[Script Info] Title: [Events] Format: Layer, Start, End, Style, Name, MarginL, MarginR, MarginV, Effect, Text Dialogue: 0,0:00:01.23,0:00:03.06,Default,,0000,0000,0000,,One, because it's going to ruin our day,\Nalright? Dialogue: 0,0:00:03.06,0:00:09.78,Default,,0000,0000,0000,,So, uh, if you know anything special\Nabout this paper, don't tell anybody. Dialogue: 0,0:00:09.78,0:00:13.38,Default,,0000,0000,0000,,What I really want you guys to do\Nis to not use the internet. Dialogue: 0,0:00:13.38,0:00:17.98,Default,,0000,0000,0000,,We're going to take a close look at this\Npaper, see what you guys think about it. Dialogue: 0,0:00:17.98,0:00:20.54,Default,,0000,0000,0000,,We're going to read it, I'm going to give\Nyou about 20 minutes Dialogue: 0,0:00:20.54,0:00:23.25,Default,,0000,0000,0000,,to read this paper and discuss it.\NMaybe half an hour. Dialogue: 0,0:00:23.25,0:00:24.72,Default,,0000,0000,0000,,Talk to your friends if you want to. Dialogue: 0,0:00:24.72,0:00:28.12,Default,,0000,0000,0000,,The idea is going to be to get through it\Nas fast as you can, and let's talk about Dialogue: 0,0:00:28.12,0:00:30.98,Default,,0000,0000,0000,,if we like this paper or not, alright? Dialogue: 0,0:00:30.98,0:00:33.43,Default,,0000,0000,0000,,Cool. Dialogue: 0,0:00:33.43,0:00:38.41,Default,,0000,0000,0000,,(crosstalk) Dialogue: 0,0:00:38.41,0:00:41.48,Default,,0000,0000,0000,,>> Put them up here.\N>> Mia apparently doesn't staple papers Dialogue: 0,0:00:41.48,0:00:43.35,Default,,0000,0000,0000,,that she reads, so they're not stapled. Dialogue: 0,0:00:43.35,0:00:46.52,Default,,0000,0000,0000,,So it's just complete mayhem. Dialogue: 0,0:00:48.48,0:00:52.19,Default,,0000,0000,0000,,>> At least I got the job done.\N>> No, not really. Dialogue: 0,0:00:53.02,0:01:13.72,Default,,0000,0000,0000,,(crosstalk) Dialogue: 0,0:01:37.14,0:01:39.98,Default,,0000,0000,0000,,>> Did anybody not get one? Dialogue: 0,0:01:41.23,0:01:44.84,Default,,0000,0000,0000,,(crosstalk) Dialogue: 0,0:01:49.84,0:01:51.50,Default,,0000,0000,0000,,>> Alright. I'll be back. Dialogue: 0,0:01:53.59,0:02:07.87,Default,,0000,0000,0000,,(crosstalk) Dialogue: 0,0:29:33.78,0:29:37.82,Default,,0000,0000,0000,,>> Alright, so, maybe read for about\Nfive more minutes, and then maybe Dialogue: 0,0:29:37.82,0:29:40.80,Default,,0000,0000,0000,,discuss this for about five or\Nten minutes. Dialogue: 0,0:29:45.03,0:29:49.79,Default,,0000,0000,0000,,So read for five more minutes,\Nthen we'll discuss Dialogue: 0,0:29:49.84,0:29:53.42,Default,,0000,0000,0000,,for five or ten minutes, and then I'll\Nlead the discussion on the paper. Dialogue: 0,0:29:53.42,0:29:56.67,Default,,0000,0000,0000,,The discussion is really going to\Ncenter around what do you find convincing? Dialogue: 0,0:29:56.67,0:29:59.33,Default,,0000,0000,0000,,What do you like and dislike? Same kind of\Ndiscussions we've had, but sort of Dialogue: 0,0:29:59.33,0:30:03.78,Default,,0000,0000,0000,,a short version, just to kind of see if\Nmaybe people will notice things Dialogue: 0,0:30:03.78,0:30:05.73,Default,,0000,0000,0000,,that other people didn't notice. Dialogue: 0,0:30:05.73,0:30:09.22,Default,,0000,0000,0000,,Does anyone know about this paper?\NAnyone know what I'm talking about here? Dialogue: 0,0:30:09.22,0:30:12.24,Default,,0000,0000,0000,,Has anyone read this paper before? Dialogue: 0,0:30:12.24,0:30:14.21,Default,,0000,0000,0000,,Alright, good, we're all\Non the same page. Dialogue: 0,0:30:14.21,0:30:17.53,Default,,0000,0000,0000,,Alright, read for a few more minutes, and\Nthen when you're ready, start discussing Dialogue: 0,0:30:17.53,0:30:21.29,Default,,0000,0000,0000,,with whoever your neighbors - or\Nwhoever you want to talk to about it. Dialogue: 0,0:30:21.29,0:30:23.45,Default,,0000,0000,0000,,Talk about this paper for\Nten or fifteen minutes. Dialogue: 0,0:30:25.22,0:30:28.65,Default,,0000,0000,0000,,See what you think about it, see if you\Ncan come up with a consensus. Dialogue: 0,0:37:36.68,0:37:59.62,Default,,0000,0000,0000,,(crosstalk) Dialogue: 0,0:44:50.32,0:44:58.19,Default,,0000,0000,0000,,>> Alright, okay, so uh, what do you\Nguys think of this paper? Dialogue: 0,0:44:58.19,0:45:00.94,Default,,0000,0000,0000,,>> Cool.\N>> Yeah, super cool, huh? Dialogue: 0,0:45:00.94,0:45:04.20,Default,,0000,0000,0000,,Like really really good.\NYeah, I think you guys got it. Dialogue: 0,0:45:04.20,0:45:05.72,Default,,0000,0000,0000,,Yeah, and what do you think? Dialogue: 0,0:45:05.72,0:45:07.80,Default,,0000,0000,0000,,>> We have a theory\Nthat it's all made up. Dialogue: 0,0:45:07.80,0:45:10.01,Default,,0000,0000,0000,,>> Ahh.\N(class laughing) Dialogue: 0,0:45:10.01,0:45:13.00,Default,,0000,0000,0000,,Anyone else think it's all made up?\N>> I was convinced. Dialogue: 0,0:45:13.00,0:45:16.98,Default,,0000,0000,0000,,>> Based purely on the fact that you\Ntold us that there was a retraction. Dialogue: 0,0:45:16.98,0:45:21.40,Default,,0000,0000,0000,,>> You can't find it, can you?\N>> You also gave us the author manuscript, Dialogue: 0,0:45:21.40,0:45:23.36,Default,,0000,0000,0000,,so, yeah.\N>> Yeah, yeah, no, no. Dialogue: 0,0:45:23.36,0:45:26.10,Default,,0000,0000,0000,,So, go do some Googling right now,\Neverybody pull up your laptop or your Dialogue: 0,0:45:26.10,0:45:29.56,Default,,0000,0000,0000,,phone and see what you think here,\Nbecause this is a really interesting Dialogue: 0,0:45:29.56,0:45:32.69,Default,,0000,0000,0000,,lesson in how to do this, right? Dialogue: 0,0:45:32.69,0:45:38.26,Default,,0000,0000,0000,,Yeah, yeah, yeah, no. But go see\Nwhat you can find about this paper. Dialogue: 0,0:45:38.26,0:45:41.08,Default,,0000,0000,0000,,It's a useful exercise. Dialogue: 0,0:45:41.08,0:45:46.08,Default,,0000,0000,0000,,A couple of minutes of your own\Nresearch by phone or laptop, Dialogue: 0,0:45:46.08,0:45:48.09,Default,,0000,0000,0000,,and then we'll have\Na little more conversation. Dialogue: 0,0:45:50.44,0:46:06.35,Default,,0000,0000,0000,,(crosstalk) Dialogue: 0,0:48:27.22,0:48:30.47,Default,,0000,0000,0000,,>> All right. That's pretty amazing,\Nhuh? Dialogue: 0,0:48:31.86,0:48:36.54,Default,,0000,0000,0000,,Okay, so not just the paper in "Cell,"\Nbut also the paper in PNAS, right? Dialogue: 0,0:48:36.54,0:48:41.01,Default,,0000,0000,0000,,So two different papers had to be\Ncompletely retracted. Dialogue: 0,0:48:41.01,0:48:46.00,Default,,0000,0000,0000,,The retraction notice here in "Cell"\Nis good reading. Dialogue: 0,0:48:46.00,0:48:53.89,Default,,0000,0000,0000,,Let's see - where's the retraction\Nnotice? Here's the retraction notice. Dialogue: 0,0:48:53.89,0:49:01.66,Default,,0000,0000,0000,,So, here we are. Dialogue: 0,0:49:01.66,0:49:04.03,Default,,0000,0000,0000,,Study reported the former family\Nblah, blah, blah. Dialogue: 0,0:49:04.03,0:49:06.88,Default,,0000,0000,0000,,Shortly after publication, a lab\Nwith whom we had shared reagents Dialogue: 0,0:49:06.88,0:49:09.57,Default,,0000,0000,0000,,noticed that cell lines that were\Nsupposed to be stably expressing Dialogue: 0,0:49:09.57,0:49:13.10,Default,,0000,0000,0000,,GFE-4 were not, we subsequently\Nfound a western blot of the paper Dialogue: 0,0:49:13.10,0:49:14.13,Default,,0000,0000,0000,,had been inappropriately manipulated. Dialogue: 0,0:49:14.13,0:49:16.54,Default,,0000,0000,0000,,And that multiple cell lines were not\Nas reported. Dialogue: 0,0:49:17.64,0:49:20.16,Default,,0000,0000,0000,,When we constructed and validated\Nnew cell lines and reagents, Dialogue: 0,0:49:20.16,0:49:23.96,Default,,0000,0000,0000,,our attempts to produce critical data\Nin the paper were unsuccessful. Dialogue: 0,0:49:23.96,0:49:30.92,Default,,0000,0000,0000,,This led to basically office -ORI,\Nis the Office of Research Integrity, Dialogue: 0,0:49:30.92,0:49:35.17,Default,,0000,0000,0000,,at the NIH, did a study, and\Nactually found that there were Dialogue: 0,0:49:35.17,0:49:38.60,Default,,0000,0000,0000,,fabrications in figures\Ntwo, three, five, six, seven, Dialogue: 0,0:49:38.60,0:49:41.86,Default,,0000,0000,0000,,and the majority of the supplement.\NAlright? Dialogue: 0,0:49:41.86,0:49:50.75,Default,,0000,0000,0000,,Now, what's even more stunning -\Nwhat? Yeah, I'm getting there. Dialogue: 0,0:49:50.75,0:49:54.28,Default,,0000,0000,0000,,(crosstalk)\N>> From the NIH? This is ridiculous. Dialogue: 0,0:49:54.28,0:49:56.34,Default,,0000,0000,0000,,>> Yeah, well, so, okay, right. Dialogue: 0,0:49:56.34,0:49:59.44,Default,,0000,0000,0000,,So an interesting thing to do\Nin these cases when you see retractions Dialogue: 0,0:49:59.44,0:50:04.10,Default,,0000,0000,0000,,is to read the ORI report, uh,\Nand the ORI report goes on for Dialogue: 0,0:50:04.10,0:50:09.22,Default,,0000,0000,0000,,pages and pages and pages of\Nall the things that were altered, Dialogue: 0,0:50:09.22,0:50:12.93,Default,,0000,0000,0000,,but the real meat of it is here. Dialogue: 0,0:50:14.03,0:50:17.01,Default,,0000,0000,0000,,This is for the "Cell" paper. Dialogue: 0,0:50:17.01,0:50:21.64,Default,,0000,0000,0000,,Results which did not originate from\Nexperimental observations, Dialogue: 0,0:50:21.64,0:50:25.07,Default,,0000,0000,0000,,which did not originate from experimental\Nobservation using selected regions Dialogue: 0,0:50:25.07,0:50:29.86,Default,,0000,0000,0000,,of the same original to represent the\Ncontrol and the rescue. Dialogue: 0,0:50:29.86,0:50:34.70,Default,,0000,0000,0000,,Lying about whether they were 2.5\Nor 3.5 microliter channels, Dialogue: 0,0:50:34.70,0:50:36.92,Default,,0000,0000,0000,,not originating from experimental. Dialogue: 0,0:50:36.92,0:50:40.27,Default,,0000,0000,0000,,And then, what's particularly crazy\Nabout this, is that there's a lot of Dialogue: 0,0:50:40.27,0:50:44.24,Default,,0000,0000,0000,,falsification data here, but almost\Nevery single figure in here has the Dialogue: 0,0:50:44.24,0:50:46.58,Default,,0000,0000,0000,,end numbers exaggerated. Dialogue: 0,0:50:46.58,0:50:49.69,Default,,0000,0000,0000,,The error bar is mislabeled, etc.,\Netc., right? Dialogue: 0,0:50:51.04,0:50:53.77,Default,,0000,0000,0000,,And so this is a relevant thing to\Nthink about. Dialogue: 0,0:50:53.77,0:50:58.34,Default,,0000,0000,0000,,So this was a very talented scientist.\NI saw her talk at Dialogue: 0,0:50:58.34,0:51:01.84,Default,,0000,0000,0000,,a Gordon research conference and\Nimmediately asked her to apply to UT. Dialogue: 0,0:51:01.84,0:51:08.42,Default,,0000,0000,0000,,I said "You should apply for a faculty job\Nat UT," completely sold on the story. Dialogue: 0,0:51:09.39,0:51:12.31,Default,,0000,0000,0000,,So was UT Southwestern, who actually\Noffered her a job Dialogue: 0,0:51:12.31,0:51:13.83,Default,,0000,0000,0000,,as an assistant professor. Dialogue: 0,0:51:14.17,0:51:18.10,Default,,0000,0000,0000,,So was the Cancer Prevention and\NResearch Institute of Texas, Dialogue: 0,0:51:18.10,0:51:21.09,Default,,0000,0000,0000,,which offered her a two million dollar\Nrecruitment grant. Dialogue: 0,0:51:22.36,0:51:26.17,Default,,0000,0000,0000,,All of which was of course rescinded\Nwhen this was discovered. Dialogue: 0,0:51:26.94,0:51:32.78,Default,,0000,0000,0000,,Turns out she had fabricated all the data\Nin a second paper in PNAS as well. Dialogue: 0,0:51:34.41,0:51:39.00,Default,,0000,0000,0000,,And so I think it's worth considering\Nthese things and sort of paying attention Dialogue: 0,0:51:39.00,0:51:40.96,Default,,0000,0000,0000,,to what happens here, right? Dialogue: 0,0:51:40.96,0:51:44.84,Default,,0000,0000,0000,,So Claire Waterman, the senior author\Non these papers is a very famous Dialogue: 0,0:51:44.84,0:51:48.12,Default,,0000,0000,0000,,cell biologist, who's been in the\Nbusiness for 25 years, Dialogue: 0,0:51:48.12,0:51:49.48,Default,,0000,0000,0000,,at least as long as I have. Dialogue: 0,0:51:50.73,0:51:54.70,Default,,0000,0000,0000,,And is very well regarded, very\Nrespected by all of her colleagues, Dialogue: 0,0:51:55.85,0:51:58.97,Default,,0000,0000,0000,,Obviously this puts her in\Nquite a bind, right? Dialogue: 0,0:52:00.64,0:52:02.01,Default,,0000,0000,0000,,And it's worth thinking about. Dialogue: 0,0:52:02.01,0:52:04.49,Default,,0000,0000,0000,,We've had faculty in this department\Nwhere this has happened, right? Dialogue: 0,0:52:04.49,0:52:08.60,Default,,0000,0000,0000,,This appears to be a case where\Na very intelligent young scientist Dialogue: 0,0:52:08.60,0:52:12.78,Default,,0000,0000,0000,,somehow felt something about the\Npressure of the job, needed to Dialogue: 0,0:52:12.78,0:52:15.94,Default,,0000,0000,0000,,make up all the data in two entire papers. Dialogue: 0,0:52:19.39,0:52:21.36,Default,,0000,0000,0000,,Then so one of the questions you ask is, Dialogue: 0,0:52:21.36,0:52:24.22,Default,,0000,0000,0000,,that you get asked a lot from\Nnon-scientists is Dialogue: 0,0:52:24.22,0:52:27.40,Default,,0000,0000,0000,,"Well, why doesn't peer review find it?" Dialogue: 0,0:52:27.87,0:52:30.13,Default,,0000,0000,0000,,Right? How does this get through\Npeer review? Dialogue: 0,0:52:30.39,0:52:32.58,Default,,0000,0000,0000,,Did anyone see anything wrong\Nwith this paper? If I had just given Dialogue: 0,0:52:32.58,0:52:35.60,Default,,0000,0000,0000,,you this paper, you'd have read\Nit and you'd have loved it, right? Dialogue: 0,0:52:36.05,0:52:40.06,Default,,0000,0000,0000,,Because if you're a smart person,\Nand you're a dedicated fraud, Dialogue: 0,0:52:40.59,0:52:42.57,Default,,0000,0000,0000,,it's very hard to get caught, right? Dialogue: 0,0:52:42.57,0:52:45.81,Default,,0000,0000,0000,,If you just make up numbers and put\Nthem on a graph, and it looks good, Dialogue: 0,0:52:46.44,0:52:49.17,Default,,0000,0000,0000,,very hard to see that in peer review.\NRight? Dialogue: 0,0:52:49.73,0:52:53.05,Default,,0000,0000,0000,,If you pick the part of the image that\Nshows what you want to show... Dialogue: 0,0:52:54.66,0:52:57.09,Default,,0000,0000,0000,,it's very easy to get away\Nwith this actually. Dialogue: 0,0:52:59.68,0:53:02.56,Default,,0000,0000,0000,,>> The only thing I was suspicious about\Nin the whole paper was that Dialogue: 0,0:53:02.56,0:53:07.41,Default,,0000,0000,0000,,it all came together so perfectly,\Nand that's just like not how it should Dialogue: 0,0:53:07.41,0:53:08.55,Default,,0000,0000,0000,,ever happen with cancer cells. Dialogue: 0,0:53:08.55,0:53:10.49,Default,,0000,0000,0000,,>> Yeah, but it does sometimes, right? Dialogue: 0,0:53:10.49,0:53:13.93,Default,,0000,0000,0000,,Yeah, right, it does, and when you sit\Nthere and you watch the data, Dialogue: 0,0:53:13.93,0:53:16.41,Default,,0000,0000,0000,,and it's from a good lab-- right? Dialogue: 0,0:53:17.08,0:53:20.60,Default,,0000,0000,0000,,It's very hard to say,\N"Ah, it's too perfect." Dialogue: 0,0:53:20.60,0:53:23.80,Default,,0000,0000,0000,,You know, you wouldn't have said\N"Oh, clearly you've made all of this up." Dialogue: 0,0:53:23.80,0:53:26.18,Default,,0000,0000,0000,,Right? Yeah, yeah, yeah. Right? Dialogue: 0,0:53:26.18,0:53:29.52,Default,,0000,0000,0000,,>> I don't - I was only suspicious\Nbecause I had thought already Dialogue: 0,0:53:29.52,0:53:31.03,Default,,0000,0000,0000,,that that's what happened with\Nthis paper. Dialogue: 0,0:53:31.03,0:53:32.65,Default,,0000,0000,0000,,>> Yeah, yeah, yeah. No. Dialogue: 0,0:53:33.51,0:53:36.44,Default,,0000,0000,0000,,It's hard to do the exercise\Nany other way. Dialogue: 0,0:53:36.86,0:53:38.47,Default,,0000,0000,0000,,August had a question and\Nthen Jifa. Dialogue: 0,0:53:38.47,0:53:42.50,Default,,0000,0000,0000,,>> No, just because we were quite - Dialogue: 0,0:53:42.50,0:53:47.76,Default,,0000,0000,0000,,you know, they made a little bit\Nfar-fetched of a claim, but Dialogue: 0,0:53:47.76,0:53:52.54,Default,,0000,0000,0000,,at the same time we can see that,\Nyeah, the phenotype's right. Dialogue: 0,0:53:52.54,0:53:55.22,Default,,0000,0000,0000,,So I think...\N>> Yeah, Jifa? Dialogue: 0,0:53:55.85,0:54:01.14,Default,,0000,0000,0000,,>> So, were the other scientists\Nhere in on it, or was this like - Dialogue: 0,0:54:01.14,0:54:02.09,Default,,0000,0000,0000,,did she orchestrate it? Dialogue: 0,0:54:02.09,0:54:05.85,Default,,0000,0000,0000,,>> No, the Office of Research Integrity\Nputs it all on the one person. Dialogue: 0,0:54:06.56,0:54:09.28,Default,,0000,0000,0000,,Basically just a dedicated fraud\Nall the way through. Dialogue: 0,0:54:10.94,0:54:14.53,Default,,0000,0000,0000,,And again, it wouldn't be that\Nhard to do, right? Dialogue: 0,0:54:14.53,0:54:18.39,Default,,0000,0000,0000,,So probably the other authors\Ninvolved are the authors who Dialogue: 0,0:54:18.39,0:54:21.79,Default,,0000,0000,0000,,generated other reagents,\Nalso possible that many of them Dialogue: 0,0:54:21.79,0:54:26.73,Default,,0000,0000,0000,,just generated reagents and gave\Nthem to this person, to do work on, Dialogue: 0,0:54:26.73,0:54:29.66,Default,,0000,0000,0000,,and then she did experiments on\Nthem and made up the results. Dialogue: 0,0:54:29.66,0:54:32.86,Default,,0000,0000,0000,,But actually in the entire\Ninvestigation, only one person Dialogue: 0,0:54:32.86,0:54:34.85,Default,,0000,0000,0000,,was found to be the root of all of this. Dialogue: 0,0:54:36.67,0:54:37.52,Default,,0000,0000,0000,,And so... Dialogue: 0,0:54:37.52,0:54:39.16,Default,,0000,0000,0000,,>> (inaudible). Dialogue: 0,0:54:39.16,0:54:39.91,Default,,0000,0000,0000,,>> Huh? Dialogue: 0,0:54:39.91,0:54:41.55,Default,,0000,0000,0000,,>> I said, it sucks for the other\Nauthors of the paper. Dialogue: 0,0:54:41.55,0:54:43.24,Default,,0000,0000,0000,,>> Oh, it sucks for everybody,\Nabsolutely. Dialogue: 0,0:54:43.95,0:54:51.82,Default,,0000,0000,0000,,>> I'm sorry, I just want to know,\Nhow about the (inaudible) Dialogue: 0,0:54:52.25,0:54:54.46,Default,,0000,0000,0000,,>> I think we don't know. I think\Nsomeone will have to go back Dialogue: 0,0:54:54.46,0:54:56.11,Default,,0000,0000,0000,,and redo all those experiments, right? Dialogue: 0,0:54:56.11,0:55:03.82,Default,,0000,0000,0000,,So these are the findings of what\Npeople said, but even those findings Dialogue: 0,0:55:03.82,0:55:10.18,Default,,0000,0000,0000,,in the first few figures, clearly the\Nnumbers are inflated, right? Dialogue: 0,0:55:12.06,0:55:15.04,Default,,0000,0000,0000,,And so I think someone will have\Nto go back and start over. Dialogue: 0,0:55:15.40,0:55:20.52,Default,,0000,0000,0000,,>> I didn't read the summary at\Nthe beginning because (inaudible), Dialogue: 0,0:55:20.52,0:55:25.96,Default,,0000,0000,0000,,so I just read the introduction, but I\Nfeel like the titles are very attractive, Dialogue: 0,0:55:25.96,0:55:33.11,Default,,0000,0000,0000,,and then I read-- briefly go the the\Nintroduction and read each figure. Dialogue: 0,0:55:34.01,0:55:40.08,Default,,0000,0000,0000,,I think they're basically true then you\Ngave us a little time so I went back Dialogue: 0,0:55:40.08,0:55:42.63,Default,,0000,0000,0000,,to read the summary.\N>> Yup. Dialogue: 0,0:55:42.64,0:55:48.08,Default,,0000,0000,0000,,>> And I felt like some of the summaries\Nthey were giving for the whole picture Dialogue: 0,0:55:48.08,0:55:53.71,Default,,0000,0000,0000,,of this paper, I felt like how could\Nit be so perfect, you know in Dialogue: 0,0:55:54.83,0:55:58.07,Default,,0000,0000,0000,,animal models, and the (inaudible) Dialogue: 0,0:55:58.07,0:56:00.24,Default,,0000,0000,0000,,>> Yeah, but every once in a while\Nyou get lucky, right? Dialogue: 0,0:56:00.24,0:56:02.25,Default,,0000,0000,0000,,And so that's the thing with fraud, right? Dialogue: 0,0:56:02.25,0:56:07.42,Default,,0000,0000,0000,,If it's really consistent and you\Nstick to your guns, it's really hard Dialogue: 0,0:56:07.42,0:56:09.88,Default,,0000,0000,0000,,to catch. Now, the funny thing is Dialogue: 0,0:56:11.36,0:56:15.26,Default,,0000,0000,0000,,that surely she must have thought\Nsomeone would try to repeat - Dialogue: 0,0:56:15.26,0:56:18.36,Default,,0000,0000,0000,,I mean it's a cell paper. She was\Non the job market, she gave Dialogue: 0,0:56:18.36,0:56:21.64,Default,,0000,0000,0000,,talks all over the country.\NShe must have known that Dialogue: 0,0:56:21.64,0:56:24.41,Default,,0000,0000,0000,,somebody was going to do\Nthese experiments. Dialogue: 0,0:56:25.35,0:56:27.32,Default,,0000,0000,0000,,And so I just don't know.\NAugust? Dialogue: 0,0:56:27.32,0:56:31.41,Default,,0000,0000,0000,,>> I'm pretty sure that Skau's\Nreputation is completely shattered, Dialogue: 0,0:56:31.41,0:56:34.42,Default,,0000,0000,0000,,but how is the reputation of\NClare Waterman? Dialogue: 0,0:56:34.42,0:56:38.18,Default,,0000,0000,0000,,>> I mean that's always a danger, right?\NAnd time will tell, right? Dialogue: 0,0:56:38.18,0:56:41.19,Default,,0000,0000,0000,,It's the only time she's ever\Nbeen associated with it. Dialogue: 0,0:56:41.19,0:56:45.81,Default,,0000,0000,0000,,The independent investigation\Nfound that it was all this one person. Dialogue: 0,0:56:46.71,0:56:48.66,Default,,0000,0000,0000,,So, time will tell. Dialogue: 0,0:56:49.96,0:56:51.94,Default,,0000,0000,0000,,But right now I would say\Nit's still very good. Dialogue: 0,0:56:51.94,0:56:53.42,Default,,0000,0000,0000,,>> Oh, okay.\N>>Right? Yeah. Dialogue: 0,0:56:54.88,0:56:59.70,Default,,0000,0000,0000,,>> This makes me wonder like, what\Nis so terribly wrong with the system Dialogue: 0,0:56:59.70,0:57:01.66,Default,,0000,0000,0000,,that somebody (inaudible) Dialogue: 0,0:57:01.66,0:57:06.62,Default,,0000,0000,0000,,>> Sure. Right? I mean I think\Nthat's one of the big questions, Dialogue: 0,0:57:06.62,0:57:09.27,Default,,0000,0000,0000,,and what's kind of related to\Nthat that I think is a really Dialogue: 0,0:57:09.27,0:57:11.32,Default,,0000,0000,0000,,subtle point - I'll get to\Nyour questions in a minute, Dialogue: 0,0:57:11.32,0:57:13.72,Default,,0000,0000,0000,,but I do want to make this point,\Nbecause it comes straight to this. Dialogue: 0,0:57:13.72,0:57:14.56,Default,,0000,0000,0000,,Right? Dialogue: 0,0:57:16.28,0:57:22.76,Default,,0000,0000,0000,,It's very easy to start believing\Nyour own bullshit. Right? Dialogue: 0,0:57:23.86,0:57:31.05,Default,,0000,0000,0000,,And there's a big difference between\Nreally making up entire papers Dialogue: 0,0:57:31.05,0:57:36.81,Default,,0000,0000,0000,,and not being honest with yourself,\Nbut they all are part of the Dialogue: 0,0:57:36.82,0:57:40.16,Default,,0000,0000,0000,,same spectrum, and something you\Nhave to guard against is Dialogue: 0,0:57:40.84,0:57:42.72,Default,,0000,0000,0000,,"Am I really doing this the right way?" Dialogue: 0,0:57:42.72,0:57:44.79,Default,,0000,0000,0000,,"Am I really seeing what\NI think I'm seeing?" Dialogue: 0,0:57:44.79,0:57:46.44,Default,,0000,0000,0000,,"Am I really being completely honest?" Dialogue: 0,0:57:46.44,0:57:51.52,Default,,0000,0000,0000,,Because especially once you get halfway\Ninto a paper, halfway into your PhD, Dialogue: 0,0:57:53.17,0:57:56.92,Default,,0000,0000,0000,,it gets, you know, there's\Na lot of pressure. Dialogue: 0,0:57:58.06,0:58:01.44,Default,,0000,0000,0000,,And it's something you have to\Nfight against, right? Dialogue: 0,0:58:01.44,0:58:04.12,Default,,0000,0000,0000,,Especially when a project's\Ngoing south, right? Dialogue: 0,0:58:04.48,0:58:07.17,Default,,0000,0000,0000,,You've invested a lot in it,\Nand everything's starting to Dialogue: 0,0:58:07.17,0:58:10.82,Default,,0000,0000,0000,,fall apart, and so you've\Ngot to be vigilant. Dialogue: 0,0:58:10.82,0:58:14.24,Default,,0000,0000,0000,,And again, I'm not saying that\Nyou're likely to decide to just Dialogue: 0,0:58:14.24,0:58:17.00,Default,,0000,0000,0000,,make up all the data in the\Nlast three figures of your paper. Dialogue: 0,0:58:18.07,0:58:21.24,Default,,0000,0000,0000,,But the system is stressful. Dialogue: 0,0:58:21.58,0:58:23.32,Default,,0000,0000,0000,,It's a very competitive system. Dialogue: 0,0:58:24.54,0:58:26.36,Default,,0000,0000,0000,,It's a very competitive world. Dialogue: 0,0:58:26.86,0:58:29.76,Default,,0000,0000,0000,,Is fraud any worse now than it used to be, Dialogue: 0,0:58:29.76,0:58:32.19,Default,,0000,0000,0000,,or can we just detect it better, right? Dialogue: 0,0:58:32.51,0:58:35.69,Default,,0000,0000,0000,,I don't actually know. My guess is that\Nwe can detect it a lot better, right? Dialogue: 0,0:58:35.69,0:58:37.48,Default,,0000,0000,0000,,There's a lot better tools for it. Dialogue: 0,0:58:37.48,0:58:40.13,Default,,0000,0000,0000,,But there's also a lot more money\Nin science than there ever was before Dialogue: 0,0:58:40.13,0:58:44.30,Default,,0000,0000,0000,,at all levels, even in academia,\Nwhich puts a big incentive in Dialogue: 0,0:58:45.42,0:58:48.56,Default,,0000,0000,0000,,for people to be unethical. Dialogue: 0,0:58:49.52,0:58:52.80,Default,,0000,0000,0000,,But I mean these are serious concerns,\NI think there's things that as Dialogue: 0,0:58:52.80,0:58:56.81,Default,,0000,0000,0000,,graduate students, you guys should\Nbe thinking about and considering. Dialogue: 0,0:58:56.81,0:58:59.73,Default,,0000,0000,0000,,There were some hands up.\NI can't remember who they all were. Dialogue: 0,0:59:00.39,0:59:01.28,Default,,0000,0000,0000,,Will? Dialogue: 0,0:59:01.100,0:59:04.91,Default,,0000,0000,0000,,>> I was just going to say that it's\Ncrazy that it seems like the Dialogue: 0,0:59:04.91,0:59:07.26,Default,,0000,0000,0000,,way that she started to get caught\Nwas that she sent Dialogue: 0,0:59:07.26,0:59:11.27,Default,,0000,0000,0000,,stably-transfected cell line, and it\Nwasn't actually stably-transfected. Dialogue: 0,0:59:11.27,0:59:13.20,Default,,0000,0000,0000,,>> Yup.\N>> It seems so basic. Dialogue: 0,0:59:14.51,0:59:17.50,Default,,0000,0000,0000,,>> Yeah, I mean but once you're there,\Nright, they ask for the line, Dialogue: 0,0:59:17.50,0:59:18.35,Default,,0000,0000,0000,,what are you going to do? Dialogue: 0,0:59:18.88,0:59:22.76,Default,,0000,0000,0000,,>> That's also easy to hand away,\Nto be like "Oh, it might have..." Dialogue: 0,0:59:22.76,0:59:27.00,Default,,0000,0000,0000,,You know, you build these lines\Nand they fall apart, so I mean... Dialogue: 0,0:59:27.46,0:59:31.74,Default,,0000,0000,0000,,and if you're this confident in\Nfalsifying data that ends up Dialogue: 0,0:59:31.74,0:59:35.100,Default,,0000,0000,0000,,in the "Cell" paper, you're probably\Nwilling to think that you can Dialogue: 0,0:59:35.100,0:59:38.60,Default,,0000,0000,0000,,argue your way out of\Nsomething like that, right? Dialogue: 0,0:59:39.67,0:59:43.95,Default,,0000,0000,0000,,Do you see what I'm saying,\Nlike the mental-- yeah, yeah. Dialogue: 0,0:59:44.32,0:59:48.90,Default,,0000,0000,0000,,>> Well but also at this level, you know\Nit's slid over into pathology, right? Dialogue: 0,0:59:48.90,0:59:54.14,Default,,0000,0000,0000,,I mean literally every single thing\Nin this paper has something Dialogue: 0,0:59:54.14,0:59:55.20,Default,,0000,0000,0000,,fraudulent about it. Dialogue: 0,0:59:56.11,0:59:58.88,Default,,0000,0000,0000,,Right, which is really evidence to me\Nthat someone has gone Dialogue: 0,0:59:58.88,1:00:03.70,Default,,0000,0000,0000,,way past "Oh crap, I've got to just\Nsave this one paper" into Dialogue: 0,1:00:03.70,1:00:04.72,Default,,0000,0000,0000,,"I'm invincible". Dialogue: 0,1:00:06.36,1:00:07.32,Default,,0000,0000,0000,,Right?\N>> Yeah. Dialogue: 0,1:00:07.32,1:00:09.79,Default,,0000,0000,0000,,>> Yeah yeah yeah, I mean\NI don't know, but yeah. Dialogue: 0,1:00:10.10,1:00:13.30,Default,,0000,0000,0000,,>> Yeah, so apart from the reputation\Nand embarrassment, what is the Dialogue: 0,1:00:13.30,1:00:15.79,Default,,0000,0000,0000,,punishment for such (inaudible)? Dialogue: 0,1:00:15.79,1:00:21.09,Default,,0000,0000,0000,,>> Right, so the punishment for her\Nis-- I mean, the punishment Dialogue: 0,1:00:21.09,1:00:23.98,Default,,0000,0000,0000,,is her entire scientific career\Nis completely ruined. Dialogue: 0,1:00:23.98,1:00:25.77,Default,,0000,0000,0000,,She'll never work in the\Nfield again, right? Dialogue: 0,1:00:25.77,1:00:28.02,Default,,0000,0000,0000,,>> What about the taxpayer's money?\N>> Right, right, right. Dialogue: 0,1:00:28.02,1:00:31.04,Default,,0000,0000,0000,,Taxpayer's money, there's nothing--\NI mean, nothing done. Dialogue: 0,1:00:31.77,1:00:35.13,Default,,0000,0000,0000,,They have these voluntary settlements\Nhere that you can read about it. Dialogue: 0,1:00:36.24,1:00:42.12,Default,,0000,0000,0000,,And these things are really built\Naround the assumption of Dialogue: 0,1:00:42.12,1:00:43.94,Default,,0000,0000,0000,,small amounts of fraud, you know? Dialogue: 0,1:00:44.18,1:00:49.67,Default,,0000,0000,0000,,You made a mistake, you're a savable\Nperson as a scientist, then they Dialogue: 0,1:00:49.67,1:00:52.10,Default,,0000,0000,0000,,put a supervisory plan in place\Nwhere someone's really Dialogue: 0,1:00:52.10,1:00:55.05,Default,,0000,0000,0000,,looking a lot more carefully at your work,\Nand then for three years, Dialogue: 0,1:00:55.05,1:00:57.79,Default,,0000,0000,0000,,you're not allowed to work for the NIH\Nand these kinds of things. Dialogue: 0,1:00:58.44,1:01:01.29,Default,,0000,0000,0000,,But at this level, her reputation\Nis just destroyed, so there's-- Dialogue: 0,1:01:01.29,1:01:03.50,Default,,0000,0000,0000,,we won't see her anywhere\Nin academic science again. Dialogue: 0,1:01:03.50,1:01:07.82,Default,,0000,0000,0000,,In terms of monetary, these kinds of\Nthings, I don't know of any, Dialogue: 0,1:01:07.82,1:01:10.49,Default,,0000,0000,0000,,and there's much more-- there was\Na big "New York Times" piece Dialogue: 0,1:01:10.49,1:01:14.59,Default,,0000,0000,0000,,about a cancer biologist at\NPenn State who's apparently Dialogue: 0,1:01:14.59,1:01:19.25,Default,,0000,0000,0000,,been under investigation for fraud\Nlike every other year for ten years, Dialogue: 0,1:01:19.25,1:01:22.54,Default,,0000,0000,0000,,and he still has millions of dollars\Nof research money and it just sort of Dialogue: 0,1:01:22.54,1:01:24.51,Default,,0000,0000,0000,,never comes home to roost, so. Dialogue: 0,1:01:25.07,1:01:27.77,Default,,0000,0000,0000,,You guys should educate yourself\Nabout the fraud situation, Dialogue: 0,1:01:28.77,1:01:29.84,Default,,0000,0000,0000,,and what's there. Dialogue: 0,1:01:30.11,1:01:31.81,Default,,0000,0000,0000,,Did someone else have a hand up? Dialogue: 0,1:01:32.28,1:01:33.59,Default,,0000,0000,0000,,>> Can I same something quick?\N>> Yeah. Dialogue: 0,1:01:33.59,1:01:37.91,Default,,0000,0000,0000,,>> I saw in the news, UT Southwestern\Nremoved a million dollar grant from her. Dialogue: 0,1:01:37.91,1:01:40.30,Default,,0000,0000,0000,,>> Yeah yeah, that's the grant.\NYeah-- oh yeah, she-- Dialogue: 0,1:01:41.13,1:01:44.33,Default,,0000,0000,0000,,the job was rescinded, the grant\Nwas rescinded, so she's not Dialogue: 0,1:01:44.33,1:01:46.40,Default,,0000,0000,0000,,getting the grant, she didn't\Nget the job, she will absolutely Dialogue: 0,1:01:46.40,1:01:47.76,Default,,0000,0000,0000,,have to leave science. Dialogue: 0,1:01:48.32,1:01:50.91,Default,,0000,0000,0000,,As I understand it, she's like a\Nprogram officer at a foundation now Dialogue: 0,1:01:50.91,1:01:52.23,Default,,0000,0000,0000,,or something. Yeah. Dialogue: 0,1:01:52.23,1:01:55.72,Default,,0000,0000,0000,,>> But not just the monetary loss,\Nwhat about killing so many mice Dialogue: 0,1:01:55.72,1:01:59.57,Default,,0000,0000,0000,,and falsifying data? (inaudible).\N(laughter) Dialogue: 0,1:02:00.66,1:02:04.40,Default,,0000,0000,0000,,>> If you go down the road that\Nkilling life is a problem, Dialogue: 0,1:02:04.40,1:02:05.99,Default,,0000,0000,0000,,then you're going to have\Na real problem. Dialogue: 0,1:02:06.24,1:02:08.23,Default,,0000,0000,0000,,>> If you're doing science, doing\Nsomething productive, Dialogue: 0,1:02:08.23,1:02:10.55,Default,,0000,0000,0000,,it makes sense but if\Nyou're falsifying data. Dialogue: 0,1:02:10.55,1:02:11.51,Default,,0000,0000,0000,,>> Yeah. Dialogue: 0,1:02:13.24,1:02:15.25,Default,,0000,0000,0000,,>> I was--\N>> Hang on, you had a hand up. Dialogue: 0,1:02:15.77,1:02:18.98,Default,,0000,0000,0000,,>> How often-- obviously this one\Nseems like it was very intentional, Dialogue: 0,1:02:18.98,1:02:21.33,Default,,0000,0000,0000,,and so that's really-- but how\Noften do people get Dialogue: 0,1:02:21.33,1:02:23.49,Default,,0000,0000,0000,,caught up in this just because\Nthey weren't careful enough Dialogue: 0,1:02:23.49,1:02:27.30,Default,,0000,0000,0000,,and they didn't force themselves\Nto be very thorough? Dialogue: 0,1:02:27.45,1:02:31.55,Default,,0000,0000,0000,,>> I mean mistakes get made in papers\Nall the time, right, and some papers Dialogue: 0,1:02:31.55,1:02:36.02,Default,,0000,0000,0000,,get retracted because we went back\Nand resequenced the mouse allele, Dialogue: 0,1:02:36.02,1:02:39.02,Default,,0000,0000,0000,,and it wasn't what we thought\Nit was, right? Dialogue: 0,1:02:39.42,1:02:42.18,Default,,0000,0000,0000,,But generally what happens is there's\Na correction. Generally when that happens, Dialogue: 0,1:02:42.18,1:02:45.10,Default,,0000,0000,0000,,it's not like the entire paper's ruined,\N"Oh, surprise, we mutated Dialogue: 0,1:02:45.10,1:02:46.86,Default,,0000,0000,0000,,totally the wrong gene". Dialogue: 0,1:02:46.86,1:02:50.57,Default,,0000,0000,0000,,Usually it's like "Oh we thought it was\Nexon 3, but in a frameshift, Dialogue: 0,1:02:50.57,1:02:53.36,Default,,0000,0000,0000,,but in fact it was something else."\NRight? Dialogue: 0,1:02:53.37,1:02:54.09,Default,,0000,0000,0000,,>> Right. Dialogue: 0,1:02:54.09,1:02:59.27,Default,,0000,0000,0000,,>> And so you get a lot of corrections\Nin papers, and some retractions, Dialogue: 0,1:02:59.27,1:03:02.96,Default,,0000,0000,0000,,but generally, you know, you've\Ngot to-- the whole paper Dialogue: 0,1:03:02.96,1:03:05.95,Default,,0000,0000,0000,,really has to be systematically\Nwrong to retract the entire paper. Dialogue: 0,1:03:05.95,1:03:09.14,Default,,0000,0000,0000,,>> So it's the dishonesty that\Ngets prosecuted. Dialogue: 0,1:03:09.14,1:03:13.29,Default,,0000,0000,0000,,>> Yeah, or I mean, it-- yeah, so the\Ndishonestly immediately you want to Dialogue: 0,1:03:13.29,1:03:16.02,Default,,0000,0000,0000,,retract the paper, because that's\Nalso what the PI is going to Dialogue: 0,1:03:16.02,1:03:17.14,Default,,0000,0000,0000,,want to do.\N>> Right. Dialogue: 0,1:03:17.14,1:03:21.29,Default,,0000,0000,0000,,>> Right? But if you just get it wrong,\Nyou know, you get it wrong, Dialogue: 0,1:03:21.29,1:03:22.17,Default,,0000,0000,0000,,we're human, right? Dialogue: 0,1:03:22.17,1:03:25.96,Default,,0000,0000,0000,,If there was no-- and there have been\Ninvestigations where they find Dialogue: 0,1:03:25.96,1:03:29.25,Default,,0000,0000,0000,,"Oh, no, they weren't unethical,\Nthey were just dumb." Dialogue: 0,1:03:29.25,1:03:29.87,Default,,0000,0000,0000,,(laughter) Dialogue: 0,1:03:29.87,1:03:31.78,Default,,0000,0000,0000,,No, seriously, right? And that can\Nhappen, right? Dialogue: 0,1:03:31.78,1:03:34.38,Default,,0000,0000,0000,,And that's not a crime. Dialogue: 0,1:03:35.47,1:03:36.59,Default,,0000,0000,0000,,So, yeah. Dialogue: 0,1:03:37.45,1:03:40.57,Default,,0000,0000,0000,,>> Who does these investigations?\NIs there like a secret service Dialogue: 0,1:03:40.57,1:03:42.07,Default,,0000,0000,0000,,for scientists, like--\N>> Yeah. Dialogue: 0,1:03:42.07,1:03:44.46,Default,,0000,0000,0000,,The Office of Research Integrity\Nat the NIH, right? Dialogue: 0,1:03:44.46,1:03:45.27,Default,,0000,0000,0000,,>> At the NIH? Dialogue: 0,1:03:45.27,1:03:49.09,Default,,0000,0000,0000,,>> Yup, and then all universities will\Nhave an office for research integrity, Dialogue: 0,1:03:49.09,1:03:52.96,Default,,0000,0000,0000,,so I'm sure that-- so if it happens at UT,\Nthere's a UT office that will investigate, Dialogue: 0,1:03:52.96,1:03:56.36,Default,,0000,0000,0000,,but the NIH will also investigate\Nif it's NIH-funded research. Dialogue: 0,1:03:57.44,1:03:59.20,Default,,0000,0000,0000,,Yeah, so several differnet bodies. Dialogue: 0,1:03:59.20,1:04:00.78,Default,,0000,0000,0000,,And there's a... Dialogue: 0,1:04:01.84,1:04:02.99,Default,,0000,0000,0000,,Yeah. Dialogue: 0,1:04:04.58,1:04:06.92,Default,,0000,0000,0000,,>> Has anyone here read\Nthe book "Bad Blood?" Dialogue: 0,1:04:07.48,1:04:08.53,Default,,0000,0000,0000,,>> "Bad Blood" what is that? Dialogue: 0,1:04:08.54,1:04:11.46,Default,,0000,0000,0000,,>> It's about the Theranos controversy\Nand (inaudible). Dialogue: 0,1:04:11.46,1:04:14.48,Default,,0000,0000,0000,,>> Oh, wow. No, is it good?\N>> It's amazing. Dialogue: 0,1:04:14.48,1:04:16.28,Default,,0000,0000,0000,,>> Really? "Bad Blood."\N>> Everyone should read it. Dialogue: 0,1:04:16.28,1:04:17.52,Default,,0000,0000,0000,,>> Okay.\N>> It's really good. Dialogue: 0,1:04:17.52,1:04:19.48,Default,,0000,0000,0000,,>> The documentary on\NHBO's pretty good. Dialogue: 0,1:04:20.14,1:04:21.53,Default,,0000,0000,0000,,>> Same title? Okay. Dialogue: 0,1:04:22.05,1:04:23.36,Default,,0000,0000,0000,,>> I think so.\N>> Okay. Dialogue: 0,1:04:23.52,1:04:25.91,Default,,0000,0000,0000,,>> So lots of these\Nkinds of things existing. Dialogue: 0,1:04:26.27,1:04:27.01,Default,,0000,0000,0000,,>> Yeah (laughs). Dialogue: 0,1:04:27.01,1:04:28.36,Default,,0000,0000,0000,,>> Just like the... Dialogue: 0,1:04:29.73,1:04:33.26,Default,,0000,0000,0000,,I don't know how to\Nsay that vitamin C is Dialogue: 0,1:04:33.26,1:04:37.68,Default,,0000,0000,0000,,for everything, and so now,\Nthe (inaudible) for everything Dialogue: 0,1:04:37.68,1:04:39.90,Default,,0000,0000,0000,,and the (inaudible) can do everything, Dialogue: 0,1:04:39.90,1:04:41.80,Default,,0000,0000,0000,,and they just make money from that. Dialogue: 0,1:04:41.80,1:04:42.54,Default,,0000,0000,0000,,(laughter) Dialogue: 0,1:04:42.57,1:04:44.71,Default,,0000,0000,0000,,>> As long as they don't kill anyone, Dialogue: 0,1:04:44.71,1:04:47.86,Default,,0000,0000,0000,,they just sell the ideas\Nto the (inaudible). Dialogue: 0,1:04:48.03,1:04:50.64,Default,,0000,0000,0000,,>> Yeah, I mean that's the entire\Nsupplement industry, right? Dialogue: 0,1:04:53.41,1:04:55.95,Default,,0000,0000,0000,,All right. Any other questions? Dialogue: 0,1:04:56.32,1:04:57.78,Default,,0000,0000,0000,,Thoughts, comments? Dialogue: 0,1:04:58.10,1:05:00.73,Default,,0000,0000,0000,,>> When is the next assignment due? Dialogue: 0,1:05:02.41,1:05:05.23,Default,,0000,0000,0000,,>> Next assignment is due\Na week from Wednesday. Dialogue: 0,1:05:07.80,1:05:10.19,Default,,0000,0000,0000,,No, so nine days from now. Dialogue: 0,1:05:10.19,1:05:11.19,Default,,0000,0000,0000,,>> Nine days? Dialogue: 0,1:05:11.19,1:05:12.11,Default,,0000,0000,0000,,>> Nine days. Dialogue: 0,1:05:12.69,1:05:15.01,Default,,0000,0000,0000,,Whatever the date is here,\Nactually I have a calendar Dialogue: 0,1:05:15.01,1:05:17.59,Default,,0000,0000,0000,,in front of me.\N>> It is the 6th so the 15th. Dialogue: 0,1:05:18.32,1:05:20.57,Default,,0000,0000,0000,,>> The 15th.\N>> Ooh, I'm good at simple math. Dialogue: 0,1:05:20.93,1:05:24.09,Default,,0000,0000,0000,,>> It is as my calendar says,\N'cause I have an 11 year old Dialogue: 0,1:05:24.09,1:05:26.63,Default,,0000,0000,0000,,girl at home, and "Riverdale"\Nseason three starts. Dialogue: 0,1:05:26.63,1:05:27.69,Default,,0000,0000,0000,,(laughter) Dialogue: 0,1:05:27.69,1:05:29.84,Default,,0000,0000,0000,,But also your assignment is due,\Nso get it done before River-- Dialogue: 0,1:05:29.84,1:05:31.16,Default,,0000,0000,0000,,>> "Riverdale" season three\Nalready happened. Dialogue: 0,1:05:31.17,1:05:33.95,Default,,0000,0000,0000,,>> What?\N(laughter) Dialogue: 0,1:05:33.95,1:05:36.50,Default,,0000,0000,0000,,Oh, no, no, it comes out\Nfree on Netflix. Yeah. Dialogue: 0,1:05:36.50,1:05:38.06,Default,,0000,0000,0000,,(laughter) Dialogue: 0,1:05:39.38,1:05:40.64,Default,,0000,0000,0000,,>> Judge me all you want. Dialogue: 0,1:05:40.64,1:05:42.36,Default,,0000,0000,0000,,>> I have a shared--\N>> I know all of you Dialogue: 0,1:05:42.36,1:05:44.09,Default,,0000,0000,0000,,watch "Game of Thrones,"\Nand I don't, so. Dialogue: 0,1:05:44.09,1:05:46.14,Default,,0000,0000,0000,,>> No, no I don't either. Dialogue: 0,1:05:46.14,1:05:47.06,Default,,0000,0000,0000,,(crosstalk) Dialogue: 0,1:05:47.06,1:05:47.79,Default,,0000,0000,0000,,>> Jifa? Dialogue: 0,1:05:47.79,1:05:49.22,Default,,0000,0000,0000,,>> What's going on Wednesday? Dialogue: 0,1:05:49.51,1:05:51.100,Default,,0000,0000,0000,,>> Haven't decided yet. It's going to\Nbe so much fun, though. Dialogue: 0,1:05:51.100,1:05:53.51,Default,,0000,0000,0000,,(laughter) Dialogue: 0,1:05:55.85,1:05:58.25,Default,,0000,0000,0000,,All right, cool. We're done. Dialogue: 0,1:05:58.25,1:06:00.63,Default,,0000,0000,0000,,(crosstalk) Dialogue: 0,1:06:07.72,1:06:11.91,Default,,0000,0000,0000,,>> I mean I sent in my paper\Njust last Friday afternoon. Dialogue: 0,1:06:11.91,1:06:13.89,Default,,0000,0000,0000,,>> Okay.\N>> Was that too late, 'cause I-- Dialogue: 0,1:06:13.89,1:06:16.26,Default,,0000,0000,0000,,>> It was too late, 'cause we\Ntold you again and again and again-- Dialogue: 0,1:06:16.26,1:06:19.23,Default,,0000,0000,0000,,>> Oh my--\N>> All right, so anyway Dialogue: 0,1:06:19.23,1:06:20.99,Default,,0000,0000,0000,,>> Sorry about that.\N>> Did you get your paper in today? Dialogue: 0,1:06:20.99,1:06:22.49,Default,,0000,0000,0000,,>> Yes. Yes, yes.\N>> Okay. Great. Dialogue: 0,1:06:22.49,1:06:25.03,Default,,0000,0000,0000,,We will survive it.\N>> Thank you, thank you. Dialogue: 0,1:06:25.03,1:06:26.68,Default,,0000,0000,0000,,>> All right. Dialogue: 0,1:06:26.68,1:06:28.37,Default,,0000,0000,0000,,(crosstalk continues) Dialogue: 0,1:06:28.37,1:06:29.62,Default,,0000,0000,0000,,>> Oh sorry, I wasn't (inaudible). Dialogue: 0,1:06:31.54,1:06:36.41,Default,,0000,0000,0000,,And on Wednesday-- I mean, this is\Nnot about the class, Dialogue: 0,1:06:36.41,1:06:40.40,Default,,0000,0000,0000,,it's slightly about the class,\Nbecause (inaudible)-- Dialogue: 0,1:06:40.40,1:06:43.11,Default,,0000,0000,0000,,invitation, having lunch--\N>> With Roy Parker? Dialogue: 0,1:06:43.11,1:06:44.89,Default,,0000,0000,0000,,Yeah, you leave early\Nand go to that. Dialogue: 0,1:06:44.89,1:06:48.25,Default,,0000,0000,0000,,>> No no, not for that, but on\NWednesday afternoon, Dialogue: 0,1:06:48.25,1:06:51.65,Default,,0000,0000,0000,,I'm flying to (inaudible) to walk\Nin the commencement. Dialogue: 0,1:06:51.65,1:06:54.28,Default,,0000,0000,0000,,>> Oh okay. So you'll\Nmiss this talk? Dialogue: 0,1:06:54.28,1:06:58.29,Default,,0000,0000,0000,,>> Yeah, I'll miss this talk likely,\Nand I'll be away for two weeks Dialogue: 0,1:06:58.29,1:07:00.53,Default,,0000,0000,0000,,because my parents are coming.\N>> No problem. Dialogue: 0,1:07:00.53,1:07:03.68,Default,,0000,0000,0000,,So send your paper in before that.\N>> So I was going to submit it Dialogue: 0,1:07:03.68,1:07:05.18,Default,,0000,0000,0000,,on Wednesday.\N>> Great, no problem. Dialogue: 0,1:07:05.59,1:07:08.05,Default,,0000,0000,0000,,Okay, cool, good, it works.\N>> Thank you. Dialogue: 0,1:07:08.05,1:07:08.68,Default,,0000,0000,0000,,>> You bet. Dialogue: 0,1:07:08.68,1:07:09.38,Default,,0000,0000,0000,,>> Mina?\N>> Yeah? Dialogue: 0,1:07:09.38,1:07:12.40,Default,,0000,0000,0000,,>> So are you going to be in\Nyour office right now, or? Dialogue: 0,1:07:12.40,1:07:15.06,Default,,0000,0000,0000,,>> Yeah yeah, I'll be here all day\Ndoing experiments, Dialogue: 0,1:07:15.06,1:07:17.13,Default,,0000,0000,0000,,so if I'm not there, just leave it\Non my desk. Dialogue: 0,1:07:17.13,1:07:17.84,Default,,0000,0000,0000,,>> Okay. Dialogue: 0,1:07:17.84,1:07:20.55,Default,,0000,0000,0000,,(crosstalk)