WEBVTT 00:00:10.025 --> 00:00:11.111 Oh the humanity! 00:00:11.930 --> 00:00:15.930 Ah...humanity... 00:00:15.930 --> 00:00:19.502 It’s a trainwreck, but I can’t look away. 00:00:20.206 --> 00:00:23.576 It’s 1843, and a debate is raging among physicians 00:00:23.576 --> 00:00:28.089 about one of the most common killers of women: childbed fever. 00:00:28.089 --> 00:00:31.569 Childbed fever strikes within days of giving birth, 00:00:31.569 --> 00:00:37.983 killing more than 70% of those infected— and nobody knows what causes it. 00:00:37.983 --> 00:00:41.846 Obstetrician Charles Meigs has a theory. 00:00:41.846 --> 00:00:46.498 Having observed abdominal inflammation in patients who go on to develop the fever, 00:00:46.498 --> 00:00:51.114 he claims this inflammation is the cause of childbed fever. 00:00:51.114 --> 00:00:54.954 Much of the medical establishment supports his theory. 00:00:54.954 --> 00:00:56.424 Oh, come on! 00:00:56.424 --> 00:01:01.114 They really leave me no choice but to teach them some skepticism. 00:01:12.511 --> 00:01:14.691 That’s better. 00:01:14.691 --> 00:01:21.687 Now, Meigs, your argument is based on a fallacy—the false cause fallacy. 00:01:21.687 --> 00:01:25.687 Correlation does not imply causation: 00:01:25.687 --> 00:01:28.927 When two phenomena regularly occur together, 00:01:28.927 --> 00:01:33.595 one does not necessarily cause the other. 00:01:33.595 --> 00:01:39.666 So you say women who have inflammation also come down with childbed fever, 00:01:39.666 --> 00:01:43.666 therefore the inflammation caused the fever. 00:01:43.666 --> 00:01:46.966 But that’s not necessarily true. 00:01:46.966 --> 00:01:51.116 Yes, yes, the inflammation comes first, then the fever, 00:01:51.116 --> 00:01:55.116 so it seems like the inflammation causes the fever. 00:01:55.116 --> 00:02:00.400 But by that logic, since babies usually grow hair before teeth, 00:02:00.400 --> 00:02:03.630 hair growth must cause tooth growth. 00:02:03.630 --> 00:02:06.460 And we all know that’s not true, right? 00:02:06.460 --> 00:02:08.280 Actually, don’t answer that. 00:02:08.280 --> 00:02:11.991 A couple of different things could be going on here. 00:02:11.991 --> 00:02:16.668 First, it’s possible that fever and inflammation are correlated 00:02:16.668 --> 00:02:19.588 purely by coincidence. 00:02:19.588 --> 00:02:25.627 Or, there could be a causal relationship that’s the opposite of what you think–– 00:02:25.627 --> 00:02:28.627 the fever causes the inflammation, 00:02:28.627 --> 00:02:31.747 rather than the inflammation causing the fever. 00:02:31.747 --> 00:02:38.535 Or both could share a common underlying cause you haven’t thought of. 00:02:38.535 --> 00:02:46.059 If I may, just what do you think causes inflammation? Nothing? 00:02:46.059 --> 00:02:49.519 It just is? Really? 00:02:49.519 --> 00:02:54.257 Humor me for a moment in discussing one of your colleague’s ideas–– 00:02:54.257 --> 00:02:56.847 Dr. Oliver Wendell Holmes. 00:02:56.847 --> 00:03:00.157 I know, I know, you don’t like his theory–– 00:03:00.157 --> 00:03:03.377 you already wrote a scathing letter about it. 00:03:03.377 --> 00:03:06.477 But let’s fill your students in, shall we? 00:03:06.477 --> 00:03:12.089 Holmes noticed a pattern: when a patient dies of childbed fever, 00:03:12.089 --> 00:03:15.199 a doctor performs an autopsy. 00:03:15.199 --> 00:03:18.599 If the doctor then treats a new patient, 00:03:18.599 --> 00:03:22.599 that patient often comes down with the fever. 00:03:22.599 --> 00:03:26.934 Based on this correlation between autopsies of fever victims 00:03:26.934 --> 00:03:32.150 and new fever patients, he proposes a possible cause. 00:03:32.150 --> 00:03:38.705 Since there’s no evidence that the autopsy causes the fever beyond this correlation, 00:03:38.705 --> 00:03:43.774 he doesn’t jump to the conclusion that autopsy causes fever. 00:03:43.774 --> 00:03:49.230 Instead, he suggests that doctors are infecting their patients 00:03:49.230 --> 00:03:54.922 via an invisible contaminant on their hands and surgical instruments. 00:03:54.922 --> 00:04:00.750 This idea outrages most doctors, who see themselves as infallible. 00:04:00.750 --> 00:04:04.880 Like Meigs here, who refuses to consider the possibility 00:04:04.880 --> 00:04:08.440 that he’s playing a role in his patients’ plight. 00:04:08.440 --> 00:04:13.523 His flawed argument doesn’t leave any path forward for further investigation— 00:04:13.523 --> 00:04:17.523 but Holmes’ does. 00:04:24.222 --> 00:04:27.492 It’s 1847, and physician Ignaz Semmelweis 00:04:27.492 --> 00:04:29.752 has reduced the number of childbed fever deaths 00:04:29.752 --> 00:04:34.832 in a clinic from 12% to 1% by requiring all medical personnel 00:04:34.832 --> 00:04:40.162 to disinfect their hands after autopsies and between patient examinations. 00:04:40.162 --> 00:04:45.252 With this initiative, he has proven the contagious nature of childbed fever. 00:04:45.552 --> 00:04:46.692 Ha! 00:04:49.738 --> 00:04:53.845 It’s 1879, and Louis Pasteur has identified 00:04:53.845 --> 00:04:58.371 the contaminant responsible for many cases of childbed fever, 00:04:58.371 --> 00:05:01.411 Hemolytic streptococcus bacteria. 00:05:04.301 --> 00:05:07.151 Hmm, my fries are cold. 00:05:07.151 --> 00:05:11.151 Must be because my ice cream melted.