0:00:01.897,0:00:03.952 - Nowadays when you take[br]a stroll down the aisle 0:00:03.952,0:00:05.520 at your local grocery store 0:00:05.520,0:00:07.052 you'll notice that a lot of foods 0:00:07.052,0:00:10.198 are labeled as Gluten free. 0:00:10.198,0:00:12.020 In fact, in 2014, 0:00:12.020,0:00:14.412 the U.S. sales of Gluten[br]free labeled products 0:00:14.412,0:00:17.999 was estimated to be[br]about 23 billion dollars. 0:00:17.999,0:00:20.019 So what exactly is Gluten 0:00:20.019,0:00:22.133 and why is everybody talking about it? 0:00:22.133,0:00:23.619 Well, from a biological standpoint 0:00:23.619,0:00:27.285 Gluten is composed of[br]two different proteins. 0:00:27.285,0:00:30.920 There is gliadin which I'll[br]represent as these blue circles. 0:00:30.920,0:00:31.873 And there's glutenin 0:00:31.873,0:00:34.078 which I'll represent as these red strings. 0:00:34.078,0:00:37.051 These two together are going[br]to form what's called gluten. 0:00:37.051,0:00:39.837 Now gluten is the main protein composite 0:00:39.837,0:00:42.170 of a lot of the grains that you eat. 0:00:42.170,0:00:45.177 This includes things[br]Wheat, Barley, and Rye. 0:00:45.177,0:00:47.800 And this is really important[br]because these are found 0:00:47.800,0:00:50.773 in a lot of the foods[br]that people typically eat. 0:00:50.773,0:00:53.301 For example, you may[br]see it in Bread, Pasta, 0:00:53.301,0:00:56.671 Salad Dressings, and even Sausages. 0:00:56.671,0:00:58.899 So this is just a handful[br]of the many, many, 0:00:58.899,0:01:02.290 many different types of foods[br]that contains these grains. 0:01:02.290,0:01:04.379 And by extension will contain the gluten. 0:01:04.379,0:01:06.767 Now why is gluten important in healthcare? 0:01:06.767,0:01:08.710 It's because there are[br]three major conditions 0:01:08.710,0:01:10.776 in which gluten can cause problems. 0:01:10.776,0:01:13.516 The first is known as Celiac Disease. 0:01:13.516,0:01:15.455 Celiac Disease is an Autoimmune Disease 0:01:15.455,0:01:17.277 in which the body's own Immune System 0:01:17.277,0:01:19.112 attacks the Small Intestine. 0:01:19.112,0:01:20.656 It isn't exactly a new condition 0:01:20.656,0:01:23.842 because it was first[br]described in the Late 1800s. 0:01:23.842,0:01:26.299 And in addition to that,[br]it's actually quite rare. 0:01:26.299,0:01:30.733 It affects about one for[br]every 70 to 300 people 0:01:30.733,0:01:32.415 depending on which country you live in. 0:01:32.415,0:01:35.596 In the U.S. that's equivalent[br]to about 2.1 million people. 0:01:35.596,0:01:37.790 The second major condition[br]is having an allergy 0:01:37.790,0:01:39.567 to the grains that contain gluten. 0:01:39.567,0:01:41.587 So much like how many[br]people have allergies 0:01:41.587,0:01:43.661 to things like peanuts or eggs 0:01:43.661,0:01:46.115 a lot of people can have[br]allergies to these grains. 0:01:46.115,0:01:49.377 However, this is even less[br]common than Celiac Disease. 0:01:49.377,0:01:51.351 So if Celiac Disease and Grain Allergies 0:01:51.351,0:01:54.509 are relatively rare, why is[br]everybody talking about gluten? 0:01:54.509,0:01:56.448 The reason is because[br]of the third condition 0:01:56.448,0:01:58.572 known as Gluten Intolerance. 0:01:58.572,0:02:00.046 The idea behind Gluten Intolerance 0:02:00.046,0:02:02.179 is that if you eat[br]something containing gluten 0:02:02.179,0:02:04.830 you'll experience all[br]sorts of different symptoms 0:02:04.830,0:02:06.454 associated with your bowels. 0:02:06.454,0:02:09.145 This can include things like[br]Diarrhea and Constipation 0:02:09.145,0:02:11.029 and Cramping and Bloating as well. 0:02:11.029,0:02:12.933 Now the whole phenomenon[br]of Gluten Intolerance 0:02:12.933,0:02:16.427 really began in 2011 when[br]a paper was published 0:02:16.427,0:02:18.853 in The American Journal[br]of Gastroenterology. 0:02:18.853,0:02:21.048 So right here I have the[br]exact title of that paper 0:02:21.048,0:02:23.869 which says, "Gluten causes[br]gastrointestinal symptoms 0:02:23.869,0:02:26.330 "in subjects without celiac disease." 0:02:26.330,0:02:28.875 Basically, this paper[br]concluded and I quote, 0:02:28.875,0:02:32.949 "gluten is indeed a trigger of[br]gut symptoms and tiredness." 0:02:32.949,0:02:35.629 Thus began the Gluten free sensation. 0:02:35.629,0:02:37.835 But in 2013, Dr. Peter Gibson 0:02:37.835,0:02:41.446 who is the author of this[br]study did a follow-up study. 0:02:41.446,0:02:43.094 Now this is actually a pretty long title 0:02:43.094,0:02:44.464 so I'm just going to read it off first 0:02:44.464,0:02:47.134 and then we're going to[br]digest it piece by piece. 0:02:47.134,0:02:49.247 So it says, "No Effects[br]of Gluten in Patients 0:02:49.247,0:02:51.906 "With Self-Reported[br]Non-Celiac Gluten Sensitivity 0:02:51.906,0:02:54.972 "After Dietary Reduction of[br]Fermentable, Poorly Absorbed, 0:02:54.972,0:02:56.747 "Short-Chain Carbohydrates." 0:02:56.747,0:02:58.894 So first we can focus on[br]this part right over here 0:02:58.894,0:03:00.554 this Fermentable, Poorly Absorbed, 0:03:00.554,0:03:02.354 Short-Chain Carbohydrates. 0:03:02.354,0:03:03.734 We have another word for this 0:03:03.734,0:03:05.093 and it's really just an acronym 0:03:05.093,0:03:06.986 it's simply known as FODMAPS. 0:03:06.986,0:03:08.705 The words in this acronym[br]are actually different 0:03:08.705,0:03:10.887 from the words here but[br]it's the same thing. 0:03:10.887,0:03:13.824 Now these FODMAPS are[br]basically just carbohydrates 0:03:13.824,0:03:16.065 that are known to cause[br]a lot of the symptoms 0:03:16.065,0:03:17.470 that I mentioned earlier. 0:03:17.470,0:03:20.244 The things like cramping, and[br]diarrhea, and constipation. 0:03:20.244,0:03:22.738 So this study basically[br]considered the fact that maybe 0:03:22.738,0:03:25.364 it's actually these FODMAPS[br]instead of the gluten 0:03:25.364,0:03:26.966 that's causing these symptoms. 0:03:26.966,0:03:28.905 So they basically did[br]mostly the same stuff 0:03:28.905,0:03:32.063 as the earlier study except[br]they removed these FODMAPS 0:03:32.063,0:03:33.549 from the situation. 0:03:33.549,0:03:35.092 It was kind of a confounding factor 0:03:35.092,0:03:36.567 and they wanted to eliminate that. 0:03:36.567,0:03:38.262 Then what they did was they put people 0:03:38.262,0:03:41.168 on first, gluten filled diets. 0:03:41.168,0:03:43.651 So I'll just label that[br]as positive (+) gluten. 0:03:43.651,0:03:46.505 And then they changed their[br]diets to gluten free diets. 0:03:46.505,0:03:48.804 So I'll just label that[br]as minus (-) gluten. 0:03:48.804,0:03:49.906 And they basically just wanted 0:03:49.906,0:03:51.171 to look at the effects of this. 0:03:51.171,0:03:52.786 So if the earlier hypothesis 0:03:52.786,0:03:54.945 that gluten causes these symptoms is true 0:03:54.945,0:03:56.651 then their symptoms should improve 0:03:56.651,0:03:58.962 because you're putting[br]them on a gluten free diet. 0:03:58.962,0:04:02.745 However, they found that there[br]were No Effects of Gluten. 0:04:02.745,0:04:04.731 So gluten actually didn't do anything. 0:04:04.731,0:04:07.818 It wasn't responsible for[br]causing all of those symptoms. 0:04:07.818,0:04:10.188 Now what does this all mean for us? 0:04:10.188,0:04:13.601 Well, if you have Celiac[br]Disease or Grain Allergies 0:04:13.601,0:04:15.900 you should absolutely avoid consuming 0:04:15.900,0:04:17.641 anything that contains Gluten in it. 0:04:17.641,0:04:19.788 However, these conditions are pretty rare 0:04:19.788,0:04:21.959 and they don't affect that many people. 0:04:21.959,0:04:22.784 So for the rest of us, 0:04:22.784,0:04:25.187 should we adopt this Gluten free diet? 0:04:25.187,0:04:27.207 Well, it's true that[br]these Gluten free diets 0:04:27.207,0:04:28.763 do tend to be healthy. 0:04:28.763,0:04:30.803 But that's not because they lack Gluten 0:04:30.803,0:04:33.082 it's because by their very[br]nature they're healthy. 0:04:33.082,0:04:35.903 They don't contain all[br]sorts of processed foods 0:04:35.903,0:04:37.319 and carbohydrates. 0:04:37.319,0:04:39.548 So because of that and not[br]because they lack Gluten 0:04:39.548,0:04:41.243 they are pretty healthy for you. 0:04:41.243,0:04:42.647 So the jury is still kind of out 0:04:42.647,0:04:44.900 on whether or not we should[br]adopt a Gluten free diet. 0:04:44.900,0:04:46.282 But the current scientific literature 0:04:46.282,0:04:48.972 probably wouldn't support[br]a Gluten free diet.