[Applause] this looks like a very mild disease like a common cold in the majority of people there are certain people who get infected and have very serious illness among them are health workers it's a very serious infection in them as they get higher dose than normal people and at the same time they have no immunity so in in the general population it's likely that the dose of virus that you receive when you are infected is much less than the dose that a health worker would receive health workers having more serious infections so your infection would be less serious hopefully so that leaves the elderly and those with comorbidities to really be the ones that we have to make sure are taken care of in hospitals well the most concerned are people who are first of all in developing countries and who don't have access to good medical care and may not have access at all to a hospital should an epidemic occur in their country those people would be a great risk especially the elderly elderly in all populations are at risk but especially those who can't get to oxygen in industrialized countries it's the very elderly who have comorbidities who have diabetes who have other diseases who are at risk the general population doesn't appear to be a great risk first of all pulmonary disease existing as a comorbidity is also important in general the elderly are a greater risk especially those over 70 because their immune systems are not as effective as they might have once been and there are more susceptible to infections in addition in some instances in China there's been a CO infection with influenza and at the same time there have been some bacterial super infections on the pneumonias that are occurring Center for Disease Control in Atlanta keeps track and has updates on a regular basis on its website also the World Health Organization in Geneva which is coordinating many of the activities going on internationally also has a website with daily updates it's our responsibility to get that information as individuals so we understand and can make sure that we can contribute in our own way to prevention of major spread that's the same problem with all new infections this is an infection that's coming to humans who have never been exposed to this virus before they don't have any antibody protection and it's not clear whether their immune system can handle this virus or not this is a virus that usually finds itself in bats or in other animals and all of a sudden it's in humans and humans just don't have experience with this virus but gradually we are beginning to learn a lot as we did with SARS and you know there are certainly a larger number of deaths than there were with SARS but when you divide that by a denominator of persons who are infected there are many many more persons infected than that where with SARS the case fatality ratio that is the ratio of deaths to the numbers of cases in SARS was about 10 percent with the current coronavirus Koba 19 is 2 percent or probably less so it's a much less virulent virus but it's still a virus that causes mortality and that's what we don't want entering human populations it's clearly understood that airports or any land borders cannot prevent the disease from entering people in the incubation period can cross that border can enter countries and can then infect others when they become sick so its borders are not a means of preventing infections from entering a country by checking temperatures borders are important because you can provide to people arriving from areas that might be at risk of having had infection providing them with an understanding either a printed understanding or a verbal understanding of what the signs and symptoms are of this infection and what they should do if they feel that they might be infected vaccines are under development right now there's a lot of research going on that research requires first that the vaccine be developed then that it be studied for safety and effectiveness in animals who are challenged with the virus when they're after they're in vaccinated and then it was going to human studies the animal studies have not yet begun but will soon begin for certain vaccines and it's thought that by the end of the year or early next year there may be some candidate vaccines that can then be studied for licensing by regulatory agencies so we're talking about at least a year until there's vaccine available that can be used in many populations that's clear we know how it transmits we don't know how easily it transmits in humans in communities or in unenclosed areas we know and for example they did in the enclosed area of a cruise ship it spread very easily we need to better understand how it will spread once it gets into more open areas where people are exposed to people who might be sick a major problem in the world today is that we look at outbreaks in developing countries there's something that we need to go and stop so when there's an outbreak of Ebola we think how can we go and stop this outbreak because we don't think about how can we help that country strengthen its capacity so that it can detect and respond to infections so we haven't invested enough in helping countries develop their core capacity in public health what we've done is invested in many mechanisms globally which can provide support to other countries to go and help stop outbreaks but we want to see a world where every country can do its best to stop its own outbreaks today there are over seven billion people and when those people come into the world they demand more food they demand a whole series of things and they live closer together in fact we're in an urban world where people live in urban areas and at the same time we're growing more animals and those animals are contributing food to humans as well so what we see is that that animal human interface is becoming closer and closer together and and this intensive agriculture of animals and this intensive increase in human populations living together on the same planet is really a melting pot where outbreaks can occur and do occur we will eventually have more and more of these outbreaks so an emerging infection today is just a warning of what will happen in the future we have to make sure that that technical collaboration in the world is there to work together to make sure that we can understand these outbreaks when they occur and rapidly provide the information necessary to control I can't predict with accuracy so all I can say is that we must all be prepared for the worst-case scenario and at the same time learn how we can protect ourselves and protect others should we become a part of that a together [Music] you