0:00:01.667,0:00:05.229 I started life as a fashion designer, 0:00:05.253,0:00:09.486 working closely with textile designers[br]and fabric suppliers. 0:00:10.458,0:00:15.323 But today, I can no longer see[br]or talk to my new collaborators, 0:00:15.347,0:00:18.434 because they're in the soil[br]beneath our feet, 0:00:18.458,0:00:20.846 on the shelves of our supermarkets 0:00:20.870,0:00:23.813 and in the beer I'm going to drink[br]when I finish this talk. 0:00:25.720,0:00:28.299 I'm talking about microbes 0:00:28.323,0:00:30.662 and designing with life. 0:00:31.958,0:00:33.149 Fifteen years ago, 0:00:33.173,0:00:36.379 I completely changed[br]both what I worked with 0:00:36.403,0:00:37.569 and how I worked, 0:00:37.593,0:00:41.061 after a revelatory collaboration[br]with a biologist. 0:00:41.775,0:00:46.664 Our project gave me[br]a different perspective on life, 0:00:46.688,0:00:49.811 introducing a whole new[br]world of possibility 0:00:49.835,0:00:52.958 around how we can design and make things. 0:00:53.561,0:00:57.378 I discovered a radical[br]manufacturing proposition: 0:00:58.323,0:00:59.679 biofabrication. 0:01:00.172,0:01:04.251 Literally, fabricating with biology. 0:01:05.212,0:01:06.632 What does that mean? 0:01:06.656,0:01:11.871 Well, instead of processing[br]plants, animals or oil 0:01:11.895,0:01:14.347 to make consumer materials, 0:01:14.371,0:01:19.991 we might grow materials directly[br]with living organisms. 0:01:20.618,0:01:24.634 In what many are terming[br]"the Fourth Industrial Revolution," 0:01:24.658,0:01:29.178 we're thinking about the new factories[br]as being living cells. 0:01:29.568,0:01:33.504 Bacteria, algae, fungi, yeast: 0:01:33.528,0:01:38.710 our latest design tools[br]include those of biotechnology. 0:01:39.212,0:01:41.887 My own journey in biofabrication 0:01:41.911,0:01:44.644 started with a project[br]called "Biocouture." 0:01:45.522,0:01:49.857 The provocation was that instead[br]of growing a plant, like cotton, 0:01:49.881,0:01:52.174 in a field over several months, 0:01:52.198,0:01:58.481 we could use microbes to grow[br]a similar cellulose material in a lab 0:01:58.505,0:01:59.934 in a few days. 0:01:59.958,0:02:04.577 Using a certain species of bacteria[br]in a nutrient-rich liquid, 0:02:04.601,0:02:07.982 we fermented threads of cellulose 0:02:08.006,0:02:12.188 that self-organized[br]into a sheet of fabric. 0:02:12.529,0:02:15.474 I dried the fabric I had grown 0:02:15.498,0:02:21.110 and cut and sewed it[br]into a range of garments, shoes and bags. 0:02:21.134,0:02:24.373 In other words,[br]in one lab we grew materials 0:02:24.397,0:02:26.761 and turned them into a range of products 0:02:26.785,0:02:28.745 in a matter of days. 0:02:28.769,0:02:33.292 And this is in contrast[br]to currents methods of fabric production, 0:02:33.316,0:02:35.808 where a plant is grown, 0:02:35.832,0:02:38.927 just the cotton part is harvested, 0:02:38.951,0:02:40.736 processed into a yarn, 0:02:40.760,0:02:42.529 woven into a fabric 0:02:42.553,0:02:45.307 and then potentially shipped across oceans 0:02:45.331,0:02:48.482 before being cut and sewn into a garment. 0:02:48.506,0:02:51.125 All of that can take months. 0:02:52.016,0:02:55.112 So these prototypes indicated a field 0:02:55.136,0:02:58.548 offering significant[br]resource efficiencies. 0:02:58.572,0:03:02.537 From reducing the water,[br]energy and chemistry needed 0:03:02.561,0:03:04.925 in the production of a material, 0:03:04.949,0:03:08.339 through to generating zero waste, 0:03:08.363,0:03:11.926 we grew fabrics to finished form -- 0:03:11.950,0:03:16.803 if you like, "biological[br]additive manufacture." 0:03:17.307,0:03:19.974 Through biofabrication, 0:03:19.998,0:03:24.299 I had replaced many[br]intensive man-made steps 0:03:24.323,0:03:26.738 with one biological step. 0:03:27.433,0:03:30.155 And as I engaged with this living system, 0:03:30.179,0:03:32.446 it transformed my design thinking. 0:03:32.973,0:03:37.234 Here was biology,[br]with no intervention from me 0:03:37.258,0:03:41.615 other than designing initial[br]conditions for growth, 0:03:41.639,0:03:45.660 efficiently producing a useful,[br]sustainable material. 0:03:46.996,0:03:53.782 So now I can't help but see all materials[br]through the lens of biofabrication. 0:03:53.806,0:03:59.300 In fact, there's a growing[br]global community of innovators 0:03:59.324,0:04:02.887 rethinking materials with biology. 0:04:03.498,0:04:08.283 Multiple companies are now[br]growing mushroom materials, 0:04:08.307,0:04:10.236 but not literally mushrooms -- 0:04:10.260,0:04:15.371 using mycelium, which is[br]the root system of fungi, 0:04:15.395,0:04:19.177 to bind together agricultural byproducts. 0:04:19.201,0:04:23.322 It's a process that's been[br]described as "nature's glue." 0:04:23.680,0:04:27.355 A common way to do this[br]is to take a 3-D mold, 0:04:27.379,0:04:32.831 fill it with a waste crop[br]like corn stalks or hemp, 0:04:32.855,0:04:34.450 add water, 0:04:34.474,0:04:38.553 wait a few days for the mycelium[br]to grow throughout, 0:04:38.577,0:04:40.029 remove the mold, 0:04:40.053,0:04:43.327 and you're left with a grown 3-D form. 0:04:44.601,0:04:48.268 Incredibly, we can grow[br]all kinds of structures 0:04:48.292,0:04:50.688 using living organisms, 0:04:50.712,0:04:54.920 from foams that can replace[br]plastics in footwear, 0:04:54.944,0:04:57.833 to leather-like materials without animals. 0:04:57.857,0:05:01.730 Furniture, flooring -- all[br]are currently being prototyped. 0:05:01.754,0:05:07.472 Fungi are able to grow materials[br]that are naturally fire retardant, 0:05:07.496,0:05:09.336 without any chemicals. 0:05:09.638,0:05:11.368 They're naturally hydrophobic, 0:05:11.392,0:05:13.622 meaning they won't absorb water. 0:05:13.646,0:05:17.107 They have higher melt[br]temperatures than plastics. 0:05:18.357,0:05:22.801 Polystyrene can take thousands[br]of years to degrade. 0:05:23.722,0:05:26.252 Mushroom packaging materials 0:05:26.276,0:05:29.950 can be naturally composted[br]in your back garden, 0:05:29.974,0:05:32.442 in as little as 30 days. 0:05:33.442,0:05:36.387 Living organisms are transforming waste 0:05:36.411,0:05:40.879 into cost-competitive,[br]performance-matching materials 0:05:40.903,0:05:43.167 that can start to replace plastics 0:05:43.191,0:05:46.319 and other CO2-emitting materials. 0:05:46.924,0:05:50.543 And once we start growing materials[br]with living organisms, 0:05:50.567,0:05:56.212 it starts to make previous methods[br]of manufacture seem illogical. 0:05:57.300,0:05:59.451 Take the humble house brick. 0:06:01.007,0:06:04.053 The cement industry generates[br]around eight percent 0:06:04.077,0:06:05.942 of global CO2 emissions. 0:06:05.966,0:06:09.355 That's more than all the planes[br]and ships each year. 0:06:09.958,0:06:15.287 The cement process[br]requires materials to be fired in a kiln 0:06:15.311,0:06:18.506 at over 2,000 degrees Fahrenheit. 0:06:19.504,0:06:22.632 Compare this to bioMASON. 0:06:23.195,0:06:27.767 They use a soil microbe[br]to transform loose aggregates, 0:06:27.791,0:06:30.409 like sand or crushed stone, 0:06:30.433,0:06:34.712 into a biofabricated, or biocement, brick. 0:06:35.028,0:06:38.782 Their process happens at room temperature, 0:06:38.806,0:06:40.837 in just a couple of days. 0:06:40.861,0:06:43.765 Think hydroponics for bricks. 0:06:43.789,0:06:48.739 An irrigation system[br]feeds nutrient-rich water 0:06:48.763,0:06:50.660 to trays of bricks 0:06:50.684,0:06:53.353 that have been inoculated with bacteria. 0:06:53.926,0:06:56.260 The bacteria produce crystals 0:06:56.284,0:06:59.346 that form around each grain of sand, 0:06:59.370,0:07:02.553 locking together all the loose particles 0:07:02.577,0:07:04.402 to form a solid brick. 0:07:05.725,0:07:09.074 We can now grow construction materials 0:07:09.098,0:07:11.613 in the elegant way nature does, 0:07:11.637,0:07:13.716 just like a coral reef. 0:07:14.831,0:07:20.434 And these biofabricated bricks[br]are nearly three times stronger 0:07:20.458,0:07:22.508 than a concrete block. 0:07:23.702,0:07:27.797 And in stark contrast[br]to traditional cement production, 0:07:27.821,0:07:30.354 they store more carbon than they make. 0:07:31.202,0:07:35.908 So if we could replace[br]the 1.2 trillion fired bricks 0:07:35.932,0:07:37.607 that are made each year 0:07:37.631,0:07:40.297 with biofabricated bricks, 0:07:40.321,0:07:42.934 we could reduce CO2 emissions 0:07:42.958,0:07:46.762 by 800 million tons every year. 0:07:48.307,0:07:54.747 (Applause) 0:07:56.034,0:07:59.533 Beyond growing materials[br]with living organisms, 0:07:59.557,0:08:01.938 we're even starting to design products 0:08:01.962,0:08:03.829 that encourage their growth. 0:08:04.338,0:08:06.687 And this comes from the realization 0:08:06.711,0:08:12.211 that the very thing we've been trying[br]to marginalize -- life -- 0:08:12.235,0:08:16.125 might actually be[br]our greatest collaborator. 0:08:16.689,0:08:20.538 To that end, we've been[br]exploring all the ways 0:08:20.562,0:08:24.640 that we can grow healthy microbes[br]in our own ecosystems. 0:08:25.482,0:08:29.713 A great example of this is architects 0:08:29.737,0:08:33.499 who are imagining the skin of a building 0:08:33.523,0:08:36.324 to function like the bark of a tree. 0:08:36.680,0:08:39.627 But not as a cosmetic green layer. 0:08:39.982,0:08:43.252 They're designing architectural barks 0:08:43.276,0:08:47.262 as hosts for evolving ecologies. 0:08:48.104,0:08:53.730 These surface structures[br]are designed to invite life in. 0:08:54.239,0:08:59.649 And if we applied the same energy[br]we currently do suppressing forms of life 0:08:59.673,0:09:02.649 towards cultivating life, 0:09:02.673,0:09:06.400 we'd turn the negative image[br]of the urban jungle 0:09:06.424,0:09:11.940 into one that literally embodies[br]a thriving, living ecosystem. 0:09:12.734,0:09:18.656 By actively encouraging surface[br]interactions with healthy microbes, 0:09:18.680,0:09:21.688 we could improve passive climate control, 0:09:21.712,0:09:23.545 stormwater management, 0:09:23.569,0:09:25.704 and even reduce CO2 emissions 0:09:25.728,0:09:29.743 by lowering the energy[br]used to heat or cool our buildings. 0:09:30.847,0:09:34.943 We're just beginning[br]to realize the potential 0:09:34.967,0:09:38.117 of nature-based technologies. 0:09:38.141,0:09:43.164 I'm excited that we're starting[br]to design and biofabricate 0:09:43.188,0:09:45.442 a new material world. 0:09:49.177,0:09:53.438 It's one that moves away[br]from the exploitation 0:09:53.462,0:09:55.915 of nonrenewable resources 0:09:55.939,0:10:00.275 to working with the original,[br]renewable life. 0:10:00.819,0:10:02.871 Instead of designing out life, 0:10:02.895,0:10:06.259 we're designing with it and for it. 0:10:06.934,0:10:10.968 Packaging, fashion, footwear,[br]furniture, construction -- 0:10:10.992,0:10:16.143 biofabricated products can be grown[br]close to centers of demand, 0:10:16.167,0:10:19.937 with local resources, less land, energy, 0:10:19.961,0:10:23.837 and even harnessing[br]industrial waste streams. 0:10:24.924,0:10:28.925 It used to be that the tools[br]of biotechnology 0:10:28.949,0:10:31.316 were the preserve of powerful, 0:10:31.340,0:10:35.528 multinational chemical[br]and biotech companies. 0:10:35.950,0:10:40.061 In the last century,[br]we expected material innovation 0:10:40.085,0:10:44.593 to come from the likes[br]of DuPont, Dow, BASF. 0:10:45.173,0:10:51.180 But this 21st-century material revolution[br]is being led by start-ups 0:10:51.204,0:10:54.347 with small teams and limited capital. 0:10:54.903,0:10:58.617 And by the way, not all their founders[br]have science degrees. 0:10:58.950,0:11:03.363 They include artists,[br]architects and designers. 0:11:04.538,0:11:08.292 Over a billion dollars[br]has already been invested 0:11:08.316,0:11:12.260 in start-ups biofabricating[br]consumer products. 0:11:13.316,0:11:17.763 I don't think we have a choice[br]but to biofabricate our future. 0:11:18.938,0:11:20.422 From the jacket you're wearing 0:11:20.446,0:11:22.002 to the chair you're sitting in 0:11:22.026,0:11:23.748 to the home you live in, 0:11:23.772,0:11:29.355 your designed material world[br]shouldn't compromise your health 0:11:29.379,0:11:31.251 or that of our planet. 0:11:31.879,0:11:33.879 If materials can't be recycled 0:11:33.903,0:11:36.442 or naturally composted at home, 0:11:36.466,0:11:37.974 we should reject them. 0:11:37.998,0:11:42.537 I'm committed to making[br]this future a reality 0:11:42.561,0:11:46.203 by shining a light on all the amazing work 0:11:46.227,0:11:47.759 being done today 0:11:47.783,0:11:50.791 and by facilitating more interactions 0:11:50.815,0:11:55.255 between designers, scientists,[br]investors and brands. 0:11:55.581,0:11:58.747 Because we need a material revolution, 0:11:58.771,0:12:00.397 and we need it now. 0:12:00.914,0:12:02.088 Thank you. 0:12:02.112,0:12:06.577 (Applause)