[Script Info]
Title: 
[Events]
Format: Layer, Start, End, Style, Name, MarginL, MarginR, MarginV, Effect, Text
Dialogue: 0,0:00:01.51,0:00:04.35,Default,,0000,0000,0000,,Po celom organizmu imamo krvne sudove,
Dialogue: 0,0:00:04.35,0:00:08.94,Default,,0000,0000,0000,,a pricali smo kako u tim krvnim sudovima
Dialogue: 0,0:00:08.94,0:00:12.62,Default,,0000,0000,0000,,imamo razlicite vrste krvnih celija.\NZnaci imamo crvena krvna zrnca
Dialogue: 0,0:00:12.62,0:00:14.58,Default,,0000,0000,0000,,koja ovde crtam
Dialogue: 0,0:00:14.58,0:00:16.34,Default,,0000,0000,0000,,\Nali ako ste gledali
Dialogue: 0,0:00:16.34,0:00:22.42,Default,,0000,0000,0000,,video o imunom sistemu znacete\Nda takodje imamo T i B celije,
Dialogue: 0,0:00:22.44,0:00:26.79,Default,,0000,0000,0000,,makrofage i trombocite (krvne plocice),
Dialogue: 0,0:00:29.25,0:00:33.78,Default,,0000,0000,0000,,i sve u svemu, postoji oko 10\Nvrsta razlicitih krvnih celija
Dialogue: 0,0:00:33.81,0:00:36.63,Default,,0000,0000,0000,,koje imamo u krvi u svako doba.
Dialogue: 0,0:00:36.63,0:00:39.49,Default,,0000,0000,0000,,U ovom videu bih zeleo da pricamo\No tome gde one nastaju
Dialogue: 0,0:00:39.54,0:00:45.14,Default,,0000,0000,0000,,sto mozda vec i znate, i od \Nkojih prekursorskih celija nastaju.
Dialogue: 0,0:00:45.14,0:00:49.04,Default,,0000,0000,0000,,Jer celije ne postaju ni iz cega,\Nnego nastaju od celija prekursora,
Dialogue: 0,0:00:49.04,0:00:51.37,Default,,0000,0000,0000,,koje se dele i proizvode nove celije.
Dialogue: 0,0:00:51.37,0:00:53.99,Default,,0000,0000,0000,,Dakle, znate li odakle sve ove celije
Dialogue: 0,0:00:53.99,0:00:57.22,Default,,0000,0000,0000,,poticu, gde su napravljene?\NNacrtacu vam odgovor -
Dialogue: 0,0:00:57.22,0:01:00.40,Default,,0000,0000,0000,,karikaturu odgovora, koja nije u \Nsrazmeri sa ovim krvnim sudom
Dialogue: 0,0:01:00.40,0:01:05.20,Default,,0000,0000,0000,,dakle, ovo je kost, i odgovor je da\Nsve ove celije dolaze iz kostne srzi,
Dialogue: 0,0:01:05.20,0:01:07.36,Default,,0000,0000,0000,,koje je u unutrasnjosti kosti.
Dialogue: 0,0:01:07.36,0:01:11.13,Default,,0000,0000,0000,,Kada sam ja ovo prvi put cuo\Npomislio sam: kako je moguce
Dialogue: 0,0:01:11.13,0:01:14.03,Default,,0000,0000,0000,,da krvne celije dolaze iz\Nunutrasnjosti kosti, prodju
Dialogue: 0,0:01:14.03,0:01:16.63,Default,,0000,0000,0000,,kroz povrsinu kosti i udju u\Nkrvni sud?
Dialogue: 0,0:01:16.63,0:01:22.12,Default,,0000,0000,0000,,Mozda ce vas iznenaditi cinjenica da\Nsu ove kosti i same dobro prokrvljene,
Dialogue: 0,0:01:22.12,0:01:25.98,Default,,0000,0000,0000,,samo su ti krvni sudovi vrlo mali\Ni tesko se vide. Znaci celijama
Dialogue: 0,0:01:25.98,0:01:29.42,Default,,0000,0000,0000,,je prilicno lako da uskoce \Nu te krvne sudove
Dialogue: 0,0:01:29.42,0:01:33.40,Default,,0000,0000,0000,,i udju u krvne sudove tela.\NA sada, hajde da popricamo o
Dialogue: 0,0:01:33.40,0:01:38.60,Default,,0000,0000,0000,,tim prekusorskim celijama.\NNesto sto dugo nismo znali
Dialogue: 0,0:01:38.60,0:01:40.35,Default,,0000,0000,0000,,ali sada znamo je da
Dialogue: 0,0:01:40.35,0:01:44.34,Default,,0000,0000,0000,,postoji jedna potentna stem (maticna) \Ncelija u kostnoj srzi
Dialogue: 0,0:01:44.34,0:01:47.58,Default,,0000,0000,0000,,koja moze da proizvede svih\N10 vrsta krvnih celija.
Dialogue: 0,0:01:47.58,0:01:51.02,Default,,0000,0000,0000,,i ta jedna, veoma potentna\Ncelija ima malo
Dialogue: 0,0:01:51.06,0:01:53.85,Default,,0000,0000,0000,,komplikovano ime, koje cu\Nispisati ovde - zove se
Dialogue: 0,0:01:53.87,0:01:58.04,Default,,0000,0000,0000,,pluripotentna - ako vam je\Nlatinski jaca strana znacete
Dialogue: 0,0:01:58.10,0:02:02.78,Default,,0000,0000,0000,,da ovo znaci "ona sto moze\Nda radi mnoge stvari"...to je
Dialogue: 0,0:02:02.78,0:02:07.45,Default,,0000,0000,0000,,dosta nesretan prevod, ali kako bilo...\Npluripotentna hematopoeticna
Dialogue: 0,0:02:07.47,0:02:11.22,Default,,0000,0000,0000,,jer je hematopoeza proces\N
Dialogue: 0,0:02:11.22,0:02:16.58,Default,,0000,0000,0000,,proizvodnje krvnih celija
Dialogue: 0,0:02:16.58,0:02:21.12,Default,,0000,0000,0000,,znaci to je pluripotentna \Nhematopoeticna maticna (stem) celija.
Dialogue: 0,0:02:21.12,0:02:23.19,Default,,0000,0000,0000,,Jer su maticne celije
Dialogue: 0,0:02:23.19,0:02:27.10,Default,,0000,0000,0000,,kao sto verovatno znate, celije\Nkoje mogu da se dele u
Dialogue: 0,0:02:27.10,0:02:29.80,Default,,0000,0000,0000,,mnoge druge vrste celija.
Dialogue: 0,0:02:29.80,0:02:35.01,Default,,0000,0000,0000,,A sad bih vas zapitao - \Nda li mislite da makrofag
Dialogue: 0,0:02:35.01,0:02:38.21,Default,,0000,0000,0000,,koji, ako ste gledali video\No imunologiji, znacete da
Dialogue: 0,0:02:38.21,0:02:40.95,Default,,0000,0000,0000,,je velika, fagocitna celija\Nkoja voli da proguta napasnike
Dialogue: 0,0:02:40.99,0:02:47.30,Default,,0000,0000,0000,,ili celijski otpad, mislite li da\Nje makrofag blizi rodjak B celiji
Dialogue: 0,0:02:47.30,0:02:49.66,Default,,0000,0000,0000,,koja, kao sto znate, \Nproizvodi antitela,
Dialogue: 0,0:02:49.67,0:02:52.55,Default,,0000,0000,0000,,ili crvenom krvnom zrncu?
Dialogue: 0,0:02:52.56,0:02:56.88,Default,,0000,0000,0000,,Mozda ce vas odgovor iznenaditi.\NOdgovor je da je on u blizem
Dialogue: 0,0:02:56.88,0:03:00.89,Default,,0000,0000,0000,,srodstvu sa crvenom krvnom celijom.\NSto je neobicno, posto su makrofagi
Dialogue: 0,0:03:00.89,0:03:04.82,Default,,0000,0000,0000,,i B celije vrste imunih celija, \Nsto crvena krvna zrnca nisu.
Dialogue: 0,0:03:04.82,0:03:08.92,Default,,0000,0000,0000,,Od ove pluripotentne \Nhematopoeticne maticne celije
Dialogue: 0,0:03:08.92,0:03:12.44,Default,,0000,0000,0000,,nastaju dve glavne krvne loze, \Nkoje cu nacrtati ovde.
Dialogue: 0,0:03:12.44,0:03:17.41,Default,,0000,0000,0000,,Prva je mijeloidna loza,
Dialogue: 0,0:03:17.41,0:03:23.66,Default,,0000,0000,0000,,a druga je limfoidna loza.
Dialogue: 0,0:03:28.17,0:03:32.32,Default,,0000,0000,0000,,Kada se ova pluripotentna\Ncelija prvi put podeli
Dialogue: 0,0:03:32.32,0:03:36.36,Default,,0000,0000,0000,,od nje moze nastati jedna\Nod ovih ili jedna od ovih celija
Dialogue: 0,0:03:36.36,0:03:40.67,Default,,0000,0000,0000,,a i ovo su prekusorske celije\Nod kojih nastaju onih 10 vrsta
Dialogue: 0,0:03:40.67,0:03:44.11,Default,,0000,0000,0000,,celija koje se nalaze u nasoj krvi.\NZnaci ovo nisu celije koje
Dialogue: 0,0:03:44.11,0:03:45.74,Default,,0000,0000,0000,,ce zavrsiti u nasoj krvi;
Dialogue: 0,0:03:45.78,0:03:48.15,Default,,0000,0000,0000,,ovi momci sede \Nu kostnoj srzi i
Dialogue: 0,0:03:48.15,0:03:50.62,Default,,0000,0000,0000,,prave celije koje ce \Nzavrsiti u nasoj krvi.
Dialogue: 0,0:03:50.74,0:03:55.64,Default,,0000,0000,0000,,Ove limfoidne progenitorske celije\Nmogu da naprave 3
Dialogue: 0,0:03:55.64,0:04:04.11,Default,,0000,0000,0000,,razlicite vrste imunih celija - \NNK celije (celije ubice),
Dialogue: 0,0:04:04.11,0:04:08.76,Default,,0000,0000,0000,,B celije, i T celije.
Dialogue: 0,0:04:16.42,0:04:21.19,Default,,0000,0000,0000,,Dakle ovo su 3 od 10 vrsta\Nkrvnih celija o kojima pricamo.
Dialogue: 0,0:04:21.30,0:04:24.94,Default,,0000,0000,0000,,Ostalih 7 ce nastati od\Nmijeloidne loze.
Dialogue: 0,0:04:24.95,0:04:28.48,Default,,0000,0000,0000,,Jedna od njih je, kao sto\Nste pretpostavili
Dialogue: 0,0:04:28.72,0:04:32.22,Default,,0000,0000,0000,,crvena krvna celija.
Dialogue: 0,0:04:32.65,0:04:37.54,Default,,0000,0000,0000,,Druga je megakariocit.
Dialogue: 0,0:04:37.63,0:04:40.27,Default,,0000,0000,0000,,Mozda se ne secate sta on radi
Dialogue: 0,0:04:40.29,0:04:43.79,Default,,0000,0000,0000,,pa cu vam reci za momenati, \Nali pokusajte da se setite;
Dialogue: 0,0:04:43.84,0:04:48.67,Default,,0000,0000,0000,,megakariocit proizvodi krvne plocice \N(trombocite).
Dialogue: 0,0:04:48.75,0:04:52.76,Default,,0000,0000,0000,,Od megakariocita se odvoje mali pupoljci
Dialogue: 0,0:04:52.81,0:04:57.50,Default,,0000,0000,0000,,citoplazme okruzeni membranom\Ni to su trombociti.
Dialogue: 0,0:05:01.95,0:05:05.41,Default,,0000,0000,0000,,Mijeloidna loza takodje proizvodi\Ngomilu imunih celija
Dialogue: 0,0:05:05.49,0:05:09.72,Default,,0000,0000,0000,,pored crvenih krvnih zrnaca\Ni krvnih plocica
Dialogue: 0,0:05:10.81,0:05:14.39,Default,,0000,0000,0000,,za koje mozda niste culi pa cu ih\Nizredjati ovde.
Dialogue: 0,0:05:14.51,0:05:20.24,Default,,0000,0000,0000,,Jedna od njih je neutrofil,\Nza koju ste najverovatnije culi.
Dialogue: 0,0:05:20.24,0:05:26.73,Default,,0000,0000,0000,,Postoje jos dve celije veoma slicne\Nneutrofilu. Jedna se zove bazofil,
Dialogue: 0,0:05:27.30,0:05:31.23,Default,,0000,0000,0000,,a druga se zove eozinofil.
Dialogue: 0,0:05:31.23,0:05:33.56,Default,,0000,0000,0000,,Nemojte se lose osecati ako
Dialogue: 0,0:05:33.56,0:05:36.52,Default,,0000,0000,0000,,niste culi za njih, posto su one \Nprilicno retke u vasoj krvi.
Dialogue: 0,0:05:36.52,0:05:39.63,Default,,0000,0000,0000,,Ima ih u krvi, ali ne mnogo.
Dialogue: 0,0:05:39.63,0:05:42.18,Default,,0000,0000,0000,,I onda imamo monocite, koji
Dialogue: 0,0:05:42.18,0:05:44.82,Default,,0000,0000,0000,,su veoma slicni sa ove 3\Nprethodne celije.
Dialogue: 0,0:05:44.82,0:05:48.55,Default,,0000,0000,0000,,Monocit je ono sto se kasnije\Npretvara u makrofag -
Dialogue: 0,0:05:48.55,0:05:50.70,Default,,0000,0000,0000,,za makrofage ste verovatno culi;
Dialogue: 0,0:05:50.76,0:05:54.28,Default,,0000,0000,0000,,monocit je samo nesto manje diferentovana
Dialogue: 0,0:05:54.28,0:05:56.43,Default,,0000,0000,0000,,verzija makrofaga.
Dialogue: 0,0:05:56.44,0:06:01.90,Default,,0000,0000,0000,,I konacno imamo mast celije.\NMast celije su one koje...
Dialogue: 0,0:06:04.81,0:06:11.77,Default,,0000,0000,0000,,Znaci to su nasih 7 ostalih celija
Dialogue: 0,0:06:13.44,0:06:16.43,Default,,0000,0000,0000,,i kao sto videte, ono sto smo
Dialogue: 0,0:06:16.43,0:06:18.83,Default,,0000,0000,0000,,rekli na samom pocetku je\Nu stvari tacno.
Dialogue: 0,0:06:18.91,0:06:21.05,Default,,0000,0000,0000,,Crvena krvna zrnca su
Dialogue: 0,0:06:21.08,0:06:26.81,Default,,0000,0000,0000,,u blizem srodstvu sa makrofagima, \Nnego sto su B ili T,
Dialogue: 0,0:06:26.96,0:06:31.31,Default,,0000,0000,0000,,ili slicne celije.
Dialogue: 0,0:06:32.24,0:06:34.96,Default,,0000,0000,0000,,I sad ubacujem dodatak\Novom videu,
Dialogue: 0,0:06:34.96,0:06:36.90,Default,,0000,0000,0000,,da bih spomenuo\Njos jednu vrstu celije
Dialogue: 0,0:06:36.93,0:06:39.10,Default,,0000,0000,0000,,o kojoj smo ranije pricali,\Nali koju nisam
Dialogue: 0,0:06:39.10,0:06:41.26,Default,,0000,0000,0000,,uvrstio u ovu shemu.
Dialogue: 0,0:06:41.26,0:06:43.42,Default,,0000,0000,0000,,A to je dendriticna celija.
Dialogue: 0,0:06:43.46,0:06:45.95,Default,,0000,0000,0000,,To je vrsta celije koja prezentuje\Nantigen.
Dialogue: 0,0:06:45.95,0:06:48.43,Default,,0000,0000,0000,,Hteo sam da vas pitam -\Nda li mislite da
Dialogue: 0,0:06:48.43,0:06:50.91,Default,,0000,0000,0000,,dendriticna celija potice od mijeloidne loze,
Dialogue: 0,0:06:50.91,0:06:53.16,Default,,0000,0000,0000,,ili od limfoidne loze?
Dialogue: 0,0:06:53.16,0:06:55.15,Default,,0000,0000,0000,,Ovo je ustvari trik-pitanje, jer
Dialogue: 0,0:06:55.15,0:06:57.56,Default,,0000,0000,0000,,je odgovor - potice od obe.\N
Dialogue: 0,0:06:57.56,0:07:02.76,Default,,0000,0000,0000,,Neke dendriticne celije (nacrtacu ih ovde)\Npoticu od mijeloidne,
Dialogue: 0,0:07:02.80,0:07:07.73,Default,,0000,0000,0000,,a druge (nacrtacu ih odmah pored)\Nod lifmoidne loze.
Dialogue: 0,0:07:08.18,0:07:13.92,Default,,0000,0000,0000,,One sto poticu od mijeloidne loze \Nnastaju od monocita,
Dialogue: 0,0:07:15.34,0:07:18.87,Default,,0000,0000,0000,,dok one sto poticu od limfoidne loze
Dialogue: 0,0:07:18.93,0:07:23.02,Default,,0000,0000,0000,,ne nastaju od B ili T celija, \Nnego od nekog limfoidnog prekursora.
Dialogue: 0,0:07:23.03,0:07:26.02,Default,,0000,0000,0000,,Znaci dendriticne celije su neka vrsta
Dialogue: 0,0:07:26.02,0:07:30.38,Default,,0000,0000,0000,,cudnog izuzetka, mogu poteci od\Nobe loze, i sad zelim da dodam jos
Dialogue: 0,0:07:30.43,0:07:33.23,Default,,0000,0000,0000,,jednu informaciju, nadam se\Nda vas necu preopteretiti,
Dialogue: 0,0:07:33.23,0:07:37.38,Default,,0000,0000,0000,,samo da vas jos jednom podsetim da\Nmonociti, pored toga sto mogu
Dialogue: 0,0:07:37.38,0:07:40.57,Default,,0000,0000,0000,,postati dendriticne celije, mogu\Ntakodje postati makrofagi.
Dialogue: 0,0:07:40.58,0:07:44.44,Default,,0000,0000,0000,,A makrofagi su nam vec\Npoznati - bar smo pricali o
Dialogue: 0,0:07:44.46,0:07:47.48,Default,,0000,0000,0000,,njima u ranijim lekcijama.. \Ni evo makrofaga.
Dialogue: 0,0:07:47.49,0:07:50.79,Default,,0000,0000,0000,,Ako se secate, makrofagi su \Nkao neki strazari. Oni cuce u
Dialogue: 0,0:07:50.79,0:07:54.91,Default,,0000,0000,0000,,tkivima i paze da ne naidju\Nnapadaci. Dendriticne celije
Dialogue: 0,0:07:54.91,0:07:58.27,Default,,0000,0000,0000,,se ponasaju isto tako.\NA sta je sa monocitom, da li
Dialogue: 0,0:07:58.27,0:08:02.25,Default,,0000,0000,0000,,i on to isto radi? U stvari ne.\NMonocit je neka cirkulisuca
Dialogue: 0,0:08:02.29,0:08:05.62,Default,,0000,0000,0000,,verzija makrofaga ili dendriticnih celija.
Dialogue: 0,0:08:05.62,0:08:07.72,Default,,0000,0000,0000,,Sta mi to znaci cirkulisuca?
Dialogue: 0,0:08:07.77,0:08:10.85,Default,,0000,0000,0000,,Pa, to da se on nalazi u \Nsamoj krvi. Znaci monocit se
Dialogue: 0,0:08:10.87,0:08:15.21,Default,,0000,0000,0000,,krece u krvi i kad predje u\Ntkivo da se tamo smesti i
Dialogue: 0,0:08:15.21,0:08:18.61,Default,,0000,0000,0000,,postane strazar, tada se on\Npretvara u makrofaga ili u
Dialogue: 0,0:08:18.61,0:08:19.80,Default,,0000,0000,0000,,dendriticnu celiju.