WEBVTT 00:00:07.367 --> 00:00:08.307 At some point, 00:00:08.307 --> 00:00:12.207 most sexually active people will be infected with human papillomavirus, 00:00:12.207 --> 00:00:13.937 or ‘HPV.’ 00:00:13.937 --> 00:00:16.347 There are over 100 types of HPV, 00:00:16.347 --> 00:00:20.247 and most of the time the body eliminates infections without symptoms– 00:00:20.247 --> 00:00:23.947 but some strains can pose serious health risks down the line. NOTE Paragraph 00:00:23.947 --> 00:00:26.937 HPV causes contact infections, 00:00:26.937 --> 00:00:30.147 which means the virus stays in the cells near the point of infection 00:00:30.147 --> 00:00:32.727 rather than spreading throughout the whole body. 00:00:32.727 --> 00:00:36.207 Since HPV is often transmitted through sexual activity, 00:00:36.207 --> 00:00:40.287 this usually means the cells of the vagina, vulva, penis, anus, 00:00:40.287 --> 00:00:41.797 mouth and throat. 00:00:41.797 --> 00:00:44.927 We can test for HPV in cells from these areas, 00:00:44.927 --> 00:00:47.797 but while testing for the virus is scientifically possible, 00:00:47.797 --> 00:00:49.347 it isn’t common. 00:00:49.347 --> 00:00:50.767 The main reason is that, 00:00:50.767 --> 00:00:54.407 while there are treatments for the adverse health effects caused by HPV, 00:00:54.407 --> 00:00:56.757 there’s no treatment for the virus itself. 00:00:56.757 --> 00:01:00.067 So testing for HPV would yield many, many positives, 00:01:00.067 --> 00:01:02.737 and although most of them won’t be cause for concern, 00:01:02.737 --> 00:01:07.247 there is still no treatment plan for clearing the body of the virus. NOTE Paragraph 00:01:07.247 --> 00:01:10.823 But there are other good ways to protect yourself from HPV. 00:01:10.823 --> 00:01:13.813 We’re going to walk through how HPV can cause harm, 00:01:13.813 --> 00:01:17.233 who’s at risk, and how to minimize those risks. NOTE Paragraph 00:01:17.233 --> 00:01:21.393 The body’s immune system is able to eradicate most strains of HPV 00:01:21.393 --> 00:01:23.478 before they cause any harm— 00:01:23.478 --> 00:01:26.808 and without people even knowing they’ve been infected. 00:01:26.808 --> 00:01:28.138 Certain other strains– 00:01:28.138 --> 00:01:30.338 like HPV 6 and 11– 00:01:30.338 --> 00:01:33.588 cause abnormalities in the cells of the infected tissue, 00:01:33.588 --> 00:01:36.228 which can develop into genital warts. 00:01:36.228 --> 00:01:39.148 While these are infectious and require treatment, 00:01:39.148 --> 00:01:41.068 usually with topical creams, 00:01:41.068 --> 00:01:45.068 wart-causing strains don’t create longer-term damage. 00:01:45.068 --> 00:01:49.788 But another 13 strains can cause DNA mutations that cause cells to divide 00:01:49.788 --> 00:01:52.033 at a much faster pace than normal, 00:01:52.033 --> 00:01:55.033 propelling the development of cancerous growths. 00:01:55.033 --> 00:01:57.863 The cells of the cervix are especially at risks. 00:01:57.863 --> 00:01:59.133 Two in particular– 00:01:59.133 --> 00:02:01.393 HPV 16 and 18– 00:02:01.393 --> 00:02:05.103 are responsible for the majority of cases of cervical cancer, 00:02:05.103 --> 00:02:08.983 which is now the fourth most common type of cancer in women. NOTE Paragraph 00:02:08.983 --> 00:02:12.383 It can take up to 20 years for cancer symptoms to appear, 00:02:12.383 --> 00:02:13.753 but with regular screening, 00:02:13.753 --> 00:02:16.783 we can discover cellular abnormalities in the cervix 00:02:16.783 --> 00:02:19.123 before they develop into cancer. 00:02:19.123 --> 00:02:22.493 Women over 21 can undergo a regular pap smear, 00:02:22.493 --> 00:02:25.923 where a sample of tissue is gently scraped from the lining of the cervix 00:02:25.923 --> 00:02:28.023 to test for abnormal cells. 00:02:28.023 --> 00:02:31.743 A positive test doesn’t mean the person has cervical cancer, 00:02:31.743 --> 00:02:34.363 but rather that there are irregular cells in the cervix 00:02:34.363 --> 00:02:37.663 that could develop into cancer in the future. NOTE Paragraph 00:02:37.663 --> 00:02:40.943 Patients are then either monitored with more frequent pap smears, 00:02:40.943 --> 00:02:43.243 or, for more severe irregularities, 00:02:43.243 --> 00:02:45.923 undergo a procedure called a colposcopy. 00:02:45.923 --> 00:02:49.873 This involves a doctor examining the cervix through a microscope, 00:02:49.873 --> 00:02:54.023 and possibly taking a small biopsy of tissue for closer examination. 00:02:54.023 --> 00:02:58.023 In some cases, the affected tissue may be removed. NOTE Paragraph 00:02:58.023 --> 00:03:02.173 HPV infections of the throat may lead to head and neck cancers, 00:03:02.173 --> 00:03:05.788 but for now there’s no equivalent of the pap smear for the throat. 00:03:05.788 --> 00:03:09.698 Using condoms helps prevent the spread of HPV during sex. 00:03:09.698 --> 00:03:15.438 And there are three safe, effective vaccines that all target HPV 16 and 18. 00:03:15.438 --> 00:03:19.038 The vaccine comes in two or three doses a few months apart, 00:03:19.038 --> 00:03:22.258 and it’s only beneficial if you receive them all. 00:03:22.258 --> 00:03:27.158 Right now the vaccine is part of standard care for girls aged 11 to 18 00:03:27.158 --> 00:03:28.596 in many countries– 00:03:28.596 --> 00:03:31.896 though it’s increasingly becoming available to boys as well. 00:03:31.896 --> 00:03:36.466 Adult women and men in countries including the United States and the United Kingdom 00:03:36.466 --> 00:03:38.442 can opt to receive the vaccine, 00:03:38.442 --> 00:03:41.262 and evidence suggests that vaccination of women and men 00:03:41.262 --> 00:03:46.902 could reduce the worldwide incidence of cervical cancer by almost 90%. 00:03:46.902 --> 00:03:49.341 Researchers are also developing an injection 00:03:49.341 --> 00:03:52.981 for people who are already infected with HPV 16 and 18, 00:03:52.981 --> 00:03:54.791 which would target the infected cells 00:03:54.791 --> 00:03:57.821 to stop them from developing into cancerous ones. 00:03:57.821 --> 00:04:00.541 So while there’s still room for improvement in screening, 00:04:00.541 --> 00:04:02.461 treatment, and access to each, 00:04:02.461 --> 00:04:05.241 condom use, vaccination, and cervical screening 00:04:05.241 --> 00:04:09.351 can each reduce the harm caused by HPV.