1
00:00:06,539 --> 00:00:09,450
Buvingiz sizni yoshligidagi jasurligi 
bilan lol qoldirsa ham,

2
00:00:09,450 --> 00:00:13,364
siz buvingiz trapez ustasi bo'lganiga
ishonishingiz qiyin bo'lsa kerak.

3
00:00:13,364 --> 00:00:18,344
Ammo bel va tirsakdagi og'rig', qariyalar
orasida keng tarqalgan tizza qirsillashi

4
00:00:18,344 --> 00:00:20,497
shunchaki “qarilik” emas.

5
00:00:20,497 --> 00:00:25,157
Aslida, bog'imdagi qotish holati 
ko'plab yoshlarni ham azoblantiradi.

6
00:00:25,157 --> 00:00:26,838
Sabachisi artrit.

7
00:00:26,838 --> 00:00:29,974
Bu kasallik bo’g’imlarda yallig’lanish va
og’riq keltiradi.

8
00:00:29,974 --> 00:00:33,694
AQShda 90 million kishilarda mavjud.

9
00:00:33,694 --> 00:00:36,567
Ammo qotgan va qirsillaydigan 
bo'g'imlar muqarrar holatmi?

10
00:00:36,567 --> 00:00:38,781
Nima sababdan artrit 
ko'p uchraydiga kasallik

11
00:00:38,781 --> 00:00:42,619
va nima uchun haligacha bu keng 
tarqalgan kasallikga da'vo topmadik?

12
00:00:42,619 --> 00:00:45,538
Birinchi to'siq bu artritning

13
00:00:45,538 --> 00:00:48,949
yuzta turli hil holatlardan iboratligi.

14
00:00:48,949 --> 00:00:53,103
Bu barcha holatlarda bo'gimda og'riq hamda
yallig'lanish kuzatiladi.

15
00:00:53,103 --> 00:00:57,120
Ammo, bularni nima keltirishi hamda
simptomlar avjligi farqlanadi.

16
00:00:57,120 --> 00:00:59,812
Hattoki, eng tarqalgan turi osteoartritni

17
00:00:59,812 --> 00:01:02,217
oldini olish biz oylagandek oson emas.

18
00:01:02,217 --> 00:01:06,242
Artrit aynan bir yosh guruhiga 
munosibligi notog'ri tushunchadir.

19
00:01:06,242 --> 00:01:10,640
Osteoartrit sababi ko'pincha
bemorning yoshligidagi

20
00:01:10,640 --> 00:01:13,681
oddiy jarohat tufayli yuzaga kelgani
aniqlanishi mumkin.

21
00:01:13,681 --> 00:01:18,211
Immunitet hujayralari tezda shikastlangan
joyni tozalash va tiklashga yordam berib,

22
00:01:18,211 --> 00:01:20,001
fermentlarni ishlab chiqaradi.

23
00:01:20,001 --> 00:01:24,065
Bu fermentlardan bir turlari bu matritca 
metalloproteinazlari va agrekanazlaridir.

24
00:01:24,065 --> 00:01:28,221
Bular shikastlangan joydagi toqimalarni 
tozalaydi va yallig'lanishni qozg'atadi.

25
00:01:28,221 --> 00:01:31,545
Tez shishish tizza bog'imining
tiklanish vaqtida himoya qilsa ham,

26
00:01:31,545 --> 00:01:36,215
lekin toqimar to'liq bitmasa immunitet
hujayralari vaqtdan ortiq qolib ketadi.

27
00:01:36,215 --> 00:01:39,741
Fermentlar to'htamay ishlab chiqarilishi
to'g'ayni yemiradi,

28
00:01:39,741 --> 00:01:43,133
bo'g'imni kuchsizlantiradi, va artrit 
holatini yaratadi.

29
00:01:43,133 --> 00:01:47,813
Artritning barcha turlari o'tmishdagi
sport shikasti tufayli emasdir.

30
00:01:47,813 --> 00:01:52,583
AQShda 1, 3 million kishida uchraydigan 
romatoid artritini misol qilib olamiz.

31
00:01:52,583 --> 00:01:55,247
Bu kasallik aslida autoimmun kasalligidir,

32
00:01:55,247 --> 00:01:58,855
autoantitanalar tabiiy holda ishlab 
chiqariladigan oqsillarga hujum qiladi.

33
00:01:58,855 --> 00:02:01,874
Bu oqsillardan bir turini bog'im tog'ayi
ishlab chiqaradi.

34
00:02:01,874 --> 00:02:04,114
Bunga sababchi nima ekanligi
hali ham no'malum.

35
00:02:04,114 --> 00:02:08,195
Ammo, hulosa shuki organizm bog'im 
toqimasini horijiy bosqinchi deb ko'radi.

36
00:02:08,195 --> 00:02:13,245
Immunitet hujayralari toqimani sozlashga
hojat bo'lmasa ham bostirib kiradi.

37
00:02:13,245 --> 00:02:15,984
Bu reaktciya surunkali yallig'lanishga
olib borib,

38
00:02:15,984 --> 00:02:18,893
suyak va to'g'ayni yemiradi.

39
00:02:18,893 --> 00:02:21,648
Yana bitta kassalik turi, 
spondiloartrit,

40
00:02:21,648 --> 00:02:24,711
bu paytgacha etib otilgan kasalliklarga
o'hshash joylari bor.

41
00:02:24,711 --> 00:02:27,766
Bemorlar bog'imlarida doimiy 
yallig'lanish kuzatiladi,

42
00:02:27,766 --> 00:02:30,909
Bu holat pay va chandirlar suyakka 
qoshiladigan, hattoki avval

43
00:02:30,909 --> 00:02:33,265
shikast yetqazilmagan joylarda
ham kuzatiladi.

44
00:02:33,265 --> 00:02:37,835
Fermentlar toshib kelib, osteoartritdagi 
yemirilish holatiga oboradi.

45
00:02:37,835 --> 00:02:42,027
Ammo, buni sababchisi 
sitokin oqsillari bo'ladi.

46
00:02:42,027 --> 00:02:44,363
Fermentlar to'g'ayni yemirgani sari,

47
00:02:44,363 --> 00:02:48,409
organizm kichik bo'g'imlarni qo'shib 
ularni barqarorlashtirishga urinadi.

48
00:02:48,409 --> 00:02:52,548
Bu jarayon paytida ba'zan suyak shporalari
deb ataladigan o'simtalar paydo bo'ladi,

49
00:02:52,548 --> 00:02:56,023
bu o'simtalar kuchli bo'g'im og'rig'i va
zichlanishiga sabab bo'ladi.

50
00:02:56,023 --> 00:02:58,296
Artrit kasalligini keltiradigan 
omillar ko'p.

51
00:02:58,296 --> 00:03:01,405
Shu bois hozirda faqat 
alomatlarni da'volash usullari qollanadi,

52
00:03:01,405 --> 00:03:03,405
kasallik sababchilarini emas.

53
00:03:03,405 --> 00:03:05,839
Bu usullarning biri МАТХ metodi bo'lib,

54
00:03:05,839 --> 00:03:09,928
to'g'ayning bo'laklaridan hujayralar 
to'planib, ulardan yangi toqima yasaladi.

55
00:03:09,928 --> 00:03:12,267
Boshqa bitta usul bu mikrofraktura.

56
00:03:12,267 --> 00:03:14,772
Hirurglar kickik teshiklar yaratib,
ular orqali

57
00:03:14,772 --> 00:03:19,182
suyak iligidan ildiz hujayralari 
oqib chiqib yangi to'g'ay yaratadi.

58
00:03:19,182 --> 00:03:20,332
Eng ohorgi chora

59
00:03:20,332 --> 00:03:24,832
to'g'ayi butunlay yemirilgan bemorning
toliq bo'g'imini almashtiriluvi.

60
00:03:24,832 --> 00:03:26,663
Ammo bu kabi keskin choralar
bo'lsa ham

61
00:03:26,663 --> 00:03:29,425
autoimmun artritni yaratuvchi sabablarini

62
00:03:29,425 --> 00:03:32,441
da'volash hali ham mushkul masaladir.

63
00:03:32,441 --> 00:03:36,828
Olimlar NOF-alfa oqsil terapiya usullarini
qollab oldinga ketayaptilar.

64
00:03:36,828 --> 00:03:40,847
Bu oqsil romatid artrit yallig'lanishing 
asosiy sababchilaridar biridir.

65
00:03:40,847 --> 00:03:46,017
Ammo, bu usul ham kasallik sababini emas,
kasallik alomatlarini da'volaydi holos.

66
00:03:46,017 --> 00:03:51,509
Bu orada esa, artrit oldini olishning eng 
yanhshi himoyasi bu hayot tarzidir, misol

67
00:03:51,509 --> 00:03:54,538
sog'lom vazn ushlash, bu bo'g'imlarga 
bosimni tushiradi, yoki

68
00:03:54,538 --> 00:03:59,258
yoga va velosiped minish kabi oson 
mashq'ulotlar bajarish, va chekmaslik.

69
00:03:59,258 --> 00:04:03,192
Bu kabi artrit oldini oladigan faoliyatlar
uzoq umr kechirishimizga yordam beradi.

70
00:04:03,192 --> 00:04:06,092
Bizlar turli hil artrit kasalliklarini 
da'volash yollarini

71
00:04:06,092 --> 00:04:09,102
tadqiqot yoli bilan izlashni 
davom etamiz.