WEBVTT 00:00:07.051 --> 00:00:09.603 The discovery of the structure of DNA 00:00:09.603 --> 00:00:14.170 was one of the most important scientific achievements in the last century, 00:00:14.170 --> 00:00:16.224 in human history, in fact. 00:00:16.224 --> 00:00:20.163 The now-famous double helix is almost synonymous with Watson and Crick, 00:00:20.163 --> 00:00:24.327 two of the scientists who won the Nobel Prize for figuring it out. 00:00:24.327 --> 00:00:26.442 But there's another name you may know, too, 00:00:26.442 --> 00:00:28.382 Rosalind Franklin. 00:00:28.382 --> 00:00:32.567 You may have heard that her data supported Watson and Crick's brilliant idea, 00:00:32.567 --> 00:00:36.850 or that she was a plain-dressing, belligerent scientist, 00:00:36.850 --> 00:00:41.859 which is how Watson actually described her in "The Double Helix." 00:00:41.859 --> 00:00:43.852 But thanks to Franklin's biographers, 00:00:43.852 --> 00:00:47.191 who investigated her life and interviewed many people close to her, 00:00:47.191 --> 00:00:50.917 we now know that that account is far from true, 00:00:50.917 --> 00:00:54.851 and her scientific contributions have been vastly underplayed. 00:00:54.851 --> 00:00:56.721 Let's hear the real story. 00:00:56.721 --> 00:01:01.475 Rosalind Elsie Franklin was born in London in 1920. 00:01:01.475 --> 00:01:04.612 She wanted to be a scientist ever since she was a teenager, 00:01:04.612 --> 00:01:08.764 which wasn't a common or easy career path for girls at that time. 00:01:08.764 --> 00:01:11.039 But she excelled at science anyway. 00:01:11.039 --> 00:01:14.325 She won a scholarship to Cambridge to study chemistry, 00:01:14.325 --> 00:01:16.112 where she earned her Ph.D., 00:01:16.112 --> 00:01:19.397 and she later conducted research on the structure of coal 00:01:19.397 --> 00:01:23.700 that led to better gas masks for the British during World War II. 00:01:23.700 --> 00:01:26.256 In 1951, she joined King's College 00:01:26.256 --> 00:01:29.790 to use x-ray techniques to study the structure of DNA, 00:01:29.790 --> 00:01:32.414 then one of the hottest topics in science. 00:01:32.414 --> 00:01:35.449 Franklin upgraded the x-ray lab and got to work 00:01:35.449 --> 00:01:40.120 shining high-energy x-rays on tiny, wet crystals of DNA. 00:01:40.120 --> 00:01:43.804 But the acadmemic culture at the time wasn't very friendly to women, 00:01:43.804 --> 00:01:46.286 and Franklin was isolated from her colleagues. 00:01:46.286 --> 00:01:48.609 She clashed with Maurice Wilkins, 00:01:48.609 --> 00:01:52.974 a labmate who assumed Franklin had been hired as his assistant. 00:01:52.974 --> 00:01:54.472 But Franklin kept working, 00:01:54.472 --> 00:02:01.193 and in 1952, she obtained Photo 51, the most famous x-ray image of DNA. 00:02:01.193 --> 00:02:03.630 Just getting the image took 100 hours, 00:02:03.630 --> 00:02:07.485 the calculations necessary to analyze it would take a year. 00:02:07.485 --> 00:02:10.448 Meanwhile, the American biologist James Watson 00:02:10.448 --> 00:02:12.787 and the British physicist Francis Crick 00:02:12.787 --> 00:02:15.730 were also working on finding DNA's structure. 00:02:15.730 --> 00:02:17.252 Without Franklin's knowledge, 00:02:17.252 --> 00:02:21.667 Wilkins took Photo 51 and showed it to Watson and Crick. 00:02:21.667 --> 00:02:25.078 Instead of calculating the exact position of every atom, 00:02:25.078 --> 00:02:27.942 they did a quick analysis of Franklin's data 00:02:27.942 --> 00:02:31.442 and used that to build a few potential structures. 00:02:31.442 --> 00:02:34.220 Eventually, they arrived at the right one. 00:02:34.220 --> 00:02:37.169 DNA is made of two helicoidal strands, 00:02:37.169 --> 00:02:42.416 one opposite the other with bases in the center like rungs of a ladder. 00:02:42.416 --> 00:02:46.670 Watson and Crick published their model in April 1953. 00:02:46.670 --> 00:02:50.215 Meanwhile, Franklin had finished her calculations, 00:02:50.215 --> 00:02:51.664 come to the same conclusion, 00:02:51.664 --> 00:02:54.398 and submitted her own manuscript. 00:02:54.398 --> 00:02:56.721 The journal published the manuscripts together, 00:02:56.721 --> 00:02:58.883 but put Franklin's last, 00:02:58.883 --> 00:03:02.882 making it look like her experiments just confirmed Watson and Crick's breakthrough 00:03:02.882 --> 00:03:05.381 instead of inspiring it. 00:03:05.381 --> 00:03:07.920 But Franklin had already stopped working on DNA 00:03:07.920 --> 00:03:11.018 and died of cancer in 1958, 00:03:11.018 --> 00:03:15.107 never knowing that Watson and Crick had seen her photographs. 00:03:15.107 --> 00:03:19.326 Watson, Crick, and Wilkins won the Nobel Prize in 1962 00:03:19.326 --> 00:03:21.421 for their work on DNA. 00:03:21.421 --> 00:03:25.006 It's often said that Franklin would have been recognized by a Nobel Prize 00:03:25.006 --> 00:03:28.288 if only they could be awarded posthumously. 00:03:28.288 --> 00:03:31.638 And, in fact, it's possible she could have won twice. 00:03:31.638 --> 00:03:37.302 Her work on the structure of viruses led to a Nobel for a colleague in 1982. 00:03:37.302 --> 00:03:42.636 It's time to tell the story of a brave woman who fought sexism in science, 00:03:42.636 --> 00:03:47.514 and whose work revolutionized medicine, biology, and agriculture. 00:03:47.514 --> 00:03:51.039 It's time to honor Rosalind Elsie Franklin, 00:03:51.039 --> 00:03:53.534 the unsung mother of the double helix.