0:00:06.898,0:00:09.219 Cigarettes aren’t good for us. 0:00:09.219,0:00:13.865 That’s hardly news--we’ve known [br]about the dangers of smoking for decades. 0:00:13.865,0:00:16.860 But how exactly do cigarettes harm us? 0:00:16.860,0:00:19.192 Let’s look at what happens [br]as their ingredients 0:00:19.192,0:00:20.851 make their way through our bodies, 0:00:20.851,0:00:25.478 and how we benefit physically [br]when we finally give up smoking. 0:00:25.478,0:00:27.358 With each inhalation, 0:00:27.358,0:00:31.158 smoke brings its more than 5,000 [br]chemical substances 0:00:31.158,0:00:33.766 into contact with the body’s tissues. 0:00:33.766,0:00:37.444 From the start, tar, [br]a black, resinous material, 0:00:37.444,0:00:39.825 begins to coat the teeth and gums, 0:00:39.825,0:00:43.708 damaging tooth enamel, [br]and eventually causing decay. 0:00:43.708,0:00:47.721 Over time, smoke also damages [br]nerve-endings in the nose, 0:00:47.721,0:00:50.006 causing loss of smell. 0:00:50.006,0:00:51.815 Inside the airways and lungs, 0:00:51.815,0:00:54.604 smoke increases [br]the likelihood of infections, 0:00:54.604,0:00:59.277 as well as chronic diseases[br]like bronchitis and emphysema. 0:00:59.277,0:01:01.707 It does this by damaging the cilia, 0:01:01.707,0:01:07.067 tiny hairlike structures whose job it is [br]to keep the airways clean. 0:01:07.067,0:01:09.504 It then fills the alveoli, 0:01:09.504,0:01:13.654 tiny air sacs that enable the exchange [br]of oxygen and carbon dioxide 0:01:13.654,0:01:15.258 between the lungs and blood. 0:01:15.258,0:01:20.251 A toxic gas called carbon monoxide [br]crosses that membrane into the blood, 0:01:20.251,0:01:21.958 binding to hemoglobin 0:01:21.958,0:01:23.561 and displacing the oxygen 0:01:23.561,0:01:26.771 it would usually have transported[br]around the body. 0:01:26.771,0:01:30.380 That’s one of the reasons smoking [br]can lead to oxygen deprivation 0:01:30.380,0:01:32.954 and shortness of breath. 0:01:32.954,0:01:35.121 Within about 10 seconds, 0:01:35.121,0:01:38.897 the bloodstream carries a stimulant [br]called nicotine to the brain, 0:01:38.897,0:01:42.413 triggering the release of dopamine [br]and other neurotransmitters 0:01:42.413,0:01:43.689 including endorphins 0:01:43.689,0:01:47.684 that create the pleasurable sensations [br]which make smoking highly addictive. 0:01:47.684,0:01:50.043 Nicotine and other chemicals [br]from the cigarette 0:01:50.043,0:01:53.006 simultaneously cause constriction [br]of blood vessels 0:01:53.006,0:01:55.942 and damage their delicate [br]endothelial lining, 0:01:55.942,0:01:57.675 restricting blood flow. 0:01:57.675,0:02:00.957 These vascular effects lead [br]to thickening of blood vessel walls 0:02:00.957,0:02:03.471 and enhance blood platelet stickiness, 0:02:03.471,0:02:06.055 increasing the likelihood [br]that clots will form 0:02:06.055,0:02:08.929 and trigger heart attacks and strokes. 0:02:08.929,0:02:12.689 Many of the chemicals inside cigarettes [br]can trigger dangerous mutations 0:02:12.689,0:02:15.965 in the body’s DNA that make cancers form. 0:02:15.965,0:02:18.955 Additionally, ingredients like arsenic [br]and nickel 0:02:18.955,0:02:21.524 may disrupt the process of DNA repair, 0:02:21.524,0:02:25.443 thus compromising the body’s ability [br]to fight many cancers. 0:02:25.443,0:02:29.175 In fact, about one of every three [br]cancer deaths in the United States 0:02:29.175,0:02:31.218 is caused by smoking. 0:02:31.218,0:02:33.571 And it’s not just lung cancer. 0:02:33.571,0:02:36.938 Smoking can cause cancer [br]in multiple tissues and organs, 0:02:36.938,0:02:38.745 as well as damaged eyesight 0:02:38.745,0:02:40.901 and weakened bones. 0:02:40.901,0:02:43.110 It makes it harder [br]for women to get pregnant. 0:02:43.110,0:02:46.088 And in men,[br]it can cause erectile dysfunction. 0:02:46.088,0:02:47.785 But for those who quit smoking, 0:02:47.785,0:02:49.763 there’s a huge positive upside 0:02:49.763,0:02:53.328 with almost immediate [br]and long-lasting physical benefits. 0:02:53.328,0:02:57.010 Just 20 minutes after [br]a smoker’s final cigarette, 0:02:57.010,0:03:00.841 their heart rate and blood pressure[br]begin to return to normal. 0:03:00.841,0:03:04.259 After 12 hours, [br]carbon monoxide levels stabilize, 0:03:04.259,0:03:07.023 increasing the blood’s [br]oxygen-carrying capacity. 0:03:07.023,0:03:08.540 A day after ceasing, 0:03:08.540,0:03:13.894 heart attack risk begins to decrease as[br]blood pressure and heart rates normalize. 0:03:13.894,0:03:15.170 After two days, 0:03:15.170,0:03:20.094 the nerve endings responsible [br]for smell and taste start to recover. 0:03:20.094,0:03:23.520 Lungs become healthier [br]after about one month, 0:03:23.520,0:03:25.875 with less coughing [br]and shortness of breath. 0:03:25.875,0:03:28.999 The delicate hair-like cilia [br]in the airways and lungs 0:03:28.999,0:03:31.077 start recovering within weeks, 0:03:31.077,0:03:35.340 and are restored after 9 months, [br]improving resistance to infection. 0:03:35.340,0:03:37.717 By the one-year anniversary of quitting, 0:03:37.717,0:03:42.761 heart disease risk plummets to half[br]as blood vessel function improves. 0:03:42.761,0:03:44.025 Five years in, 0:03:44.025,0:03:46.845 the chance of a clot forming[br]dramatically declines, 0:03:46.845,0:03:49.751 and the risk of stroke [br]continues to reduce. 0:03:49.751,0:03:53.352 After ten years, the chances [br]of developing fatal lung cancer 0:03:53.352,0:03:55.398 go down by 50%, 0:03:55.398,0:04:00.169 probably because the body’s ability [br]to repair DNA is once again restored. 0:04:00.169,0:04:04.008 Fifteen years in, the likelihood [br]of developing coronary heart disease 0:04:04.008,0:04:07.522 is essentially the same [br]as that of a non-smoker. 0:04:07.522,0:04:10.818 There’s no point pretending [br]this is all easy to achieve. 0:04:10.818,0:04:13.640 Quitting can lead to anxiety [br]and depression, 0:04:13.640,0:04:15.582 resulting from nicotine withdrawal. 0:04:15.582,0:04:19.292 But fortunately, [br]such effects are usually temporary. 0:04:19.292,0:04:23.980 And quitting is getting easier,[br]thanks to a growing arsenal of tools. 0:04:23.980,0:04:26.426 Nicotine replacement therapy through gum, 0:04:26.426,0:04:27.655 skin patches, 0:04:27.655,0:04:28.439 lozenges, 0:04:28.439,0:04:29.352 and sprays 0:04:29.352,0:04:32.345 may help wean smokers off cigarettes. 0:04:32.345,0:04:35.458 They work by stimulating [br]nicotine receptors in the brain 0:04:35.458,0:04:37.850 and thus preventing withdrawal symptoms, 0:04:37.850,0:04:40.758 without the addition [br]of other harmful chemicals. 0:04:40.758,0:04:42.470 Counselling and support groups, 0:04:42.470,0:04:44.413 cognitive behavioral therapy, 0:04:44.413,0:04:46.606 and moderate intensity exercise 0:04:46.606,0:04:50.061 also help smokers stay cigarette-free. 0:04:50.061,0:04:51.608 That’s good news, 0:04:51.608,0:04:56.256 since quitting puts you and your body [br]on the path back to health.