[Script Info] Title: [Events] Format: Layer, Start, End, Style, Name, MarginL, MarginR, MarginV, Effect, Text Dialogue: 0,0:00:00.75,0:00:04.48,Default,,0000,0000,0000,,Știm din ultimul video că dacă\Navem o concentrație mare Dialogue: 0,0:00:04.48,0:00:09.04,Default,,0000,0000,0000,,de calciu ionic în celula musculară, \Nacești ioni Dialogue: 0,0:00:09.04,0:00:13.50,Default,,0000,0000,0000,,de calciu se vor lega \Nde troponină care va le Dialogue: 0,0:00:13.50,0:00:17.14,Default,,0000,0000,0000,,schimba formele într-un fel\Nîn care tropomiozina va Dialogue: 0,0:00:17.14,0:00:20.58,Default,,0000,0000,0000,,fi dată la o parte și deci apoi \Ncapetele de miozină pot Dialogue: 0,0:00:20.58,0:00:23.31,Default,,0000,0000,0000,,urca de-a lungul\Nfilamentelor de actină și apoi vom Dialogue: 0,0:00:23.31,0:00:24.95,Default,,0000,0000,0000,,avea de fapt, \Ncontracții musculare. Dialogue: 0,0:00:24.95,0:00:29.14,Default,,0000,0000,0000,,Deci concentrație ridicată de calciu, \Nsau concentrația ionilor de calciu, Dialogue: 0,0:00:29.14,0:00:30.85,Default,,0000,0000,0000,,avem contracție. Dialogue: 0,0:00:30.85,0:00:35.56,Default,,0000,0000,0000,,Concentrație scăzută de ioni de calciu,\Naceste proteine ​​troponine merg la Dialogue: 0,0:00:35.56,0:00:39.06,Default,,0000,0000,0000,,confirmarea lor standard și\Nele trag-- sau poți spune Dialogue: 0,0:00:39.06,0:00:42.60,Default,,0000,0000,0000,,mută tropomiozina înapoi \Nîn calea capetelor de Dialogue: 0,0:00:42.60,0:00:44.16,Default,,0000,0000,0000,,miozină-- și nu avem contracție. Dialogue: 0,0:00:53.75,0:00:57.14,Default,,0000,0000,0000,,Deci următoarea întrebare firească este, \Ncum regulează mușchiul Dialogue: 0,0:00:57.14,0:00:59.85,Default,,0000,0000,0000,,dacă avem concentrația\Nde calciu ridicată și Dialogue: 0,0:00:59.85,0:01:03.35,Default,,0000,0000,0000,,contracția sau concentrația\Nde calciu scăzută și relaxare? Dialogue: 0,0:01:03.35,0:01:04.94,Default,,0000,0000,0000,,Sau chiar o întrebare\Nmai bună este, cum face Dialogue: 0,0:01:04.94,0:01:05.83,Default,,0000,0000,0000,,sistemul nervos asta? Dialogue: 0,0:01:05.83,0:01:09.49,Default,,0000,0000,0000,,Cum le spune sistemul nervos \Nmușchilor să se contracte, Dialogue: 0,0:01:09.49,0:01:11.55,Default,,0000,0000,0000,,să facă concentrația de calciu ridicată și Dialogue: 0,0:01:11.55,0:01:14.01,Default,,0000,0000,0000,,contracție sau să o facă \Nscăzută din nou și relaxare? Dialogue: 0,0:01:14.01,0:01:17.90,Default,,0000,0000,0000,,Și pentru a înțelege asta, \Nhai să facem o mică recenzie a Dialogue: 0,0:01:17.90,0:01:20.79,Default,,0000,0000,0000,,ceea ce am învățat în\Nvideoclipurile despre neuroni. Dialogue: 0,0:01:20.79,0:01:24.00,Default,,0000,0000,0000,,Lasă-mă să desenez terminalul jocțiunei Dialogue: 0,0:01:24.00,0:01:27.50,Default,,0000,0000,0000,,unui axon, aici. Dialogue: 0,0:01:27.50,0:01:30.54,Default,,0000,0000,0000,,În loc să aibă o sinapsă \Ncu o dendrită a unui alt Dialogue: 0,0:01:30.54,0:01:32.89,Default,,0000,0000,0000,,neuron, va avea o sinapsă cu o Dialogue: 0,0:01:32.89,0:01:35.13,Default,,0000,0000,0000,,celulă musculară reală. Dialogue: 0,0:01:35.13,0:01:37.14,Default,,0000,0000,0000,,Deci aici este sinapsa\Ncu celula musculară reală. Dialogue: 0,0:01:44.42,0:01:47.17,Default,,0000,0000,0000,,Asta este o sinapsă cu o celulă musculară. Dialogue: 0,0:01:47.17,0:01:50.07,Default,,0000,0000,0000,,Lasă-mă să notez tot \Npentru a nu deveni confuz. Dialogue: 0,0:01:50.07,0:01:51.47,Default,,0000,0000,0000,,Acesta este axonul. Dialogue: 0,0:01:51.47,0:01:53.47,Default,,0000,0000,0000,,Îl putem numi capătul \Nterminalului unui axon. Dialogue: 0,0:01:57.61,0:01:58.86,Default,,0000,0000,0000,,Asta este sinapsa. Dialogue: 0,0:02:05.44,0:02:08.15,Default,,0000,0000,0000,,Doar puțină terminologie din\Nvideoclipurile despre neuroni-- acest spațiu Dialogue: 0,0:02:08.15,0:02:10.21,Default,,0000,0000,0000,,era o despicătură sinaptică. Dialogue: 0,0:02:10.21,0:02:13.65,Default,,0000,0000,0000,,Acesta este neuronul presinaptic. Dialogue: 0,0:02:13.65,0:02:15.43,Default,,0000,0000,0000,,Ăsta este-- cred că \Nîl poți vedea cumva-- Dialogue: 0,0:02:15.43,0:02:16.83,Default,,0000,0000,0000,,celula postsinaptică. Dialogue: 0,0:02:16.83,0:02:19.05,Default,,0000,0000,0000,,Nu este un neuron în acest caz. Dialogue: 0,0:02:19.05,0:02:21.09,Default,,0000,0000,0000,,Și apoi așa avem-- acesta este Dialogue: 0,0:02:21.09,0:02:30.24,Default,,0000,0000,0000,,membrane celulei musculare. Dialogue: 0,0:02:30.24,0:02:32.54,Default,,0000,0000,0000,,Și voi face-- probabil \Nurmătorul video sau poate Dialogue: 0,0:02:32.54,0:02:34.53,Default,,0000,0000,0000,,un video după asta,\Nîți voi arăta anatomia Dialogue: 0,0:02:34.53,0:02:35.61,Default,,0000,0000,0000,,unei celule musculare. Dialogue: 0,0:02:35.61,0:02:37.23,Default,,0000,0000,0000,,Aici, va fi puțin abstract\Ndeoarece chiar Dialogue: 0,0:02:37.23,0:02:39.30,Default,,0000,0000,0000,,vrem să înțelegem cum concentrația Dialogue: 0,0:02:39.30,0:02:42.81,Default,,0000,0000,0000,,ionului de calciu este regulată. Dialogue: 0,0:02:42.81,0:02:44.06,Default,,0000,0000,0000,,Aceasta se\Nnumește sarcolemă. Dialogue: 0,0:02:53.58,0:02:56.12,Default,,0000,0000,0000,,Deci asta este membrana celulei musculare. Dialogue: 0,0:02:56.12,0:02:59.07,Default,,0000,0000,0000,,Iar asta de aici-- ți-ai putea\Nimagina că este doar un pliu Dialogue: 0,0:02:59.07,0:03:00.98,Default,,0000,0000,0000,,în membrana celulei musculare. Dialogue: 0,0:03:00.98,0:03:04.00,Default,,0000,0000,0000,,Dacă ar fi să mă uit \Nla suprafața celulei musculare, Dialogue: 0,0:03:04.00,0:03:05.85,Default,,0000,0000,0000,,ar arăta puțin cam ca o gaură sau Dialogue: 0,0:03:05.85,0:03:09.04,Default,,0000,0000,0000,,o indentare care intră în celulă,\Ndar aici am făcut o Dialogue: 0,0:03:09.04,0:03:14.00,Default,,0000,0000,0000,,secțiune transversală, \Nașa că îți poți imagina pliindu-se, dar dacă Dialogue: 0,0:03:14.00,0:03:16.59,Default,,0000,0000,0000,,ai înțepat cu un ac sau ceva, asta este Dialogue: 0,0:03:16.59,0:03:17.24,Default,,0000,0000,0000,,ceea ce vei primi. Dialogue: 0,0:03:17.24,0:03:19.10,Default,,0000,0000,0000,,Vei avea un pliu în membrană. Dialogue: 0,0:03:19.10,0:03:20.46,Default,,0000,0000,0000,,Iar ăsta de aici \Neste numit tubul T. Dialogue: 0,0:03:26.36,0:03:28.10,Default,,0000,0000,0000,,Iar T-ul vine de la transversal. Dialogue: 0,0:03:28.10,0:03:31.72,Default,,0000,0000,0000,,Merge transversal către\Nsuprafața membranei. Dialogue: 0,0:03:31.72,0:03:35.06,Default,,0000,0000,0000,,Și chiar aici-- iar acesta \Neste un lucru foarte important în Dialogue: 0,0:03:35.06,0:03:36.56,Default,,0000,0000,0000,,acest video, \Nsau organita foarte Dialogue: 0,0:03:36.56,0:03:37.52,Default,,0000,0000,0000,,importantă din acest video. Dialogue: 0,0:03:37.52,0:03:42.41,Default,,0000,0000,0000,,Ai acest organit în celula musculară numit Dialogue: 0,0:03:42.41,0:03:43.89,Default,,0000,0000,0000,,reticulul sarcoplasmic. Dialogue: 0,0:03:54.74,0:03:57.70,Default,,0000,0000,0000,,Și este de fapt destul de \Nasemănător cu un reticul Dialogue: 0,0:03:57.70,0:04:03.18,Default,,0000,0000,0000,,endoplasmatic într-un fel sau poate este Dialogue: 0,0:04:03.18,0:04:06.75,Default,,0000,0000,0000,,legat de un reticul endoplasmatic-- \Ndar aici principala funcție Dialogue: 0,0:04:06.75,0:04:07.76,Default,,0000,0000,0000,,este stocarea. Dialogue: 0,0:04:07.76,0:04:10.40,Default,,0000,0000,0000,,În timp ce un reticul endoplasmatic, \Neste implicat în Dialogue: 0,0:04:10.40,0:04:14.47,Default,,0000,0000,0000,,dezvoltarea proteinei\Nși are ribozomi atașați, dar Dialogue: 0,0:04:14.47,0:04:18.86,Default,,0000,0000,0000,,dar acesta este doar un organit depozit. Dialogue: 0,0:04:18.86,0:04:22.50,Default,,0000,0000,0000,,Ceea ce face reticulul sarcoplasmic \Neste că are pompe Dialogue: 0,0:04:22.50,0:04:32.92,Default,,0000,0000,0000,,de calciu ionic pe membrană \Nși acestea sunt ATPaze, Dialogue: 0,0:04:32.92,0:04:37.53,Default,,0000,0000,0000,,ceea ce înseamnă că folosesc ATP\Npentru a alimenta pompa. Dialogue: 0,0:04:37.53,0:04:42.45,Default,,0000,0000,0000,,Deci ai ATP, ATP-ul\Nse atașează de ea, și poate un Dialogue: 0,0:04:42.45,0:04:52.62,Default,,0000,0000,0000,,ion de calciu se va atașa,\Nși când ATP-ul este hidrolizat Dialogue: 0,0:04:52.62,0:05:01.47,Default,,0000,0000,0000,,în ADP plus o grupare fosfat, care schimbă Dialogue: 0,0:05:01.47,0:05:04.14,Default,,0000,0000,0000,,confirmarea acestei proteine și pompează Dialogue: 0,0:05:04.14,0:05:05.70,Default,,0000,0000,0000,,ionul de calciu înăuntru. Dialogue: 0,0:05:05.70,0:05:08.23,Default,,0000,0000,0000,,Deci ionii de calciu \Nsunt pompați înăuntru. Dialogue: 0,0:05:08.23,0:05:12.61,Default,,0000,0000,0000,,Deci efectul tuturor\Npompelor de calciu ionic de pe Dialogue: 0,0:05:12.61,0:05:16.54,Default,,0000,0000,0000,,membrana reticulului sarcoplasmic \Neste într-un mușchi Dialogue: 0,0:05:16.54,0:05:20.70,Default,,0000,0000,0000,,în repaus, vom avea o concentrație\Nfoarte mare de ioni de calciu Dialogue: 0,0:05:20.70,0:05:21.95,Default,,0000,0000,0000,,înăuntru. Dialogue: 0,0:05:26.63,0:05:28.57,Default,,0000,0000,0000,,Acum, cred că ai putea ghici probabil Dialogue: 0,0:05:28.57,0:05:29.98,Default,,0000,0000,0000,,unde duce asta. Dialogue: 0,0:05:29.98,0:05:33.01,Default,,0000,0000,0000,,Când mușchiul trebuie să se contracte, \Nacești ioni de calciu Dialogue: 0,0:05:33.01,0:05:37.32,Default,,0000,0000,0000,,sunt aruncați în citoplasma celulei. Dialogue: 0,0:05:37.32,0:05:42.61,Default,,0000,0000,0000,,Și apoi sunt capabili\Nsă se lege de troponina de aici, Dialogue: 0,0:05:42.61,0:05:45.12,Default,,0000,0000,0000,,și să facă tot ce\Nam vorbit în ultimul video. Dialogue: 0,0:05:45.12,0:05:49.18,Default,,0000,0000,0000,,Deci ceea ce ne interesează este, \Ndoar cum știe când să-și arunce Dialogue: 0,0:05:49.18,0:05:51.76,Default,,0000,0000,0000,,ionii de calciu în restul celulei? Dialogue: 0,0:05:51.76,0:05:53.14,Default,,0000,0000,0000,,Acesta este\Ninteriorul celulei. Dialogue: 0,0:06:00.37,0:06:06.36,Default,,0000,0000,0000,,Și deci această suprafață este\Nceea ce filamentele de actină și capetele Dialogue: 0,0:06:06.36,0:06:09.35,Default,,0000,0000,0000,,de miozină și tot restul, și troponina, și Dialogue: 0,0:06:09.35,0:06:12.23,Default,,0000,0000,0000,,tropomiozina-- sunt toate expuse mediului Dialogue: 0,0:06:12.23,0:06:13.32,Default,,0000,0000,0000,,care este aici. Dialogue: 0,0:06:13.32,0:06:15.28,Default,,0000,0000,0000,,Deci îți poți imagina--\Naș putea să desenez aici Dialogue: 0,0:06:15.28,0:06:16.53,Default,,0000,0000,0000,,pentru a clarifica. Dialogue: 0,0:06:21.48,0:06:22.69,Default,,0000,0000,0000,,Îl voi desena foarte abstract. Dialogue: 0,0:06:22.69,0:06:24.48,Default,,0000,0000,0000,,Vom vedea mai mult\Ndin structură într-un video viitor. Dialogue: 0,0:06:38.65,0:06:40.87,Default,,0000,0000,0000,,Acesta este un desen foarte abstract, \Ndar cred că-ți va Dialogue: 0,0:06:40.87,0:06:42.65,Default,,0000,0000,0000,,da un sens a ceea ce se întâmplă. Dialogue: 0,0:06:42.65,0:06:45.51,Default,,0000,0000,0000,,Deci să spunem că acest neuron--\Nși îl vom numi un neuron Dialogue: 0,0:06:45.51,0:06:54.38,Default,,0000,0000,0000,,motor-- semnalează pentru\No contracție musculară. Dialogue: 0,0:06:54.38,0:06:57.61,Default,,0000,0000,0000,,Pentru început, știm cum\Ntraversează semnalele neuronii, Dialogue: 0,0:06:57.61,0:07:01.10,Default,,0000,0000,0000,,în special prin axoni cu\Nun potențial de acțiune. Dialogue: 0,0:07:01.10,0:07:04.46,Default,,0000,0000,0000,,Am putea avea un canal sodic chiar aici. Dialogue: 0,0:07:04.46,0:07:07.41,Default,,0000,0000,0000,,Are voltaj, deci ai puțină tensiune Dialogue: 0,0:07:07.41,0:07:08.50,Default,,0000,0000,0000,,pozitivă acolo. Dialogue: 0,0:07:08.50,0:07:12.42,Default,,0000,0000,0000,,Asta spune acestei tensiuni\Nlegată de canalul sodic să se deschidă. Dialogue: 0,0:07:12.42,0:07:16.16,Default,,0000,0000,0000,,Deci se deschide și permite \Nsă intre chiar mai mult sodiu. Dialogue: 0,0:07:16.16,0:07:18.34,Default,,0000,0000,0000,,Asta îl face puțin mai pozitiv aici. Dialogue: 0,0:07:18.34,0:07:21.88,Default,,0000,0000,0000,, Dialogue: 0,0:07:21.88,0:07:25.01,Default,,0000,0000,0000,, Dialogue: 0,0:07:25.01,0:07:28.41,Default,,0000,0000,0000,, Dialogue: 0,0:07:28.41,0:07:32.59,Default,,0000,0000,0000,, Dialogue: 0,0:07:36.06,0:07:37.68,Default,,0000,0000,0000,, Dialogue: 0,0:07:37.68,0:07:39.74,Default,,0000,0000,0000,, Dialogue: 0,0:07:39.74,0:07:41.76,Default,,0000,0000,0000,, Dialogue: 0,0:07:41.76,0:07:44.29,Default,,0000,0000,0000,, Dialogue: 0,0:07:44.29,0:07:46.30,Default,,0000,0000,0000,, Dialogue: 0,0:07:46.30,0:07:50.06,Default,,0000,0000,0000,, Dialogue: 0,0:07:50.06,0:07:53.95,Default,,0000,0000,0000,, Dialogue: 0,0:07:53.95,0:07:54.85,Default,,0000,0000,0000,, Dialogue: 0,0:07:54.85,0:07:56.01,Default,,0000,0000,0000,, Dialogue: 0,0:07:56.01,0:08:00.99,Default,,0000,0000,0000,, Dialogue: 0,0:08:00.99,0:08:08.17,Default,,0000,0000,0000,, Dialogue: 0,0:08:08.17,0:08:09.42,Default,,0000,0000,0000,, Dialogue: 0,0:08:13.25,0:08:17.50,Default,,0000,0000,0000,, Dialogue: 0,0:08:17.50,0:08:18.84,Default,,0000,0000,0000,, Dialogue: 0,0:08:18.84,0:08:22.85,Default,,0000,0000,0000,, Dialogue: 0,0:08:22.85,0:08:25.19,Default,,0000,0000,0000,, Dialogue: 0,0:08:25.19,0:08:26.60,Default,,0000,0000,0000,, Dialogue: 0,0:08:26.60,0:08:28.67,Default,,0000,0000,0000,, Dialogue: 0,0:08:28.67,0:08:31.47,Default,,0000,0000,0000,, Dialogue: 0,0:08:31.47,0:08:32.49,Default,,0000,0000,0000,, Dialogue: 0,0:08:32.49,0:08:34.50,Default,,0000,0000,0000,, Dialogue: 0,0:08:34.50,0:08:38.81,Default,,0000,0000,0000,, Dialogue: 0,0:08:38.81,0:08:39.45,Default,,0000,0000,0000,, Dialogue: 0,0:08:39.45,0:08:41.06,Default,,0000,0000,0000,, Dialogue: 0,0:08:47.13,0:08:49.32,Default,,0000,0000,0000,, Dialogue: 0,0:08:49.32,0:08:53.99,Default,,0000,0000,0000,, Dialogue: 0,0:08:53.99,0:08:57.41,Default,,0000,0000,0000,, Dialogue: 0,0:08:57.41,0:08:58.82,Default,,0000,0000,0000,, Dialogue: 0,0:08:58.82,0:09:02.33,Default,,0000,0000,0000,, Dialogue: 0,0:09:02.33,0:09:07.21,Default,,0000,0000,0000,, Dialogue: 0,0:09:07.21,0:09:11.15,Default,,0000,0000,0000,, Dialogue: 0,0:09:11.15,0:09:16.24,Default,,0000,0000,0000,, Dialogue: 0,0:09:16.24,0:09:18.58,Default,,0000,0000,0000,, Dialogue: 0,0:09:18.58,0:09:19.99,Default,,0000,0000,0000,, Dialogue: 0,0:09:19.99,0:09:22.51,Default,,0000,0000,0000,, Dialogue: 0,0:09:22.51,0:09:26.68,Default,,0000,0000,0000,, Dialogue: 0,0:09:26.68,0:09:29.10,Default,,0000,0000,0000,, Dialogue: 0,0:09:29.10,0:09:32.38,Default,,0000,0000,0000,, Dialogue: 0,0:09:32.38,0:09:35.08,Default,,0000,0000,0000,, Dialogue: 0,0:09:35.08,0:09:37.04,Default,,0000,0000,0000,, Dialogue: 0,0:09:37.04,0:09:38.87,Default,,0000,0000,0000,, Dialogue: 0,0:09:38.87,0:09:41.97,Default,,0000,0000,0000,, Dialogue: 0,0:09:41.97,0:09:43.17,Default,,0000,0000,0000,, Dialogue: 0,0:09:43.17,0:09:44.78,Default,,0000,0000,0000,, Dialogue: 0,0:09:44.78,0:09:47.71,Default,,0000,0000,0000,, Dialogue: 0,0:09:47.71,0:09:49.75,Default,,0000,0000,0000,, Dialogue: 0,0:09:49.75,0:09:51.25,Default,,0000,0000,0000,, Dialogue: 0,0:09:51.25,0:09:53.23,Default,,0000,0000,0000,, Dialogue: 0,0:09:53.23,0:09:57.95,Default,,0000,0000,0000,, Dialogue: 0,0:09:57.95,0:10:00.23,Default,,0000,0000,0000,, Dialogue: 0,0:10:00.23,0:10:03.93,Default,,0000,0000,0000,, Dialogue: 0,0:10:03.93,0:10:06.37,Default,,0000,0000,0000,, Dialogue: 0,0:10:06.37,0:10:07.88,Default,,0000,0000,0000,, Dialogue: 0,0:10:07.88,0:10:10.56,Default,,0000,0000,0000,, Dialogue: 0,0:10:10.56,0:10:13.67,Default,,0000,0000,0000,, Dialogue: 0,0:10:13.67,0:10:17.86,Default,,0000,0000,0000,, Dialogue: 0,0:10:17.86,0:10:20.94,Default,,0000,0000,0000,, Dialogue: 0,0:10:20.94,0:10:23.01,Default,,0000,0000,0000,, Dialogue: 0,0:10:23.01,0:10:28.60,Default,,0000,0000,0000,, Dialogue: 0,0:10:28.60,0:10:31.18,Default,,0000,0000,0000,, Dialogue: 0,0:10:31.18,0:10:34.97,Default,,0000,0000,0000,, Dialogue: 0,0:10:34.97,0:10:36.27,Default,,0000,0000,0000,, Dialogue: 0,0:10:36.27,0:10:44.17,Default,,0000,0000,0000,, Dialogue: 0,0:10:44.17,0:10:51.18,Default,,0000,0000,0000,, Dialogue: 0,0:10:56.29,0:10:59.55,Default,,0000,0000,0000,, Dialogue: 0,0:10:59.55,0:11:04.55,Default,,0000,0000,0000,, Dialogue: 0,0:11:04.55,0:11:06.72,Default,,0000,0000,0000,, Dialogue: 0,0:11:06.72,0:11:09.88,Default,,0000,0000,0000,, Dialogue: 0,0:11:09.88,0:11:16.28,Default,,0000,0000,0000,, Dialogue: 0,0:11:16.28,0:11:17.61,Default,,0000,0000,0000,, Dialogue: 0,0:11:17.61,0:11:20.92,Default,,0000,0000,0000,, Dialogue: 0,0:11:20.92,0:11:23.93,Default,,0000,0000,0000,, Dialogue: 0,0:11:23.93,0:11:27.79,Default,,0000,0000,0000,, Dialogue: 0,0:11:27.79,0:11:30.33,Default,,0000,0000,0000,, Dialogue: 0,0:11:30.33,0:11:31.01,Default,,0000,0000,0000,, Dialogue: 0,0:11:31.01,0:11:33.10,Default,,0000,0000,0000,, Dialogue: 0,0:11:33.10,0:11:36.98,Default,,0000,0000,0000,, Dialogue: 0,0:11:36.98,0:11:40.07,Default,,0000,0000,0000,, Dialogue: 0,0:11:40.07,0:11:42.26,Default,,0000,0000,0000,, Dialogue: 0,0:11:42.26,0:11:45.92,Default,,0000,0000,0000,, Dialogue: 0,0:11:45.92,0:11:47.10,Default,,0000,0000,0000,, Dialogue: 0,0:11:47.10,0:11:49.03,Default,,0000,0000,0000,, Dialogue: 0,0:11:49.03,0:11:52.57,Default,,0000,0000,0000,, Dialogue: 0,0:11:52.57,0:11:57.29,Default,,0000,0000,0000,, Dialogue: 0,0:11:57.29,0:12:03.87,Default,,0000,0000,0000,, Dialogue: 0,0:12:03.87,0:12:07.61,Default,,0000,0000,0000,, Dialogue: 0,0:12:07.61,0:12:10.23,Default,,0000,0000,0000,, Dialogue: 0,0:12:10.23,0:12:12.55,Default,,0000,0000,0000,, Dialogue: 0,0:12:12.55,0:12:14.67,Default,,0000,0000,0000,, Dialogue: 0,0:12:14.67,0:12:17.39,Default,,0000,0000,0000,, Dialogue: 0,0:12:17.39,0:12:18.75,Default,,0000,0000,0000,, Dialogue: 0,0:12:18.75,0:12:23.39,Default,,0000,0000,0000,, Dialogue: 0,0:12:23.39,0:12:26.52,Default,,0000,0000,0000,, Dialogue: 0,0:12:26.52,0:12:30.05,Default,,0000,0000,0000,, Dialogue: 0,0:12:30.05,0:12:35.03,Default,,0000,0000,0000,, Dialogue: 0,0:12:35.03,0:12:39.29,Default,,0000,0000,0000,, Dialogue: 0,0:12:39.29,0:12:41.18,Default,,0000,0000,0000,, Dialogue: 0,0:12:41.18,0:12:45.07,Default,,0000,0000,0000,, Dialogue: 0,0:12:45.07,0:12:46.09,Default,,0000,0000,0000,, Dialogue: 0,0:12:46.09,0:12:49.07,Default,,0000,0000,0000,, Dialogue: 0,0:12:49.07,0:12:52.44,Default,,0000,0000,0000,, Dialogue: 0,0:12:52.44,0:12:55.33,Default,,0000,0000,0000,, Dialogue: 0,0:12:55.33,0:12:58.83,Default,,0000,0000,0000,, Dialogue: 0,0:12:58.83,0:13:00.33,Default,,0000,0000,0000,, Dialogue: 0,0:13:00.33,0:13:03.19,Default,,0000,0000,0000,, Dialogue: 0,0:13:03.19,0:13:06.04,Default,,0000,0000,0000,, Dialogue: 0,0:13:06.04,0:13:11.28,Default,,0000,0000,0000,, Dialogue: 0,0:13:11.28,0:13:12.09,Default,,0000,0000,0000,, Dialogue: 0,0:13:12.09,0:13:14.16,Default,,0000,0000,0000,, Dialogue: 0,0:13:14.16,0:13:16.20,Default,,0000,0000,0000,, Dialogue: 0,0:13:16.20,0:13:19.14,Default,,0000,0000,0000,, Dialogue: 0,0:13:19.14,0:13:21.36,Default,,0000,0000,0000,, Dialogue: 0,0:13:21.36,0:13:22.33,Default,,0000,0000,0000,, Dialogue: 0,0:13:22.33,0:13:25.74,Default,,0000,0000,0000,, Dialogue: 0,0:13:25.74,0:13:27.90,Default,,0000,0000,0000,, Dialogue: 0,0:13:27.90,0:13:31.63,Default,,0000,0000,0000,, Dialogue: 0,0:13:31.63,0:13:34.21,Default,,0000,0000,0000,, Dialogue: 0,0:13:34.21,0:13:37.05,Default,,0000,0000,0000,, Dialogue: 0,0:13:37.05,0:13:37.77,Default,,0000,0000,0000,, Dialogue: 0,0:13:37.77,0:13:41.96,Default,,0000,0000,0000,, Dialogue: 0,0:13:41.96,0:13:44.75,Default,,0000,0000,0000,, Dialogue: 0,0:13:44.75,0:13:47.44,Default,,0000,0000,0000,, Dialogue: 0,0:13:47.44,0:13:48.49,Default,,0000,0000,0000,, Dialogue: 0,0:13:48.49,0:13:49.77,Default,,0000,0000,0000,, Dialogue: 0,0:13:49.77,0:13:53.77,Default,,0000,0000,0000,, Dialogue: 0,0:13:53.77,0:14:00.24,Default,,0000,0000,0000,, Dialogue: 0,0:14:00.24,0:14:03.49,Default,,0000,0000,0000,, Dialogue: 0,0:14:03.49,0:14:04.59,Default,,0000,0000,0000,, Dialogue: 0,0:14:04.59,0:14:07.24,Default,,0000,0000,0000,, Dialogue: 0,0:14:07.24,0:14:08.74,Default,,0000,0000,0000,, Dialogue: 0,0:14:08.74,0:14:11.98,Default,,0000,0000,0000,, Dialogue: 0,0:14:11.98,0:14:16.90,Default,,0000,0000,0000,, Dialogue: 0,0:14:16.90,0:14:19.07,Default,,0000,0000,0000,, Dialogue: 0,0:14:19.07,0:14:22.10,Default,,0000,0000,0000,, Dialogue: 0,0:14:22.10,0:14:25.82,Default,,0000,0000,0000,, Dialogue: 0,0:14:25.82,0:14:28.87,Default,,0000,0000,0000,, Dialogue: 0,0:14:28.87,0:14:33.52,Default,,0000,0000,0000,, Dialogue: 0,0:14:33.52,0:14:34.67,Default,,0000,0000,0000,, Dialogue: 0,0:14:34.67,0:14:37.50,Default,,0000,0000,0000,, Dialogue: 0,0:14:37.50,0:14:40.03,Default,,0000,0000,0000,, Dialogue: 0,0:14:40.03,0:14:41.84,Default,,0000,0000,0000,,