[Script Info]
Title: 
[Events]
Format: Layer, Start, End, Style, Name, MarginL, MarginR, MarginV, Effect, Text
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Science.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,The very word for many of you conjures\Nunhappy memories of boredom
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,in high school biology or physics class.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,But let me assure that what you did there
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,had very little to do with science.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,That was really the "what" of science.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,It was the history of what\Nother people had discovered.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,What I'm most interested in as a scientist
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,is the "how" of science.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Because science is knowledge in process.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We make an observation,\Nguess an explanation for that observation,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and then make a prediction\Nthat we can test
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,with an experiment or other observation.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,A couple of examples.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,First of all, people noticed\Nthat the Earth was below, the sky above,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and both the Sun and the Moon\Nseemed to go around them.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Their guessed explanation was that\Nthe Earth must be the center
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,of the Universe.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,The prediction: everything\Nshould circle around the Earth.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,This was first really tested\Nwhen Galileo got his hands
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,on one of the first telescopes,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and as he gazed into the night sky,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,what he found there was a planet, Jupiter,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,with four moons circling around it.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,He then used those moons\Nto follow the path of Jupiter
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and found that Jupiter also\Nwas not going around the Earth
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,but around the Sun.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,So the prediction test failed.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,And this led to the discarding\Nof the theory
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,that the Earth was the center\Nof the Universe.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Another example: Sir Isaac Newton\Nnoticed that things fall to the Earth.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,The guessed explanation was gravity,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,the prediction that everything\Nshould fall to the Earth.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,But of course, not everything\Ndoes fall to the Earth.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,So did we discard gravity?
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,No. We revised the theory and said,\Ngravity pulls things to the Earth
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,unless there is an equal\Nand opposite force in the other direction.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,This led us to learn something new.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We began to pay more attention\Nto the bird and the bird's wings,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and just think of all the discoveries
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,that have flown from\Nthat line of thinking.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,So the test failures, the exceptions,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,the outliers, teach us what we don't know
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and lead us to something new.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,This is how science moves forward.\NThis is how science learns.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Sometimes in the media,\Nand even more rarely,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,but sometimes even scientists will say
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,that something or has been\Nscientifically proven.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,But I hope that you understand\Nthat science never proves anything
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,definitively forever.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Hopefully science remains curious enough
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,to look for
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and humble enough to recognize
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,when we have found
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,the next outlier,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,the next exception,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,which, like Jupiter's moons,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,teaches us what we don't actually know.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We're going to change gears\Nhere for a second.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,The caduceus, or the symbol of medicine,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,means a lot of different things\Nto different people,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,but most of our public\Ndiscourse on medicine
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,really turns it into\Nan engineering problem.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We have the hallways of Congress,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and the boardrooms of insurance companies
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,that try to figure out how to pay for it.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,The ethicists and epidemiologists\Ntry to figure out how best
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,to distribute medicine,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and the hospitals and physicians\Nare absolutely obsessed
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,with their protocols and checklists,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,trying to figure out how best\Nto safely apply medicine.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,These are all good things.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,However, they also all assume
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,at some level
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,that the textbook of medicine is closed.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We start to measure the quality\Nof our healthcare
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,by how quickly we can access it.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,It doesn't surprise me that\Nin this climate,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,many of our institutions for\Nfor the provision of healthcare
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,start to look a heck of a lot\Nlike Jiffy Lube.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,(Laughter)
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,The only problem is that when\NI graduated from medical school,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,I didn't get one of those\Nlittle doohickeys
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,that your mechanic has\Nto plug into your car
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and find out exactly what's wrong with it,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,because the textbook of medicine
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,is not closed.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Medicine is science.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Medicine is knowledge in process.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We make an observation,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,we guess an explanation\Nof that observation,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and then we make a prediction\Nthat we can test.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Now the testing ground
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,of most predictions in medicine
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,is populations,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and you may remember from those\Nboring days in biology class
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,that populations tend to distribute
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,around a mean
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,as a Gaussian or a normal curve.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Therefore, in medicine,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,after we make a prediction\Nfrom a guessed explanation,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,we test it in a population.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,That means that what we know in medicine,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,our knowledge and our knowhow,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,comes from populations,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,but extends only as far
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,as the next outlier,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,the next exception,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,which, like Jupiter's moons,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,will teach us what we don't actually know.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Now I am a surgeon
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,who looks after patients with sarcoma.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Sarcoma is a very rare form of cancer.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,It's the cancer of flesh and bones.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,And I would tell you that every one\Nof my patients is an outlier,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,is an exception.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,There is no surgery I have ever performed\Nfor a sarcoma patient
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,that has ever been guided
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,by a randomized controlled clinical trial,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,what we consider the best kind\Nof population-based evidence in medicine.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,People talk about thinking\Noutside the box,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,but we don't even have a box
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,in sarcoma.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,What we do have as we take\Na bath in the uncertainty
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and unknowns and exceptions\Nand outliers that surround us in sarcoma
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,is easy access to what I think are\Nthose two more important values
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,for any science:
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,humility and curiosity.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Because if I am humble and curious,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,when a patient asks me a question,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and I don't know the answer,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,I'll ask a colleague who may have\Na similar albeit distinct patient
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,with sarcoma.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We'll even establish international\Ncollaborations.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Those patients will start to talk\Nto each other through chatrooms
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and support groups.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,It's through this kind of\Nhumbly curious communication
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,that we begin to try and learn new things.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,As an example, this is a patient of mine
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,who had a cancer near his knee.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Because of humbly curious communication
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,in international collaborations,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,we have learned that we can repurpose\Nthe ankle to serve as the knee
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,when we have to remove the knee\Nwith the cancer.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,He can then wear a prosthetic\Nand run and jump and play.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,This opportunity was available to him
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,because of international collaborations.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,It was desirable to him
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,because he had contacted other patients
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,who had experienced it.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,And so exceptions and outliers in medicine
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,teach us what we don't know,\Nbut also lead us to new thinking.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Now very importantly,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,all the new thinking that outliers
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and exceptions lead us to in medicine
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,does not only apply\Nto the outliers and exceptions.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,It is not that we only learn\Nfrom sarcoma patients
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,ways to manage sarcoma patients.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Sometimes, the outliers
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and the exceptions
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,teach us things that matter\Nquite a lot to the general population.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Like a tree standing outside a forests,\Nthe outliers and the exceptions
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,draw our attention
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and lead us into a much greater sense
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,of perhaps what a tree is.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We often talk about losing the forests\Nfor the trees,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,but one also loses a tree
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,within a forest.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,But the tree that stands out by itself
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,makes those relationships
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,that define a tree,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,the relationships between trunk\Nand roots and branches,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,much more apparent.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Even if that tree is crooked
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,or even if that tree
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,has very unusual relationships\Nbetween trunk and roots and branches,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,it nonetheless draws our attention
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and allows us to make observation
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,that we can then test\Nin the general population.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,I told you that sarcomas are rare.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,They make up about 1 percent\Nof all cancers.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,You also probably know that cancer\Nis considered a genetic disease.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,By genetic disease, we mean that cancer\Nis caused by oncogenes
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,that are turned on in cancer
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and tumor suppressor genes\Nthat are turned off to cause cancer.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,You might think that we learned\Nabout oncogenes
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and tumor suppressor genes\Nfrom common cancers
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,like breast cancer and prostate cancer\Nand lung cancer,
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,but you'd be wrong.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We learned about oncogenes\Nand tumor suppressor genes
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,for the first time
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,in that itty bitty little one percent\Ncancers called sarcoma.
Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,In 1966, Peyton Rous