[Script Info]
Title: 
[Events]
Format: Layer, Start, End, Style, Name, MarginL, MarginR, MarginV, Effect, Text
Dialogue: 0,0:00:04.24,0:00:06.84,Default,,0000,0000,0000,,"You have cancer."
Dialogue: 0,0:00:08.68,0:00:13.12,Default,,0000,0000,0000,,Sadly, about 40 percent of us will hear\Nthose three words within our lifetime,
Dialogue: 0,0:00:13.84,0:00:15.96,Default,,0000,0000,0000,,and half will not survive.
Dialogue: 0,0:00:16.96,0:00:20.82,Default,,0000,0000,0000,,This means that two out of five\Nof your closest friends and relatives
Dialogue: 0,0:00:20.84,0:00:23.30,Default,,0000,0000,0000,,will be diagnosed\Nwith some form of cancer,
Dialogue: 0,0:00:23.32,0:00:24.80,Default,,0000,0000,0000,,and one will die.
Dialogue: 0,0:00:27.28,0:00:28.74,Default,,0000,0000,0000,,Beyond the physical hardships,
Dialogue: 0,0:00:28.76,0:00:31.94,Default,,0000,0000,0000,,roughly one-third\Nof cancer survivors here in the US
Dialogue: 0,0:00:31.96,0:00:33.70,Default,,0000,0000,0000,,will go into debt from treatment.
Dialogue: 0,0:00:33.72,0:00:37.46,Default,,0000,0000,0000,,And they're at least two and a half times\Nmore likely to declare bankruptcy
Dialogue: 0,0:00:37.48,0:00:38.72,Default,,0000,0000,0000,,than those without cancer.
Dialogue: 0,0:00:39.68,0:00:42.06,Default,,0000,0000,0000,,This disease is pervasive.
Dialogue: 0,0:00:42.08,0:00:43.66,Default,,0000,0000,0000,,It's emotionally draining
Dialogue: 0,0:00:43.68,0:00:44.90,Default,,0000,0000,0000,,and, for many,
Dialogue: 0,0:00:44.92,0:00:46.32,Default,,0000,0000,0000,,financially destructive.
Dialogue: 0,0:00:47.88,0:00:51.44,Default,,0000,0000,0000,,But a cancer diagnosis\Ndoesn't have to be a death sentence.
Dialogue: 0,0:00:51.92,0:00:53.78,Default,,0000,0000,0000,,Finding cancer early,
Dialogue: 0,0:00:53.80,0:00:55.02,Default,,0000,0000,0000,,closer its genesis,
Dialogue: 0,0:00:55.04,0:00:58.66,Default,,0000,0000,0000,,is one of the critical factors\Nto improving treatment options,
Dialogue: 0,0:00:58.68,0:01:00.66,Default,,0000,0000,0000,,reducing its emotional impact
Dialogue: 0,0:01:00.68,0:01:02.64,Default,,0000,0000,0000,,and minimizing financial burdens.
Dialogue: 0,0:01:03.56,0:01:04.78,Default,,0000,0000,0000,,Most importantly,
Dialogue: 0,0:01:04.80,0:01:06.06,Default,,0000,0000,0000,,finding cancer early --
Dialogue: 0,0:01:06.08,0:01:08.98,Default,,0000,0000,0000,,which is one of the primary\Naims of my research --
Dialogue: 0,0:01:09.00,0:01:11.16,Default,,0000,0000,0000,,greatly enhances your odds of survival.
Dialogue: 0,0:01:12.12,0:01:14.86,Default,,0000,0000,0000,,If we just look at the case\Nof breast cancer for example,
Dialogue: 0,0:01:14.88,0:01:18.38,Default,,0000,0000,0000,,we find that those who are diagnosed\Nand treated at stage one
Dialogue: 0,0:01:18.40,0:01:22.16,Default,,0000,0000,0000,,have a five-year survival rate\Nof nearly 100 percent --
Dialogue: 0,0:01:22.76,0:01:26.76,Default,,0000,0000,0000,,odds that decrease to just 22 percent\Nif treated at stage four.
Dialogue: 0,0:01:28.04,0:01:32.00,Default,,0000,0000,0000,,And similar trends are found\Nfor colorectal and ovarian cancer.
Dialogue: 0,0:01:34.00,0:01:39.46,Default,,0000,0000,0000,,Now, we're all aware\Nthat an early diagnosis that is accurate
Dialogue: 0,0:01:39.48,0:01:41.60,Default,,0000,0000,0000,,is critical for survival.
Dialogue: 0,0:01:43.60,0:01:47.42,Default,,0000,0000,0000,,The problem is that many\Ncancer diagnostic tools are invasive,
Dialogue: 0,0:01:47.44,0:01:48.66,Default,,0000,0000,0000,,costly,
Dialogue: 0,0:01:48.68,0:01:49.90,Default,,0000,0000,0000,,often inaccurate
Dialogue: 0,0:01:49.92,0:01:53.56,Default,,0000,0000,0000,,and they can take an agonizing\Namount of time to get the results back.
Dialogue: 0,0:01:54.52,0:01:56.94,Default,,0000,0000,0000,,Still worse, when it comes\Nto some forms of cancer,
Dialogue: 0,0:01:56.96,0:02:01.26,Default,,0000,0000,0000,,such as ovarian,\Nliver or pancreatic cancer,
Dialogue: 0,0:02:01.28,0:02:03.96,Default,,0000,0000,0000,,good screening methods simply don't exist,
Dialogue: 0,0:02:04.88,0:02:08.94,Default,,0000,0000,0000,,meaning that often people wait\Nuntil physical symptoms surface,
Dialogue: 0,0:02:08.96,0:02:12.44,Default,,0000,0000,0000,,which are themselves already\Nindicators of late-stage progression.
Dialogue: 0,0:02:13.92,0:02:17.50,Default,,0000,0000,0000,,Like a tornado strike in an area\Nwithout an early warning system,
Dialogue: 0,0:02:17.52,0:02:19.42,Default,,0000,0000,0000,,there is no alarm to warn,
Dialogue: 0,0:02:19.44,0:02:22.30,Default,,0000,0000,0000,,for the danger is already at your doorstep
Dialogue: 0,0:02:22.32,0:02:25.36,Default,,0000,0000,0000,,when your odds of survival\Nare greatly reduced.
Dialogue: 0,0:02:27.40,0:02:31.66,Default,,0000,0000,0000,,Having the convenience and accessibility\Nof regular screening options
Dialogue: 0,0:02:31.68,0:02:37.02,Default,,0000,0000,0000,,that are affordable, noninvasive\Nand could provide results much sooner,
Dialogue: 0,0:02:37.04,0:02:41.48,Default,,0000,0000,0000,,would provide us with a formidable\Nweapon in the fight against cancer.
Dialogue: 0,0:02:42.76,0:02:45.82,Default,,0000,0000,0000,,An early warning would allow us\Nto get out ahead of the disease
Dialogue: 0,0:02:45.84,0:02:48.58,Default,,0000,0000,0000,,instead of merely\Nfollowing in its relentless wake.
Dialogue: 0,0:02:48.60,0:02:50.58,Default,,0000,0000,0000,,And this is exactly what I've been doing.
Dialogue: 0,0:02:50.60,0:02:53.74,Default,,0000,0000,0000,,For the past three years,\NI've been developing technologies
Dialogue: 0,0:02:53.76,0:02:55.50,Default,,0000,0000,0000,,that could ultimately aid clinicians
Dialogue: 0,0:02:55.52,0:02:58.44,Default,,0000,0000,0000,,with rapid, early-stage\Ncancer diagnostics.
Dialogue: 0,0:02:58.92,0:03:02.78,Default,,0000,0000,0000,,And I've been fueled\Nby a deep scientific curiosity,
Dialogue: 0,0:03:02.80,0:03:05.32,Default,,0000,0000,0000,,and a passion to change these statistics.
Dialogue: 0,0:03:06.88,0:03:08.08,Default,,0000,0000,0000,,Last year however,
Dialogue: 0,0:03:08.96,0:03:10.72,Default,,0000,0000,0000,,this fight became much more personal
Dialogue: 0,0:03:12.04,0:03:14.36,Default,,0000,0000,0000,,when my wife was diagnosed\Nwith breast cancer.
Dialogue: 0,0:03:15.56,0:03:19.98,Default,,0000,0000,0000,,It was an experience that added a strong\Nand unexpected emotional dimension
Dialogue: 0,0:03:20.00,0:03:21.20,Default,,0000,0000,0000,,to these efforts.
Dialogue: 0,0:03:23.24,0:03:26.52,Default,,0000,0000,0000,,I know firsthand how life-altering\Ntreatment can be,
Dialogue: 0,0:03:27.52,0:03:30.18,Default,,0000,0000,0000,,and I'm keenly aware\Nof the emotional havoc
Dialogue: 0,0:03:30.20,0:03:32.66,Default,,0000,0000,0000,,that cancer can wreak on a family,
Dialogue: 0,0:03:32.68,0:03:35.08,Default,,0000,0000,0000,,which in our case\Nincluded our two young daughters.
Dialogue: 0,0:03:36.40,0:03:39.54,Default,,0000,0000,0000,,Because we found it early\Nduring a routine mammogram,
Dialogue: 0,0:03:39.56,0:03:43.26,Default,,0000,0000,0000,,we were able to focus\Nprimarily on treatment options
Dialogue: 0,0:03:43.28,0:03:44.82,Default,,0000,0000,0000,,for the localized tumor,
Dialogue: 0,0:03:44.84,0:03:49.24,Default,,0000,0000,0000,,reaffirming to me\Nhow important an early diagnosis is.
Dialogue: 0,0:03:50.96,0:03:52.44,Default,,0000,0000,0000,,Unlike other forms of cancer,
Dialogue: 0,0:03:53.40,0:03:57.06,Default,,0000,0000,0000,,mammograms do offer an early-stage\Nscreening option for breast cancer.
Dialogue: 0,0:03:57.08,0:03:59.30,Default,,0000,0000,0000,,Still, not everyone has this done,
Dialogue: 0,0:03:59.32,0:04:00.91,Default,,0000,0000,0000,,or they may develop breast cancer
Dialogue: 0,0:04:00.93,0:04:04.05,Default,,0000,0000,0000,,before the middle age recommendation\Nfor having a mammogram.
Dialogue: 0,0:04:05.56,0:04:07.82,Default,,0000,0000,0000,,So, there's still\Na lot of room for improvement,
Dialogue: 0,0:04:07.84,0:04:10.10,Default,,0000,0000,0000,,even for cancers\Nthat do have screening options,
Dialogue: 0,0:04:10.12,0:04:12.96,Default,,0000,0000,0000,,and, of course, considerable benefits\Nfor those that don't.
Dialogue: 0,0:04:13.68,0:04:16.42,Default,,0000,0000,0000,,A key challenge then\Nfor cancer researchers
Dialogue: 0,0:04:16.44,0:04:17.74,Default,,0000,0000,0000,,is to develop methods
Dialogue: 0,0:04:17.76,0:04:21.30,Default,,0000,0000,0000,,that make regular screening\Nfor many types of cancers
Dialogue: 0,0:04:21.32,0:04:22.56,Default,,0000,0000,0000,,much more accessible.
Dialogue: 0,0:04:23.92,0:04:26.98,Default,,0000,0000,0000,,Imagine a scenario\Nwhere during your regular checkup,
Dialogue: 0,0:04:27.00,0:04:30.78,Default,,0000,0000,0000,,your doctor can take\Na simple, noninvasive urine sample,
Dialogue: 0,0:04:30.80,0:04:32.04,Default,,0000,0000,0000,,or other liquid biopsy,
Dialogue: 0,0:04:32.72,0:04:36.24,Default,,0000,0000,0000,,and present you with the results\Nbefore you even leave the doctor's office.
Dialogue: 0,0:04:36.80,0:04:40.34,Default,,0000,0000,0000,,Such a technology could\Ndramatically reduce the number of people
Dialogue: 0,0:04:40.36,0:04:43.60,Default,,0000,0000,0000,,who slip through the net\Nof an early-stage cancer diagnosis.
Dialogue: 0,0:04:44.84,0:04:47.66,Default,,0000,0000,0000,,My research team\Nof engineers and biochemists
Dialogue: 0,0:04:47.68,0:04:49.72,Default,,0000,0000,0000,,is working on exactly this challenge.
Dialogue: 0,0:04:50.32,0:04:55.46,Default,,0000,0000,0000,,We're working on ways to frequently\Nactivate an early-stage cancer alarm
Dialogue: 0,0:04:55.48,0:04:59.82,Default,,0000,0000,0000,,by enabling regular screenings\Nthat would start when a person is healthy
Dialogue: 0,0:04:59.84,0:05:04.14,Default,,0000,0000,0000,,so that action could be taken\Nto stop cancer the moment it emerges,
Dialogue: 0,0:05:04.16,0:05:06.84,Default,,0000,0000,0000,,and before it can progress\Nbeyond its infancy.
Dialogue: 0,0:05:08.64,0:05:11.66,Default,,0000,0000,0000,,The silver bullet in this case\Nare tiny vesicles,
Dialogue: 0,0:05:11.68,0:05:16.12,Default,,0000,0000,0000,,little escape pods regularly shed\Nby cells called exosomes.
Dialogue: 0,0:05:16.68,0:05:19.42,Default,,0000,0000,0000,,Exosomes are important biomarkers
Dialogue: 0,0:05:19.44,0:05:22.72,Default,,0000,0000,0000,,that provide an early-warning system\Nfor the development of cancer.
Dialogue: 0,0:05:23.72,0:05:27.14,Default,,0000,0000,0000,,And because they're abundantly present\Nin just about every bodily fluid,
Dialogue: 0,0:05:27.16,0:05:29.66,Default,,0000,0000,0000,,including blood, urine and saliva,
Dialogue: 0,0:05:29.68,0:05:33.88,Default,,0000,0000,0000,,they're extremely attractive\Nfor noninvasive liquid biopsies.
Dialogue: 0,0:05:35.04,0:05:36.62,Default,,0000,0000,0000,,There's just one problem.
Dialogue: 0,0:05:36.64,0:05:40.94,Default,,0000,0000,0000,,An automated system for rapidly sorting\Nthese important biomarkers
Dialogue: 0,0:05:40.96,0:05:42.56,Default,,0000,0000,0000,,is not currently available.
Dialogue: 0,0:05:43.68,0:05:46.98,Default,,0000,0000,0000,,We've created a technology\Nthat we call nano-DLD
Dialogue: 0,0:05:47.00,0:05:49.12,Default,,0000,0000,0000,,that is capable of precisely this:
Dialogue: 0,0:05:49.92,0:05:52.62,Default,,0000,0000,0000,,automated exosome isolation
Dialogue: 0,0:05:52.64,0:05:55.12,Default,,0000,0000,0000,,to aid rapid cancer diagnostics.
Dialogue: 0,0:05:56.04,0:05:59.58,Default,,0000,0000,0000,,Exosomes are the newest\Nearly-warning weapon, if you will,
Dialogue: 0,0:05:59.60,0:06:01.66,Default,,0000,0000,0000,,to emerge on the liquid biopsy front.
Dialogue: 0,0:06:01.68,0:06:03.98,Default,,0000,0000,0000,,And they're really, really small.
Dialogue: 0,0:06:04.00,0:06:07.52,Default,,0000,0000,0000,,They measure just 30 to 150\Nnanometers in diameter.
Dialogue: 0,0:06:08.28,0:06:09.58,Default,,0000,0000,0000,,This is so tiny
Dialogue: 0,0:06:09.60,0:06:13.24,Default,,0000,0000,0000,,that you could fit about a million\Nof them into a single red blood cell.
Dialogue: 0,0:06:13.80,0:06:16.14,Default,,0000,0000,0000,,That's roughly the difference\Nbetween a golf ball
Dialogue: 0,0:06:16.16,0:06:17.88,Default,,0000,0000,0000,,and a fine grain piece of sand.
Dialogue: 0,0:06:18.92,0:06:22.62,Default,,0000,0000,0000,,Once thought to be little bins\Nfor unwanted cellular waste,
Dialogue: 0,0:06:22.64,0:06:25.62,Default,,0000,0000,0000,,it has been found\Nthat cells actually communicate
Dialogue: 0,0:06:25.64,0:06:28.78,Default,,0000,0000,0000,,by producing and absorbing these exosomes
Dialogue: 0,0:06:28.80,0:06:31.18,Default,,0000,0000,0000,,which contain surface receptors,
Dialogue: 0,0:06:31.20,0:06:35.20,Default,,0000,0000,0000,,proteins and other genetic material\Ncollected from their cell of origin.
Dialogue: 0,0:06:36.52,0:06:39.18,Default,,0000,0000,0000,,When absorbed by a neighboring cell,
Dialogue: 0,0:06:39.20,0:06:43.02,Default,,0000,0000,0000,,exosomes release their contents\Ninto the receiving cell,
Dialogue: 0,0:06:43.04,0:06:46.26,Default,,0000,0000,0000,,and can set in motion\Nfundamental changes in gene expression --
Dialogue: 0,0:06:46.28,0:06:47.50,Default,,0000,0000,0000,,some good,
Dialogue: 0,0:06:47.52,0:06:49.26,Default,,0000,0000,0000,,and this is where cancer comes in,
Dialogue: 0,0:06:49.28,0:06:50.86,Default,,0000,0000,0000,,some bad.
Dialogue: 0,0:06:50.88,0:06:54.66,Default,,0000,0000,0000,,Because they are clothed\Nin the material of the mother cell,
Dialogue: 0,0:06:54.68,0:06:56.62,Default,,0000,0000,0000,,and contain a sample of its environment,
Dialogue: 0,0:06:56.64,0:07:01.72,Default,,0000,0000,0000,,they provide a genetic snapshot\Nof that cell's health and its origin.
Dialogue: 0,0:07:03.20,0:07:06.34,Default,,0000,0000,0000,,All of these qualities\Nmake exosomes invaluable messengers
Dialogue: 0,0:07:06.36,0:07:07.98,Default,,0000,0000,0000,,that potentially allow physicians
Dialogue: 0,0:07:08.00,0:07:10.92,Default,,0000,0000,0000,,to eavesdrop on your health\Nat the cellular level.
Dialogue: 0,0:07:12.08,0:07:13.74,Default,,0000,0000,0000,,To catch cancer early, however,
Dialogue: 0,0:07:13.76,0:07:16.70,Default,,0000,0000,0000,,you have to frequently\Nintercept these messages
Dialogue: 0,0:07:16.72,0:07:20.22,Default,,0000,0000,0000,,to determine when cancer-causing\Ntroublemakers within your body
Dialogue: 0,0:07:20.24,0:07:22.06,Default,,0000,0000,0000,,decide to start staging a coup,
Dialogue: 0,0:07:22.08,0:07:25.10,Default,,0000,0000,0000,,which is why regular\Nscreening is so critical
Dialogue: 0,0:07:25.12,0:07:27.96,Default,,0000,0000,0000,,and why we're developing\Ntechnologies to make this possible.
Dialogue: 0,0:07:29.12,0:07:34.78,Default,,0000,0000,0000,,While the first exosome-based diagnostics\Nemerged on the market just this year,
Dialogue: 0,0:07:34.80,0:07:38.08,Default,,0000,0000,0000,,they are not yet part\Nof mainstream healthcare options.
Dialogue: 0,0:07:39.32,0:07:41.18,Default,,0000,0000,0000,,In addition to their recent emergence,
Dialogue: 0,0:07:41.20,0:07:44.66,Default,,0000,0000,0000,,another factor that's limiting\Ntheir widespread adoption
Dialogue: 0,0:07:44.68,0:07:48.62,Default,,0000,0000,0000,,is that currently, no automated\Nexosome isolation system exists
Dialogue: 0,0:07:48.64,0:07:51.84,Default,,0000,0000,0000,,to make regular screening\Neconomically accessible.
Dialogue: 0,0:07:52.80,0:07:55.54,Default,,0000,0000,0000,,The current gold standard\Nfor exosome isolation
Dialogue: 0,0:07:55.56,0:07:57.50,Default,,0000,0000,0000,,includes ultracentrifugation,
Dialogue: 0,0:07:57.52,0:08:00.78,Default,,0000,0000,0000,,a process requiring\Nexpensive laboratory equipment,
Dialogue: 0,0:08:00.80,0:08:02.06,Default,,0000,0000,0000,,a trained lab tech
Dialogue: 0,0:08:02.08,0:08:05.12,Default,,0000,0000,0000,,and about 30 hours of time\Nto process a sample.
Dialogue: 0,0:08:06.60,0:08:11.26,Default,,0000,0000,0000,,We've come up with a different approach\Nfor achieving automated exosome isolation
Dialogue: 0,0:08:11.28,0:08:12.72,Default,,0000,0000,0000,,from a sample such as urine.
Dialogue: 0,0:08:13.56,0:08:17.82,Default,,0000,0000,0000,,We use a chip-based, continuous flow\Nseparation technique
Dialogue: 0,0:08:17.84,0:08:20.82,Default,,0000,0000,0000,,called deterministic lateral displacement.
Dialogue: 0,0:08:20.84,0:08:22.22,Default,,0000,0000,0000,,And we have done with it
Dialogue: 0,0:08:22.24,0:08:26.70,Default,,0000,0000,0000,,what the semiconductor industry has done\Nso successfully for the past 50 years.
Dialogue: 0,0:08:26.72,0:08:28.78,Default,,0000,0000,0000,,We shrunk the dimensions\Nof this technology
Dialogue: 0,0:08:28.80,0:08:31.44,Default,,0000,0000,0000,,from the micron scale\Nto the true nanoscale.
Dialogue: 0,0:08:32.72,0:08:34.18,Default,,0000,0000,0000,,So how does it work?
Dialogue: 0,0:08:34.20,0:08:35.46,Default,,0000,0000,0000,,In a nutshell,
Dialogue: 0,0:08:35.48,0:08:39.46,Default,,0000,0000,0000,,a set of tiny pillars\Nseparated by nanoscopic gaps
Dialogue: 0,0:08:39.48,0:08:40.74,Default,,0000,0000,0000,,are arranged in such a way
Dialogue: 0,0:08:40.76,0:08:43.82,Default,,0000,0000,0000,,that the system divides\Nthe fluid into streamlines,
Dialogue: 0,0:08:43.84,0:08:47.22,Default,,0000,0000,0000,,with the larger cancer-related\Nnanoparticles being separated
Dialogue: 0,0:08:47.24,0:08:51.14,Default,,0000,0000,0000,,through a process of redirection\Nfrom the smaller, healthier ones,
Dialogue: 0,0:08:51.16,0:08:52.70,Default,,0000,0000,0000,,which can in contrast
Dialogue: 0,0:08:52.72,0:08:55.26,Default,,0000,0000,0000,,move around the pillars\Nin a zigzag-type motion
Dialogue: 0,0:08:55.28,0:08:56.84,Default,,0000,0000,0000,,in the direction of fluid flow.
Dialogue: 0,0:08:58.08,0:09:02.08,Default,,0000,0000,0000,,The net result is a complete separation\Nof these two particle populations.
Dialogue: 0,0:09:03.44,0:09:07.14,Default,,0000,0000,0000,,You can visualize this separation process
Dialogue: 0,0:09:07.16,0:09:11.02,Default,,0000,0000,0000,,similar to traffic on a highway\Nthat separates into two roads,
Dialogue: 0,0:09:11.04,0:09:14.50,Default,,0000,0000,0000,,with one road going into\Na low-clearance tunnel under a mountain,
Dialogue: 0,0:09:14.52,0:09:16.58,Default,,0000,0000,0000,,and the other road going around it.
Dialogue: 0,0:09:16.60,0:09:19.38,Default,,0000,0000,0000,,Here, smaller cars\Ncan go through the tunnel
Dialogue: 0,0:09:19.40,0:09:22.70,Default,,0000,0000,0000,,while larger trucks,\Ncarrying potentially hazardous material,
Dialogue: 0,0:09:22.72,0:09:24.48,Default,,0000,0000,0000,,are forced to take the detour route.
Dialogue: 0,0:09:25.60,0:09:29.70,Default,,0000,0000,0000,,Traffic is effectively separated\Nby size and contents
Dialogue: 0,0:09:29.72,0:09:31.74,Default,,0000,0000,0000,,without impeding its flow.
Dialogue: 0,0:09:31.76,0:09:36.04,Default,,0000,0000,0000,,And this is exactly how our system works\Non a much, much smaller scale.
Dialogue: 0,0:09:37.60,0:09:41.46,Default,,0000,0000,0000,,The idea here is that\Nthe separation process for screening
Dialogue: 0,0:09:41.48,0:09:45.54,Default,,0000,0000,0000,,could be as simple as processing\Na sample of urine, blood or saliva,
Dialogue: 0,0:09:45.56,0:09:48.86,Default,,0000,0000,0000,,which is a near-term possibility\Nwithin the next few years.
Dialogue: 0,0:09:48.88,0:09:54.18,Default,,0000,0000,0000,,Ultimately, it could be used\Nto isolate and detect target exosomes
Dialogue: 0,0:09:54.20,0:09:57.42,Default,,0000,0000,0000,,associated with\Na particular type of cancer,
Dialogue: 0,0:09:57.44,0:09:59.88,Default,,0000,0000,0000,,sensing and reporting\Ntheir presence within minutes.
Dialogue: 0,0:10:00.60,0:10:03.80,Default,,0000,0000,0000,,This would make rapid diagnostics\Nvirtually painless.
Dialogue: 0,0:10:04.72,0:10:05.98,Default,,0000,0000,0000,,Broadly speaking,
Dialogue: 0,0:10:06.00,0:10:08.66,Default,,0000,0000,0000,,the ability to separate\Nand enrich biomarkers
Dialogue: 0,0:10:08.68,0:10:11.40,Default,,0000,0000,0000,,with nanoscale precision\Nin an automated way,
Dialogue: 0,0:10:12.32,0:10:15.78,Default,,0000,0000,0000,,opens the door to better understanding\Ndiseases such as cancer,
Dialogue: 0,0:10:15.80,0:10:19.78,Default,,0000,0000,0000,,with applications ranging\Nfrom sample preparation to diagnostics,
Dialogue: 0,0:10:19.80,0:10:22.28,Default,,0000,0000,0000,,and from drug resistance\Nmonitoring to therapeutics.
Dialogue: 0,0:10:23.44,0:10:25.46,Default,,0000,0000,0000,,Even before my wife's bout with cancer,
Dialogue: 0,0:10:25.48,0:10:28.96,Default,,0000,0000,0000,,it was a dream of mine to facilitate\Nthe automation of this process --
Dialogue: 0,0:10:29.84,0:10:32.78,Default,,0000,0000,0000,,to make regular screening more accessible,
Dialogue: 0,0:10:32.80,0:10:35.70,Default,,0000,0000,0000,,similar to the way Henry Ford\Nmade the automobile accessible
Dialogue: 0,0:10:35.72,0:10:37.30,Default,,0000,0000,0000,,to the general population
Dialogue: 0,0:10:37.32,0:10:39.58,Default,,0000,0000,0000,,through development of the assembly line.
Dialogue: 0,0:10:39.60,0:10:42.36,Default,,0000,0000,0000,,Automation is the key to accessibility.
Dialogue: 0,0:10:44.28,0:10:46.14,Default,,0000,0000,0000,,And in the spirit of the Hoover dream,
Dialogue: 0,0:10:46.16,0:10:49.06,Default,,0000,0000,0000,,"a chicken in every pot\Nand a car in every garage,"
Dialogue: 0,0:10:49.08,0:10:50.50,Default,,0000,0000,0000,,we're developing a technology
Dialogue: 0,0:10:50.52,0:10:54.34,Default,,0000,0000,0000,,that could ultimately place\Nan early-warning cancer detection system
Dialogue: 0,0:10:54.36,0:10:55.56,Default,,0000,0000,0000,,in every home.
Dialogue: 0,0:10:56.00,0:10:58.06,Default,,0000,0000,0000,,This would allow\Nevery man, woman and child
Dialogue: 0,0:10:58.08,0:11:02.22,Default,,0000,0000,0000,,the opportunity to be regularly tested\Nwhile they're still healthy,
Dialogue: 0,0:11:02.24,0:11:04.12,Default,,0000,0000,0000,,catching cancer when it first emerges.
Dialogue: 0,0:11:05.40,0:11:06.90,Default,,0000,0000,0000,,It is my hope and dream
Dialogue: 0,0:11:06.92,0:11:10.62,Default,,0000,0000,0000,,to help people around the world\Navoid the high costs --
Dialogue: 0,0:11:10.64,0:11:13.18,Default,,0000,0000,0000,,physical, financial and emotional --
Dialogue: 0,0:11:13.20,0:11:14.92,Default,,0000,0000,0000,,faced by today's cancer patients,
Dialogue: 0,0:11:15.60,0:11:17.92,Default,,0000,0000,0000,,hardships that I'm well acquainted with.
Dialogue: 0,0:11:19.40,0:11:23.78,Default,,0000,0000,0000,,I'm also happy to report that because\Nwe caught my wife's cancer early,
Dialogue: 0,0:11:23.80,0:11:25.46,Default,,0000,0000,0000,,her treatment was successful,
Dialogue: 0,0:11:25.48,0:11:27.74,Default,,0000,0000,0000,,and she is now, thankfully, cancer-free.
Dialogue: 0,0:11:27.76,0:11:29.96,Default,,0000,0000,0000,,(Applause)
Dialogue: 0,0:11:36.16,0:11:40.56,Default,,0000,0000,0000,,It is an outcome that I would like to see\Nfor everyone with a cancer diagnosis.
Dialogue: 0,0:11:41.28,0:11:43.34,Default,,0000,0000,0000,,With the work that my team\Nhas already done
Dialogue: 0,0:11:43.36,0:11:46.10,Default,,0000,0000,0000,,on separation of nanoscale biomarkers
Dialogue: 0,0:11:46.12,0:11:49.06,Default,,0000,0000,0000,,for rapid, early-stage cancer diagnostics,
Dialogue: 0,0:11:49.08,0:11:51.62,Default,,0000,0000,0000,,I am optimistic\Nthat within the next decade,
Dialogue: 0,0:11:51.64,0:11:54.22,Default,,0000,0000,0000,,this type of technology will be available,
Dialogue: 0,0:11:54.24,0:11:58.12,Default,,0000,0000,0000,,helping protect our friends,\Nour family and future generations.
Dialogue: 0,0:11:58.68,0:12:02.58,Default,,0000,0000,0000,,Even if we are so unlucky\Nas to be diagnosed with cancer,
Dialogue: 0,0:12:02.60,0:12:05.48,Default,,0000,0000,0000,,that early-stage alarm\Nwill provide a strong beacon of hope.
Dialogue: 0,0:12:06.28,0:12:07.50,Default,,0000,0000,0000,,Thank you.
Dialogue: 0,0:12:07.52,0:12:13.31,Default,,0000,0000,0000,,(Applause)