WEBVTT 00:00:00.113 --> 00:00:02.024 ♪ (guitar music) ♪ 00:00:02.024 --> 00:00:05.011 (Peter) These days, you hear music all the time. 00:00:05.595 --> 00:00:09.401 It wakes us up, motivates our workouts, 00:00:09.401 --> 00:00:11.280 keeps us company on our commutes. 00:00:11.834 --> 00:00:13.832 It doesn't matter what kind of music it is, 00:00:13.832 --> 00:00:17.234 music itself has the ability to affect our moods and our bodies 00:00:17.234 --> 00:00:18.812 in all sorts of ways. 00:00:18.974 --> 00:00:22.136 We nod our heads, we sway, dance. 00:00:22.136 --> 00:00:23.500 Music can give us chills, 00:00:23.500 --> 00:00:24.916 even make us cry. 00:00:24.916 --> 00:00:28.775 Music activates every area of the brain that we have so far mapped. 00:00:28.775 --> 00:00:30.942 There's no area of the brain we know about 00:00:30.942 --> 00:00:33.145 that music doesn't touch in some way. 00:00:33.145 --> 00:00:34.490 But what's behind all that? 00:00:34.490 --> 00:00:36.928 What exactly does music do to us? 00:00:37.204 --> 00:00:39.578 To find out, I went to a whole series of tests 00:00:39.578 --> 00:00:41.831 designed to measure my responses to music. 00:00:42.592 --> 00:00:45.240 I met some kids whose brains may actually be changing, 00:00:45.240 --> 00:00:48.122 thanks to those hours of learning, practice, and performing. 00:00:48.523 --> 00:00:50.857 I spoke with a therapist who used music 00:00:50.857 --> 00:00:53.158 to help former congresswoman Gabrielle Giffords 00:00:53.158 --> 00:00:54.770 learn to speak again, 00:00:54.770 --> 00:00:56.159 and got a glimpse inside the brain 00:00:56.159 --> 00:00:57.704 of a two-time Grammy-winning artist 00:00:57.704 --> 00:00:58.705 while he played... 00:00:58.705 --> 00:01:00.646 ♪ (playing and singing) ♪ 00:01:00.646 --> 00:01:03.153 ...all to find out how music affects us. 00:01:05.217 --> 00:01:07.183 ♪ (upbeat music) ♪ 00:01:07.539 --> 00:01:09.941 So what's going on when we listen to music? 00:01:09.941 --> 00:01:13.141 We visited the USC Brain and Creativity Institute, 00:01:13.141 --> 00:01:15.665 where I had my head examined, literally, 00:01:15.665 --> 00:01:16.922 to try to figure it out. 00:01:16.922 --> 00:01:19.420 I'm going to go into this fMRI machine. 00:01:19.420 --> 00:01:21.289 A tiny tube will surround me. 00:01:21.289 --> 00:01:23.306 We'll get a baseline reading of my brain. 00:01:23.306 --> 00:01:25.191 Then I'm going to listen to some music, 00:01:25.191 --> 00:01:27.343 and we're going to see how my brain responds. 00:01:27.343 --> 00:01:28.604 Just close your eyes, relax, 00:01:28.604 --> 00:01:30.765 and try and get into the music as best you can, okay? 00:01:30.765 --> 00:01:31.889 ♪ (classical music) ♪ 00:01:31.889 --> 00:01:33.269 (Peter) And here's what we saw. 00:01:33.269 --> 00:01:34.591 These are scans of my brain. 00:01:34.591 --> 00:01:37.240 The areas in red are where my activity is above average; 00:01:37.240 --> 00:01:38.507 in blue, below average. 00:01:38.507 --> 00:01:41.806 As you can see, there's red activity all over my brain, 00:01:41.806 --> 00:01:43.826 not just in one specific area. 00:01:43.826 --> 00:01:45.040 (Daniel) Twenty-five years ago, 00:01:45.040 --> 00:01:48.076 the idea was that language is on the left side of the brain 00:01:48.076 --> 00:01:50.106 and music is in the right side of the brain. 00:01:50.106 --> 00:01:53.283 But now that we've got better quality tools, 00:01:53.604 --> 00:01:57.435 higher resolution neuroimaging, and better experimental methods, 00:01:57.845 --> 00:02:00.290 we've discovered that's not at all right. 00:02:00.290 --> 00:02:02.896 How does that play out in different regions of the brain? 00:02:02.896 --> 00:02:04.910 When music enters and then gets shuttled off 00:02:04.910 --> 00:02:06.328 to different parts of the brain, 00:02:06.328 --> 00:02:10.362 it stops at specialized processing units in auditory cortex. 00:02:10.362 --> 00:02:12.663 They track loudness and pitch and rhythm 00:02:12.663 --> 00:02:14.929 and timbre and things like that. 00:02:14.929 --> 00:02:18.928 There's visual cortex activation when you're reading music as a musician 00:02:18.928 --> 00:02:20.365 or watching music. 00:02:20.365 --> 00:02:22.560 Motor cortex when you're tapping your feet, 00:02:22.560 --> 00:02:24.761 snapping your fingers, clapping your hands. 00:02:24.761 --> 00:02:27.775 And cerebellum which mediates the emotional responses. 00:02:27.775 --> 00:02:30.229 The memory system and the hippocampus, 00:02:30.229 --> 00:02:32.114 hearing a familiar passage, 00:02:32.114 --> 00:02:34.797 finding it somewhere in your memory banks. 00:02:34.797 --> 00:02:37.178 Music is going on in both halves of your brain, 00:02:37.178 --> 00:02:39.194 the left and the right, the front and the back, 00:02:39.194 --> 00:02:41.076 the inside and the outside. 00:02:41.756 --> 00:02:44.245 ♪ (singing) ♪ 00:02:44.862 --> 00:02:46.820 (Peter) So what about a musician's brain? 00:02:47.147 --> 00:02:50.111 To play a piece of music engages so many things: 00:02:50.111 --> 00:02:52.255 motor systems, timing systems, 00:02:52.688 --> 00:02:55.180 memory systems, hearing systems. 00:02:55.180 --> 00:02:58.194 There's all sorts of brain activity happening. 00:02:58.194 --> 00:03:00.857 It's a very robust thing to play music. 00:03:00.857 --> 00:03:04.645 ♪ (Chopin, "Fantaisie-Impromptu") ♪ 00:03:04.645 --> 00:03:05.949 I'm Alex Jacob Robertson. 00:03:05.949 --> 00:03:07.507 I'm Nathan Glenn Robertson. 00:03:07.507 --> 00:03:09.326 (Peter) We asked these 11-year old musicians 00:03:09.326 --> 00:03:11.564 to tell us what's going through their minds when they play. 00:03:11.564 --> 00:03:14.961 Some of the most important things are, I think, good postures, 00:03:14.961 --> 00:03:16.490 getting the note right, 00:03:16.490 --> 00:03:18.978 legato, staccato. 00:03:18.978 --> 00:03:20.928 ♪ (violin) ♪ 00:03:21.512 --> 00:03:25.761 For the violin, you need to hold your hand at the right place, 00:03:25.761 --> 00:03:28.078 and you need to be in tune, 00:03:28.078 --> 00:03:31.595 and then you also have to have not only the right intonation 00:03:31.595 --> 00:03:33.114 but the right sound, 00:03:33.114 --> 00:03:35.625 and then you also need to have great vibrato. 00:03:35.625 --> 00:03:37.397 There's lot of things to think about. 00:03:37.397 --> 00:03:38.574 (Peter) Back at USC, 00:03:38.574 --> 00:03:42.095 researchers have been studying kids who play music over the past five years 00:03:42.095 --> 00:03:44.382 to see how it affects their development. 00:03:44.382 --> 00:03:48.111 The multi-tasking areas of their brains understandably lit up, 00:03:48.111 --> 00:03:49.917 but they've seen other results, too. 00:03:49.917 --> 00:03:52.073 Music training over the course of five years 00:03:52.073 --> 00:03:55.445 has had benefits in cognitive skills and decision making, 00:03:55.445 --> 00:03:58.182 also had some benefits in social behavior, 00:03:58.182 --> 00:04:01.823 and we've also seen changes in the associated brain structures. 00:04:01.823 --> 00:04:04.538 (Peter) Did you hear that? Changes in brain structures! 00:04:04.538 --> 00:04:07.007 They found that the brains of children who have studied music 00:04:07.007 --> 00:04:09.728 have stronger connections between the left and right hemispheres, 00:04:09.728 --> 00:04:13.390 and that can make them better, more creative problem-solvers. 00:04:13.390 --> 00:04:15.068 And then there's emotion. 00:04:15.536 --> 00:04:17.006 ♪ (violin) ♪ 00:04:18.744 --> 00:04:20.419 When you hear a piece like this... 00:04:20.419 --> 00:04:23.299 ♪ (Saint-Saëns, "Le Cygne") ♪ 00:04:23.299 --> 00:04:26.625 ...it's easy to understand why emotions play such a big part in music. 00:04:27.479 --> 00:04:29.712 This song by Camille Saint-Saëns 00:04:29.712 --> 00:04:32.355 is known as the music for The Dying Swan in ballet. 00:04:33.878 --> 00:04:35.844 While it might move ballerinas to dance, 00:04:35.844 --> 00:04:38.065 it inspires different reactions in others. 00:04:38.195 --> 00:04:40.161 ♪ (violin continues) ♪ 00:04:43.595 --> 00:04:45.739 Some people get goosebumps, chills. 00:04:46.411 --> 00:04:48.319 That weird tingly sensation that you get 00:04:48.319 --> 00:04:51.084 when a great piece of music just hits you in the right way? 00:04:51.084 --> 00:04:53.319 It's called frisson, and not everyone gets it. 00:04:54.148 --> 00:04:55.822 But it turns out I do. 00:04:55.822 --> 00:04:59.010 Now we're going to have you listen to some pieces of music. 00:04:59.010 --> 00:05:01.164 When you experience a chill, if you do, 00:05:01.164 --> 00:05:03.479 I want you to just press this space bar so we have an indication 00:05:03.479 --> 00:05:06.767 of when those peak moments of enjoyment are happening. 00:05:07.025 --> 00:05:09.862 (Peter) Matt Sachs, a PhD candidate at USC, 00:05:09.862 --> 00:05:12.391 wired me up to measure my physiological response. 00:05:12.972 --> 00:05:15.644 So when I'm feeling that emotional connection 00:05:15.644 --> 00:05:18.055 that has a physical manifestation, 00:05:18.055 --> 00:05:20.258 we'll see what my body is actually doing? 00:05:20.258 --> 00:05:21.273 Exactly. 00:05:21.843 --> 00:05:25.159 ♪ (Saint-Saëns, "Le Cygne") ♪ 00:05:30.179 --> 00:05:31.530 Alright, how was that? 00:05:31.530 --> 00:05:33.553 That was-- That had a lot of them. 00:05:33.553 --> 00:05:34.617 We got them all. 00:05:34.617 --> 00:05:37.546 (Peter) Now full disclosure: back in the day, I played the cello, 00:05:37.546 --> 00:05:40.802 which might have something to do with why that particular song affected me. 00:05:40.802 --> 00:05:41.805 Nice hair! 00:05:41.805 --> 00:05:44.376 But it turns out the brain is at work here too. 00:05:44.376 --> 00:05:46.627 We processed the difference between this pathway 00:05:46.627 --> 00:05:50.146 that connects the auditory regions, which is on the side of the brain here, 00:05:50.146 --> 00:05:51.394 to the emotional regions, 00:05:51.394 --> 00:05:54.627 and we showed that the tract actually that connects those two regions 00:05:54.627 --> 00:05:55.769 is stronger. 00:05:55.769 --> 00:05:58.342 There's more fibers in that region in people who get chills. 00:05:58.342 --> 00:05:59.709 (Peter) Which means that some people's brains 00:05:59.709 --> 00:06:03.289 might have better communication between what they hear and how they feel. 00:06:03.289 --> 00:06:05.543 The music itself also plays a role in frisson. 00:06:05.543 --> 00:06:08.997 Sachs uses different songs in his lectures to see if students get it. 00:06:08.997 --> 00:06:10.395 I'll say, "Raise your hand when you get a chill," 00:06:10.395 --> 00:06:11.897 and I play a piece of music, a classical piece, 00:06:11.897 --> 00:06:13.599 and maybe half the people will get it. 00:06:13.599 --> 00:06:15.332 (Peter) But then he plays this... 00:06:15.332 --> 00:06:18.475 ♪ (The Rolling Stones, "Gimme Shelter") ♪ 00:06:18.475 --> 00:06:20.546 Rolling Stone's Gimme Shelter. 00:06:20.546 --> 00:06:22.533 Have you ever seen the movie 20 Feet from Stardom? 00:06:22.533 --> 00:06:24.416 - The documentary about backup singers? - Yeah. 00:06:24.416 --> 00:06:27.983 There's a part where they isolate the vocals from Gimme Shelter. 00:06:27.983 --> 00:06:30.792 ♪ (backup vocals) ♪ 00:06:35.580 --> 00:06:36.464 And I play that, 00:06:36.464 --> 00:06:38.347 and 90% of the people experience chills, 00:06:38.347 --> 00:06:40.014 sort of independent of where I go. 00:06:40.014 --> 00:06:42.797 I have to tell you, bringing that up made me think about it 00:06:42.797 --> 00:06:46.213 and I got that little kind of thing at the back of my neck. 00:06:46.213 --> 00:06:47.495 (Peter) But why would that happen? 00:06:47.495 --> 00:06:50.899 The high pitched notes that she hit almost sounds like a scream 00:06:50.899 --> 00:06:53.428 and it's very important ancestrally for us 00:06:53.428 --> 00:06:54.912 to be able to pay attention to a scream, 00:06:54.912 --> 00:06:56.366 figure out what's going on, 00:06:56.366 --> 00:06:58.796 and either run or fight, whatever we need to do. 00:06:58.796 --> 00:07:00.780 (Peter) So how come that manifests as pleasure? 00:07:00.780 --> 00:07:02.983 Well it's because our pre-frontal cortex, 00:07:02.983 --> 00:07:05.546 the more rational, thinking part of the brain kicks in. 00:07:05.546 --> 00:07:08.163 So you realize very quickly, 00:07:08.163 --> 00:07:10.880 after you have this really quick startle reflex, 00:07:10.880 --> 00:07:13.530 that there's nothing actually threatening about the piece of music, 00:07:13.530 --> 00:07:17.596 that you're sitting in a safe space with your headphones on, 00:07:17.596 --> 00:07:19.264 and it's in that reappraisal 00:07:19.264 --> 00:07:22.129 that we tend to think of the pleasure responses emerging. 00:07:22.129 --> 00:07:25.347 And whether you find listening to music so pleasurable you get chills 00:07:25.347 --> 00:07:28.032 or you absolutely despise a song, 00:07:28.032 --> 00:07:31.146 it can produce absolutely fascinating effects in the brain. 00:07:31.146 --> 00:07:33.129 According to [Levitan], music we enjoy 00:07:33.129 --> 00:07:35.716 triggers the brain's internal opioid system-- 00:07:35.716 --> 00:07:37.166 yes, opioid system. 00:07:37.166 --> 00:07:39.381 And just like the opioids that come in pill form 00:07:39.381 --> 00:07:42.133 these chemicals make you feel good and help relieve pain. 00:07:42.133 --> 00:07:44.904 And music you don't like? Well, that releases cortisol, 00:07:44.904 --> 00:07:46.397 the notorious stress hormone. 00:07:46.397 --> 00:07:49.333 But that's not even the half of what music can do in the brain. 00:07:49.333 --> 00:07:55.580 Can you turn on the lights? 00:07:55.580 --> 00:07:57.331 (Peter) When former Congresswomen Gabrielle Giffords 00:07:57.331 --> 00:07:58.967 was shot in 2011 00:07:58.967 --> 00:08:01.149 the left side of her brain was severely damaged, 00:08:01.149 --> 00:08:02.731 leaving her struggling to speak, 00:08:02.731 --> 00:08:04.533 a condition called aphasia. 00:08:04.533 --> 00:08:07.847 Gabby, are you frustrated? 00:08:07.847 --> 00:08:09.747 (Peter) But to get an idea 00:08:09.747 --> 00:08:12.635 of just how powerful music's effect on the brain can be, 00:08:12.635 --> 00:08:13.848 watch this video. 00:08:13.848 --> 00:08:14.997 You ready? 00:08:14.997 --> 00:08:20.431 (together) This little light of mine I'm gonna let it shine. 00:08:20.431 --> 00:08:22.380 (Peter) That word that she'd been struggling to say, "light," 00:08:22.380 --> 00:08:24.331 came easily in song. 00:08:24.331 --> 00:08:29.164 Why would she be able to sing a word when she's unable to say it? 00:08:29.164 --> 00:08:30.797 What we know about the brain 00:08:30.797 --> 00:08:35.148 is that the left hemisphere controls language, 00:08:35.148 --> 00:08:37.665 and there are many other parts of the brain 00:08:37.665 --> 00:08:40.980 that have music access. 00:08:40.980 --> 00:08:42.797 Music therapist Maegan Morrow's job 00:08:42.797 --> 00:08:46.682 is to help patients use those other pathways to regain language. 00:08:46.682 --> 00:08:49.481 Sometimes I compare it to being in traffic, 00:08:49.481 --> 00:08:51.064 and you can't move any further, 00:08:51.064 --> 00:08:54.201 but you might need to exit and take the feeder road 00:08:54.201 --> 00:08:56.680 to get you to your destination. 00:08:56.680 --> 00:09:00.514 So music is basically like that feeder road 00:09:00.514 --> 00:09:01.882 to the new destination. 00:09:01.882 --> 00:09:03.050 (Peter) Like a detour. 00:09:03.050 --> 00:09:06.631 So we know that music can help us relearn things like speech 00:09:06.631 --> 00:09:09.183 by accessing alternative pathways in the brain 00:09:09.183 --> 00:09:12.330 and that learning to play music can help strengthen brain connections. 00:09:12.330 --> 00:09:14.982 But what about making music? 00:09:14.982 --> 00:09:18.733 To make music is like-- 00:09:18.733 --> 00:09:20.397 it's the language of humanity. 00:09:20.397 --> 00:09:22.114 No matter where I go in the world, 00:09:22.114 --> 00:09:23.582 if I'm playing something, 00:09:23.582 --> 00:09:25.300 it doesn't matter if someone can't speak the language-- 00:09:25.300 --> 00:09:28.580 if they're into it, they're into it. 00:09:28.580 --> 00:09:32.150 (Peter) This is Xavier Dphrepaulezz, better known as Fantastic Negrito. 00:09:32.150 --> 00:09:35.831 We brought him to UCSF to meet Charles Limb, 00:09:35.831 --> 00:09:38.347 a neuroscientist who studies musical creativity. 00:09:38.347 --> 00:09:39.449 The Duffler's up next. 00:09:39.449 --> 00:09:41.815 (Peter) To understand how Fantastic Negrito's brain works 00:09:41.815 --> 00:09:42.916 when making music, 00:09:42.916 --> 00:09:46.484 Dr. Limb had him play on of his songs while going through the fMRI. 00:09:46.484 --> 00:09:51.881 (Fantastic Negrito singing) 00:09:51.881 --> 00:09:53.981 (Peter) So how did his brain respond? 00:09:53.981 --> 00:09:56.916 The areas that process sensory and motor skills, along with sounds, 00:09:56.916 --> 00:09:57.733 lit up. 00:09:57.733 --> 00:09:59.614 You can see them here in red and yellow. 00:09:59.614 --> 00:10:00.980 Makes sense, right? 00:10:00.980 --> 00:10:02.684 But here's the really interesting part. 00:10:02.684 --> 00:10:04.168 Limb asked him to improvise 00:10:04.168 --> 00:10:07.200 to see what happens when he's creating something totally original. 00:10:07.200 --> 00:10:10.481 (Fantastic Negrito singing) 00:10:18.382 --> 00:10:19.698 Now watch what happens to his brain? 00:10:19.698 --> 00:10:20.399 Stop! 00:10:20.399 --> 00:10:21.035 (laughter) 00:10:21.035 --> 00:10:22.185 Now watch what happens to his brain. 00:10:22.185 --> 00:10:23.651 The areas that were active before, 00:10:23.651 --> 00:10:25.385 the ones that deal with motor skills and sounds, 00:10:25.385 --> 00:10:26.835 are even more active. 00:10:26.835 --> 00:10:29.384 But see how there's way more blue in the front of his brain? 00:10:29.384 --> 00:10:30.835 That's the pre-frontal cortex, 00:10:30.835 --> 00:10:32.751 and it's associated with effortful planning 00:10:32.751 --> 00:10:34.516 and conscience self-monitoring, 00:10:34.516 --> 00:10:36.968 and it's blue because it's less active. 00:10:36.968 --> 00:10:38.215 We see that the pre-frontal cortex 00:10:38.215 --> 00:10:42.052 appears to be really shutting down in these moments of high creativity, 00:10:42.052 --> 00:10:46.249 kind of like letting of of these conscious self-censoring or self-monitoring areas 00:10:46.249 --> 00:10:50.481 that normally are there to help control our output. 00:10:50.481 --> 00:10:52.767 (Peter) And Limb says it's about more than just letting go. 00:10:52.767 --> 00:10:55.898 You view it from a perspective of survival. 00:10:55.898 --> 00:10:58.832 If human beings only could do memorized route responses, 00:10:58.832 --> 00:11:00.318 we'd be long gone. 00:11:00.318 --> 00:11:04.132 It is not just the thing that happens in clubs and in jazz bars, 00:11:04.132 --> 00:11:06.665 it's actually maybe the most fundamental form 00:11:06.665 --> 00:11:08.151 of what it means to be human, 00:11:08.151 --> 00:11:09.266 to come up with new ideas. 00:11:09.266 --> 00:11:11.931 (singing) 00:11:15.231 --> 00:11:18.234 (Peter) So music is so much more than notes on a page. 00:11:18.234 --> 00:11:21.199 It can change the way we think and speak and feel. 00:11:21.199 --> 00:11:24.466 But is there a limit to what science can tell us about music? 00:11:24.466 --> 00:11:26.767 Just when I discovered the answer to one thing, 00:11:26.767 --> 00:11:30.664 five new questions pop up that are more interesting than the first, 00:11:30.664 --> 00:11:33.182 and I've gained an appreciation 00:11:33.182 --> 00:11:39.048 for how complex the music-making and music-listening system is. 00:11:39.048 --> 00:11:41.064 It's not demystified for me at all. 00:11:41.064 --> 00:11:43.364 It's more mysterious than ever. 00:11:43.364 --> 00:11:45.465 (singing) 00:11:57.515 --> 00:11:59.732 (applause)