0:00:06.746,0:00:10.129 Imagine something small enough to float[br]on a particle of dust 0:00:10.129,0:00:15.946 that holds the keys to understanding[br]cancer, virology, and genetics. 0:00:15.946,0:00:17.075 Luckily for us, 0:00:17.075,0:00:20.324 such a thing exists in the form [br]of trillions upon trillions 0:00:20.324,0:00:24.606 of human lab-grown cells[br]called HeLa. 0:00:24.606,0:00:26.696 Let's take a step back for a second. 0:00:26.696,0:00:30.535 Scientists grow human cells in the lab[br]to study how they function, 0:00:30.535,0:00:32.529 understand how diseases develop, 0:00:32.529,0:00:35.750 and test new treatments without[br]endangering patients. 0:00:35.750,0:00:39.005 To make sure that they can repeat[br]these experiments over and over, 0:00:39.005,0:00:41.696 and compare the results [br]with other scientists, 0:00:41.696,0:00:44.311 they need huge populations [br]of identical cells 0:00:44.311,0:00:47.269 that can duplicate themselves [br]faithfully for years, 0:00:47.269,0:00:51.817 but until 1951, all human cell lines[br]that researchers tried to grow 0:00:51.817,0:00:54.093 had died after a few days. 0:00:54.093,0:00:57.050 Then a John Hopkins scientist[br]named George Gey 0:00:57.050,0:01:00.389 received a sample of [br]a strange looking tumor: 0:01:00.389,0:01:04.195 dark purple, shiny, jelly-like. 0:01:04.195,0:01:05.714 This sample was special. 0:01:05.714,0:01:07.949 Some of its cells just kept dividing, 0:01:07.949,0:01:09.032 and dividing, 0:01:09.032,0:01:10.571 and dividing. 0:01:10.571,0:01:12.311 When individual cells died, 0:01:12.311,0:01:16.171 generations of copies took their place[br]and thrived. 0:01:16.171,0:01:21.385 The result was an endless source of[br]identical cells that's still around today. 0:01:21.385,0:01:24.894 The very first immortal human cell line. 0:01:24.894,0:01:30.532 Gey labeled it "HeLa" after the patient[br]with the unusual tumor, Henrietta Lacks. 0:01:30.532,0:01:32.624 Born on a tobacco farm in Virginia, 0:01:32.624,0:01:35.618 she lived in Baltimore with her husband[br]and five children. 0:01:35.618,0:01:38.043 She died of aggressive cervical cancer 0:01:38.043,0:01:40.903 a few months after her tumorous cells[br]were harvested, 0:01:40.903,0:01:43.154 and she never knew about them. 0:01:43.154,0:01:46.076 So what's so special about the cells[br]from Henrietta Lacks 0:01:46.076,0:01:49.621 that lets them survive[br]when other cell lines die? 0:01:49.621,0:01:53.066 The short answer is[br]we don't entirely know. 0:01:53.066,0:01:56.115 Normal human cells have built-in[br]control mechanisms. 0:01:56.115,0:01:59.818 They can divide about 50 times[br]before they self destruct 0:01:59.818,0:02:02.330 in a process called apoptosis. 0:02:02.330,0:02:04.654 This prevents the propagation[br]of genetic errors 0:02:04.654,0:02:07.877 that creep in after [br]repeated rounds of division. 0:02:07.877,0:02:11.279 But cancer cells ignore these signals,[br]dividing indefinitely 0:02:11.279,0:02:13.466 and crowding out normal cells. 0:02:13.466,0:02:18.970 Still, most cell lines eventually die off,[br]especially outside the human body. 0:02:18.970,0:02:22.996 Not HeLa, though, and that's the part[br]we can't yet explain. 0:02:22.996,0:02:28.238 Regardless, when Dr. Gey realized he had[br]the first immortal line of human cells, 0:02:28.238,0:02:31.237 he sent samples [br]to labs all over the world. 0:02:31.237,0:02:33.584 Soon the world's first [br]cell production facility 0:02:33.584,0:02:37.065 was churning out [br]6 trillion HeLa cells a week, 0:02:37.065,0:02:41.469 and scientists put them to work[br]in an ethically problematic way, 0:02:41.469,0:02:44.209 building careers and fortunes[br]off of Henrietta's cells 0:02:44.209,0:02:49.843 without her or her family's consent,[br]or even knowledge until decades later. 0:02:49.843,0:02:53.972 The polio epidemic was at its peak[br]in the early 50s. 0:02:53.972,0:02:57.374 HeLa cells, which easily took up[br]and replicated the virus, 0:02:57.374,0:03:00.879 allowed Jonas Salk to test his vaccine. 0:03:00.879,0:03:02.627 They've been used to study diseases, 0:03:02.627,0:03:03.713 including measles, 0:03:03.713,0:03:04.704 mumps, 0:03:04.704,0:03:05.774 HIV, 0:03:05.774,0:03:07.381 and ebola. 0:03:07.381,0:03:09.670 We know that human [br]cells have 46 chromosomes 0:03:09.670,0:03:13.242 because a scientist working with HeLa[br]discovered a chemcial 0:03:13.242,0:03:15.598 that makes chromosomes visible. 0:03:15.598,0:03:20.573 HeLa cells themselves actually have[br]around 80 highly mutated chromosomes. 0:03:20.573,0:03:24.543 HeLa cells were the first to be cloned. 0:03:24.543,0:03:27.271 They've traveled to outer space. 0:03:27.271,0:03:28.347 Telomerase, 0:03:28.347,0:03:32.587 an enzyme that helps cancer cells evade[br]destruction by repairing their DNA, 0:03:32.587,0:03:34.873 was discovered first in HeLa cells. 0:03:34.873,0:03:36.520 In an interesting turn of fate, 0:03:36.520,0:03:42.018 thanks to HeLa, we know that cervical[br]cancer can be caused by a virus called HPV 0:03:42.018,0:03:44.557 and now there's a vaccine. 0:03:44.557,0:03:48.843 HeLa-fueled discoveries have filled[br]thousands of scientific papers, 0:03:48.843,0:03:52.251 and that number is probably even higher[br]than anyone knows. 0:03:52.251,0:03:57.052 HeLa cells are so resilient that they [br]can travel on almost any surface: 0:03:57.052,0:03:58.942 a lab worker's hand, 0:03:58.942,0:04:00.782 a piece of dust, 0:04:00.782,0:04:05.283 invading cultures of other cells [br]and taking over like weeds, 0:04:05.283,0:04:10.879 countless cures, patents and discoveries[br]all made thanks to Henrieta Lacks.