0:00:00.197,0:00:02.177 - [Voiceover] All right, Part D. 0:00:02.177,0:00:04.837 To investigate the claim[br]that exposure to light 0:00:04.837,0:00:08.581 overrides the genetically-controlled[br]circadian rhythm, 0:00:08.581,0:00:10.873 the researchers plan to[br]repeat the experiment 0:00:10.873,0:00:12.972 with mutant mice lacking a gene 0:00:12.972,0:00:15.525 that controls the circadian rhythm. 0:00:15.525,0:00:17.903 Predict the observed activity pattern 0:00:17.903,0:00:21.374 of the mutant mice[br]under L12:D12 conditions 0:00:21.374,0:00:24.607 and under DD, continuous[br]darkness conditions, 0:00:24.607,0:00:27.494 that would support the[br]claim that light overrides 0:00:27.494,0:00:30.596 the genetically-controlled[br]circadian rhythm. 0:00:30.596,0:00:34.134 All right, so let me write[br]this down. So, Part D. 0:00:34.134,0:00:37.222 So under some mutant mice, 0:00:37.222,0:00:41.152 mutant mice, 0:00:41.152,0:00:43.587 under, so let me make two columns, 0:00:43.587,0:00:46.872 mutant mice under L12, 0:00:46.872,0:00:50.152 L12:D12, and then 0:00:50.152,0:00:55.054 under continuous, continuous[br]darkness, what would I expect? 0:00:55.054,0:00:56.870 What would I expect? 0:00:56.870,0:00:59.155 So they predict the[br]observed activity pattern. 0:00:59.155,0:01:01.183 So the mutant mice, they don't have, 0:01:01.183,0:01:04.087 they have some, they're lacking genes 0:01:04.087,0:01:07.286 that control circadian[br]rhythm, but under L12:D12, 0:01:07.286,0:01:10.496 they don't need the[br]genetic circadian patterns, 0:01:10.496,0:01:13.119 the genetically-influenced[br]ones, because they get the ones 0:01:13.119,0:01:15.663 from their environment,[br]the light and the darkness. 0:01:15.663,0:01:17.518 They didn't get, this isn't a gene 0:01:17.518,0:01:20.157 that somehow makes them[br]not sensitive to light. 0:01:20.157,0:01:23.510 So I would assume under the L12:D12, 0:01:23.510,0:01:26.364 they would behave, they[br]would have activity pattern 0:01:26.364,0:01:30.982 similar to non-mutant mice, activity 0:01:32.082,0:01:36.100 same as non-mutant, 0:01:36.100,0:01:41.020 as non-mutant, 0:01:41.020,0:01:44.927 mutant mice, 0:01:44.927,0:01:49.890 non, or inactivity, inactivity 0:01:49.890,0:01:54.468 during L12, 0:01:54.468,0:01:59.442 activity, activity 0:02:00.612,0:02:04.591 during D12. 0:02:04.591,0:02:05.707 That's what I would expect. 0:02:05.707,0:02:07.356 They still could react to the light 0:02:07.356,0:02:08.394 and the darkness the same way 0:02:08.394,0:02:10.119 that a non-mutant mice would. 0:02:10.119,0:02:12.084 Now, what about continuous darkness? 0:02:12.084,0:02:14.215 The non-mutant mice, we said that they, 0:02:14.215,0:02:16.533 they went off of a 24-hour cycle, 0:02:16.533,0:02:18.994 but they still had a cycle[br]where they were inactive, 0:02:18.994,0:02:23.350 active, inactive, active,[br]and it was less than 12 hours 0:02:23.350,0:02:25.367 for each cycle, but it was close to it. 0:02:25.367,0:02:28.149 It was maybe 9, 10, or[br]11 hours of activity, 0:02:28.149,0:02:31.354 followed by 9, 10, or[br]11 hours of inactivity. 0:02:31.354,0:02:33.135 I would guess that a mutant mouse 0:02:33.135,0:02:35.466 that has no, that doesn't have some 0:02:35.466,0:02:37.841 of these genes for circadian rhythm, 0:02:37.841,0:02:39.409 well, for them, it's just gonna be, 0:02:39.409,0:02:40.486 it's just gonna be random, 0:02:40.486,0:02:43.090 it's just gonna be much more sporadic. 0:02:43.090,0:02:47.353 So, much, much 0:02:47.353,0:02:51.491 more sporadic, 0:02:51.491,0:02:54.779 sporadic activity, 0:02:54.779,0:02:59.779 activity, fewer, 0:02:59.836,0:03:03.370 fewer continuous, 0:03:03.370,0:03:05.610 continuous, 0:03:05.610,0:03:08.925 or I would say, maybe,[br]less continuous periods, 0:03:08.925,0:03:12.036 or shorter continuous periods, 0:03:12.036,0:03:16.289 shorter continuous 0:03:16.289,0:03:20.912 periods of activity 0:03:20.912,0:03:22.896 and inactivity, 0:03:22.896,0:03:25.165 activity slash 0:03:25.165,0:03:29.016 inactivity. 0:03:29.016,0:03:32.798 All right, now let's look at Part E now. 0:03:32.798,0:03:35.652 So that was my predictions[br]that I would see 0:03:35.652,0:03:37.316 for mutant mice in either of these. 0:03:37.316,0:03:39.664 So now let's go to Part E. 0:03:39.664,0:03:42.172 In nature, mice are potential prey 0:03:42.172,0:03:46.109 for some predatory birds[br]that hunt during the day. 0:03:46.109,0:03:49.667 Describe two features of[br]a model that represents 0:03:49.667,0:03:51.748 how the predator-prey relationship 0:03:51.748,0:03:55.202 between the birds and the[br]mice may have resulted 0:03:55.202,0:03:56.705 in the evolution 0:03:56.705,0:04:01.304 of the observed activity pattern of mice. 0:04:01.304,0:04:06.304 Well, if the birds hunt during the day, 0:04:06.433,0:04:11.174 if birds hunt 0:04:11.174,0:04:15.617 during day 0:04:15.617,0:04:16.697 a mouse is more likely 0:04:16.697,0:04:21.275 to be eaten by a bird if[br]it's active during the day. 0:04:21.275,0:04:25.052 Mouse, then, 0:04:25.052,0:04:29.337 then the mouse 0:04:29.337,0:04:34.277 is more likely 0:04:34.277,0:04:38.536 to be eaten, 0:04:38.536,0:04:42.510 eaten if it is 0:04:42.510,0:04:44.398 active during the day, 0:04:44.398,0:04:47.036 if it is active 0:04:47.036,0:04:51.987 during the day. 0:04:53.548,0:04:54.721 And if it is, I guess you could say 0:04:54.721,0:04:57.440 that's one, that's one[br]feature of our model, 0:04:57.440,0:04:59.761 that you're just more likely to be eaten 0:04:59.761,0:05:02.009 if you're active when[br]the birds are hunting. 0:05:02.009,0:05:03.969 And then the second one[br]is, if you're more likely 0:05:03.969,0:05:08.268 to be eaten, then you're[br]less likely to reproduce. 0:05:08.268,0:05:11.350 If, actually that should be capital I, 0:05:11.350,0:05:15.480 if, if the mouse 0:05:17.260,0:05:22.172 is more likely 0:05:22.172,0:05:25.422 to be eaten 0:05:25.422,0:05:29.189 by being 0:05:29.189,0:05:31.540 active 0:05:31.540,0:05:35.755 during the day, 0:05:37.765,0:05:40.727 then it is less likely to reproduce, 0:05:40.727,0:05:44.628 then it is less 0:05:44.628,0:05:46.728 likely 0:05:46.728,0:05:49.393 to reproduce. 0:05:49.393,0:05:53.091 And if I were, if I were[br]taking the AP test here, 0:05:53.091,0:05:55.220 I would try to put as[br]much context as possible, 0:05:55.220,0:05:56.435 because you're not exactly sure 0:05:56.435,0:05:58.920 how they're, they're[br]going to mark this thing, 0:05:58.920,0:06:01.544 to grade this thing, so[br]you could give more context 0:06:01.544,0:06:04.646 that therefore, the mice 0:06:04.646,0:06:06.852 that are active during, 0:06:06.852,0:06:11.659 therefore, therefore, 0:06:11.659,0:06:16.110 mice that are 0:06:16.110,0:06:18.708 active 0:06:18.708,0:06:21.348 during night, 0:06:21.348,0:06:22.954 they have to be active sometime, 0:06:22.954,0:06:27.075 active during night and inactive 0:06:28.185,0:06:31.972 during day 0:06:31.972,0:06:36.214 will be selected for, will 0:06:36.214,0:06:40.520 be selected for, 0:06:41.370,0:06:45.558 less likely to be eaten, less likely 0:06:45.558,0:06:48.714 to be hunted, 0:06:48.714,0:06:53.438 I guess you could say, and[br]more likely to reproduce, 0:06:53.438,0:06:58.403 more likely to reproduce, 0:06:58.403,0:07:02.535 reproduce, and we are done.