1 00:00:00,197 --> 00:00:02,177 - [Voiceover] All right, Part D. 2 00:00:02,177 --> 00:00:04,837 To investigate the claim that exposure to light 3 00:00:04,837 --> 00:00:08,581 overrides the genetically-controlled circadian rhythm, 4 00:00:08,581 --> 00:00:10,873 the researchers plan to repeat the experiment 5 00:00:10,873 --> 00:00:12,972 with mutant mice lacking a gene 6 00:00:12,972 --> 00:00:15,525 that controls the circadian rhythm. 7 00:00:15,525 --> 00:00:17,903 Predict the observed activity pattern 8 00:00:17,903 --> 00:00:21,374 of the mutant mice under L12:D12 conditions 9 00:00:21,374 --> 00:00:24,607 and under DD, continuous darkness conditions, 10 00:00:24,607 --> 00:00:27,494 that would support the claim that light overrides 11 00:00:27,494 --> 00:00:30,596 the genetically-controlled circadian rhythm. 12 00:00:30,596 --> 00:00:34,134 All right, so let me write this down. So, Part D. 13 00:00:34,134 --> 00:00:37,222 So under some mutant mice, 14 00:00:37,222 --> 00:00:41,152 mutant mice, 15 00:00:41,152 --> 00:00:43,587 under, so let me make two columns, 16 00:00:43,587 --> 00:00:46,872 mutant mice under L12, 17 00:00:46,872 --> 00:00:50,152 L12:D12, and then 18 00:00:50,152 --> 00:00:55,054 under continuous, continuous darkness, what would I expect? 19 00:00:55,054 --> 00:00:56,870 What would I expect? 20 00:00:56,870 --> 00:00:59,155 So they predict the observed activity pattern. 21 00:00:59,155 --> 00:01:01,183 So the mutant mice, they don't have, 22 00:01:01,183 --> 00:01:04,087 they have some, they're lacking genes 23 00:01:04,087 --> 00:01:07,286 that control circadian rhythm, but under L12:D12, 24 00:01:07,286 --> 00:01:10,496 they don't need the genetic circadian patterns, 25 00:01:10,496 --> 00:01:13,119 the genetically-influenced ones, because they get the ones 26 00:01:13,119 --> 00:01:15,663 from their environment, the light and the darkness. 27 00:01:15,663 --> 00:01:17,518 They didn't get, this isn't a gene 28 00:01:17,518 --> 00:01:20,157 that somehow makes them not sensitive to light. 29 00:01:20,157 --> 00:01:23,510 So I would assume under the L12:D12, 30 00:01:23,510 --> 00:01:26,364 they would behave, they would have activity pattern 31 00:01:26,364 --> 00:01:30,982 similar to non-mutant mice, activity 32 00:01:32,082 --> 00:01:36,100 same as non-mutant, 33 00:01:36,100 --> 00:01:41,020 as non-mutant, 34 00:01:41,020 --> 00:01:44,927 mutant mice, 35 00:01:44,927 --> 00:01:49,890 non, or inactivity, inactivity 36 00:01:49,890 --> 00:01:54,468 during L12, 37 00:01:54,468 --> 00:01:59,442 activity, activity 38 00:02:00,612 --> 00:02:04,591 during D12. 39 00:02:04,591 --> 00:02:05,707 That's what I would expect. 40 00:02:05,707 --> 00:02:07,356 They still could react to the light 41 00:02:07,356 --> 00:02:08,394 and the darkness the same way 42 00:02:08,394 --> 00:02:10,119 that a non-mutant mice would. 43 00:02:10,119 --> 00:02:12,084 Now, what about continuous darkness? 44 00:02:12,084 --> 00:02:14,215 The non-mutant mice, we said that they, 45 00:02:14,215 --> 00:02:16,533 they went off of a 24-hour cycle, 46 00:02:16,533 --> 00:02:18,994 but they still had a cycle where they were inactive, 47 00:02:18,994 --> 00:02:23,350 active, inactive, active, and it was less than 12 hours 48 00:02:23,350 --> 00:02:25,367 for each cycle, but it was close to it. 49 00:02:25,367 --> 00:02:28,149 It was maybe 9, 10, or 11 hours of activity, 50 00:02:28,149 --> 00:02:31,354 followed by 9, 10, or 11 hours of inactivity. 51 00:02:31,354 --> 00:02:33,135 I would guess that a mutant mouse 52 00:02:33,135 --> 00:02:35,466 that has no, that doesn't have some 53 00:02:35,466 --> 00:02:37,841 of these genes for circadian rhythm, 54 00:02:37,841 --> 00:02:39,409 well, for them, it's just gonna be, 55 00:02:39,409 --> 00:02:40,486 it's just gonna be random, 56 00:02:40,486 --> 00:02:43,090 it's just gonna be much more sporadic. 57 00:02:43,090 --> 00:02:47,353 So, much, much 58 00:02:47,353 --> 00:02:51,491 more sporadic, 59 00:02:51,491 --> 00:02:54,779 sporadic activity, 60 00:02:54,779 --> 00:02:59,779 activity, fewer, 61 00:02:59,836 --> 00:03:03,370 fewer continuous, 62 00:03:03,370 --> 00:03:05,610 continuous, 63 00:03:05,610 --> 00:03:08,925 or I would say, maybe, less continuous periods, 64 00:03:08,925 --> 00:03:12,036 or shorter continuous periods, 65 00:03:12,036 --> 00:03:16,289 shorter continuous 66 00:03:16,289 --> 00:03:20,912 periods of activity 67 00:03:20,912 --> 00:03:22,896 and inactivity, 68 00:03:22,896 --> 00:03:25,165 activity slash 69 00:03:25,165 --> 00:03:29,016 inactivity. 70 00:03:29,016 --> 00:03:32,798 All right, now let's look at Part E now. 71 00:03:32,798 --> 00:03:35,652 So that was my predictions that I would see 72 00:03:35,652 --> 00:03:37,316 for mutant mice in either of these. 73 00:03:37,316 --> 00:03:39,664 So now let's go to Part E. 74 00:03:39,664 --> 00:03:42,172 In nature, mice are potential prey 75 00:03:42,172 --> 00:03:46,109 for some predatory birds that hunt during the day. 76 00:03:46,109 --> 00:03:49,667 Describe two features of a model that represents 77 00:03:49,667 --> 00:03:51,748 how the predator-prey relationship 78 00:03:51,748 --> 00:03:55,202 between the birds and the mice may have resulted 79 00:03:55,202 --> 00:03:56,705 in the evolution 80 00:03:56,705 --> 00:04:01,304 of the observed activity pattern of mice. 81 00:04:01,304 --> 00:04:06,304 Well, if the birds hunt during the day, 82 00:04:06,433 --> 00:04:11,174 if birds hunt 83 00:04:11,174 --> 00:04:15,617 during day 84 00:04:15,617 --> 00:04:16,697 a mouse is more likely 85 00:04:16,697 --> 00:04:21,275 to be eaten by a bird if it's active during the day. 86 00:04:21,275 --> 00:04:25,052 Mouse, then, 87 00:04:25,052 --> 00:04:29,337 then the mouse 88 00:04:29,337 --> 00:04:34,277 is more likely 89 00:04:34,277 --> 00:04:38,536 to be eaten, 90 00:04:38,536 --> 00:04:42,510 eaten if it is 91 00:04:42,510 --> 00:04:44,398 active during the day, 92 00:04:44,398 --> 00:04:47,036 if it is active 93 00:04:47,036 --> 00:04:51,987 during the day. 94 00:04:53,548 --> 00:04:54,721 And if it is, I guess you could say 95 00:04:54,721 --> 00:04:57,440 that's one, that's one feature of our model, 96 00:04:57,440 --> 00:04:59,761 that you're just more likely to be eaten 97 00:04:59,761 --> 00:05:02,009 if you're active when the birds are hunting. 98 00:05:02,009 --> 00:05:03,969 And then the second one is, if you're more likely 99 00:05:03,969 --> 00:05:08,268 to be eaten, then you're less likely to reproduce. 100 00:05:08,268 --> 00:05:11,350 If, actually that should be capital I, 101 00:05:11,350 --> 00:05:15,480 if, if the mouse 102 00:05:17,260 --> 00:05:22,172 is more likely 103 00:05:22,172 --> 00:05:25,422 to be eaten 104 00:05:25,422 --> 00:05:29,189 by being 105 00:05:29,189 --> 00:05:31,540 active 106 00:05:31,540 --> 00:05:35,755 during the day, 107 00:05:37,765 --> 00:05:40,727 then it is less likely to reproduce, 108 00:05:40,727 --> 00:05:44,628 then it is less 109 00:05:44,628 --> 00:05:46,728 likely 110 00:05:46,728 --> 00:05:49,393 to reproduce. 111 00:05:49,393 --> 00:05:53,091 And if I were, if I were taking the AP test here, 112 00:05:53,091 --> 00:05:55,220 I would try to put as much context as possible, 113 00:05:55,220 --> 00:05:56,435 because you're not exactly sure 114 00:05:56,435 --> 00:05:58,920 how they're, they're going to mark this thing, 115 00:05:58,920 --> 00:06:01,544 to grade this thing, so you could give more context 116 00:06:01,544 --> 00:06:04,646 that therefore, the mice 117 00:06:04,646 --> 00:06:06,852 that are active during, 118 00:06:06,852 --> 00:06:11,659 therefore, therefore, 119 00:06:11,659 --> 00:06:16,110 mice that are 120 00:06:16,110 --> 00:06:18,708 active 121 00:06:18,708 --> 00:06:21,348 during night, 122 00:06:21,348 --> 00:06:22,954 they have to be active sometime, 123 00:06:22,954 --> 00:06:27,075 active during night and inactive 124 00:06:28,185 --> 00:06:31,972 during day 125 00:06:31,972 --> 00:06:36,214 will be selected for, will 126 00:06:36,214 --> 00:06:40,520 be selected for, 127 00:06:41,370 --> 00:06:45,558 less likely to be eaten, less likely 128 00:06:45,558 --> 00:06:48,714 to be hunted, 129 00:06:48,714 --> 00:06:53,438 I guess you could say, and more likely to reproduce, 130 00:06:53,438 --> 00:06:58,403 more likely to reproduce, 131 00:06:58,403 --> 00:07:02,535 reproduce, and we are done.