thing that looks small here had gone\Nthrough Dialogue: 0,0:40:47.05,0:40:49.09,Default,,0000,0000,0000,,the back of the bronchus Dialogue: 0,0:40:49.09,0:40:52.91,Default,,0000,0000,0000,,this is all neoplasm kind of in case the\Nheartbeat was Dialogue: 0,0:40:52.91,0:40:56.00,Default,,0000,0000,0000,,hopeless from from from the get go\Nswimmin cell Dialogue: 0,0:40:56.00,0:40:58.81,Default,,0000,0000,0000,,carcinoma Dialogue: 0,0:40:58.81,0:41:02.09,Default,,0000,0000,0000,,sestalo market was the benign one of my\Nsmooth surfaces Dialogue: 0,0:41:02.09,0:41:05.28,Default,,0000,0000,0000,,inside this this will line when i see\Nyou Dialogue: 0,0:41:05.28,0:41:06.82,Default,,0000,0000,0000,,had a feeling of Dialogue: 0,0:41:06.82,0:41:12.01,Default,,0000,0000,0000,,here's the malignant counterpart you can\Nsee the steiner's than other ovarian Dialogue: 0,0:41:12.01,0:41:13.18,Default,,0000,0000,0000,,neoplasm Dialogue: 0,0:41:13.18,0:41:17.11,Default,,0000,0000,0000,,it's mulligan and so we call it sister i\Ndon't know Dialogue: 0,0:41:17.11,0:41:18.06,Default,,0000,0000,0000,,carcinoma Dialogue: 0,0:41:18.06,0:41:20.02,Default,,0000,0000,0000,,masses there than normal Dialogue: 0,0:41:20.02,0:41:22.01,Default,,0000,0000,0000,,disassemble carcinoma Dialogue: 0,0:41:22.01,0:41:26.07,Default,,0000,0000,0000,,the thing and then would immediately\Ntook us to say this isn't just a simple Dialogue: 0,0:41:26.07,0:41:27.04,Default,,0000,0000,0000,,system nama Dialogue: 0,0:41:27.04,0:41:30.07,Default,,0000,0000,0000,,is a surface is no longer smooth like\Nthis everywhere Dialogue: 0,0:41:30.07,0:41:31.97,Default,,0000,0000,0000,,this guy Dialogue: 0,0:41:31.97,0:41:33.95,Default,,0000,0000,0000,,very furry looking growth Dialogue: 0,0:41:33.95,0:41:36.83,Default,,0000,0000,0000,,all over the surface Dialogue: 0,0:41:36.83,0:41:42.34,Default,,0000,0000,0000,,and the bubbles inside ourselves Dialogue: 0,0:41:42.34,0:41:44.35,Default,,0000,0000,0000,,neoplasm growing from the lining of the\Ntrouble Dialogue: 0,0:41:44.35,0:41:47.07,Default,,0000,0000,0000,,in other words the many of you can see\Nsome bubbles so there are some cystic Dialogue: 0,0:41:47.07,0:41:48.06,Default,,0000,0000,0000,,spaces Dialogue: 0,0:41:48.06,0:41:53.76,Default,,0000,0000,0000,,but many of the previously cystic spaces\Nare filled with his rapidly growing Dialogue: 0,0:41:53.76,0:41:54.48,Default,,0000,0000,0000,,neoplasm Dialogue: 0,0:41:54.48,0:41:57.02,Default,,0000,0000,0000,,so this is sister adamo Dialogue: 0,0:41:57.02,0:41:59.11,Default,,0000,0000,0000,,carcinoma Dialogue: 0,0:41:59.11,0:42:04.24,Default,,0000,0000,0000,,i don't have an illustration of it but\Nyou can imagine papillary tumor Dialogue: 0,0:42:04.24,0:42:07.66,Default,,0000,0000,0000,,being eight papillary carcinoma greta\Npapilloma Dialogue: 0,0:42:07.66,0:42:11.56,Default,,0000,0000,0000,,or papillary carcinoma Dialogue: 0,0:42:11.56,0:42:14.04,Default,,0000,0000,0000,,so learn to to handle Dialogue: 0,0:42:14.04,0:42:16.09,Default,,0000,0000,0000,,these uh... the moment but sure here Dialogue: 0,0:42:16.09,0:42:22.25,Default,,0000,0000,0000,,as i say quite quite played by reflex Dialogue: 0,0:42:22.25,0:42:23.01,Default,,0000,0000,0000,,let's switch Dialogue: 0,0:42:23.01,0:42:37.30,Default,,0000,0000,0000,,away from apathy leo Dialogue: 0,0:42:37.30,0:42:39.01,Default,,0000,0000,0000,,uh... Dialogue: 0,0:42:39.01,0:42:40.32,Default,,0000,0000,0000,,this along Dialogue: 0,0:42:40.32,0:42:45.07,Default,,0000,0000,0000,,answer to that but al stroke by a long\Nbeard and say thanks a lot of experience Dialogue: 0,0:42:45.07,0:42:48.41,Default,,0000,0000,0000,,under the microscope you would see not\Nonly Dialogue: 0,0:42:48.41,0:42:51.47,Default,,0000,0000,0000,,growth of these fingers but you see\Ninvasion Dialogue: 0,0:42:51.47,0:42:53.76,Default,,0000,0000,0000,,you'd also see more panoply here Dialogue: 0,0:42:53.76,0:42:56.71,Default,,0000,0000,0000,,in you know psychologically it's a\Ncombination of things but that's a Dialogue: 0,0:42:56.71,0:42:58.51,Default,,0000,0000,0000,,that's a very good point Dialogue: 0,0:42:58.51,0:43:01.06,Default,,0000,0000,0000,,and sometimes it's and it's a devilish\Nproblem i see a lot of Dialogue: 0,0:43:01.06,0:43:04.10,Default,,0000,0000,0000,,stuff growing out we've gotta make\Nmultiple sections and see if any of its Dialogue: 0,0:43:04.10,0:43:07.23,Default,,0000,0000,0000,,invading Dialogue: 0,0:43:07.23,0:43:09.58,Default,,0000,0000,0000,,now getting away from Dialogue: 0,0:43:09.58,0:43:11.20,Default,,0000,0000,0000,,as helium Dialogue: 0,0:43:11.20,0:43:13.08,Default,,0000,0000,0000,,getting too nice a little dish is what\Nwe call Dialogue: 0,0:43:13.08,0:43:18.71,Default,,0000,0000,0000,,a supporting tissue or missing coble\Ntissues Dialogue: 0,0:43:18.71,0:43:19.87,Default,,0000,0000,0000,,fibrous tissue Dialogue: 0,0:43:19.87,0:43:23.01,Default,,0000,0000,0000,,smooth muscles column also bone\Ncartilage those of the things we're Dialogue: 0,0:43:23.01,0:43:25.07,Default,,0000,0000,0000,,talking about Dialogue: 0,0:43:25.07,0:43:28.77,Default,,0000,0000,0000,,but when i got your becomes easy if you\Nknow a little and then great Dialogue: 0,0:43:28.77,0:43:30.06,Default,,0000,0000,0000,,if you have a Dialogue: 0,0:43:30.06,0:43:35.100,Default,,0000,0000,0000,,benign tumor of fatty tissue adipose\Ntissue recall well-lit Dialogue: 0,0:43:35.100,0:43:37.00,Default,,0000,0000,0000,,wal-mart Dialogue: 0,0:43:37.00,0:43:39.00,Default,,0000,0000,0000,,like mama Dialogue: 0,0:43:39.00,0:43:42.66,Default,,0000,0000,0000,,benign neoplasm carl agin this tissue Dialogue: 0,0:43:42.66,0:43:44.95,Default,,0000,0000,0000,,kong drama Dialogue: 0,0:43:44.95,0:43:47.05,Default,,0000,0000,0000,,the minute plasma fibrous tissue Dialogue: 0,0:43:47.05,0:43:50.08,Default,,0000,0000,0000,,five romana etcetera etcetera Dialogue: 0,0:43:50.08,0:43:52.37,Default,,0000,0000,0000,,thursday after the latin and greek Dialogue: 0,0:43:52.37,0:43:57.15,Default,,0000,0000,0000,,the system here is if it's malignancy Dialogue: 0,0:43:57.15,0:43:59.94,Default,,0000,0000,0000,,milkar carcinoma because that's that's\Nreally all Dialogue: 0,0:43:59.94,0:44:04.05,Default,,0000,0000,0000,,if it's malignant an album as likable as\Nsupporting tissue which holidays Dialogue: 0,0:44:04.05,0:44:06.05,Default,,0000,0000,0000,,star Dialogue: 0,0:44:06.05,0:44:07.06,Default,,0000,0000,0000,,you've all heard these words Dialogue: 0,0:44:07.06,0:44:11.80,Default,,0000,0000,0000,,but now you have to be used in precisely Dialogue: 0,0:44:11.80,0:44:16.01,Default,,0000,0000,0000,,malignant neoplasm a fatty tissue is a\Nlight posts are calm Dialogue: 0,0:44:16.01,0:44:18.90,Default,,0000,0000,0000,,in malignant neoplasm of Dialogue: 0,0:44:18.90,0:44:20.07,Default,,0000,0000,0000,,carl edge in this issue is that Dialogue: 0,0:44:20.07,0:44:22.26,Default,,0000,0000,0000,,conroe sarcoma Dialogue: 0,0:44:22.26,0:44:25.11,Default,,0000,0000,0000,,and so forth Dialogue: 0,0:44:25.11,0:44:28.75,Default,,0000,0000,0000,,the interesting thing about these is\Nthere not organ specific as many organs Dialogue: 0,0:44:28.75,0:44:31.77,Default,,0000,0000,0000,,have smooth muscle in the wall many\Norgans have Dialogue: 0,0:44:31.77,0:44:32.10,Default,,0000,0000,0000,,cartilage Dialogue: 0,0:44:32.10,0:44:35.61,Default,,0000,0000,0000,,many places in the body have owned Dialogue: 0,0:44:35.61,0:44:39.11,Default,,0000,0000,0000,,many uh... everything in the body\Npractice fibrous tissue so you can see Dialogue: 0,0:44:39.11,0:44:40.34,Default,,0000,0000,0000,,these tumors Dialogue: 0,0:44:40.34,0:44:43.37,Default,,0000,0000,0000,,arising in a variety of places Dialogue: 0,0:44:43.37,0:44:46.15,Default,,0000,0000,0000,,hears a strange one Dialogue: 0,0:44:46.15,0:44:49.66,Default,,0000,0000,0000,,incidental autopsy findings guide that\Nis something completely different had no Dialogue: 0,0:44:49.66,0:44:53.63,Default,,0000,0000,0000,,g{\u1}i{\u0} problems this is a little piece of\Ncoal have opened it up here Dialogue: 0,0:44:53.63,0:44:55.29,Default,,0000,0000,0000,,mucous membrane hearing here Dialogue: 0,0:44:55.29,0:44:59.24,Default,,0000,0000,0000,,and you look at that you say that a lot\Nof it Dialogue: 0,0:44:59.24,0:45:01.15,Default,,0000,0000,0000,,fatty tissue Dialogue: 0,0:45:01.15,0:45:04.91,Default,,0000,0000,0000,,buffer size only to turn on a big golf\Nball onset Dialogue: 0,0:45:04.91,0:45:06.03,Default,,0000,0000,0000,,uh... Dialogue: 0,0:45:06.03,0:45:09.10,Default,,0000,0000,0000,,histologically that was perfectly well\Ndifferentiated i couldn't tell it from Dialogue: 0,0:45:09.10,0:45:14.02,Default,,0000,0000,0000,,normal facile in the center of that big\Nglob of Dialogue: 0,0:45:14.02,0:45:17.100,Default,,0000,0000,0000,,adipose tissue that's a light palm up Dialogue: 0,0:45:17.100,0:45:20.98,Default,,0000,0000,0000,,they do a currently Dialogue: 0,0:45:20.98,0:45:22.09,Default,,0000,0000,0000,,their coats of the uh... Dialogue: 0,0:45:22.09,0:45:28.02,Default,,0000,0000,0000,,of the bal but it's quite rare where do\Nyou suppose locals were coming Dialogue: 0,0:45:28.02,0:45:30.17,Default,,0000,0000,0000,,well where there's a lot of fatty tissue Dialogue: 0,0:45:30.17,0:45:33.63,Default,,0000,0000,0000,,very common subcutaneously there may be\Nsome like homelessness room like a Dialogue: 0,0:45:33.63,0:45:36.04,Default,,0000,0000,0000,,chilly at least one Dialogue: 0,0:45:36.04,0:45:39.47,Default,,0000,0000,0000,,they're they're not at all on common and\Nthey're they're perfectly Dialogue: 0,0:45:39.47,0:45:41.20,Default,,0000,0000,0000,,but revealing holiness Dialogue: 0,0:45:41.20,0:45:44.58,Default,,0000,0000,0000,,they harbor didn't produce any symptoms Dialogue: 0,0:45:44.58,0:45:46.08,Default,,0000,0000,0000,,alright nearest here's a uterus Dialogue: 0,0:45:46.08,0:45:50.100,Default,,0000,0000,0000,,and each one of these is what you would\Ncall a fibroid Dialogue: 0,0:45:50.100,0:45:54.02,Default,,0000,0000,0000,,but now i will give you the correct\Nnomenclature Dialogue: 0,0:45:54.02,0:45:59.04,Default,,0000,0000,0000,,these tumors are benign air rising from\Nthe muscle of the uterus so they are my Dialogue: 0,0:45:59.04,0:46:00.09,Default,,0000,0000,0000,,yo mas Dialogue: 0,0:46:00.09,0:46:02.83,Default,,0000,0000,0000,,and wyoming muscle Dialogue: 0,0:46:02.83,0:46:06.37,Default,,0000,0000,0000,,and because the particular kind of\Nmuscle which you learn about his smooth Dialogue: 0,0:46:06.37,0:46:06.92,Default,,0000,0000,0000,,muscle Dialogue: 0,0:46:06.92,0:46:08.06,Default,,0000,0000,0000,,this is a Dialogue: 0,0:46:08.06,0:46:09.59,Default,,0000,0000,0000,,lower these are multiple Dialogue: 0,0:46:09.59,0:46:14.28,Default,,0000,0000,0000,,lightly or my omens Dialogue: 0,0:46:14.28,0:46:15.04,Default,,0000,0000,0000,,none of my culture Dialogue: 0,0:46:15.04,0:46:20.13,Default,,0000,0000,0000,,these can produce a variety of\Nmechanical systems hyper memory a Dialogue: 0,0:46:20.13,0:46:24.26,Default,,0000,0000,0000,,the big bowl compelled us as you\Nmentioned and some of the many a Dialogue: 0,0:46:24.26,0:46:25.78,Default,,0000,0000,0000,,marriage symptomatic Dialogue: 0,0:46:25.78,0:46:28.99,Default,,0000,0000,0000,,even at this size believe it or not Dialogue: 0,0:46:28.99,0:46:30.75,Default,,0000,0000,0000,,here is a Dialogue: 0,0:46:30.75,0:46:33.02,Default,,0000,0000,0000,,malignancy moment Dialogue: 0,0:46:33.02,0:46:34.35,Default,,0000,0000,0000,,uh... Dialogue: 0,0:46:34.35,0:46:36.01,Default,,0000,0000,0000,,here's the x_-ray even see Dialogue: 0,0:46:36.01,0:46:39.05,Default,,0000,0000,0000,,this is what the bone should look like\Nit's very dense in here is obviously Dialogue: 0,0:46:39.05,0:46:41.24,Default,,0000,0000,0000,,more bone being made Dialogue: 0,0:46:41.24,0:46:44.98,Default,,0000,0000,0000,,the outer membrane a perry asked him\Nabout has been lifted Dialogue: 0,0:46:44.98,0:46:48.04,Default,,0000,0000,0000,,by something pushing out in here it is Dialogue: 0,0:46:48.04,0:46:51.37,Default,,0000,0000,0000,,here's the bone here is the bone for me\Nto more here Dialogue: 0,0:46:51.37,0:46:53.04,Default,,0000,0000,0000,,has broken through the cortex Dialogue: 0,0:46:53.04,0:46:57.69,Default,,0000,0000,0000,,news out into the soft tissues so this\Nis a sarcoma Dialogue: 0,0:46:57.69,0:46:58.71,Default,,0000,0000,0000,,osteo Dialogue: 0,0:46:58.71,0:46:59.09,Default,,0000,0000,0000,,sarcoma Dialogue: 0,0:46:59.09,0:47:02.01,Default,,0000,0000,0000,,this is by a large a tumor just Dialogue: 0,0:47:02.01,0:47:04.01,Default,,0000,0000,0000,,in passing of Dialogue: 0,0:47:04.01,0:47:07.05,Default,,0000,0000,0000,,growing bones teenage kids young adults Dialogue: 0,0:47:07.05,0:47:11.58,Default,,0000,0000,0000,,uh... a highly malignant intent in the\Npast size early on Dialogue: 0,0:47:11.58,0:47:14.53,Default,,0000,0000,0000,,cut to the longest Dialogue: 0,0:47:14.53,0:47:19.56,Default,,0000,0000,0000,,nothing is immune here is a tumor rising\Nin the soft-tissue beside harry fleshy Dialogue: 0,0:47:19.56,0:47:21.01,Default,,0000,0000,0000,,looking Dialogue: 0,0:47:21.01,0:47:26.02,Default,,0000,0000,0000,,is derived from scalable muscle mild\Nsarcoma but this time it isn't wyo Dialogue: 0,0:47:26.02,0:47:27.93,Default,,0000,0000,0000,,it's rad though Dialogue: 0,0:47:27.93,0:47:32.37,Default,,0000,0000,0000,,yo-yo learn these details but you should\Nbe able look at bay a name like that and Dialogue: 0,0:47:32.37,0:47:33.03,Default,,0000,0000,0000,,say hello Dialogue: 0,0:47:33.03,0:47:41.60,Default,,0000,0000,0000,,this is a supporting vision neoplasm\Nsome sort Dialogue: 0,0:47:41.60,0:47:42.93,Default,,0000,0000,0000,,classes are common Dialogue: 0,0:47:42.93,0:47:46.22,Default,,0000,0000,0000,,well i'll again it's a long answer to\Nthat these days and then when i started Dialogue: 0,0:47:46.22,0:47:48.86,Default,,0000,0000,0000,,out all you could lose amputated hope\Nfor the best Dialogue: 0,0:47:48.86,0:47:53.26,Default,,0000,0000,0000,,now other forms of chemotherapy and\Npartial resection of the bone with it Dialogue: 0,0:47:53.26,0:47:56.50,Default,,0000,0000,0000,,with insertion of other bone and so\Nforth a lot of Dialogue: 0,0:47:56.50,0:47:58.33,Default,,0000,0000,0000,,nice fancy things they could do now Dialogue: 0,0:47:58.33,0:48:01.54,Default,,0000,0000,0000,,so it's nowhere near as does move that\Nused to be a bit upset this is a highly Dialogue: 0,0:48:01.54,0:48:04.49,Default,,0000,0000,0000,,aggressive tumor Dialogue: 0,0:48:04.49,0:48:07.73,Default,,0000,0000,0000,,friday quickly now Dialogue: 0,0:48:07.73,0:48:08.75,Default,,0000,0000,0000,,another Dialogue: 0,0:48:08.75,0:48:12.94,Default,,0000,0000,0000,,crying of neoplasm we talk about\Nepithelial tissue we talk about Dialogue: 0,0:48:12.94,0:48:14.74,Default,,0000,0000,0000,,supporting on his ankle both issues Dialogue: 0,0:48:14.74,0:48:16.48,Default,,0000,0000,0000,,there are Dialogue: 0,0:48:16.48,0:48:20.51,Default,,0000,0000,0000,,neoplasms of the lymphoid tissues and\Nthe invite him out of poetic i mean Dialogue: 0,0:48:20.51,0:48:22.11,Default,,0000,0000,0000,,blood forming Dialogue: 0,0:48:22.11,0:48:23.01,Default,,0000,0000,0000,,tissues Dialogue: 0,0:48:23.01,0:48:26.09,Default,,0000,0000,0000,,there are uh... neoplasms of these Dialogue: 0,0:48:26.09,0:48:31.68,Default,,0000,0000,0000,,and here is where you get into some sort\Nof a key terminology Dialogue: 0,0:48:31.68,0:48:36.47,Default,,0000,0000,0000,,neoplasms of the lymphoid tissues are\Nreferred to as lymphomas Dialogue: 0,0:48:36.47,0:48:38.86,Default,,0000,0000,0000,,and you would say well that sounds\Nbenign Dialogue: 0,0:48:38.86,0:48:40.31,Default,,0000,0000,0000,,there's not nice Dialogue: 0,0:48:40.31,0:48:42.32,Default,,0000,0000,0000,,behind me a plasma lymphocytes Dialogue: 0,0:48:42.32,0:48:46.41,Default,,0000,0000,0000,,faso there's no such thing as a good\Nnine lymphoma Dialogue: 0,0:48:46.41,0:48:48.01,Default,,0000,0000,0000,,we don't recognize them Dialogue: 0,0:48:48.01,0:48:50.06,Default,,0000,0000,0000,,if there are we don't recognize them Dialogue: 0,0:48:50.06,0:48:53.02,Default,,0000,0000,0000,,so when you hear the word lymphoma\Ndespite Dialogue: 0,0:48:53.02,0:48:54.04,Default,,0000,0000,0000,,what it sounds like Dialogue: 0,0:48:54.04,0:49:00.04,Default,,0000,0000,0000,,that's a malignant neoplasm of lymphoid\Ntissue Dialogue: 0,0:49:00.04,0:49:04.61,Default,,0000,0000,0000,,similarly well i'll get to this but\Nleukemia refers to any any situation Dialogue: 0,0:49:04.61,0:49:05.23,Default,,0000,0000,0000,,really Dialogue: 0,0:49:05.23,0:49:09.98,Default,,0000,0000,0000,,where the malignant cells in the usually\Nblood forming cells Dialogue: 0,0:49:09.98,0:49:12.09,Default,,0000,0000,0000,,on mass in the circulation Dialogue: 0,0:49:12.09,0:49:16.30,Default,,0000,0000,0000,,refer to that is leukemia white blood Dialogue: 0,0:49:16.30,0:49:18.47,Default,,0000,0000,0000,,the old german was vices looked Dialogue: 0,0:49:18.47,0:49:21.86,Default,,0000,0000,0000,,there was described by them farmers Dialogue: 0,0:49:21.86,0:49:23.36,Default,,0000,0000,0000,,interesting they may present Dialogue: 0,0:49:23.36,0:49:27.01,Default,,0000,0000,0000,,as seemingly localized tumors with some\Nlocal spread Dialogue: 0,0:49:27.01,0:49:30.77,Default,,0000,0000,0000,,but because lymphocytes there there's\Nlymphoid tissue all of the body Dialogue: 0,0:49:30.77,0:49:34.08,Default,,0000,0000,0000,,and lymphocytes you'll learn move around\Nthe body Dialogue: 0,0:49:34.08,0:49:37.00,Default,,0000,0000,0000,,lymphomas frequently present as systemic\Ndiseases Dialogue: 0,0:49:37.00,0:49:39.15,Default,,0000,0000,0000,,rather than localized Dialogue: 0,0:49:39.15,0:49:41.57,Default,,0000,0000,0000,,sometimes localize it very often Dialogue: 0,0:49:41.57,0:49:42.10,Default,,0000,0000,0000,,systemic Dialogue: 0,0:49:42.10,0:49:43.84,Default,,0000,0000,0000,,this man came in Dialogue: 0,0:49:43.84,0:49:46.11,Default,,0000,0000,0000,,this is an old old photograph Dialogue: 0,0:49:46.11,0:49:49.02,Default,,0000,0000,0000,,and you see general swelling in his neck\Nhere Dialogue: 0,0:49:49.02,0:49:53.08,Default,,0000,0000,0000,,you can see here's his classical he's\Ngot a super cobra killer mode there Dialogue: 0,0:49:53.08,0:49:56.49,Default,,0000,0000,0000,,similar supercritical in though there Dialogue: 0,0:49:56.49,0:49:58.69,Default,,0000,0000,0000,,he noticed those but his armpits Dialogue: 0,0:49:58.69,0:50:03.04,Default,,0000,0000,0000,,were full of enlarged lymph nodes by\Nchest x_-ray has me this time was Dialogue: 0,0:50:03.04,0:50:07.27,Default,,0000,0000,0000,,widened and full of lymph nodes his\Nabdomen was full of enlargement bones he Dialogue: 0,0:50:07.27,0:50:07.08,Default,,0000,0000,0000,,presented Dialogue: 0,0:50:07.08,0:50:10.41,Default,,0000,0000,0000,,with a systemic disease Dialogue: 0,0:50:10.41,0:50:11.10,Default,,0000,0000,0000,,this was a a Dialogue: 0,0:50:11.10,0:50:14.19,Default,,0000,0000,0000,,widely disseminated lymphoma Dialogue: 0,0:50:14.19,0:50:15.02,Default,,0000,0000,0000,,lymphoma can Dialogue: 0,0:50:15.02,0:50:18.02,Default,,0000,0000,0000,,dennis like too many different Dialogue: 0,0:50:18.02,0:50:19.53,Default,,0000,0000,0000,,lymphoid tissues in the body Dialogue: 0,0:50:19.53,0:50:22.01,Default,,0000,0000,0000,,this is the rapture para commanders a\Nkidney kidney Dialogue: 0,0:50:22.01,0:50:24.09,Default,,0000,0000,0000,,knows you behind a really happening Dialogue: 0,0:50:24.09,0:50:26.07,Default,,0000,0000,0000,,this is a mass Dialogue: 0,0:50:26.07,0:50:29.11,Default,,0000,0000,0000,,of lymph nodes enlarge they should be Dialogue: 0,0:50:29.11,0:50:32.34,Default,,0000,0000,0000,,uh... at the most p size and these are\Nvery big Dialogue: 0,0:50:32.34,0:50:36.65,Default,,0000,0000,0000,,lymph nodes all matted together this was\Nmalignant lymphoma Dialogue: 0,0:50:36.65,0:50:38.44,Default,,0000,0000,0000,,dimeric preparing him Dialogue: 0,0:50:38.44,0:50:40.19,Default,,0000,0000,0000,,spleen Dialogue: 0,0:50:40.19,0:50:42.12,Default,,0000,0000,0000,,started Dialogue: 0,0:50:42.12,0:50:45.56,Default,,0000,0000,0000,,manuals of malignant lymphocytes if you\Nwill Dialogue: 0,0:50:45.56,0:50:47.01,Default,,0000,0000,0000,,one former swings Dialogue: 0,0:50:47.01,0:50:50.76,Default,,0000,0000,0000,,even the kidneys any organ can be\Ninfiltrated Dialogue: 0,0:50:50.76,0:50:53.35,Default,,0000,0000,0000,,lymphoma cells Dialogue: 0,0:50:53.35,0:50:55.21,Default,,0000,0000,0000,,and sometimes the marrow Dialogue: 0,0:50:55.21,0:50:57.64,Default,,0000,0000,0000,,the bone marrow is overrun Dialogue: 0,0:50:57.64,0:51:01.68,Default,,0000,0000,0000,,and the malignant lymphocytes spill in\Ngreat numbers into the bloodstream and Dialogue: 0,0:51:01.68,0:51:07.19,Default,,0000,0000,0000,,you have a lymphocytic form of leukemia Dialogue: 0,0:51:07.19,0:51:09.27,Default,,0000,0000,0000,,generically leukemia Dialogue: 0,0:51:09.27,0:51:13.02,Default,,0000,0000,0000,,re first to be the presence of Dialogue: 0,0:51:13.02,0:51:16.06,Default,,0000,0000,0000,,malignant he mad about whether to remove\Nwhat elements in circulation Dialogue: 0,0:51:16.06,0:51:20.62,Default,,0000,0000,0000,,so we see other forms of leukemia where\Nthe merrill just a bone marrow itself Dialogue: 0,0:51:20.62,0:51:21.89,Default,,0000,0000,0000,,has gone bad Dialogue: 0,0:51:21.89,0:51:25.41,Default,,0000,0000,0000,,can you see malignant precursors of Dialogue: 0,0:51:25.41,0:51:26.60,Default,,0000,0000,0000,,leukocytes Dialogue: 0,0:51:26.60,0:51:30.05,Default,,0000,0000,0000,,possibly red cells and little bit more\Nrarely or even even platelets so Dialogue: 0,0:51:30.05,0:51:34.08,Default,,0000,0000,0000,,this morning so you know the marrow\Ntissue is circulating widely circulated Dialogue: 0,0:51:34.08,0:51:39.69,Default,,0000,0000,0000,,malignant cells infiltration of organs\Nand so forth Dialogue: 0,0:51:39.69,0:51:41.86,Default,,0000,0000,0000,,register wrap it up Dialogue: 0,0:51:41.86,0:51:46.12,Default,,0000,0000,0000,,make the point of no tissue and the\Nbody's immune from Dialogue: 0,0:51:46.12,0:51:49.57,Default,,0000,0000,0000,,neoplasm even see it in the central\Nnervous system Dialogue: 0,0:51:49.57,0:51:52.81,Default,,0000,0000,0000,,please see the neoplasms of the\Ncoverings of the brain the so-called Dialogue: 0,0:51:52.81,0:51:54.01,Default,,0000,0000,0000,,minmin geez Dialogue: 0,0:51:54.01,0:51:57.71,Default,,0000,0000,0000,,and typically eminem geo money is benign Dialogue: 0,0:51:57.71,0:51:59.81,Default,,0000,0000,0000,,has thrown his activities was Dialogue: 0,0:51:59.81,0:52:01.66,Default,,0000,0000,0000,,the uh... Dialogue: 0,0:52:01.66,0:52:04.53,Default,,0000,0000,0000,,no my culture is strange again Dialogue: 0,0:52:04.53,0:52:05.01,Default,,0000,0000,0000,,glioma Dialogue: 0,0:52:05.01,0:52:10.00,Default,,0000,0000,0000,,is actually uh... you neoplasm arising\Nin the brain tissue from the supporting Dialogue: 0,0:52:10.00,0:52:12.37,Default,,0000,0000,0000,,cells called glial cells Dialogue: 0,0:52:12.37,0:52:15.70,Default,,0000,0000,0000,,now has told a man in juneau alaska nine Dialogue: 0,0:52:15.70,0:52:18.02,Default,,0000,0000,0000,,we almost sounds benign Dialogue: 0,0:52:18.02,0:52:20.09,Default,,0000,0000,0000,,they're just varying degrees of\Nmalignancy Dialogue: 0,0:52:20.09,0:52:23.08,Default,,0000,0000,0000,,they're all bad Dialogue: 0,0:52:23.08,0:52:26.01,Default,,0000,0000,0000,,and i'll show you why they're bad here's\Na brain with the glioma Dialogue: 0,0:52:26.01,0:52:28.97,Default,,0000,0000,0000,,is a normal side of the brain Dialogue: 0,0:52:28.97,0:52:32.68,Default,,0000,0000,0000,,and at first glance into well you know\Nyou might see some things out but Dialogue: 0,0:52:32.68,0:52:33.34,Default,,0000,0000,0000,,basically Dialogue: 0,0:52:33.34,0:52:34.71,Default,,0000,0000,0000,,this is all Dialogue: 0,0:52:34.71,0:52:35.89,Default,,0000,0000,0000,,we all month Dialogue: 0,0:52:35.89,0:52:40.12,Default,,0000,0000,0000,,and it's very hard to describe where it\Nstops this infiltrates Dialogue: 0,0:52:40.12,0:52:41.02,Default,,0000,0000,0000,,diffuse lee Dialogue: 0,0:52:41.02,0:52:44.50,Default,,0000,0000,0000,,numerically almost sells way out here in\Nhere in here Dialogue: 0,0:52:44.50,0:52:46.01,Default,,0000,0000,0000,,is just Dialogue: 0,0:52:46.01,0:52:50.38,Default,,0000,0000,0000,,so orderly diffuse that it's very\Ndifficult to handle Dialogue: 0,0:52:50.38,0:52:51.60,Default,,0000,0000,0000,,the uh... Dialogue: 0,0:52:51.60,0:52:54.21,Default,,0000,0000,0000,,well differentiated low-grade Dialogue: 0,0:52:54.21,0:52:58.60,Default,,0000,0000,0000,,gliomas last a little longer patient\Nlasts a little longer the high-grade Dialogue: 0,0:52:58.60,0:53:01.34,Default,,0000,0000,0000,,generally don't do so well with some Dialogue: 0,0:53:01.34,0:53:02.94,Default,,0000,0000,0000,,promising interventions Dialogue: 0,0:53:02.94,0:53:05.34,Default,,0000,0000,0000,,this is a sort of thing that senator Dialogue: 0,0:53:05.34,0:53:07.39,Default,,0000,0000,0000,,noticed any Dialogue: 0,0:53:07.39,0:53:10.58,Default,,0000,0000,0000,,only looked good the other night so Dialogue: 0,0:53:10.58,0:53:13.01,Default,,0000,0000,0000,,yahoo and i think that uh... that\Ncentral nervous system Dialogue: 0,0:53:13.01,0:53:15.56,Default,,0000,0000,0000,,then finally Dialogue: 0,0:53:15.56,0:53:17.08,Default,,0000,0000,0000,,uh... Dialogue: 0,0:53:17.08,0:53:20.13,Default,,0000,0000,0000,,there Dialogue: 0,0:53:20.13,0:53:21.63,Default,,0000,0000,0000,,next time to talk with us Dialogue: 0,0:53:21.63,0:53:24.07,Default,,0000,0000,0000,,these are these are before like an\Ninteresting Dialogue: 0,0:53:24.07,0:53:27.31,Default,,0000,0000,0000,,you can afterwards where you got a\Ncouple of different kinds of Dialogue: 0,0:53:27.31,0:53:28.32,Default,,0000,0000,0000,,differentiation Dialogue: 0,0:53:28.32,0:53:29.10,Default,,0000,0000,0000,,for instance we may see Dialogue: 0,0:53:29.10,0:53:31.20,Default,,0000,0000,0000,,uh... Dialogue: 0,0:53:31.20,0:53:34.85,Default,,0000,0000,0000,,roscommon salivary gland to where where\Nyou see glandular elements proliferating Dialogue: 0,0:53:34.85,0:53:36.71,Default,,0000,0000,0000,,and cartilage Dialogue: 0,0:53:36.71,0:53:38.02,Default,,0000,0000,0000,,of all things Dialogue: 0,0:53:38.02,0:53:40.52,Default,,0000,0000,0000,,and those are referred to as mixed\Ntumors Dialogue: 0,0:53:40.52,0:53:43.60,Default,,0000,0000,0000,,of salivary gland or more often now we\Ncall them Dialogue: 0,0:53:43.60,0:53:46.18,Default,,0000,0000,0000,,cleo morrissette and almost Dialogue: 0,0:53:46.18,0:53:48.36,Default,,0000,0000,0000,,meaning a mixed form Dialogue: 0,0:53:48.36,0:53:48.100,Default,,0000,0000,0000,,adenoma Dialogue: 0,0:53:48.100,0:53:52.83,Default,,0000,0000,0000,,they're such things as fight broke up\Nenormous Dialogue: 0,0:53:52.83,0:53:56.25,Default,,0000,0000,0000,,perfectly benign fibrous and granular Dialogue: 0,0:53:56.25,0:53:59.93,Default,,0000,0000,0000,,mumbling inside there's such things as Dialogue: 0,0:53:59.93,0:54:02.41,Default,,0000,0000,0000,,carson or sarcomas Dialogue: 0,0:54:02.41,0:54:05.79,Default,,0000,0000,0000,,through passive differentiation Dialogue: 0,0:54:05.79,0:54:07.100,Default,,0000,0000,0000,,apathy little glandular Dialogue: 0,0:54:07.100,0:54:11.04,Default,,0000,0000,0000,,any appeal in supporting both both\Nmalignant Dialogue: 0,0:54:11.04,0:54:12.04,Default,,0000,0000,0000,,the odds are right here Dialogue: 0,0:54:12.04,0:54:14.03,Default,,0000,0000,0000,,as it is a really Dialogue: 0,0:54:14.03,0:54:20.01,Default,,0000,0000,0000,,mixed kind of tumor that arises from\Ntotally potential sales Dialogue: 0,0:54:20.01,0:54:25.00,Default,,0000,0000,0000,,and in these tumors are the rumors of\Nall of the embryonic journalists Dialogue: 0,0:54:25.00,0:54:26.06,Default,,0000,0000,0000,,criticism mara was saying Dialogue: 0,0:54:26.06,0:54:28.79,Default,,0000,0000,0000,,as you've predicted arise Dialogue: 0,0:54:28.79,0:54:31.30,Default,,0000,0000,0000,,mostly in gold ads Dialogue: 0,0:54:31.30,0:54:35.93,Default,,0000,0000,0000,,but uh... also another two should have\Nseen in the media steinem i've seen them Dialogue: 0,0:54:35.93,0:54:37.78,Default,,0000,0000,0000,,in uh... the throat Dialogue: 0,0:54:37.78,0:54:39.45,Default,,0000,0000,0000,,but mostly gone mad or Dialogue: 0,0:54:39.45,0:54:41.48,Default,,0000,0000,0000,,the yeah Dialogue: 0,0:54:41.48,0:54:45.06,Default,,0000,0000,0000,,bad news for the guys is most testicular\Nterra com is a malignant Dialogue: 0,0:54:45.06,0:54:46.73,Default,,0000,0000,0000,,highly malignant Dialogue: 0,0:54:46.73,0:54:51.33,Default,,0000,0000,0000,,good news for the women is a very\Nintercom asar almost invariably benign Dialogue: 0,0:54:51.33,0:54:55.46,Default,,0000,0000,0000,,they're not uncommon there in your age\Ngroup usually an incidental finding but Dialogue: 0,0:54:55.46,0:55:00.36,Default,,0000,0000,0000,,they're endlessly fascinating and allen\Nby showing you a couple Dialogue: 0,0:55:00.36,0:55:02.01,Default,,0000,0000,0000,,there's a terra com of the ovary Dialogue: 0,0:55:02.01,0:55:06.28,Default,,0000,0000,0000,,i've cut the over his size of tennis\Nball it should have a surface like that Dialogue: 0,0:55:06.28,0:55:12.86,Default,,0000,0000,0000,,i kind of open along the whole blonde\Nhair Dialogue: 0,0:55:12.86,0:55:16.82,Default,,0000,0000,0000,,looking at his ovary under the\Nmicroscope it had not only hair Dialogue: 0,0:55:16.82,0:55:21.31,Default,,0000,0000,0000,,follicles but it has construction sweat\Nglands today shes clams Dialogue: 0,0:55:21.31,0:55:23.24,Default,,0000,0000,0000,,it had cartilage Dialogue: 0,0:55:23.24,0:55:25.04,Default,,0000,0000,0000,,bronchial lining Dialogue: 0,0:55:25.04,0:55:27.80,Default,,0000,0000,0000,,it had something to look like i just\Nsubtract Dialogue: 0,0:55:27.80,0:55:30.82,Default,,0000,0000,0000,,and even had some brain tissue Dialogue: 0,0:55:30.82,0:55:33.91,Default,,0000,0000,0000,,weenies irwin marvelous mixtures Dialogue: 0,0:55:33.91,0:55:37.78,Default,,0000,0000,0000,,amal solicit perfectly benign and when\Nwe get one of the operating room Dialogue: 0,0:55:37.78,0:55:42.96,Default,,0000,0000,0000,,neighboring it goes we cuddle we see\Nhere we say Dialogue: 0,0:55:42.96,0:55:47.47,Default,,0000,0000,0000,,for some reason in the ovarian tumors\Nmost often it line by skin like Dialogue: 0,0:55:47.47,0:55:50.10,Default,,0000,0000,0000,,structures and sometimes called the\Nramones Dialogue: 0,0:55:50.10,0:55:53.09,Default,,0000,0000,0000,,but they do usually got a great mixture\Nof stuff Dialogue: 0,0:55:53.09,0:55:55.73,Default,,0000,0000,0000,,here's another one what do you suppose\Nthis was Dialogue: 0,0:55:55.73,0:56:00.02,Default,,0000,0000,0000,,for these were Dialogue: 0,0:56:00.02,0:56:03.10,Default,,0000,0000,0000,,that showed up as calcification mommy Dialogue: 0,0:56:03.10,0:56:05.49,Default,,0000,0000,0000,,public phil Dialogue: 0,0:56:05.49,0:56:06.43,Default,,0000,0000,0000,,and then Dialogue: 0,0:56:06.43,0:56:11.57,Default,,0000,0000,0000,,glass one i'm absolutely quitters might\Nmy favorite this came out of recovery Dialogue: 0,0:56:11.57,0:56:13.79,Default,,0000,0000,0000,,looks like a chain with Dialogue: 0,0:56:13.79,0:56:15.03,Default,,0000,0000,0000,,five o'clock shadow Dialogue: 0,0:56:15.03,0:56:16.07,Default,,0000,0000,0000,,the nice Dialogue: 0,0:56:16.07,0:56:18.99,Default,,0000,0000,0000,,dental arch there and so forth Dialogue: 0,0:56:18.99,0:56:20.00,Default,,0000,0000,0000,,well that's a Dialogue: 0,0:56:20.00,0:56:22.62,Default,,0000,0000,0000,,but i've done is basically teased you Dialogue: 0,0:56:22.62,0:56:24.67,Default,,0000,0000,0000,,into uh... Dialogue: 0,0:56:24.67,9:59:59.99,Default,,0000,0000,0000,,being interested non-college annual deal\Nwith the rest of your life now