[Script Info]
Title: 
[Events]
Format: Layer, Start, End, Style, Name, MarginL, MarginR, MarginV, Effect, Text
Dialogue: 0,0:00:00.00,0:00:00.00,Default,,0000,0000,0000,,-
Dialogue: 0,0:00:00.00,0:00:03.00,Default,,0000,0000,0000,,Ne videon e fundit, u kam informuar se si duket neuroni
Dialogue: 0,0:00:03.00,0:00:05.00,Default,,0000,0000,0000,,dhe kemi folur rreth pjeseve qe e formojne neuronin,
Dialogue: 0,0:00:05.00,0:00:08.00,Default,,0000,0000,0000,,u kam shpjeguar gjithashtu ne vija te trasha funksionin e neuronit
Dialogue: 0,0:00:08.00,0:00:11.00,Default,,0000,0000,0000,,Stimulohet tek dendritet--dhe
Dialogue: 0,0:00:11.00,0:00:13.00,Default,,0000,0000,0000,,sa i perket stimulimit do te flasim ne videot e ardhme
Dialogue: 0,0:00:13.00,0:00:16.00,Default,,0000,0000,0000,,se cka do te thote stimulim--dhe si impulsi
Dialogue: 0,0:00:16.00,0:00:19.00,Default,,0000,0000,0000,,apo sinjali, informata shumohet.
Dialogue: 0,0:00:19.00,0:00:22.00,Default,,0000,0000,0000,,Nese ekzistojne stimulime te shumta ne dendrite
Dialogue: 0,0:00:22.00,0:00:25.00,Default,,0000,0000,0000,,te ndryshme, keto mblidhen dhe nese arrohet njefare nivel
Dialogue: 0,0:00:25.00,0:00:28.00,Default,,0000,0000,0000,,i pragut, do te krijohet ky potencial i veprimit apo
Dialogue: 0,0:00:28.00,0:00:34.00,Default,,0000,0000,0000,,sinjlai i cili udheton pergjate aksonit e me gjase stimulon edhe
Dialogue: 0,0:00:34.00,0:00:38.00,Default,,0000,0000,0000,,neuronet apo muskujt tjere sepse keto pika terminale
Dialogue: 0,0:00:38.00,0:00:41.00,Default,,0000,0000,0000,,te akosoneve mudn te jene te lidhura me dendritet
Dialogue: 0,0:00:41.00,0:00:44.00,Default,,0000,0000,0000,,e neuroneve tjera apo qelizave muskulare.
Dialogue: 0,0:00:44.00,0:00:46.00,Default,,0000,0000,0000,,Cfare dua te realizoj ne ekete video eshte venja
Dialogue: 0,0:00:46.00,0:00:50.00,Default,,0000,0000,0000,,e disa blloqeve ndertuese rreth temes se cka eshte sinjali apo si
Dialogue: 0,0:00:50.00,0:00:54.00,Default,,0000,0000,0000,,neuroni e percjell nje informate
Dialogue: 0,0:00:54.00,0:00:56.00,Default,,0000,0000,0000,,pergjate aksonit--ne fakt, si perhapet nga
Dialogue: 0,0:00:56.00,0:00:59.00,Default,,0000,0000,0000,,dendriti per ne akson?
Dialogue: 0,0:00:59.00,0:01:01.00,Default,,0000,0000,0000,,Para se te flas per kete teme, na duhet te
Dialogue: 0,0:01:01.00,0:01:07.00,Default,,0000,0000,0000,,i vendosim ca rregulla bazike--apo nje sqarim bazik lidhur
Dialogue: 0,0:01:07.00,0:01:10.00,Default,,0000,0000,0000,,me potencalin voltazhik aktual pegjate
Dialogue: 0,0:01:10.00,0:01:11.00,Default,,0000,0000,0000,,membranes se neuronit.
Dialogue: 0,0:01:11.00,0:01:14.00,Default,,0000,0000,0000,,ne fakt te gjitha qelizat kane nje gradient potenciali voltazhik,
Dialogue: 0,0:01:14.00,0:01:15.00,Default,,0000,0000,0000,,dhe se eshte ne vecanti relevant kur ne
Dialogue: 0,0:01:15.00,0:01:18.00,Default,,0000,0000,0000,,flasim rreth neuronit dhe aftesise se tij qe te barte sinjale.
Dialogue: 0,0:01:18.00,0:01:20.00,Default,,0000,0000,0000,,Te bejme nje zmadhim ne nivel te qelizes neuronale.
Dialogue: 0,0:01:20.00,0:01:25.00,Default,,0000,0000,0000,,,
Dialogue: 0,0:01:25.00,0:01:27.00,Default,,0000,0000,0000,,Do mund te beje nje rritje ne cilndo pike te qelizes e cila
Dialogue: 0,0:01:27.00,0:01:30.00,Default,,0000,0000,0000,,nuk eshte e mbeshtjellur me cipen mielinike.
Dialogue: 0,0:01:30.00,0:01:32.00,Default,,0000,0000,0000,,do te beje nje zmadhim ne mebranen e saj.
Dialogue: 0,0:01:32.00,0:01:39.00,Default,,0000,0000,0000,,Te themi se kjo eshte membrana e
Dialogue: 0,0:01:39.00,0:01:43.00,Default,,0000,0000,0000,,neuronit, mu keshtu.
Dialogue: 0,0:01:43.00,0:01:45.00,Default,,0000,0000,0000,,Kjo eshte membrana.
Dialogue: 0,0:01:45.00,0:01:50.00,Default,,0000,0000,0000,,Kjo eshte pjesa e jashtme e qelizes neuronale.
Dialogue: 0,0:01:50.00,0:01:56.00,Default,,0000,0000,0000,,Kjo eshte brendia e qelizes neuronale.
Dialogue: 0,0:01:56.00,0:01:59.00,Default,,0000,0000,0000,,Tani, keni jonet e natriumit dhe te kaliumit
Dialogue: 0,0:01:59.00,0:02:00.00,Default,,0000,0000,0000,,te cilat notojne perreth.
Dialogue: 0,0:02:00.00,0:02:01.00,Default,,0000,0000,0000,,Do te vizatoj natriumin ne kete menyre.
Dialogue: 0,0:02:01.00,0:02:03.00,Default,,0000,0000,0000,,Natriumi do te bej me nje rreth.
Dialogue: 0,0:02:03.00,0:02:06.00,Default,,0000,0000,0000,,Pra ky eshte natriumi dhe jonet e tij me ngarkese pozitive
Dialogue: 0,0:02:06.00,0:02:09.00,Default,,0000,0000,0000,,kane ngarkese plus 1 dhe kaliumi, do i paraqes si
Dialogue: 0,0:02:09.00,0:02:11.00,Default,,0000,0000,0000,,trekendesha te vegjel.
Dialogue: 0,0:02:11.00,0:02:13.00,Default,,0000,0000,0000,,Te themi se ky eshte kaliumi--simboli per
Dialogue: 0,0:02:13.00,0:02:14.00,Default,,0000,0000,0000,,kaliumin eshte K.
Dialogue: 0,0:02:14.00,0:02:16.00,Default,,0000,0000,0000,,Ka ngarkese pozitive.
Dialogue: 0,0:02:16.00,0:02:17.00,Default,,0000,0000,0000,,Dhe ndodhen te pezulluara mu perreth.
Dialogue: 0,0:02:17.00,0:02:19.00,Default,,0000,0000,0000,,Te themi se nisemi nga pjese e brendshme
Dialogue: 0,0:02:19.00,0:02:21.00,Default,,0000,0000,0000,,dhe pjesa e jashtme e qelizes.
Dialogue: 0,0:02:21.00,0:02:38.00,Default,,0000,0000,0000,,,
Dialogue: 0,0:02:38.00,0:02:40.00,Default,,0000,0000,0000,,Te gjitha kane ngarkese pozitive.
Dialogue: 0,0:02:40.00,0:02:43.00,Default,,0000,0000,0000,,Natriumi brenda, nje pjese e natriumit jashte.
Dialogue: 0,0:02:43.00,0:02:48.00,Default,,0000,0000,0000,,Tash na del qe qelizat kane me shume ngarkese pozitive
Dialogue: 0,0:02:48.00,0:02:50.00,Default,,0000,0000,0000,,ne pjesen e jashtme te membranes se sa
Dialogue: 0,0:02:50.00,0:02:51.00,Default,,0000,0000,0000,,ne pjesen brendshme te membranes.
Dialogue: 0,0:02:51.00,0:02:53.00,Default,,0000,0000,0000,,Ne fakt kemi nje ndryshim potenciali qe poqese
Dialogue: 0,0:02:53.00,0:02:56.00,Default,,0000,0000,0000,,membrana nuk do te ishte, ngarkesat negative do te donin te
Dialogue: 0,0:02:56.00,0:02:59.00,Default,,0000,0000,0000,,iknin jashte dhe jonet pozitive
Dialogue: 0,0:02:59.00,0:03:01.00,Default,,0000,0000,0000,,do te hynin brenda.
Dialogue: 0,0:03:01.00,0:03:03.00,Default,,0000,0000,0000,,Pjesa e jashtme mbetet me pozitive, dhe do e spjegojme
Dialogue: 0,0:03:03.00,0:03:04.00,Default,,0000,0000,0000,,se pse.
Dialogue: 0,0:03:04.00,0:03:10.00,Default,,0000,0000,0000,,,
Dialogue: 0,0:03:10.00,0:03:14.00,Default,,0000,0000,0000,,Pra ky eshte gradienti i potencialit elektrik, apo jo?
Dialogue: 0,0:03:14.00,0:03:18.00,Default,,0000,0000,0000,,Nese kjo eshte me pozitive--nese kam nje ngarkese
Dialogue: 0,0:03:18.00,0:03:19.00,Default,,0000,0000,0000,,poztieve ketu, do te deshiron te shkon ne drejtim te anes
Dialogue: 0,0:03:19.00,0:03:20.00,Default,,0000,0000,0000,,me pozitive.
Dialogue: 0,0:03:20.00,0:03:21.00,Default,,0000,0000,0000,,Do te donte te largohet nga
Dialogue: 0,0:03:21.00,0:03:22.00,Default,,0000,0000,0000,,ngarkesat e tjera pozitive.
Dialogue: 0,0:03:22.00,0:03:25.00,Default,,0000,0000,0000,,prapesohet nga ngarkesat e tjera pozitive.
Dialogue: 0,0:03:25.00,0:03:27.00,Default,,0000,0000,0000,,Ne te njejten frome, nese e kam nje ngarkese naegative ketu, do te donte te shkonte
Dialogue: 0,0:03:27.00,0:03:30.00,Default,,0000,0000,0000,,ne anen tjeter--apo ngarkesa pozitive, supozoj, do te ishte me e lumtur
Dialogue: 0,0:03:30.00,0:03:32.00,Default,,0000,0000,0000,,te jete ketu, se sa ketu.
Dialogue: 0,0:03:32.00,0:03:34.00,Default,,0000,0000,0000,,Pyetja eshte, si ndosh kjo?
Dialogue: 0,0:03:34.00,0:03:36.00,Default,,0000,0000,0000,,Per shkakun se po te lihen vetvetiu, ngarkesat
Dialogue: 0,0:03:36.00,0:03:38.00,Default,,0000,0000,0000,,do te shperndaheshin dhe nuk kishit per ta papsur kete gradient te potencialit.
Dialogue: 0,0:03:38.00,0:03:41.00,Default,,0000,0000,0000,,Ne nje fomr duhet te e sistemojme energjine ne menyre
Dialogue: 0,0:03:41.00,0:03:46.00,Default,,0000,0000,0000,,qe te prodhojme kete gjendje ku kemi me shume pozitivitet
Dialogue: 0,0:03:46.00,0:03:49.00,Default,,0000,0000,0000,,ne anene e jashtme, se sa qe kemi ne anen e brendshme.
Dialogue: 0,0:03:49.00,0:03:52.00,Default,,0000,0000,0000,,Dhe kjo arrihet permes pompes natrium-kalium.
Dialogue: 0,0:03:52.00,0:03:55.00,Default,,0000,0000,0000,,do te e viztoj kete ne menyren time.
Dialogue: 0,0:03:55.00,0:03:57.00,Default,,0000,0000,0000,,qartazi, qe kjo nuk eshte dujka e vertete e proteines, por
Dialogue: 0,0:03:57.00,0:04:00.00,Default,,0000,0000,0000,,do te u jep nje ide se si e ben pompimin perjashta.
Dialogue: 0,0:04:00.00,0:04:03.00,Default,,0000,0000,0000,,,
Dialogue: 0,0:04:03.00,0:04:05.00,Default,,0000,0000,0000,,Do e paraqes ate pjese te proteines.
Dialogue: 0,0:04:05.00,0:04:08.00,Default,,0000,0000,0000,,Ndoshta duket keshtu, besoj qe e keni idene se pse
Dialogue: 0,0:04:08.00,0:04:10.00,Default,,0000,0000,0000,,e vizatova keshtu.
Dialogue: 0,0:04:10.00,0:04:14.00,Default,,0000,0000,0000,,dhe kjo pjese e proteines apo enzimes--dhe mepastaj
Dialogue: 0,0:04:14.00,0:04:15.00,Default,,0000,0000,0000,,pjesa tjeter, do e vizatoj ne kete menyre.
Dialogue: 0,0:04:15.00,0:04:18.00,Default,,0000,0000,0000,,Duket disi keshtu, natyrishte qe proteina e vertete
Dialogue: 0,0:04:18.00,0:04:19.00,Default,,0000,0000,0000,,nuk duket keshtu.
Dialogue: 0,0:04:19.00,0:04:22.00,Default,,0000,0000,0000,,E keni pare paraqitjen qe u kam bere proteinave.
Dialogue: 0,0:04:22.00,0:04:25.00,Default,,0000,0000,0000,,Atoo duken sikur konstelacione te medha dhe shume komplekse.
Dialogue: 0,0:04:25.00,0:04:27.00,Default,,0000,0000,0000,,Pjese te ndryshme te proteinave mund te lidhen
Dialogue: 0,0:04:27.00,0:04:31.00,Default,,0000,0000,0000,,per komponente te ndryshme dhe kur keto komponente lidhen per proteinat, ato e nderrojne formen.
Dialogue: 0,0:04:31.00,0:04:33.00,Default,,0000,0000,0000,,Prandaj une po e bej ketu vetem nje paraqitje te thjeshte grafike dhe cka
Dialogue: 0,0:04:33.00,0:04:37.00,Default,,0000,0000,0000,,dua te u shpjejgoj, kjo eshte pompa e natrium-kaliumit ne
Dialogue: 0,0:04:37.00,0:04:38.00,Default,,0000,0000,0000,,gjendjen e saj inaktive.
Dialogue: 0,0:04:38.00,0:04:40.00,Default,,0000,0000,0000,,Cfare ndodh ne kete situate eshte
Dialogue: 0,0:04:40.00,0:04:44.00,Default,,0000,0000,0000,,lidhja e natriumit per keto pjese te vecanta ketu.
Dialogue: 0,0:04:44.00,0:04:49.00,Default,,0000,0000,0000,,Ne kete situate, natriumi mund te lidhet per keto pjese
Dialogue: 0,0:04:49.00,0:04:52.00,Default,,0000,0000,0000,,per enzimin appo proteinen.
Dialogue: 0,0:04:52.00,0:04:54.00,Default,,0000,0000,0000,,Ne rast se lemi lidhje te natriumit, por ne te njejten kohe
Dialogue: 0,0:04:54.00,0:04:56.00,Default,,0000,0000,0000,,nuk kemi pasur energji e cila gjenerohet ne sistem, me kete nuk do te ndodh asgje.
Dialogue: 0,0:04:56.00,0:04:58.00,Default,,0000,0000,0000,,Thjeshte, do te mbetet ne kete gjendje.
Dialogue: 0,0:04:58.00,0:05:01.00,Default,,0000,0000,0000,,Proteina aktuale mudn te duket si dic trente.
Dialogue: 0,0:05:01.00,0:05:05.00,Default,,0000,0000,0000,,Proteina aktuale do mund te ishte proteine e madhe mjegullore
Dialogue: 0,0:05:05.00,0:05:09.00,Default,,0000,0000,0000,,natriumet lidhen ketu, ketu dhe ketu.
Dialogue: 0,0:05:09.00,0:05:11.00,Default,,0000,0000,0000,,Me gjase eshte nje nje forme ne brendi te proteines, por ende asgje
Dialogue: 0,0:05:11.00,0:05:15.00,Default,,0000,0000,0000,,nuk ka per te ndodhur kur kemi lidhje te natriumit ne kete pjese
Dialogue: 0,0:05:15.00,0:05:16.00,Default,,0000,0000,0000,,te proteines.
Dialogue: 0,0:05:16.00,0:05:18.00,Default,,0000,0000,0000,,Ne menyre qe te kryej pune
Dialogue: 0,0:05:18.00,0:05:24.00,Default,,0000,0000,0000,,do thote per te pompuar perjashta, e shfrytezon energjine nga ATP-ja.
Dialogue: 0,0:05:24.00,0:05:27.00,Default,,0000,0000,0000,,Kemi pasur gjithe ato video lidhur me respirimin dhe u kam thene
Dialogue: 0,0:05:27.00,0:05:30.00,Default,,0000,0000,0000,,qe ATP-ja eshte monedha e energjise per qelizen--pra,
Dialogue: 0,0:05:30.00,0:05:33.00,Default,,0000,0000,0000,,kjo eshte dicka e dobishme per ATP qe ta bej.
Dialogue: 0,0:05:33.00,0:05:38.00,Default,,0000,0000,0000,,iATP--apo adenozin trifosfati--do mund te shkonte
Dialogue: 0,0:05:38.00,0:05:42.00,Default,,0000,0000,0000,,ne pjese te tjera te enzimit tone, por ne kete paraqitje tonen
Dialogue: 0,0:05:42.00,0:05:44.00,Default,,0000,0000,0000,,me gjase qendron ne kete pjese te enzimit.
Dialogue: 0,0:05:44.00,0:05:47.00,Default,,0000,0000,0000,,,
Dialogue: 0,0:05:47.00,0:05:50.00,Default,,0000,0000,0000,,Ky enzim, eshte nje lloj i ATP-azes.
Dialogue: 0,0:05:50.00,0:05:54.00,Default,,0000,0000,0000,,Kur them ATP-aza, e shkeput fosfatin nga ATP-ja
Dialogue: 0,0:05:54.00,0:05:56.00,Default,,0000,0000,0000,,dhe kjo vetem nga virityti i formes.
Dialogue: 0,0:05:56.00,0:05:57.00,Default,,0000,0000,0000,,eshte i afte qe ta shkepus.
Dialogue: 0,0:05:57.00,0:06:01.00,Default,,0000,0000,0000,,Kur e shkeput fosfatin, e ndryshon formen.
Dialogue: 0,0:06:01.00,0:06:06.00,Default,,0000,0000,0000,,,
Dialogue: 0,0:06:06.00,0:06:11.00,Default,,0000,0000,0000,,Pra, hapi i pare, i kemi jonet e natriumit--le te i
Dialogue: 0,0:06:11.00,0:06:13.00,Default,,0000,0000,0000,,bejme nje numerim te tyre.
Dialogue: 0,0:06:13.00,0:06:16.00,Default,,0000,0000,0000,,I kemi tri natriume--keto jane raportet aktuale--tri
Dialogue: 0,0:06:16.00,0:06:23.00,Default,,0000,0000,0000,,jone te natriumit nga pjesa e brendshme e qelizes appo neuronit.
Dialogue: 0,0:06:23.00,0:06:29.00,Default,,0000,0000,0000,,Keto lidhen per pompen, qe ne fakt eshte nje proteine e cila e pershkon
Dialogue: 0,0:06:29.00,0:06:30.00,Default,,0000,0000,0000,,membranen.
Dialogue: 0,0:06:30.00,0:06:34.00,Default,,0000,0000,0000,,Tani, hapi i dyte, e kemi poashtu edhe ATP-en.
Dialogue: 0,0:06:34.00,0:06:41.00,Default,,0000,0000,0000,,ATP zbethehet ne ADP plus fosfati ne proteinen
Dialogue: 0,0:06:41.00,0:06:43.00,Default,,0000,0000,0000,,aktuale dhe kjo e nderron formen.
Dialogue: 0,0:06:43.00,0:06:51.00,Default,,0000,0000,0000,,Kjo gjithashtu gjeneron energjine per te ndryshuar formen e pompes.
Dialogue: 0,0:06:51.00,0:06:55.00,Default,,0000,0000,0000,,,
Dialogue: 0,0:06:55.00,0:06:57.00,Default,,0000,0000,0000,,Kjo eshte gjendja e pompes me pare.
Dialogue: 0,0:06:57.00,0:07:01.00,Default,,0000,0000,0000,,Me pas, pompa mund te duket dicka keshtu.
Dialogue: 0,0:07:01.00,0:07:03.00,Default,,0000,0000,0000,,Te bej nje pastrim te kesaj hapesire keshtu.
Dialogue: 0,0:07:03.00,0:07:05.00,Default,,0000,0000,0000,,Do e vizatoj pompen si duket me pas, mu aty.
Dialogue: 0,0:07:05.00,0:07:07.00,Default,,0000,0000,0000,,,
Dialogue: 0,0:07:07.00,0:07:09.00,Default,,0000,0000,0000,,Pra kjo eshte pompa me perpara.
Dialogue: 0,0:07:09.00,0:07:13.00,Default,,0000,0000,0000,,Pasi qe fosfati te shkeputet nga ATP-ja, do mund te duket
Dialogue: 0,0:07:13.00,0:07:14.00,Default,,0000,0000,0000,,dicka keshtu.
Dialogue: 0,0:07:14.00,0:07:18.00,Default,,0000,0000,0000,,Ne vend te te pasurit kete strukture, hapet ne drejtimin
Dialogue: 0,0:07:18.00,0:07:19.00,Default,,0000,0000,0000,,e kundert.
Dialogue: 0,0:07:19.00,0:07:21.00,Default,,0000,0000,0000,,Tani do mund te dukej disi keshtu.
Dialogue: 0,0:07:21.00,0:07:24.00,Default,,0000,0000,0000,,,
Dialogue: 0,0:07:24.00,0:07:27.00,Default,,0000,0000,0000,,natyrishte qe i bart edhe keto grupe fosfatike.
Dialogue: 0,0:07:27.00,0:07:28.00,Default,,0000,0000,0000,,Keto kane ngarkese pozitive.
Dialogue: 0,0:07:28.00,0:07:31.00,Default,,0000,0000,0000,,,
Dialogue: 0,0:07:31.00,0:07:32.00,Default,,0000,0000,0000,,Hapja duket kesisoji.
Dialogue: 0,0:07:32.00,0:07:36.00,Default,,0000,0000,0000,,Kjo ane tani duket kesisoji.
Dialogue: 0,0:07:36.00,0:07:38.00,Default,,0000,0000,0000,,Tani grupet fosfatike lirohen ne pjesen e jashtme.
Dialogue: 0,0:07:38.00,0:07:40.00,Default,,0000,0000,0000,,Pra jane pompuar ne anen e jashtme.
Dialogue: 0,0:07:40.00,0:07:42.00,Default,,0000,0000,0000,,Mbani ne mend, kjo eshte energjia e kerkuar sepse leviz
Dialogue: 0,0:07:42.00,0:07:43.00,Default,,0000,0000,0000,,ne drejtim te kundert me gradientin natyral.
Dialogue: 0,0:07:43.00,0:07:46.00,Default,,0000,0000,0000,,Jeni duke e marr ngarkesen pozitive dhe jeni duke e zhvendosur
Dialogue: 0,0:07:46.00,0:07:50.00,Default,,0000,0000,0000,,ne ambientin i cili eshte edhe me pozitiv dhe jeni duke
Dialogue: 0,0:07:50.00,0:07:53.00,Default,,0000,0000,0000,,e zhvendosur ne nje ambient ne te cilin ka me shumice
Dialogue: 0,0:07:53.00,0:07:55.00,Default,,0000,0000,0000,,natrium, duke sjell ne kete menyre edhe me shume natrium.
Dialogue: 0,0:07:55.00,0:07:58.00,Default,,0000,0000,0000,,Do te thote levizni kunder gradientit natyral te ngarkesave
Dialogue: 0,0:07:58.00,0:07:59.00,Default,,0000,0000,0000,,dhe kunder gradientit te natriumit.
Dialogue: 0,0:07:59.00,0:08:03.00,Default,,0000,0000,0000,,Tani- supozoj kete e quajme si hapi i trete--natriumi lirohet
Dialogue: 0,0:08:03.00,0:08:07.00,Default,,0000,0000,0000,,ne pjesen e jashtme te qelizes.
Dialogue: 0,0:08:07.00,0:08:10.00,Default,,0000,0000,0000,,dhe kur kjo e nderrron formen, nuk eshte aq i pershtatshem per te u lidhur
Dialogue: 0,0:08:10.00,0:08:11.00,Default,,0000,0000,0000,,me natriuminm me.
Dialogue: 0,0:08:11.00,0:08:13.00,Default,,0000,0000,0000,,Me gjase edhe kjo do te behet pak me ndryshe, pra
Dialogue: 0,0:08:13.00,0:08:16.00,Default,,0000,0000,0000,,natriumi nuk do te lidhet me per kete strukture te re
Dialogue: 0,0:08:16.00,0:08:20.00,Default,,0000,0000,0000,,strukture qe e ka ndryshuar proteina si rezultat i ATP-es.
Dialogue: 0,0:08:20.00,0:08:26.00,Default,,0000,0000,0000,,Pra hapi i trete, keto tri pluse te natriumit, jone te natriumit--
Dialogue: 0,0:08:26.00,0:08:28.00,Default,,0000,0000,0000,,lirohen ne pjesen e jashtme.
Dialogue: 0,0:08:28.00,0:08:31.00,Default,,0000,0000,0000,,,
Dialogue: 0,0:08:31.00,0:08:33.00,Default,,0000,0000,0000,,tani perderisa e ka kete strukuture, kemi te tera
Dialogue: 0,0:08:33.00,0:08:35.00,Default,,0000,0000,0000,,keto jone pozitive ne kete pjese ketu.
Dialogue: 0,0:08:35.00,0:08:38.00,Default,,0000,0000,0000,,Keto ngarkesa pozitive do te doni te largoheshin sa me shume nga njera tjetra
Dialogue: 0,0:08:38.00,0:08:39.00,Default,,0000,0000,0000,,sa me shume qe eshte e mundur.
Dialogue: 0,0:08:39.00,0:08:42.00,Default,,0000,0000,0000,,Me gjase do te terhiqeshin per vet qelizen
Dialogue: 0,0:08:42.00,0:08:44.00,Default,,0000,0000,0000,,sepse qeliza ka ngarkese me te ulet pozitive ne pjesen e brendshme.
Dialogue: 0,0:08:44.00,0:08:48.00,Default,,0000,0000,0000,,Nga kjo keto jone pozitive--dhe ne vecanti, kaliumi--
Dialogue: 0,0:08:48.00,0:08:52.00,Default,,0000,0000,0000,,lidhet me kete ane te proteines kur ndodhet ne kete--
Dialogue: 0,0:08:52.00,0:08:55.00,Default,,0000,0000,0000,,mund te themi ne kete strukture te aktivizuar.
Dialogue: 0,0:08:55.00,0:08:58.00,Default,,0000,0000,0000,,Tani, kete, supozoj ta emerojme se hapi i katert.
Dialogue: 0,0:08:58.00,0:09:01.00,Default,,0000,0000,0000,,,
Dialogue: 0,0:09:01.00,0:09:07.00,Default,,0000,0000,0000,,Kemi dy jone te natriumit te lidhur--supozoj do mund ta quanim
Dialogue: 0,0:09:07.00,0:09:12.00,Default,,0000,0000,0000,,pompen aktive--pompen e ndryshuar.
Dialogue: 0,0:09:12.00,0:09:15.00,Default,,0000,0000,0000,,Apo ndoshta do mund te themi ne formen e saj te hapur.
Dialogue: 0,0:09:15.00,0:09:18.00,Default,,0000,0000,0000,,Pra keto vijne ketu dhe kur te lidhen, e ri-ndryshojne
Dialogue: 0,0:09:18.00,0:09:24.00,Default,,0000,0000,0000,,formen e kesaj proteine ne kete forme, ne
Dialogue: 0,0:09:24.00,0:09:25.00,Default,,0000,0000,0000,,strukturen e saj te hapur.
Dialogue: 0,0:09:25.00,0:09:27.00,Default,,0000,0000,0000,,Me rastin e kalimit ne formen e hapur, keto komponente
Dialogue: 0,0:09:27.00,0:09:30.00,Default,,0000,0000,0000,,nuk ndodhen me ketu, por i kemi keto ody komponente te vendndodhura ketu
Dialogue: 0,0:09:30.00,0:09:33.00,Default,,0000,0000,0000,,dhe ne kete dorme, mu ketu, keto gropeza krejt rastesishte==
Dialogue: 0,0:09:33.00,0:09:34.00,Default,,0000,0000,0000,,ndoshta edhe nuk jane gropeza.
Dialogue: 0,0:09:34.00,0:09:37.00,Default,,0000,0000,0000,,Ne realitet jane pjese ne kete konstellacion te madh proteinik.
Dialogue: 0,0:09:37.00,0:09:42.00,Default,,0000,0000,0000,,Nuk jane aq te mira qe te qendrojne lidhur dhe mbajtur per keto
Dialogue: 0,0:09:42.00,0:09:47.00,Default,,0000,0000,0000,,jone te natrumit, nga kjo jonet e natriumit lirohen apo futen brenda ne qelize.
Dialogue: 0,0:09:47.00,0:09:53.00,Default,,0000,0000,0000,,Pra hapi i peste. pompa--kjo e nderron formen e pompes.
Dialogue: 0,0:09:53.00,0:09:56.00,Default,,0000,0000,0000,,Dhe pompa me kete rast kalon ne formen e saj origjinale.
Dialogue: 0,0:09:56.00,0:10:05.00,Default,,0000,0000,0000,,,
Dialogue: 0,0:10:05.00,0:10:09.00,Default,,0000,0000,0000,,dhe posa te jemi ne kete ne kete pozite origjinale, keto dy jone te natriumit
Dialogue: 0,0:10:09.00,0:10:15.00,Default,,0000,0000,0000,,futen brenda qelizes.
Dialogue: 0,0:10:15.00,0:10:17.00,Default,,0000,0000,0000,,Do shohim ne videot ne vijim se pse eshte e dobishme te i kemi
Dialogue: 0,0:10:17.00,0:10:19.00,Default,,0000,0000,0000,,keto jone te natriumit ne brendi.
Dialogue: 0,0:10:19.00,0:10:21.00,Default,,0000,0000,0000,,Do mund te thonit, epo, pse nuk vazhdojme te bejme pompim te ketyre komponenteve
Dialogue: 0,0:10:21.00,0:10:23.00,Default,,0000,0000,0000,,ne pjesen e jashtme ne menyre qe te kemi ndryshim te potencialit?
Dialogue: 0,0:10:23.00,0:10:24.00,Default,,0000,0000,0000,,Por, do e shohim qe keto jone te natriumit jane
Dialogue: 0,0:10:24.00,0:10:26.00,Default,,0000,0000,0000,,ne te vertete poashtu shume te dobishme.
Dialogue: 0,0:10:26.00,0:10:28.00,Default,,0000,0000,0000,,dhe cili eshte efekti neto i ketij procesi?
Dialogue: 0,0:10:28.00,0:10:35.00,Default,,0000,0000,0000,,Perfundojme me nje sasi me te madhe te joeneve te natriumit ne pjesen e jashtme
Dialogue: 0,0:10:35.00,0:10:40.00,Default,,0000,0000,0000,,dhe me nje sasi me te madhe te joeneve te kaliumit ne pjesen e brendshme, por sic ju thash
Dialogue: 0,0:10:40.00,0:10:42.00,Default,,0000,0000,0000,,pjesa e brendshme eshte me pak pozitive se sa pjesa e jashtme.
Dialogue: 0,0:10:42.00,0:10:44.00,Default,,0000,0000,0000,,Por, keto te dy jane pozitive.
Dialogue: 0,0:10:44.00,0:10:46.00,Default,,0000,0000,0000,,Nuk me intereson nese kam me shume kalium appo natrium, por nese i keni
Dialogue: 0,0:10:46.00,0:10:50.00,Default,,0000,0000,0000,,kushtuar vemendje raporteve per te cilat kam folur, cdo here
Dialogue: 0,0:10:50.00,0:10:54.00,Default,,0000,0000,0000,,qe shfrytezoje me nje ATP, pompojme per jashta tri jone te natriumit
Dialogue: 0,0:10:54.00,0:10:58.00,Default,,0000,0000,0000,,dhe pompojme dy jone te kaliumit perbrenda, apo jo?
Dialogue: 0,0:10:58.00,0:11:02.00,Default,,0000,0000,0000,,Kemi pompuar tri jone te natriumit dhe dy jone te kaliumit. Secila prej tyre
Dialogue: 0,0:11:02.00,0:11:06.00,Default,,0000,0000,0000,,ka ngarkese plus 1, por sa here qe e realizojme kete, jemi duke
Dialogue: 0,0:11:06.00,0:11:08.00,Default,,0000,0000,0000,,shtuar nje net ngarkese 1 ne pjesen e jashtme, apo jo?
Dialogue: 0,0:11:08.00,0:11:10.00,Default,,0000,0000,0000,,3 ne pjesen e jashtme, 2 ne pjesen e brendshme.
Dialogue: 0,0:11:10.00,0:11:14.00,Default,,0000,0000,0000,,Kemi net ngarkesen 1--kemi plus 1 ne pjesen e jashtme.
Dialogue: 0,0:11:14.00,0:11:17.00,Default,,0000,0000,0000,,Me kete pjesa e jashtme behet me pozitive, ne vecanti ne
Dialogue: 0,0:11:17.00,0:11:19.00,Default,,0000,0000,0000,,raport me pjesen e brendshme.
Dialogue: 0,0:11:19.00,0:11:21.00,Default,,0000,0000,0000,,dhe kjo eshte ajo qe e krijon ndryshimin e potencialit.
Dialogue: 0,0:11:21.00,0:11:24.00,Default,,0000,0000,0000,,Nese e mirni voltmetrin--voltmetri e mat
Dialogue: 0,0:11:24.00,0:11:27.00,Default,,0000,0000,0000,,ndryshimin e potencilait elektrik--dhe me kete e masni
Dialogue: 0,0:11:27.00,0:11:31.00,Default,,0000,0000,0000,,ndryshimin voltazhik ne mes kesaj dhe asaj pike--apo me
Dialogue: 0,0:11:31.00,0:11:34.00,Default,,0000,0000,0000,,me specifikisht, ne mese kesaj dhe asaj pike, nese
Dialogue: 0,0:11:34.00,0:11:37.00,Default,,0000,0000,0000,,kishit me e zbritur voltazhen ketu nga voltazha
Dialogue: 0,0:11:37.00,0:11:43.00,Default,,0000,0000,0000,,atje, do te fitonit nje vlere prej 70 milivolt, qe ne pergjithesi
Dialogue: 0,0:11:43.00,0:11:46.00,Default,,0000,0000,0000,,konsiderohet si diferenca voltazhike ne gjendje te qetesise, diferenca
Dialogue: 0,0:11:46.00,0:11:49.00,Default,,0000,0000,0000,,e potencialit pergjate membranes se neuronit ne gjendjen
Dialogue: 0,0:11:49.00,0:11:51.00,Default,,0000,0000,0000,,e qetesise.
Dialogue: 0,0:11:51.00,0:11:55.00,Default,,0000,0000,0000,,Pra ne kete video, ne nje menyre i kam shtrire themelet e asaj se si qeliza
Dialogue: 0,0:11:55.00,0:11:59.00,Default,,0000,0000,0000,,ben shfrytezimin e ATP-es nga ana e qelizes, shfrytezimin e energjise
Dialogue: 0,0:11:59.00,0:12:02.00,Default,,0000,0000,0000,,dhe se, si e mban ndryshimin e potencialit pergjate membranes
Dialogue: 0,0:12:02.00,0:12:06.00,Default,,0000,0000,0000,,ku pjesa e jashtme eshte lehtas me shume pozitive se sa pjesa e brendshme.
Dialogue: 0,0:12:06.00,0:12:08.00,Default,,0000,0000,0000,,Ne realitet kemi nje ndryshim potenciali negativ nese e krahasojme
Dialogue: 0,0:12:08.00,0:12:10.00,Default,,0000,0000,0000,,pjesen e brendshme me ate te jashtme.
Dialogue: 0,0:12:10.00,0:12:13.00,Default,,0000,0000,0000,,Ngarkesa pozitive do donte te leviz ne drejtim perbrenda nese kishin per te u
Dialogue: 0,0:12:13.00,0:12:15.00,Default,,0000,0000,0000,,lejuar, dhe ngarkesa negatibe do donte te levizte perjashta nese
Dialogue: 0,0:12:15.00,0:12:17.00,Default,,0000,0000,0000,,kishte me u lejuar.
Dialogue: 0,0:12:17.00,0:12:18.00,Default,,0000,0000,0000,,Tani do mund te kishim nje pyetje te fundit.
Dialogue: 0,0:12:18.00,0:12:23.00,Default,,0000,0000,0000,,Do mund te thonit, epo, nese vazhdojme te shtojme ngarkese kendej
Dialogue: 0,0:12:23.00,0:12:25.00,Default,,0000,0000,0000,,ndryshimi yne voltazhik vertet do te behej negativ.
Dialogue: 0,0:12:25.00,0:12:29.00,Default,,0000,0000,0000,,Kjo do te behej shume me shume negativ se sa pjesa e jashtme.
Dialogue: 0,0:12:29.00,0:12:32.00,Default,,0000,0000,0000,,Pse stabilizohet ne vleren prej 70?
Dialogue: 0,0:12:32.00,0:12:34.00,Default,,0000,0000,0000,,Per te u pergjegjur kesaj pyetje--keto do te vihen ne loje
Dialogue: 0,0:12:34.00,0:12:37.00,Default,,0000,0000,0000,,ne me shume detaje ne videot e ardhme--gjithashtu keni
Dialogue: 0,0:12:37.00,0:12:42.00,Default,,0000,0000,0000,,kanalet, te cilat ne te vertet struktura proteinike qe ne pozicionin
Dialogue: 0,0:12:42.00,0:12:46.00,Default,,0000,0000,0000,,e tyre te hapur do te lejojne kalimin e natriumit pergjate tyre.
Dialogue: 0,0:12:46.00,0:12:48.00,Default,,0000,0000,0000,,Poashtu ekzistojne kanalet qe ne pozicionin e tyre
Dialogue: 0,0:12:48.00,0:12:51.00,Default,,0000,0000,0000,,te hapur, do te lejojne kalimin e kaliumit pergjate tyre.
Dialogue: 0,0:12:51.00,0:12:53.00,Default,,0000,0000,0000,,Jam duke e vizatuar pozicionin e tyre te mbyllur.
Dialogue: 0,0:12:53.00,0:12:54.00,Default,,0000,0000,0000,,Do te flasim ne videot e rradhes se cka ndodh
Dialogue: 0,0:12:54.00,0:12:55.00,Default,,0000,0000,0000,,kur keto hapen.
Dialogue: 0,0:12:55.00,0:12:57.00,Default,,0000,0000,0000,,Edhe ne pozicioni e tyre te mbyllur jane
Dialogue: 0,0:12:57.00,0:12:58.00,Default,,0000,0000,0000,,ngapak pershkuese.
Dialogue: 0,0:12:58.00,0:13:03.00,Default,,0000,0000,0000,,,
Dialogue: 0,0:13:03.00,0:13:06.00,Default,,0000,0000,0000,,Dhe nese them qe koncentrimi i joneve te kaliumit behet shume i larte
Dialogue: 0,0:13:06.00,0:13:11.00,Default,,0000,0000,0000,,ketu poshte--dhe shume e larte e ka kuptimin kur fillojne te
Dialogue: 0,0:13:11.00,0:13:14.00,Default,,0000,0000,0000,,arrijne pragun prej 70 milivolteve--apo me sakte,
Dialogue: 0,0:13:14.00,0:13:16.00,Default,,0000,0000,0000,,kur natriumi vjen ne sasi te madhe ne kete pjese, vetem disa nga to do te
Dialogue: 0,0:13:16.00,0:13:17.00,Default,,0000,0000,0000,,rrjedhin poshte.
Dialogue: 0,0:13:17.00,0:13:20.00,Default,,0000,0000,0000,,Kur koncentrimi behet shume i larte dhe ky eshte
Dialogue: 0,0:13:20.00,0:13:22.00,Default,,0000,0000,0000,,pozitiv per shkak te potencialit elektrik, disa
Dialogue: 0,0:13:22.00,0:13:23.00,Default,,0000,0000,0000,,nga to do te pershkohen permes.
Dialogue: 0,0:13:23.00,0:13:26.00,Default,,0000,0000,0000,,Dhe do e ,mbajne vleren prej 70 milivolteve.
Dialogue: 0,0:13:26.00,0:13:29.00,Default,,0000,0000,0000,,Nese shkojme me poshte, ndoshta nje asi e kaliumit do te rrejdhe
Dialogue: 0,0:13:29.00,0:13:30.00,Default,,0000,0000,0000,,ne nje rruge tjeter.
Dialogue: 0,0:13:30.00,0:13:33.00,Default,,0000,0000,0000,,Pra edhe atehere kur keto jane te mbyllura--nese behet shume
Dialogue: 0,0:13:33.00,0:13:37.00,Default,,0000,0000,0000,,qesharake--nese arrihet vlera 80 apo 90 milivolt
Dialogue: 0,0:13:37.00,0:13:39.00,Default,,0000,0000,0000,,krej papritmas, do te kemi nje nxitje te madhe per disa
Dialogue: 0,0:13:39.00,0:13:42.00,Default,,0000,0000,0000,,keto keto komponente qe te pershkohen neper kanalet e tyre respektive.
Dialogue: 0,0:13:42.00,0:13:44.00,Default,,0000,0000,0000,,Pra kjo eshte ajo qe na mundeson te qendrojme
Dialogue: 0,0:13:44.00,0:13:46.00,Default,,0000,0000,0000,,ne kete potencail voltazhik stabil.
Dialogue: 0,0:13:46.00,0:13:48.00,Default,,0000,0000,0000,,Ne videto ne vijim do te shohim se cka ndodh me
Dialogue: 0,0:13:48.00,0:13:52.00,Default,,0000,0000,0000,,me ket potencial voltazhik kur kemi stimulim te neuronit.
Dialogue: 0,0:13:52.00,0:13:52.00,Default,,0000,0000,0000,,,