[Script Info] Title: [Events] Format: Layer, Start, End, Style, Name, MarginL, MarginR, MarginV, Effect, Text Dialogue: 0,0:00:00.00,0:00:03.00,Default,,0000,0000,0000,,We see with the eyes, Dialogue: 0,0:00:03.00,0:00:06.00,Default,,0000,0000,0000,,but we see with the brain as well. Dialogue: 0,0:00:06.00,0:00:10.00,Default,,0000,0000,0000,,And seeing with the brain\Nis often called imagination. Dialogue: 0,0:00:10.00,0:00:15.00,Default,,0000,0000,0000,,And we are familiar with\Nthe landscapes of our own imagination, Dialogue: 0,0:00:15.00,0:00:19.00,Default,,0000,0000,0000,,our inscapes. \NWe've lived with them all our lives. Dialogue: 0,0:00:19.00,0:00:23.00,Default,,0000,0000,0000,,But there are also hallucinations as well, Dialogue: 0,0:00:23.00,0:00:26.00,Default,,0000,0000,0000,,and hallucinations \Nare completely different. Dialogue: 0,0:00:26.00,0:00:28.00,Default,,0000,0000,0000,,They don't seem to be of our creation. Dialogue: 0,0:00:28.00,0:00:30.00,Default,,0000,0000,0000,,They don't seem to be under our control. Dialogue: 0,0:00:30.00,0:00:32.00,Default,,0000,0000,0000,,They seem to come from the outside, Dialogue: 0,0:00:32.00,0:00:35.00,Default,,0000,0000,0000,,and to mimic perception. Dialogue: 0,0:00:35.00,0:00:39.00,Default,,0000,0000,0000,,So I am going to be talking\Nabout hallucinations, Dialogue: 0,0:00:39.00,0:00:43.00,Default,,0000,0000,0000,,and a particular sort\Nof visual hallucination Dialogue: 0,0:00:43.00,0:00:48.00,Default,,0000,0000,0000,,which I see among my patients. Dialogue: 0,0:00:48.00,0:00:52.00,Default,,0000,0000,0000,,A few months ago, I got a phone call Dialogue: 0,0:00:52.00,0:00:54.00,Default,,0000,0000,0000,,from a nursing home where I work. Dialogue: 0,0:00:54.00,0:00:59.00,Default,,0000,0000,0000,,They told me that one of their residents,\Nan old lady in her 90s, Dialogue: 0,0:00:59.00,0:01:01.00,Default,,0000,0000,0000,,was seeing things, Dialogue: 0,0:01:01.00,0:01:04.00,Default,,0000,0000,0000,,and they wondered if she'd gone bonkers Dialogue: 0,0:01:04.00,0:01:06.00,Default,,0000,0000,0000,,or, because she was an old lady, Dialogue: 0,0:01:06.00,0:01:09.00,Default,,0000,0000,0000,,whether she'd had a stroke,\Nor whether she had Alzheimer's. Dialogue: 0,0:01:09.00,0:01:14.00,Default,,0000,0000,0000,,And so they asked me if\NI would come and see Rosalie, Dialogue: 0,0:01:14.00,0:01:16.00,Default,,0000,0000,0000,,the old lady. Dialogue: 0,0:01:16.00,0:01:18.00,Default,,0000,0000,0000,,I went in to see her. Dialogue: 0,0:01:18.00,0:01:20.00,Default,,0000,0000,0000,,It was evident straight away Dialogue: 0,0:01:20.00,0:01:23.00,Default,,0000,0000,0000,,that she was perfectly sane Dialogue: 0,0:01:23.00,0:01:26.00,Default,,0000,0000,0000,,and lucid and \Nof good intelligence, Dialogue: 0,0:01:26.00,0:01:30.00,Default,,0000,0000,0000,,but she'd been very startled\Nand very bewildered, Dialogue: 0,0:01:30.00,0:01:33.00,Default,,0000,0000,0000,,because she'd been seeing things. Dialogue: 0,0:01:33.00,0:01:36.00,Default,,0000,0000,0000,,And she told me -- Dialogue: 0,0:01:36.00,0:01:38.00,Default,,0000,0000,0000,,the nurses hadn't mentioned this -- Dialogue: 0,0:01:38.00,0:01:40.00,Default,,0000,0000,0000,,that she was blind, Dialogue: 0,0:01:40.00,0:01:45.00,Default,,0000,0000,0000,,that she had been completely blind\Nfrom macular degeneration for five years. Dialogue: 0,0:01:45.00,0:01:48.00,Default,,0000,0000,0000,,But now, for the last few days,\Nshe'd been seeing things. Dialogue: 0,0:01:48.00,0:01:51.00,Default,,0000,0000,0000,,So I said, "What sort of things?" Dialogue: 0,0:01:51.00,0:01:54.00,Default,,0000,0000,0000,,And she said, "People in Eastern dress, Dialogue: 0,0:01:54.00,0:01:58.00,Default,,0000,0000,0000,,in drapes, walking up and down stairs. Dialogue: 0,0:01:58.00,0:02:01.00,Default,,0000,0000,0000,,A man who turns towards me and smiles. Dialogue: 0,0:02:01.00,0:02:05.00,Default,,0000,0000,0000,,But he has huge teeth\Non one side of his mouth. Dialogue: 0,0:02:05.00,0:02:07.00,Default,,0000,0000,0000,,Animals too. Dialogue: 0,0:02:07.00,0:02:10.00,Default,,0000,0000,0000,,I see a white building.\NIt's snowing, a soft snow. Dialogue: 0,0:02:10.00,0:02:15.00,Default,,0000,0000,0000,,I see this horse with a harness,\Ndragging the snow away. Dialogue: 0,0:02:15.00,0:02:19.00,Default,,0000,0000,0000,,Then, one night, the scene changes. Dialogue: 0,0:02:19.00,0:02:21.00,Default,,0000,0000,0000,,I see cats and dogs walking towards me. Dialogue: 0,0:02:21.00,0:02:24.00,Default,,0000,0000,0000,,They come to a certain point\Nand then stop. Dialogue: 0,0:02:24.00,0:02:26.00,Default,,0000,0000,0000,,Then it changes again. Dialogue: 0,0:02:26.00,0:02:29.00,Default,,0000,0000,0000,,I see a lot of children.\NThey are walking up and down stairs. Dialogue: 0,0:02:29.00,0:02:32.00,Default,,0000,0000,0000,,They wear bright colors, rose and blue, Dialogue: 0,0:02:32.00,0:02:35.00,Default,,0000,0000,0000,,like Eastern dress." Dialogue: 0,0:02:35.00,0:02:38.00,Default,,0000,0000,0000,,Sometimes, she said,\Nbefore the people come on, Dialogue: 0,0:02:38.00,0:02:42.00,Default,,0000,0000,0000,,she may hallucinate\Npink and blue squares on the floor, Dialogue: 0,0:02:42.00,0:02:45.00,Default,,0000,0000,0000,,which seem to go up to the ceiling. Dialogue: 0,0:02:45.00,0:02:49.00,Default,,0000,0000,0000,,I said, "Is this like a dream?" Dialogue: 0,0:02:49.00,0:02:52.00,Default,,0000,0000,0000,,And she said, "No, it's not\Nlike a dream. It's like a movie." Dialogue: 0,0:02:52.00,0:02:55.00,Default,,0000,0000,0000,,She said, "It's got color.\NIt's got motion. Dialogue: 0,0:02:55.00,0:02:59.00,Default,,0000,0000,0000,,But it's completely silent,\Nlike a silent movie." Dialogue: 0,0:02:59.00,0:03:01.00,Default,,0000,0000,0000,,And she said that\Nit's a rather boring movie. Dialogue: 0,0:03:01.00,0:03:04.00,Default,,0000,0000,0000,,She said, "All these people\Nwith Eastern dress, Dialogue: 0,0:03:04.00,0:03:09.00,Default,,0000,0000,0000,,walking up and down,\Nvery repetitive, very limited." Dialogue: 0,0:03:09.00,0:03:11.00,Default,,0000,0000,0000,,(Laughter) Dialogue: 0,0:03:11.00,0:03:13.00,Default,,0000,0000,0000,,And she has a sense of humor. Dialogue: 0,0:03:13.00,0:03:15.00,Default,,0000,0000,0000,,She knew it was a hallucination. Dialogue: 0,0:03:15.00,0:03:17.00,Default,,0000,0000,0000,,But she was frightened.\NShe'd lived 95 years Dialogue: 0,0:03:17.00,0:03:20.00,Default,,0000,0000,0000,,and she'd never had\Na hallucination before. Dialogue: 0,0:03:20.00,0:03:23.00,Default,,0000,0000,0000,,She said that the hallucinations\Nwere unrelated Dialogue: 0,0:03:23.00,0:03:27.00,Default,,0000,0000,0000,,to anything she was thinking\Nor feeling or doing, Dialogue: 0,0:03:27.00,0:03:31.00,Default,,0000,0000,0000,,that they seemed to come on\Nby themselves, or disappear. Dialogue: 0,0:03:31.00,0:03:33.00,Default,,0000,0000,0000,,She had no control over them. Dialogue: 0,0:03:33.00,0:03:35.00,Default,,0000,0000,0000,,She said she didn't recognize Dialogue: 0,0:03:35.00,0:03:37.00,Default,,0000,0000,0000,,any of the people or places Dialogue: 0,0:03:37.00,0:03:39.00,Default,,0000,0000,0000,,in the hallucinations. Dialogue: 0,0:03:39.00,0:03:41.00,Default,,0000,0000,0000,,And none of the people\Nor the animals, Dialogue: 0,0:03:41.00,0:03:45.00,Default,,0000,0000,0000,,well, they all seemed oblivious of her. Dialogue: 0,0:03:45.00,0:03:47.00,Default,,0000,0000,0000,,And she didn't know what was going on. Dialogue: 0,0:03:47.00,0:03:49.00,Default,,0000,0000,0000,,She wondered if she was going mad Dialogue: 0,0:03:49.00,0:03:51.00,Default,,0000,0000,0000,,or losing her mind. Dialogue: 0,0:03:51.00,0:03:53.00,Default,,0000,0000,0000,,Well, I examined her carefully. Dialogue: 0,0:03:53.00,0:03:55.00,Default,,0000,0000,0000,,She was a bright old lady, Dialogue: 0,0:03:55.00,0:03:59.00,Default,,0000,0000,0000,,perfectly sane. She had\Nno medical problems. Dialogue: 0,0:03:59.00,0:04:03.00,Default,,0000,0000,0000,,She wasn't on any medications\Nwhich could produce hallucinations. Dialogue: 0,0:04:03.00,0:04:05.00,Default,,0000,0000,0000,,But she was blind. Dialogue: 0,0:04:05.00,0:04:07.00,Default,,0000,0000,0000,,And I then said to her, Dialogue: 0,0:04:07.00,0:04:09.00,Default,,0000,0000,0000,,"I think I know what you have." Dialogue: 0,0:04:09.00,0:04:13.00,Default,,0000,0000,0000,,I said, "There is a special form\Nof visual hallucination Dialogue: 0,0:04:13.00,0:04:17.00,Default,,0000,0000,0000,,which may go with deteriorating\Nvision or blindness. Dialogue: 0,0:04:17.00,0:04:20.00,Default,,0000,0000,0000,,This was originally described," I said, Dialogue: 0,0:04:20.00,0:04:22.00,Default,,0000,0000,0000,,"right back in the 18th century, Dialogue: 0,0:04:22.00,0:04:25.00,Default,,0000,0000,0000,,by a man called Charles Bonnet. Dialogue: 0,0:04:25.00,0:04:28.00,Default,,0000,0000,0000,,And you have Charles Bonnet syndrome. Dialogue: 0,0:04:28.00,0:04:30.00,Default,,0000,0000,0000,,There is nothing wrong with your brain.\NThere is nothing wrong with your mind. Dialogue: 0,0:04:30.00,0:04:33.00,Default,,0000,0000,0000,,You have Charles Bonnet syndrome." Dialogue: 0,0:04:33.00,0:04:36.00,Default,,0000,0000,0000,,And she was very relieved at this, Dialogue: 0,0:04:36.00,0:04:40.00,Default,,0000,0000,0000,,that there was nothing\Nseriously the matter, Dialogue: 0,0:04:40.00,0:04:43.00,Default,,0000,0000,0000,,and also rather curious. Dialogue: 0,0:04:43.00,0:04:45.00,Default,,0000,0000,0000,,She said, "Who is this Charles Bonnet?" Dialogue: 0,0:04:45.00,0:04:48.00,Default,,0000,0000,0000,,She said, "Did he have them himself?" Dialogue: 0,0:04:48.00,0:04:51.00,Default,,0000,0000,0000,,And she said, "Tell all the nurses Dialogue: 0,0:04:51.00,0:04:54.00,Default,,0000,0000,0000,,that I have Charles Bonnet syndrome." Dialogue: 0,0:04:54.00,0:04:56.00,Default,,0000,0000,0000,,(Laughter) Dialogue: 0,0:04:56.00,0:05:00.00,Default,,0000,0000,0000,,"I'm not crazy. I'm not demented.\NI have Charles Bonnet syndrome." Dialogue: 0,0:05:00.00,0:05:02.00,Default,,0000,0000,0000,,Well, so I did tell the nurses. Dialogue: 0,0:05:02.00,0:05:05.00,Default,,0000,0000,0000,,Now this, for me, is a common situation. Dialogue: 0,0:05:05.00,0:05:07.00,Default,,0000,0000,0000,,I work in old-age homes, largely. Dialogue: 0,0:05:07.00,0:05:09.00,Default,,0000,0000,0000,,I see a lot of elderly people Dialogue: 0,0:05:09.00,0:05:13.00,Default,,0000,0000,0000,,who are hearing impaired\Nor visually impaired. Dialogue: 0,0:05:13.00,0:05:15.00,Default,,0000,0000,0000,,About 10 percent\Nof the hearing impaired people Dialogue: 0,0:05:15.00,0:05:18.00,Default,,0000,0000,0000,,get musical hallucinations. Dialogue: 0,0:05:18.00,0:05:21.00,Default,,0000,0000,0000,,And about 10 percent\Nof the visually impaired people Dialogue: 0,0:05:21.00,0:05:23.00,Default,,0000,0000,0000,,get visual hallucinations. Dialogue: 0,0:05:23.00,0:05:25.00,Default,,0000,0000,0000,,You don't have to be completely blind, Dialogue: 0,0:05:25.00,0:05:27.00,Default,,0000,0000,0000,,only sufficiently impaired. Dialogue: 0,0:05:27.00,0:05:31.00,Default,,0000,0000,0000,,Now with the original description\Nin the 18th century, Dialogue: 0,0:05:31.00,0:05:33.00,Default,,0000,0000,0000,,Charles Bonnet did not have them. Dialogue: 0,0:05:33.00,0:05:36.00,Default,,0000,0000,0000,,His grandfather had these hallucinations. Dialogue: 0,0:05:36.00,0:05:39.00,Default,,0000,0000,0000,,His grandfather was a magistrate,\Nan elderly man. Dialogue: 0,0:05:39.00,0:05:42.00,Default,,0000,0000,0000,,He'd had cataract surgery. Dialogue: 0,0:05:42.00,0:05:44.00,Default,,0000,0000,0000,,His vision was pretty poor. Dialogue: 0,0:05:44.00,0:05:49.00,Default,,0000,0000,0000,,And in 1759, he described to his grandson Dialogue: 0,0:05:49.00,0:05:51.00,Default,,0000,0000,0000,,various things he was seeing. Dialogue: 0,0:05:51.00,0:05:53.00,Default,,0000,0000,0000,,The first thing he said was he saw Dialogue: 0,0:05:53.00,0:05:55.00,Default,,0000,0000,0000,,a handkerchief in midair. Dialogue: 0,0:05:55.00,0:05:57.00,Default,,0000,0000,0000,,It was a large blue handkerchief Dialogue: 0,0:05:57.00,0:05:59.00,Default,,0000,0000,0000,,with four orange circles. Dialogue: 0,0:05:59.00,0:06:02.00,Default,,0000,0000,0000,,And he knew it was a hallucination. Dialogue: 0,0:06:02.00,0:06:04.00,Default,,0000,0000,0000,,You don't have handkerchiefs in midair. Dialogue: 0,0:06:04.00,0:06:08.00,Default,,0000,0000,0000,,And then he saw a big wheel in midair. Dialogue: 0,0:06:08.00,0:06:13.00,Default,,0000,0000,0000,,But sometimes he wasn't sure\Nwhether he was hallucinating or not, Dialogue: 0,0:06:13.00,0:06:15.00,Default,,0000,0000,0000,,because the hallucinations would fit Dialogue: 0,0:06:15.00,0:06:17.00,Default,,0000,0000,0000,,in the context of the visions. Dialogue: 0,0:06:17.00,0:06:20.00,Default,,0000,0000,0000,,So on one occasion,\Nwhen his granddaughters were visiting them, Dialogue: 0,0:06:20.00,0:06:25.00,Default,,0000,0000,0000,,he said, "And who are these\Nhandsome young men with you?" Dialogue: 0,0:06:25.00,0:06:29.00,Default,,0000,0000,0000,,And they said, "Alas, Grandpapa,\Nthere are no handsome young men." Dialogue: 0,0:06:29.00,0:06:33.00,Default,,0000,0000,0000,,And then the handsome\Nyoung men disappeared. Dialogue: 0,0:06:33.00,0:06:36.00,Default,,0000,0000,0000,,It's typical of these hallucinations Dialogue: 0,0:06:36.00,0:06:39.00,Default,,0000,0000,0000,,that they may come in a flash\Nand disappear in a flash. Dialogue: 0,0:06:39.00,0:06:41.00,Default,,0000,0000,0000,,They don't usually fade in and out. Dialogue: 0,0:06:41.00,0:06:44.00,Default,,0000,0000,0000,,They are rather sudden,\Nand they change suddenly. Dialogue: 0,0:06:44.00,0:06:47.00,Default,,0000,0000,0000,,Charles Lullin, the grandfather, Dialogue: 0,0:06:47.00,0:06:50.00,Default,,0000,0000,0000,,saw hundreds of different figures, Dialogue: 0,0:06:50.00,0:06:52.00,Default,,0000,0000,0000,,different landscapes of all sorts. Dialogue: 0,0:06:52.00,0:06:56.00,Default,,0000,0000,0000,,On one occasion, he saw a man\Nin a bathrobe smoking a pipe, Dialogue: 0,0:06:56.00,0:06:59.00,Default,,0000,0000,0000,,and realized it was himself. Dialogue: 0,0:06:59.00,0:07:02.00,Default,,0000,0000,0000,,That was the only figure he recognized. Dialogue: 0,0:07:02.00,0:07:06.00,Default,,0000,0000,0000,,On one occasion when he was walking\Nin the streets of Paris, Dialogue: 0,0:07:06.00,0:07:09.00,Default,,0000,0000,0000,,he saw -- this was real -- a scaffolding. Dialogue: 0,0:07:09.00,0:07:12.00,Default,,0000,0000,0000,,But when he got back home,\Nhe saw a miniature of the scaffolding Dialogue: 0,0:07:12.00,0:07:16.00,Default,,0000,0000,0000,,six inches high, on his study table. Dialogue: 0,0:07:16.00,0:07:19.00,Default,,0000,0000,0000,,This repetition of perception Dialogue: 0,0:07:19.00,0:07:21.00,Default,,0000,0000,0000,,is sometimes called palinopsia. Dialogue: 0,0:07:21.00,0:07:26.00,Default,,0000,0000,0000,,With him and with Rosalie, Dialogue: 0,0:07:26.00,0:07:28.00,Default,,0000,0000,0000,,what seems to be going on -- Dialogue: 0,0:07:28.00,0:07:30.00,Default,,0000,0000,0000,,and Rosalie said, "What's going on?" -- Dialogue: 0,0:07:30.00,0:07:33.00,Default,,0000,0000,0000,,and I said that as you lose vision, Dialogue: 0,0:07:33.00,0:07:36.00,Default,,0000,0000,0000,,as the visual parts of the brain\Nare no longer getting any input, Dialogue: 0,0:07:36.00,0:07:39.00,Default,,0000,0000,0000,,they become hyperactive and excitable, Dialogue: 0,0:07:39.00,0:07:41.00,Default,,0000,0000,0000,,and they start to fire spontaneously. Dialogue: 0,0:07:41.00,0:07:44.00,Default,,0000,0000,0000,,And you start to see things. Dialogue: 0,0:07:44.00,0:07:47.00,Default,,0000,0000,0000,,The things you see\Ncan be very complicated indeed. Dialogue: 0,0:07:47.00,0:07:51.00,Default,,0000,0000,0000,,With another patient of mine, Dialogue: 0,0:07:51.00,0:07:53.00,Default,,0000,0000,0000,,who, also had some vision, Dialogue: 0,0:07:53.00,0:07:57.00,Default,,0000,0000,0000,,the vision she had could be disturbing. Dialogue: 0,0:07:57.00,0:08:00.00,Default,,0000,0000,0000,,On one occasion, she said she saw Dialogue: 0,0:08:00.00,0:08:03.00,Default,,0000,0000,0000,,a man in a striped shirt in a restaurant. Dialogue: 0,0:08:03.00,0:08:05.00,Default,,0000,0000,0000,,And he turned around. And then Dialogue: 0,0:08:05.00,0:08:08.00,Default,,0000,0000,0000,,he divided into six figures\Nin striped shirts, Dialogue: 0,0:08:08.00,0:08:11.00,Default,,0000,0000,0000,,who started walking towards her. Dialogue: 0,0:08:11.00,0:08:14.00,Default,,0000,0000,0000,,And then the six figures came together again,\Nlike a concertina. Dialogue: 0,0:08:14.00,0:08:16.00,Default,,0000,0000,0000,,Once, when she was driving, Dialogue: 0,0:08:16.00,0:08:18.00,Default,,0000,0000,0000,,or rather, her husband was driving, Dialogue: 0,0:08:18.00,0:08:20.00,Default,,0000,0000,0000,,the road divided into four Dialogue: 0,0:08:20.00,0:08:24.00,Default,,0000,0000,0000,,and she felt herself going\Nsimultaneously up four roads. Dialogue: 0,0:08:24.00,0:08:29.00,Default,,0000,0000,0000,,She had very mobile\Nhallucinations as well. Dialogue: 0,0:08:29.00,0:08:32.00,Default,,0000,0000,0000,,A lot of them had to do with a car. Dialogue: 0,0:08:32.00,0:08:34.00,Default,,0000,0000,0000,,Sometimes she would see a teenage boy Dialogue: 0,0:08:34.00,0:08:37.00,Default,,0000,0000,0000,,sitting on the hood of the car. Dialogue: 0,0:08:37.00,0:08:39.00,Default,,0000,0000,0000,,He was very tenacious\Nand he moved rather gracefully Dialogue: 0,0:08:39.00,0:08:41.00,Default,,0000,0000,0000,,when the car turned. Dialogue: 0,0:08:41.00,0:08:44.00,Default,,0000,0000,0000,,And then when they came to a stop, Dialogue: 0,0:08:44.00,0:08:47.00,Default,,0000,0000,0000,,the boy would do a sudden vertical takeoff,\N100 foot in the air, Dialogue: 0,0:08:47.00,0:08:50.00,Default,,0000,0000,0000,,and then disappear. Dialogue: 0,0:08:50.00,0:08:55.00,Default,,0000,0000,0000,,Another patient of mine\Nhad a different sort of hallucination. Dialogue: 0,0:08:55.00,0:08:58.00,Default,,0000,0000,0000,,This was a woman who\Ndidn't have trouble with her eyes, Dialogue: 0,0:08:58.00,0:09:00.00,Default,,0000,0000,0000,,but the visual parts of her brain, Dialogue: 0,0:09:00.00,0:09:03.00,Default,,0000,0000,0000,,a little tumor in the occipital cortex. Dialogue: 0,0:09:03.00,0:09:08.00,Default,,0000,0000,0000,,And, above all, she would see cartoons. Dialogue: 0,0:09:08.00,0:09:13.00,Default,,0000,0000,0000,,These cartoons would be transparent Dialogue: 0,0:09:13.00,0:09:16.00,Default,,0000,0000,0000,,and would cover\Nhalf the visual field, like a screen. Dialogue: 0,0:09:16.00,0:09:22.00,Default,,0000,0000,0000,,And especially she saw\Ncartoons of Kermit the Frog. Dialogue: 0,0:09:22.00,0:09:23.00,Default,,0000,0000,0000,,(Laughter) Dialogue: 0,0:09:23.00,0:09:26.00,Default,,0000,0000,0000,,Now, I don't watch Sesame Street, Dialogue: 0,0:09:26.00,0:09:29.00,Default,,0000,0000,0000,,but she made a point of saying, Dialogue: 0,0:09:29.00,0:09:33.00,Default,,0000,0000,0000,,"Why Kermit?" she said,\N"Kermit the Frog means nothing to me. Dialogue: 0,0:09:33.00,0:09:36.00,Default,,0000,0000,0000,,You know, I was wondering\Nabout Freudian determinants. Dialogue: 0,0:09:36.00,0:09:38.00,Default,,0000,0000,0000,,Why Kermit? Dialogue: 0,0:09:38.00,0:09:40.00,Default,,0000,0000,0000,,Kermit the Frog means nothing to me." Dialogue: 0,0:09:40.00,0:09:42.00,Default,,0000,0000,0000,,She didn't mind the cartoons too much. Dialogue: 0,0:09:42.00,0:09:46.00,Default,,0000,0000,0000,,But what did disturb her\Nwas she got very persistent Dialogue: 0,0:09:46.00,0:09:49.00,Default,,0000,0000,0000,,images or hallucinations of faces Dialogue: 0,0:09:49.00,0:09:52.00,Default,,0000,0000,0000,,and as with Rosalie,\Nthe faces were often deformed, Dialogue: 0,0:09:52.00,0:09:56.00,Default,,0000,0000,0000,,with very large teeth or very large eyes. Dialogue: 0,0:09:56.00,0:09:59.00,Default,,0000,0000,0000,,And these frightened her. Dialogue: 0,0:09:59.00,0:10:03.00,Default,,0000,0000,0000,,Well, what is going on with these people? Dialogue: 0,0:10:03.00,0:10:06.00,Default,,0000,0000,0000,,As a physician, I have to try\Nand define what's going on, Dialogue: 0,0:10:06.00,0:10:08.00,Default,,0000,0000,0000,,and to reassure people, Dialogue: 0,0:10:08.00,0:10:12.00,Default,,0000,0000,0000,,especially to reassure them\Nthat they're not going insane. Dialogue: 0,0:10:12.00,0:10:15.00,Default,,0000,0000,0000,,Something like 10 percent, as I said, Dialogue: 0,0:10:15.00,0:10:18.00,Default,,0000,0000,0000,,of visually impaired people get these. Dialogue: 0,0:10:18.00,0:10:22.00,Default,,0000,0000,0000,,But no more than one percent\Nof the people acknowledge them, Dialogue: 0,0:10:22.00,0:10:25.00,Default,,0000,0000,0000,,because they are afraid\Nthey will be seen as insane or something. Dialogue: 0,0:10:25.00,0:10:27.00,Default,,0000,0000,0000,,And if they do mention them\Nto their own doctors Dialogue: 0,0:10:27.00,0:10:30.00,Default,,0000,0000,0000,,they may be misdiagnosed. Dialogue: 0,0:10:30.00,0:10:32.00,Default,,0000,0000,0000,,In particular,\Nthe notion is that if you see Dialogue: 0,0:10:32.00,0:10:35.00,Default,,0000,0000,0000,,things or hear things, you're going mad, Dialogue: 0,0:10:35.00,0:10:38.00,Default,,0000,0000,0000,,but the psychotic hallucinations \Nare quite different. Dialogue: 0,0:10:38.00,0:10:41.00,Default,,0000,0000,0000,,Psychotic hallucinations,\Nwhether they are visual or vocal, Dialogue: 0,0:10:41.00,0:10:43.00,Default,,0000,0000,0000,,they address you. They accuse you. Dialogue: 0,0:10:43.00,0:10:45.00,Default,,0000,0000,0000,,They seduce you. They humiliate you. Dialogue: 0,0:10:45.00,0:10:48.00,Default,,0000,0000,0000,,They jeer at you. Dialogue: 0,0:10:48.00,0:10:50.00,Default,,0000,0000,0000,,You interact with them. Dialogue: 0,0:10:50.00,0:10:53.00,Default,,0000,0000,0000,,There is none of this quality\Nof being addressed Dialogue: 0,0:10:53.00,0:10:56.00,Default,,0000,0000,0000,,with these Charles Bonnet hallucinations. Dialogue: 0,0:10:56.00,0:11:00.00,Default,,0000,0000,0000,,There is a film. You're seeing a film\Nwhich has nothing to do with you, Dialogue: 0,0:11:00.00,0:11:03.00,Default,,0000,0000,0000,,or that's how people think about it. Dialogue: 0,0:11:03.00,0:11:07.00,Default,,0000,0000,0000,,There is also a rare thing\Ncalled temporal lobe epilepsy, Dialogue: 0,0:11:07.00,0:11:10.00,Default,,0000,0000,0000,,and sometimes, if one has this, Dialogue: 0,0:11:10.00,0:11:12.00,Default,,0000,0000,0000,,one may feel oneself transported back Dialogue: 0,0:11:12.00,0:11:15.00,Default,,0000,0000,0000,,to a time and place in the past. Dialogue: 0,0:11:15.00,0:11:17.00,Default,,0000,0000,0000,,You're at a particular road junction. Dialogue: 0,0:11:17.00,0:11:19.00,Default,,0000,0000,0000,,You smell chestnuts roasting. Dialogue: 0,0:11:19.00,0:11:22.00,Default,,0000,0000,0000,,You hear the traffic.\NAll the senses are involved. Dialogue: 0,0:11:22.00,0:11:24.00,Default,,0000,0000,0000,,And you're waiting for your girl. Dialogue: 0,0:11:24.00,0:11:28.00,Default,,0000,0000,0000,,And it's that Tuesday\Nevening back in 1982. Dialogue: 0,0:11:28.00,0:11:30.00,Default,,0000,0000,0000,,And the temporal lobe hallucinations Dialogue: 0,0:11:30.00,0:11:32.00,Default,,0000,0000,0000,,are all-sense hallucinations, Dialogue: 0,0:11:32.00,0:11:35.00,Default,,0000,0000,0000,,full of feeling, full of familiarity, Dialogue: 0,0:11:35.00,0:11:37.00,Default,,0000,0000,0000,,located in space and time, Dialogue: 0,0:11:37.00,0:11:39.00,Default,,0000,0000,0000,,coherent, dramatic. Dialogue: 0,0:11:39.00,0:11:42.00,Default,,0000,0000,0000,,The Charles Bonnet\Nones are quite different. Dialogue: 0,0:11:42.00,0:11:46.00,Default,,0000,0000,0000,,So in the Charles Bonnet hallucinations, Dialogue: 0,0:11:46.00,0:11:48.00,Default,,0000,0000,0000,,you have all sorts of levels, Dialogue: 0,0:11:48.00,0:11:50.00,Default,,0000,0000,0000,,from the geometrical hallucinations -- Dialogue: 0,0:11:50.00,0:11:53.00,Default,,0000,0000,0000,,the pink and blue squares the woman had -- Dialogue: 0,0:11:53.00,0:11:57.00,Default,,0000,0000,0000,,up to quite elaborate hallucinations Dialogue: 0,0:11:57.00,0:12:00.00,Default,,0000,0000,0000,,with figures and especially faces. Dialogue: 0,0:12:00.00,0:12:03.00,Default,,0000,0000,0000,,Faces, and sometimes deformed faces, Dialogue: 0,0:12:03.00,0:12:06.00,Default,,0000,0000,0000,,are the single commonest thing Dialogue: 0,0:12:06.00,0:12:08.00,Default,,0000,0000,0000,,in these hallucinations. Dialogue: 0,0:12:08.00,0:12:11.00,Default,,0000,0000,0000,,And one of the second\Ncommonest is cartoons. Dialogue: 0,0:12:11.00,0:12:14.00,Default,,0000,0000,0000,,So, what is going on? Dialogue: 0,0:12:14.00,0:12:16.00,Default,,0000,0000,0000,,Fascinatingly, in the last few years, Dialogue: 0,0:12:16.00,0:12:20.00,Default,,0000,0000,0000,,it's been possible to do\Nfunctional brain imagery, Dialogue: 0,0:12:20.00,0:12:24.00,Default,,0000,0000,0000,,to do fMRI on people\Nas they are hallucinating. Dialogue: 0,0:12:24.00,0:12:28.00,Default,,0000,0000,0000,,And in fact, to find that different parts Dialogue: 0,0:12:28.00,0:12:31.00,Default,,0000,0000,0000,,of the visual brain are activated Dialogue: 0,0:12:31.00,0:12:33.00,Default,,0000,0000,0000,,as they are hallucinating. Dialogue: 0,0:12:33.00,0:12:36.00,Default,,0000,0000,0000,,When people have these\Nsimple geometrical hallucinations, Dialogue: 0,0:12:36.00,0:12:40.00,Default,,0000,0000,0000,,the primary visual cortex is activated. Dialogue: 0,0:12:40.00,0:12:43.00,Default,,0000,0000,0000,,This is the part of the brain\Nwhich perceives edges and patterns. Dialogue: 0,0:12:43.00,0:12:47.00,Default,,0000,0000,0000,,You don't form images\Nwith your primary visual cortex. Dialogue: 0,0:12:47.00,0:12:50.00,Default,,0000,0000,0000,,When images are formed, Dialogue: 0,0:12:50.00,0:12:52.00,Default,,0000,0000,0000,,a higher part of the visual cortex Dialogue: 0,0:12:52.00,0:12:54.00,Default,,0000,0000,0000,,is involved in the temporal lobe. Dialogue: 0,0:12:54.00,0:12:59.00,Default,,0000,0000,0000,,And in particular,\None area of the temporal lobe Dialogue: 0,0:12:59.00,0:13:01.00,Default,,0000,0000,0000,,is called the fusiform gyrus. Dialogue: 0,0:13:01.00,0:13:05.00,Default,,0000,0000,0000,,And it's known that if people\Nhave damage in the fusiform gyrus, Dialogue: 0,0:13:05.00,0:13:09.00,Default,,0000,0000,0000,,they maybe lose\Nthe ability to recognize faces. Dialogue: 0,0:13:09.00,0:13:13.00,Default,,0000,0000,0000,,But if there is an abnormal activity\Nin the fusiform gyrus, Dialogue: 0,0:13:13.00,0:13:15.00,Default,,0000,0000,0000,,they may hallucinate faces, Dialogue: 0,0:13:15.00,0:13:18.00,Default,,0000,0000,0000,,and this is exactly what you find\Nin some of these people. Dialogue: 0,0:13:18.00,0:13:22.00,Default,,0000,0000,0000,,There is an area\Nin the anterior part of this gyrus Dialogue: 0,0:13:22.00,0:13:27.00,Default,,0000,0000,0000,,where teeth and eyes are represented, Dialogue: 0,0:13:27.00,0:13:30.00,Default,,0000,0000,0000,,and that part of the gyrus is activated Dialogue: 0,0:13:30.00,0:13:34.00,Default,,0000,0000,0000,,when people get\Nthe deformed hallucinations. Dialogue: 0,0:13:34.00,0:13:36.00,Default,,0000,0000,0000,,There is another part of the brain Dialogue: 0,0:13:36.00,0:13:38.00,Default,,0000,0000,0000,,which is especially activated Dialogue: 0,0:13:38.00,0:13:40.00,Default,,0000,0000,0000,,when one sees cartoons. Dialogue: 0,0:13:40.00,0:13:43.00,Default,,0000,0000,0000,,It's activated when\None recognizes cartoons, Dialogue: 0,0:13:43.00,0:13:47.00,Default,,0000,0000,0000,,when one draws cartoons,\Nand when one hallucinates them. Dialogue: 0,0:13:47.00,0:13:50.00,Default,,0000,0000,0000,,It's very interesting\Nthat that should be specific. Dialogue: 0,0:13:50.00,0:13:53.00,Default,,0000,0000,0000,,There are other parts of the brain\Nwhich are specifically involved Dialogue: 0,0:13:53.00,0:13:55.00,Default,,0000,0000,0000,,with the recognition and hallucination Dialogue: 0,0:13:55.00,0:13:58.00,Default,,0000,0000,0000,,of buildings and landscapes. Dialogue: 0,0:13:58.00,0:14:01.00,Default,,0000,0000,0000,,Around 1970, it was found\Nthat there were not only parts of the brain, Dialogue: 0,0:14:01.00,0:14:03.00,Default,,0000,0000,0000,,but particular cells. Dialogue: 0,0:14:03.00,0:14:08.00,Default,,0000,0000,0000,,"Face cells" were discovered around 1970. Dialogue: 0,0:14:08.00,0:14:10.00,Default,,0000,0000,0000,,And now we know\Nthat there are hundreds of other Dialogue: 0,0:14:10.00,0:14:12.00,Default,,0000,0000,0000,,sorts of cells, Dialogue: 0,0:14:12.00,0:14:14.00,Default,,0000,0000,0000,,which can be very, very specific. Dialogue: 0,0:14:14.00,0:14:16.00,Default,,0000,0000,0000,,So you may not only have Dialogue: 0,0:14:16.00,0:14:18.00,Default,,0000,0000,0000,,"car" cells, Dialogue: 0,0:14:18.00,0:14:21.00,Default,,0000,0000,0000,,you may have "Aston Martin" cells. Dialogue: 0,0:14:21.00,0:14:23.00,Default,,0000,0000,0000,,(Laughter) Dialogue: 0,0:14:23.00,0:14:25.00,Default,,0000,0000,0000,,I saw an Aston Martin this morning. Dialogue: 0,0:14:25.00,0:14:27.00,Default,,0000,0000,0000,,I had to bring it in. Dialogue: 0,0:14:27.00,0:14:30.00,Default,,0000,0000,0000,,And now it's in there somewhere. Dialogue: 0,0:14:30.00,0:14:33.00,Default,,0000,0000,0000,,(Laughter) Dialogue: 0,0:14:33.00,0:14:37.00,Default,,0000,0000,0000,,Now, at this level, in what's called\Nthe inferotemporal cortex, Dialogue: 0,0:14:37.00,0:14:40.00,Default,,0000,0000,0000,,there are only visual images, Dialogue: 0,0:14:40.00,0:14:43.00,Default,,0000,0000,0000,,or figments or fragments. Dialogue: 0,0:14:43.00,0:14:46.00,Default,,0000,0000,0000,,It's only at higher levels Dialogue: 0,0:14:46.00,0:14:48.00,Default,,0000,0000,0000,,that the other senses join in Dialogue: 0,0:14:48.00,0:14:50.00,Default,,0000,0000,0000,,and there are connections\Nwith memory and emotion. Dialogue: 0,0:14:50.00,0:14:53.00,Default,,0000,0000,0000,,And in the Charles Bonnet syndrome, Dialogue: 0,0:14:53.00,0:14:55.00,Default,,0000,0000,0000,,you don't go to those higher levels. Dialogue: 0,0:14:55.00,0:14:58.00,Default,,0000,0000,0000,,You're in these levels\Nof inferior visual cortex Dialogue: 0,0:14:58.00,0:15:00.00,Default,,0000,0000,0000,,where you have thousands\Nand tens of thousands Dialogue: 0,0:15:00.00,0:15:03.00,Default,,0000,0000,0000,,and millions of images, Dialogue: 0,0:15:03.00,0:15:05.00,Default,,0000,0000,0000,,or figments,\Nor fragmentary figments, Dialogue: 0,0:15:05.00,0:15:07.00,Default,,0000,0000,0000,,all neurally encoded Dialogue: 0,0:15:07.00,0:15:11.00,Default,,0000,0000,0000,,in particular cells\Nor small clusters of cells. Dialogue: 0,0:15:11.00,0:15:14.00,Default,,0000,0000,0000,,Normally these are all part of Dialogue: 0,0:15:14.00,0:15:18.00,Default,,0000,0000,0000,,the integrated stream\Nof perception, or imagination, Dialogue: 0,0:15:18.00,0:15:21.00,Default,,0000,0000,0000,,and one is not conscious of them. Dialogue: 0,0:15:21.00,0:15:25.00,Default,,0000,0000,0000,,It is only if one\Nis visually impaired or blind Dialogue: 0,0:15:25.00,0:15:27.00,Default,,0000,0000,0000,,that the process is interrupted. Dialogue: 0,0:15:27.00,0:15:30.00,Default,,0000,0000,0000,,And instead of getting normal perception, Dialogue: 0,0:15:30.00,0:15:32.00,Default,,0000,0000,0000,,you're getting an anarchic, Dialogue: 0,0:15:32.00,0:15:35.00,Default,,0000,0000,0000,,convulsive stimulation, or release, Dialogue: 0,0:15:35.00,0:15:37.00,Default,,0000,0000,0000,,of all of these visual cells Dialogue: 0,0:15:37.00,0:15:39.00,Default,,0000,0000,0000,,in the inferotemporal cortex. Dialogue: 0,0:15:39.00,0:15:42.00,Default,,0000,0000,0000,,So, suddenly you see a face.\NSuddenly you see a car. Dialogue: 0,0:15:42.00,0:15:45.00,Default,,0000,0000,0000,,Suddenly this, and suddenly that. Dialogue: 0,0:15:45.00,0:15:47.00,Default,,0000,0000,0000,,The mind does its best to organize Dialogue: 0,0:15:47.00,0:15:50.00,Default,,0000,0000,0000,,and to give some sort\Nof coherence to this, Dialogue: 0,0:15:50.00,0:15:52.00,Default,,0000,0000,0000,,but not terribly successfully. Dialogue: 0,0:15:52.00,0:15:54.00,Default,,0000,0000,0000,,When these were first described, Dialogue: 0,0:15:54.00,0:15:58.00,Default,,0000,0000,0000,,it was thought that\Nthey could be interpreted like dreams. Dialogue: 0,0:15:58.00,0:16:00.00,Default,,0000,0000,0000,,But in fact people say, Dialogue: 0,0:16:00.00,0:16:03.00,Default,,0000,0000,0000,,"I don't recognize the people.\NI can't form any associations." Dialogue: 0,0:16:03.00,0:16:06.00,Default,,0000,0000,0000,,"Kermit means nothing to me." Dialogue: 0,0:16:06.00,0:16:11.00,Default,,0000,0000,0000,,You don't get anywhere\Nthinking of them as dreams. Dialogue: 0,0:16:11.00,0:16:16.00,Default,,0000,0000,0000,,Well, I've more\Nor less said what I wanted. Dialogue: 0,0:16:16.00,0:16:19.00,Default,,0000,0000,0000,,I think I just want to recapitulate Dialogue: 0,0:16:19.00,0:16:21.00,Default,,0000,0000,0000,,and say this is common. Dialogue: 0,0:16:21.00,0:16:23.00,Default,,0000,0000,0000,,Think of the number of blind people. Dialogue: 0,0:16:23.00,0:16:25.00,Default,,0000,0000,0000,,There must be hundreds\Nof thousands of blind people Dialogue: 0,0:16:25.00,0:16:27.00,Default,,0000,0000,0000,,who have these hallucinations, Dialogue: 0,0:16:27.00,0:16:29.00,Default,,0000,0000,0000,,but are too scared to mention them. Dialogue: 0,0:16:29.00,0:16:32.00,Default,,0000,0000,0000,,So this sort of thing\Nneeds to be brought into Dialogue: 0,0:16:32.00,0:16:38.00,Default,,0000,0000,0000,,notice, for patients,\Nfor doctors, for the public. Dialogue: 0,0:16:38.00,0:16:40.00,Default,,0000,0000,0000,,Finally, I think they are Dialogue: 0,0:16:40.00,0:16:43.00,Default,,0000,0000,0000,,infinitely interesting and valuable, Dialogue: 0,0:16:43.00,0:16:47.00,Default,,0000,0000,0000,,for giving one some insight\Nas to how the brain works. Dialogue: 0,0:16:47.00,0:16:50.00,Default,,0000,0000,0000,,Charles Bonnet said, 250 years ago -- Dialogue: 0,0:16:50.00,0:16:54.00,Default,,0000,0000,0000,,he wondered how,\Nthinking these hallucinations, Dialogue: 0,0:16:54.00,0:16:57.00,Default,,0000,0000,0000,,how, as he put it,\Nthe theater of the mind Dialogue: 0,0:16:57.00,0:17:00.00,Default,,0000,0000,0000,,could be generated\Nby the machinery of the brain. Dialogue: 0,0:17:00.00,0:17:03.00,Default,,0000,0000,0000,,Now, 250 years later, Dialogue: 0,0:17:03.00,0:17:06.00,Default,,0000,0000,0000,,I think we're beginning\Nto glimpse how this is done. Dialogue: 0,0:17:06.00,0:17:08.00,Default,,0000,0000,0000,,Thanks very much. Dialogue: 0,0:17:08.00,0:17:11.00,Default,,0000,0000,0000,,(Applause) Dialogue: 0,0:17:11.00,0:17:14.00,Default,,0000,0000,0000,,Chris Anderson: That was superb.\NThank you so much. Dialogue: 0,0:17:14.00,0:17:16.00,Default,,0000,0000,0000,,You speak about these things\Nwith so much insight Dialogue: 0,0:17:16.00,0:17:19.00,Default,,0000,0000,0000,,and empathy for your patients. Dialogue: 0,0:17:19.00,0:17:24.00,Default,,0000,0000,0000,,Have you yourself experienced\Nany of the syndromes you write about? Dialogue: 0,0:17:24.00,0:17:26.00,Default,,0000,0000,0000,,Oliver Sacks: I was afraid you'd ask that. Dialogue: 0,0:17:26.00,0:17:27.00,Default,,0000,0000,0000,,(Laughter) Dialogue: 0,0:17:27.00,0:17:30.00,Default,,0000,0000,0000,,Well, yeah, a lot of them. Dialogue: 0,0:17:30.00,0:17:33.00,Default,,0000,0000,0000,,And actually I'm a little\Nvisually impaired myself. Dialogue: 0,0:17:33.00,0:17:36.00,Default,,0000,0000,0000,,I'm blind in one eye,\Nand not terribly good in the other. Dialogue: 0,0:17:36.00,0:17:40.00,Default,,0000,0000,0000,,And I see the geometrical hallucinations. Dialogue: 0,0:17:40.00,0:17:42.00,Default,,0000,0000,0000,,But they stop there. Dialogue: 0,0:17:42.00,0:17:44.00,Default,,0000,0000,0000,,CA: And they don't disturb you? Dialogue: 0,0:17:44.00,0:17:46.00,Default,,0000,0000,0000,,Because you understand what's doing it,\Nit doesn't make you worried? Dialogue: 0,0:17:46.00,0:17:50.00,Default,,0000,0000,0000,,OS: Well they don't disturb me\Nany more than my tinnitus, Dialogue: 0,0:17:50.00,0:17:53.00,Default,,0000,0000,0000,,which I ignore. Dialogue: 0,0:17:53.00,0:17:55.00,Default,,0000,0000,0000,,They occasionally interest me, Dialogue: 0,0:17:55.00,0:17:58.00,Default,,0000,0000,0000,,and I have many pictures\Nof them in my notebooks. Dialogue: 0,0:17:58.00,0:18:01.00,Default,,0000,0000,0000,,I've gone and had an fMRI myself, Dialogue: 0,0:18:01.00,0:18:04.00,Default,,0000,0000,0000,,to see how my visual cortex\Nis taking over. Dialogue: 0,0:18:04.00,0:18:08.00,Default,,0000,0000,0000,,And when I see all these hexagons Dialogue: 0,0:18:08.00,0:18:10.00,Default,,0000,0000,0000,,and complex things,\Nwhich I also have, Dialogue: 0,0:18:10.00,0:18:12.00,Default,,0000,0000,0000,,in visual migraine, Dialogue: 0,0:18:12.00,0:18:14.00,Default,,0000,0000,0000,,I wonder whether everyone\Nsees things like this, Dialogue: 0,0:18:14.00,0:18:17.00,Default,,0000,0000,0000,,and whether things\Nlike cave art or ornamental art Dialogue: 0,0:18:17.00,0:18:20.00,Default,,0000,0000,0000,,may have been derived from them a bit. Dialogue: 0,0:18:20.00,0:18:22.00,Default,,0000,0000,0000,,CA: That was an utterly,\Nutterly fascinating talk. Dialogue: 0,0:18:22.00,0:18:24.00,Default,,0000,0000,0000,,Thank you so much for sharing. Dialogue: 0,0:18:24.00,0:18:26.00,Default,,0000,0000,0000,,OS: Thank you. Thank you. Dialogue: 0,0:18:26.00,0:18:28.00,Default,,0000,0000,0000,,(Applause)