WEBVTT 00:00:07.377 --> 00:00:12.365 The question is, is it necessary and possible to improve the brain? 00:00:12.744 --> 00:00:14.225 Indeed. 00:00:14.743 --> 00:00:20.983 The brain's an incredibly efficient organ which serves to survive, not to think. 00:00:21.070 --> 00:00:25.810 But thinking is very helpful for survival, 00:00:25.810 --> 00:00:29.198 that's why the brain thinks too. 00:00:29.198 --> 00:00:30.025 (Applause) 00:00:30.025 --> 00:00:35.716 Throughout 400 million years, the brain has been evolving, 00:00:35.776 --> 00:00:38.820 from a big shark with a small brain, 00:00:38.874 --> 00:00:40.352 to the human brain. 00:00:40.352 --> 00:00:44.077 In the last 3 million years, a transition from ape to human took place. 00:00:44.077 --> 00:00:51.649 In the last 2 years, a Brazilian scientist Suzana Herculano-Houzel, 00:00:51.881 --> 00:00:57.979 has revolutionized what we know about the brain. 00:00:58.189 --> 00:01:03.353 The primate's brain is more organized than that of other animals, 00:01:03.446 --> 00:01:08.009 including rodents or ungulates, which means we have great features. 00:01:08.050 --> 00:01:10.001 Our brain is very good, 00:01:10.001 --> 00:01:15.743 and now the human brain has begun to evolve even more. 00:01:15.903 --> 00:01:19.920 The bigger the brain, the greater the possibilites of thinking, learning 00:01:20.000 --> 00:01:22.702 and ruling the world. 00:01:22.751 --> 00:01:25.834 From the brain of Australopithecus, 00:01:25.834 --> 00:01:29.935 through the upright man who knew fire, 00:01:29.935 --> 00:01:33.984 a Neanderthal who was already religious, 00:01:34.096 --> 00:01:36.315 to the brain of a caveman, 00:01:36.316 --> 00:01:37.543 a man from Cro-Magnon, 00:01:37.543 --> 00:01:39.777 language, culture, everything. 00:01:39.777 --> 00:01:42.774 Is that all? I guess not. 00:01:42.774 --> 00:01:44.855 The world is constantly changing, 00:01:45.080 --> 00:01:46.664 we ourselves change the world. 00:01:46.780 --> 00:01:51.144 That's why our brain works on the edge of efficiency. 00:01:51.320 --> 00:01:53.330 So the question is: 00:01:53.444 --> 00:01:57.073 Can we improve our brain more? 00:01:57.539 --> 00:02:01.586 Evolution didn't stop with the caveman, for sure. 00:02:01.799 --> 00:02:06.256 Anatomic and genetic research proves that brain evolution is still in progress. 00:02:06.517 --> 00:02:09.131 Let's not get into details, 00:02:09.131 --> 00:02:10.688 but where does it come from? 00:02:10.688 --> 00:02:14.792 A hundred years ago, a farmer following a plow, 00:02:14.792 --> 00:02:18.777 I mean how much information did his brain process? 00:02:18.812 --> 00:02:26.434 Today, when traveling in a great traffic jam, we have a lot of information. 00:02:26.474 --> 00:02:30.173 Nowadays, the brain has to process an enormous amount of information 00:02:30.173 --> 00:02:31.648 and it has to do it in a flash. 00:02:31.648 --> 00:02:34.127 It's not a problem whether a crow flies over a horse, 00:02:34.127 --> 00:02:36.859 but whether or not a motocyclist crashes into us. 00:02:37.911 --> 00:02:44.180 I won't describe it in great detail, but there's a gene 00:02:44.332 --> 00:02:48.955 whose one form changes in a way that indicates the speed of evolution. 00:02:49.027 --> 00:02:52.888 We can see that the evolution of the brain evolves all over the world. 00:02:53.258 --> 00:02:57.042 However, depending on the region, it is stronger or slower. 00:02:57.103 --> 00:03:00.294 The darker those black circles are, the faster the evolution is. 00:03:00.294 --> 00:03:02.549 Where was this evolution rapid? 00:03:02.585 --> 00:03:05.936 In places where races and cultures merged. 00:03:05.966 --> 00:03:08.636 The evolution in Latin America was progressing fast. 00:03:08.636 --> 00:03:11.922 In places where the environment was stable and where nothing changed, 00:03:11.922 --> 00:03:13.373 the brain didn't have to grow. 00:03:13.373 --> 00:03:18.190 In Sub-Saharan Africa, the evolution is slower. 00:03:18.312 --> 00:03:20.799 But it doesn't mean that it can't accelerate, 00:03:20.799 --> 00:03:24.758 because the brain evolution speeds up all over the world, and we know it. 00:03:24.758 --> 00:03:29.899 A New Zealander scientist, James Flynn, 00:03:29.969 --> 00:03:32.619 noticed that human intelligence, 00:03:32.619 --> 00:03:39.437 if measured by IQ tests, now and back in time, 00:03:39.437 --> 00:03:43.276 seemed to have been rising 00:03:43.301 --> 00:03:45.392 from generation to generation, very much so. 00:03:45.392 --> 00:03:47.165 Take a look at the data about Europe. 00:03:47.165 --> 00:03:54.074 Half a century ago, in 1942, the average Britisher 00:03:54.244 --> 00:03:58.442 had IQ 73, so he was a complete fool. 00:03:58.712 --> 00:04:02.662 Look how everything is growing right now. 00:04:02.785 --> 00:04:05.445 And what was actually going on with the mankind? 00:04:05.505 --> 00:04:06.604 It's terrifying. 00:04:06.644 --> 00:04:10.339 All those fantastic pyramid builders 00:04:10.339 --> 00:04:12.877 had IQ 50, or so. 00:04:13.047 --> 00:04:16.720 Rome, the Renaissance... 00:04:16.813 --> 00:04:22.120 It wasn't until the industrial revolution that intelligence started to speed up. 00:04:22.263 --> 00:04:27.273 So intelligence speeds up, perhaps a bit slower now. 00:04:27.547 --> 00:04:32.888 But there are still differences between social groups and races. 00:04:33.082 --> 00:04:35.914 A lot depends on education. 00:04:36.013 --> 00:04:40.407 In the USA there are two groups whose IQ is much higher than that of the rest. 00:04:40.657 --> 00:04:45.717 The Ashkenazi Jews, raised in schools in the Talmudu base, 00:04:45.857 --> 00:04:50.818 and The Oriental Japanese and the Chinese with Confucian tradition. 00:04:50.857 --> 00:04:55.020 So the way we are taught may greatly increase our learning abilities. 00:04:55.020 --> 00:04:57.679 Just like reading and writing skills 00:04:57.679 --> 00:05:00.634 improve connection between two cerebral hemispheres. 00:05:00.996 --> 00:05:06.605 Are we able to speed up the natural evolution progress even more? 00:05:06.793 --> 00:05:12.976 Some say, the brain is such a great organ that nothing more can be done. 00:05:13.910 --> 00:05:18.538 However, if we take a closer look, we can see that the process of cognition 00:05:18.538 --> 00:05:21.070 is composed of other smaller processes. 00:05:21.070 --> 00:05:24.936 There are biochemical reactions in each of them, 00:05:25.036 --> 00:05:27.901 which enable us to make them work faster. 00:05:27.981 --> 00:05:32.664 This in turn makes the brain work faster. 00:05:32.736 --> 00:05:34.852 What can we currently do about it? 00:05:35.045 --> 00:05:38.317 We can surely speed up mental processes 00:05:38.317 --> 00:05:40.474 of people with mental retardation. 00:05:40.474 --> 00:05:43.874 For example in schizophrenia or hebetude. 00:05:43.874 --> 00:05:46.567 We can do something, we have good medicaments. 00:05:46.605 --> 00:05:49.018 The question is, can therapeutic treatments, 00:05:49.018 --> 00:05:50.721 which help the damaged brain, 00:05:50.721 --> 00:05:53.061 help the normal brain as well? 00:05:53.061 --> 00:05:55.493 It seems so. 00:05:56.715 --> 00:06:01.041 We apply many kinds of non-therapeutic technologies. 00:06:01.041 --> 00:06:07.275 We want to improve our memory, concentration, scope of attention 00:06:07.625 --> 00:06:10.730 and decision-making. 00:06:11.041 --> 00:06:16.216 When we look at this, there are two goals. 00:06:16.285 --> 00:06:18.875 First, we want to improve the brain permanently, 00:06:18.875 --> 00:06:21.971 meaning slowly, methodically, to make it better and better, 00:06:21.971 --> 00:06:23.859 so we can be more and more inteligent. 00:06:24.049 --> 00:06:28.698 Secondly, there are sudden challenges, exams, TED lectures. 00:06:28.815 --> 00:06:32.166 I want to do something quickly, so I take a pill before the lecture 00:06:32.166 --> 00:06:36.997 to face the new challenge that suddenly emerges. 00:06:36.997 --> 00:06:41.933 A long-term brain improvement is commonly accepted. 00:06:42.245 --> 00:06:46.501 On one hand, it is supposed to be a mind training. 00:06:46.570 --> 00:06:51.260 On the other, it is a healthy lifestyle, crucial for a good brain work. 00:06:51.454 --> 00:06:54.836 Furthermore, we increase some areas of the cortex. 00:06:54.836 --> 00:06:58.345 For instance, meditation increases the volume of the cortex 00:06:58.345 --> 00:07:02.876 in areas where thoughts and decisions are made. 00:07:03.032 --> 00:07:07.583 Finally, different types of vitamins and supplements. 00:07:07.583 --> 00:07:11.128 There has been a lot of talk about the role of the vitamin D3. 00:07:11.450 --> 00:07:15.264 Therefore, there are non-pharmacological methods that enhance the brain. 00:07:15.264 --> 00:07:19.686 For example, glucose improves memory and makes it easier to memorize. 00:07:19.856 --> 00:07:24.960 Caffeine, coffee with sugar and espresso work really great. 00:07:25.460 --> 00:07:28.456 Physical exercise is essential, 00:07:28.456 --> 00:07:34.153 as it releases the substance nourishing the nerves, 00:07:34.193 --> 00:07:35.902 BDNF neurothrophins. 00:07:36.072 --> 00:07:40.202 A sleep or a nap after studying increases consolidation 00:07:40.202 --> 00:07:45.913 and transition from the short-term to the long-term memory. 00:07:46.037 --> 00:07:50.586 Meditation, mnemonics, computer training, electrical brain stimulation... 00:07:50.622 --> 00:07:53.205 All of these things are essential. 00:07:53.248 --> 00:07:57.691 On the other hand, we work hard and we are exhausted. 00:07:57.691 --> 00:08:00.996 We need to wake up quickly somehow. 00:08:00.996 --> 00:08:04.161 We usually use pharmacological methods to do so. 00:08:04.205 --> 00:08:08.147 There are so-called promnestic medicaments. 00:08:08.394 --> 00:08:12.525 These medicaments affect the biochemistry of our brain, 00:08:12.541 --> 00:08:15.289 which makes these processes faster. 00:08:15.306 --> 00:08:17.447 These medicaments become more and more common. 00:08:17.447 --> 00:08:22.278 Some politicians or ethicists have concerns, other people less so. 00:08:22.467 --> 00:08:26.015 When improving the brain, we can observe something that happens in sports. 00:08:26.015 --> 00:08:28.075 We appreciate sportsmen, 00:08:28.075 --> 00:08:30.849 the effort they put into training. 00:08:30.869 --> 00:08:36.986 But we don't like those who use doping before the competition. 00:08:37.086 --> 00:08:40.053 So, how is it? 00:08:40.064 --> 00:08:45.318 We want to stimulate our brain to work 00:08:45.365 --> 00:08:49.216 and we have medicaments for that, 00:08:49.266 --> 00:08:54.756 like caffeine in coffee or energy drinks. 00:08:54.861 --> 00:08:57.062 We also have three very precious stimulants, 00:08:57.062 --> 00:09:00.495 like amphetamine, methylphenidate and modafinil. 00:09:00.593 --> 00:09:04.342 Only coffeine is available without limits. 00:09:06.712 --> 00:09:11.491 After all, energy drinks have saved lives of plenty of passerbys, 00:09:11.604 --> 00:09:15.021 as they'd prevent the drivers from falling asleep at the wheel. 00:09:15.409 --> 00:09:17.318 These are different types of stimulants. 00:09:17.318 --> 00:09:21.942 They are used for illness treatments, 00:09:22.084 --> 00:09:24.322 most often in ADHD. 00:09:24.380 --> 00:09:30.026 For example, Adderall, a mixture of amphetamine salts, 00:09:30.196 --> 00:09:32.557 used to be sold in Poland as amphetamine. 00:09:32.557 --> 00:09:36.488 When I was a student, we'd go to a doctor. 00:09:36.488 --> 00:09:40.023 She would prescribe us two pills of amphetamine. 00:09:40.073 --> 00:09:42.082 I would have never passed maths... 00:09:42.120 --> 00:09:45.322 (Applause) 00:09:47.270 --> 00:09:50.271 Or I would have had to study much more. 00:09:50.271 --> 00:09:52.756 It's dangerous, because it may be addictive. 00:09:52.816 --> 00:09:57.629 In ADHD and narcolepsy, methylphenidate is used. 00:09:57.629 --> 00:09:59.314 It is known as Ritalin, 00:09:59.314 --> 00:10:04.884 which is now promoted for children. 00:10:04.884 --> 00:10:09.535 Take a look at this marvellous powder with Ritalin. 00:10:09.646 --> 00:10:15.611 It may be an exaggeration, but it does improve the child's brain. 00:10:15.611 --> 00:10:19.955 Modafinil, more and more popular, is less addictive. 00:10:19.991 --> 00:10:23.263 It improves accuracy of performed tasks 00:10:23.263 --> 00:10:25.593 and decision-making. 00:10:25.655 --> 00:10:29.675 Four years ago, the market for Modafinil 00:10:29.675 --> 00:10:33.971 reached 700 million dollars. 00:10:33.971 --> 00:10:40.000 Interestingly, 90% of the world production is used for non-medical purposes. 00:10:40.155 --> 00:10:44.922 In the USA, it is good to have a younger sibling suffering from ADHD. 00:10:44.962 --> 00:10:48.322 You can pilfer their medicaments and pass your exams easily. 00:10:48.322 --> 00:10:50.443 (Applause) 00:10:51.083 --> 00:10:54.494 This is atomoxetine, a new medicament. 00:10:54.547 --> 00:10:58.328 It can be treated as a lifestyle. 00:10:58.373 --> 00:11:01.301 It becomes and more popular among people 00:11:01.301 --> 00:11:05.512 who are forced to hard brainwork. 00:11:05.575 --> 00:11:08.614 That's what students and teachers do. 00:11:08.694 --> 00:11:10.488 They take mainly methylphenidate. 00:11:10.561 --> 00:11:12.682 It looks differently in different countries. 00:11:12.682 --> 00:11:14.094 For example, you can see here 00:11:14.094 --> 00:11:19.333 how academic staff in the USA and Great Britain do it. 00:11:20.278 --> 00:11:23.029 An American takes it when he suffers from "jet lag," 00:11:23.029 --> 00:11:25.879 An Englishwoman admits she takes it once every two weeks 00:11:25.879 --> 00:11:27.041 to keep her spirits up 00:11:27.041 --> 00:11:29.305 and when she has to write a grant application. 00:11:29.305 --> 00:11:32.767 Where do they get it from? The American gets it from a family doctor. 00:11:32.797 --> 00:11:36.457 The Englishwoman buys it online, which is possible in Poland too. 00:11:36.537 --> 00:11:39.415 And they both claim it gives certain effects, 00:11:39.445 --> 00:11:42.024 which are not stunning, but very desirable. 00:11:42.233 --> 00:11:45.148 But there are neuroethic issues. 00:11:45.241 --> 00:11:46.545 Can we really do that? 00:11:46.545 --> 00:11:48.554 Some compare it to doping in sports. 00:11:48.564 --> 00:11:50.487 For me, that's really not the case. 00:11:50.487 --> 00:11:52.117 In sports we want to know 00:11:52.117 --> 00:11:53.875 if somebody equally strong will win. 00:11:53.875 --> 00:11:55.544 But here, it's not about competing. 00:11:55.544 --> 00:11:59.014 If I want my students to learn a new language faster, 00:11:59.014 --> 00:12:03.920 then why not let them take something that will let them achieve that? 00:12:03.988 --> 00:12:06.148 (Applause) 00:12:08.052 --> 00:12:12.272 It's worse with the exam sessions, or competitive examination. 00:12:12.300 --> 00:12:14.947 Can we consider it as doping? 00:12:15.042 --> 00:12:18.260 This is really pretty. 00:12:18.415 --> 00:12:25.319 It says: "I'm confident you'll succeed at any job 00:12:25.319 --> 00:12:27.227 that requires no urine drug tests. 00:12:27.227 --> 00:12:30.476 Because if they run the tests, those drugs will be revealed. 00:12:30.521 --> 00:12:33.206 I think we won't avoid using these medicaments. 00:12:33.216 --> 00:12:37.479 But we shouldn't overdo it, we should be reasonable. 00:12:37.538 --> 00:12:40.523 Thinking about future technologies, there's still a lot to do. 00:12:40.543 --> 00:12:44.569 There will be target gene therapies, magnetic stimulation through the skull. 00:12:44.649 --> 00:12:47.439 Interface between the brain and the computer. 00:12:47.539 --> 00:12:50.879 Implanted neurochips, hippocampus prosthesis. 00:12:50.895 --> 00:12:52.040 And new medicaments. 00:12:52.040 --> 00:12:56.085 I want to add what experts say about it. 00:12:56.204 --> 00:13:02.475 Nora Volkow, the head of NIDA, the drug-combating organization. 00:13:02.505 --> 00:13:06.007 She should be against it, but she claims that if a drug can be created, 00:13:06.007 --> 00:13:09.703 one which has no side effects, then it shouldn't be banned. 00:13:09.723 --> 00:13:12.240 The human brain has come to the stage of evolution 00:13:12.240 --> 00:13:15.262 where it can improve the evolution by itself. 00:13:15.352 --> 00:13:20.848 David Nutt, a controversial figure, was fired from the British Drug Council 00:13:20.848 --> 00:13:27.200 after he said that horse riding accidents were 30 times as frequent as 00:13:27.200 --> 00:13:28.777 those after taking ecstasy. 00:13:28.847 --> 00:13:30.779 That's why he was given the sack. 00:13:30.848 --> 00:13:36.078 He claims that the discovery of these boosters is a milestone in the evolution. 00:13:36.268 --> 00:13:43.201 We no longer have to rely on the random story about genes, 00:13:43.251 --> 00:13:46.540 This is my humble opinion. 00:13:46.560 --> 00:13:50.704 I think those pharmacological resources, used to improve the mind, 00:13:50.774 --> 00:13:54.824 are disapproved of by dumb people whom nothing will help. 00:13:54.854 --> 00:13:55.704 (Laughter) 00:13:55.704 --> 00:13:57.850 (Applause) 00:14:01.559 --> 00:14:09.377 Chemistry itself is not enough for success, but it can help a lot. 00:14:09.450 --> 00:14:10.552 Thank you very much. 00:14:10.592 --> 00:14:13.209 (Applause)