♪ (music) ♪

(narrator) These days, 
you hear music all the time.

It wakes us up, motivates our workouts,

keeps us company on our commutes.

It doesn't matter
what kind of music it is,

music itself has the ability
to affect our moods and our bodies

in all sorts of ways.

We nod our heads, we sway, dance.

Music can give us chills,

even make us cry.

Music activates every area
of the brain that we have so far mapped.

In fact, there's no area
of the brain we know about

that music doesn't touch in some way.

But what's behind all that?

What exactly does music do to us?

To find out, I went to a whole series of tests

designed to measure my responses to music.

I met some kids whose brains
may actually be changing,

thanks to those hours
of learning, practice, and performing.

I spoke with a therapist who used music

to help former congresswoman
Gabrielle Giffords

learn to speak again,

and got a glimpse inside the brain

of a two-time winning artist
while he played...

( )

...all to find out how music affects us.

♪ (music) ♪

So what's going on
when we listen to music?

We visited the USC Brain
and Creativity Institute,

where I had my head examined, literally,

to try to figure it out.

I'm going to go into this [FMRI] machine,

a tiny tube will surround me.

We'll get a baseline reading of my brain,

and then I'm going to listen
to some music.

We're going to see how my brain responds.

Just close your eyes, relax,

and try and get into the music
as best you can, okay?

♪ (music) ♪

And here's what we saw.

These are scans of my brain.

The areas in red are where
my activity is above average;

in blue, below average.

As you can see, 
there is red activity all over my brain,

not just in one specific area.

Twenty-five years ago,

the idea was that language
is on the left side of the brain

and music is in
the right side of the brain.

But now that we've got
better quality tools,

higher resolution neuro-imaging
and better experimental methods,

we've discovered that's not at all right.

How does that play out
in different regions of the brain?

When music enters
and then gets shuttled off

to different parts of the brain,

it stops at specialized processing units
in auditory cortex,

they track loudness and pitch and rhythm

and [tambour] and things like that.

There's visual cortex activation
when you're reading music as a musician

or watching music,

motor cortex
when you're tapping your feet,

snapping your fingers, clapping you hands;

and cerebellum which mediates
the emotional responses;

the memory and the hippocampus,

hearing a familiar passage,

finding it somewhere in your memory banks.

Music is going on
in both halves of your brain,

the left and the right,

the front and the back,

the inside and the outside.

♪ (music) ♪

So what about a musicians's brain?

To play a piece of music
engages so many things:

motor systems, timing systems,

memory systems, hearing systems.

There's all sorts
of brain activity happening.

It's a very robust thing to play music.

♪ (music) ♪

I'm Alex Jacob Robertson.

I'm Nathan Glenn Robertson.

We asked these 11-year old musicians

to tell us what's going through
their minds when they play.

Some of the most important things
are I think good postures,

getting the note right,

legato, staccato.

[violin playing]

For the violin, you need to hold
your hand at the right place,

and you need to be in tune,

and then you also have to have
not only the right intonation

but the right sound,

and then you also need
to have great vibrato.

There's lot of things to think about.

[violin playing]

(narrator) Back at USC,

researchers have been studying kids
who play music over the past five years

to see how it affects their development.

The multi-tasking areas of their brains
understandable lit up,

but they've seen other results too.

Music training
over the course of five years

has had benefits in cognitive skills
and decision making,

also had some benefits in social behavior,

and we've also seen changes
in the associated brain structures.

(narrator) Did you hear that?

Changes in brain structures!

They found that the brains of children
who have studied music

have stronger connections
between the left and right hemispheres,

and that can make them better,
more creative problem solvers.

And then there's emotion.

[emotional music]

When you hear a piece like this,

it's easy to understand why emotions
play such a big part in music.

This song by Camille Saint-Saëns is known
as the music for the dying swan in ballet.

While it might move ballerinas to dance,
it inspires different reactions in others.

( )

Some people get goosebumps, chills.

That weird tingly sensation that you get

when a great piece of music
just hits you in the right way?

It's called frisson, 
and not everyone gets it,

but it turns out I do.

Now we're going to have you listen
to some pieces of music.

Okay.

When you experience a chill, if you do,

I want you to just press this space bar

so we have an indication

of when those peak moments
of enjoyment are happening.

Okay.

Matt Sachs, a PhD candidate at USC,

wired me up to measure
my physiological response.

So when I'm feeling
that emotional connection

that has a physical manifestation,

we'll see what my body is actually doing?

Exactly.

[dramatic music]

Alright, how was that?

That was-- that had a lot of them.

We got them all.

Now full disclosure:

Back in the day, I played the cello,

which might have something to do
with why that particular song affected me.

Nice hair!

But it turns out the brain
is at work here too.

We processed the difference
between this pathway

that connects the auditory regions
is on the side of the brain here,

to the emotional regions,

and we showed that the tract
actually that connects those two regions

is stronger,

there's more fibers in that region
in the people who get chills.

(narrator) Which means
that some people's brains

might have better communication

between what they hear and how they feel.

The music itself also plays
a role in frisson.

Sachs uses different songs in his lectures
to see if students get it.

I'll say raise your hand
when you get a chill

and I'll play a piece of music, 
a classical piece,

and maybe half the people will get it.

(narrator) Then he plays this..

( )

Rolling Stone's Give me Shelter.

Have you ever seen the movie
<i>20 Feet from Stardom</i>?

The documentary about back up singers?

Yeah.

There's a part where they isolate
the vocals from Give me Shelter.

♪ ( ) ♪

And I play that,

and 90% of the people experience chills,

sort of independent of where I go.

I have to tell you, bringing that up
made me think about it

and I got that little kind of thing
at the back of my neck.

(narrator) But why would that happen?

The high pitched notes that she hit
almost sounds like a scream

and it's very important ancestrally for us

to be able to pay attention to a scream,

figure out what's going on,

and either run or fight, 
whatever we need to do.

(narrator) So how come
that manifests as pleasure?

Well it's because our pre-frontal cortex,

the more rational, thinking part
of the brain kicks in.

So you realize very quickly,

after you have
this really quick startle reflex,

that there's nothing actually threatening
about the piece of music,

that you're sitting in a safe space
with your headphones on,

and it's in that reappraisal

that we tend to think
of the pleasure responses emerging.

And whether you find listening to music
so pleasurable you get chills

or you absolutely despise a song,

it can produce absolutely
fascinating effects in the brain.

According to [Levitan], music we enjoy

triggers the brain's
internal opioid system,

yes, opioid system.

And just like the opioids
that come in pill form

these chemicals make you feel good
and help relive pain.

And music you don't like? 
Well, that releases cortisol,

the notorious stress hormone.

But that's not even the half of what music
can do in the brain.

The high pitched notes that she hits
almost sounds like a scream and
it's very important ancestrally for us
to be able to pay attention
to a scream, figure out what's going on
and either run or fight, whatever we need to do.

[Narrator] So how come
that manifests as pleasure?

Well it's because our pre-frontal cortex

the more rational, thinking part of the brain kicks in.

So you realize very quickly after you have
this really quick startle reflex

that there's nothing actually threatening
about the piece of music

that you're sitting in a safe space
with your headphones on

and it's in that reappraisal that we tend to think

of the pleasure responses emerging.

And whether you find listening to music
so pleasurable that you get chills

or you absolutely despise a song

it can produce absolutely fascinating
effects in the brain.

According to Levitan music we enjoy triggers
the brain's internal opiod system, yes, opiod system.

And just like the opioids that come in pill form

these chemicals make you feel good and help relive pain.

And music you don't like well that releases cortisol,

the notorious stress hormone.

But that's not even the half of what music
can do in the brain.

Can you turn on the lights?

[Narrator] When former Congresswomen Gabrielle Giffords
was shot in 2011

the left side of her brain
was severely damaged

leaving her struggling to speak,

a condition called aphasia.

Gabby are you frustrated?

[Narrator] But to get an idea

of just how powerful
music's effect on the brain can be

watch this video.

You ready?

[Together] This little light of mine
I'm gonna let it shine.

That words that she'd been
struggling to say, light,

can easily be in song.

Why would she be able to sing a word
when she's unable to say it?

What we know about the brain

is that the left hemisphere controls language

and there are many other parts of the brain
that have music access.

Music therapist Maegan Morrow's job

is to help patients use those other
pathways to regain language.

Sometimes I compare it to being in traffic

and you can't move any further

but you might need to exit
and take the feeder road

to get you to your destination.

So music is basically like that feeder road

to the new destination.

Like a detour, so we know that music
can help us relearn things like speech

by accessing alternative pathways in the brain

and that learning to play music can help
strengthen brain connections.

But what about making music?

To make music is like,

it's the language of humanity,

no matter where I go in the world,

if I'm playing something,

it doesn't matter if
someone can't speak the language,

if they're into it they're into it.

[Narrator] This is Xavier Dphrepaulezz better known as Fantastic Negrito.

We brought him to UCSF to meet Charles Limb

a neuroscientist who studies musical creativity.

The Duffler's up next.

[Narrator] To understand how Fantastic Negrito's brain works when making music

Dr. Limb had him play on of his songs
while going through the fMRI.

[Fantastic Negrito singing]

so how did his brain respond?

The areas that process sensory and motor skills
along with sounds lit up,

you can see them here.

Red and yellow, makes sense right?

But here's the really interesting part,

Limb asked him to improvise

to see what happens when he's creating
something totally original.

[Fantastic Negrito singing]

now watch what happens to his brain.

The areas that were active before
the ones that deal with motor skills and sounds

are even more active.

And see how there's way more blue
in the front of his brain?

That's the pre-frontal cortex

and it's associated with effortful planning
and conscience self-monitoring

and it's blue because it's less active.

We see that the pre-frontal cortex

appears to be really shutting down
in these moments of high creativity

kind of like letting of of these conscious
self-censoring or self-monitoring areas

that normally are there to help control our output.

[Narrator] And Limb says
it's about more than just letting go.

You view it from perspective of survival

if human beings only could do memorized route responses,

we'd be long gone.

It is not just the thing that happens
in clubs and in jazz bars,

it's actually maybe
the most fundamental form

of what it means to be human

to come up with new ideas.

[singing]

[Narrator] So music is so much more
than notes on a page,

it can change the way we think and speak and feel

but is there a limit to what science can tell us about music?

Just when I discover the answer to one thing

five new questions pop up that are more

interesting than the first and I've gained

an appreciation for how complex the music making

and music listening system is.

It's not demystified to me at all.

It's more mysterious than ever.

[signing]

[clapping]