[Script Info] Title: [Events] Format: Layer, Start, End, Style, Name, MarginL, MarginR, MarginV, Effect, Text Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,When I was a kid, the disaster\Nwe worried about most Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,was a nuclear war. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,That's why we had a barrel like this\Ndown in our basement, Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,filled with food and water. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,When the nuclear attack came, Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,we were supposed to go downstairs, Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,hunker down, and eat out of that barrel. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Today the greatest risk \Nof global catastrophe\N Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,doesn't look like this. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Instead, it looks like this. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,If anything kills over 10 million people\Nin the next few decades, Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,it's most likely to be \Na highly infectious virus Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,rather than a war. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Not missles, but microbes. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Now part of the reason for this\N Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,is that we've invested a huge amount\Nin nuclear deterrants. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,But we've actually invested very little \Nin a system to stop an epidemic. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We're not ready for the next epidemic. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Let's look at Ebola. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,I'm sure all of you read about \Nit in the newspaper, Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,lots of touch challenges. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,I followed it carefully through \Nthe case analysis tools we use Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,to track polio eradication. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,And as you look at what went on, Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,the problem wasn't that there was\Na system that didn't work well enough, Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,the problem was that we didn't have\Na system at all. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,In fact, there's some pretty obvious\Nkey missing pieces. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We didn't have a group of epidemiologists\Nready to go Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,who would have gone, \Nseen what the disease was, Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,seen how far it had spread. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,The case reports came in on paper. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,It was very delayed before they\Nwere put online Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and they were extremely inaccurate. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We didn't have a medical team ready to go. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We didn't have a way of preparing people. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Now Médecins Sans Frontières did a \Ngreat job orchestrating volunteers. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,But even so, we were far slower\Nthan we should have been Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,getting the thousands of workers\Ninto these countries. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,And a large epidemic would require\Nus to have hundreds of thousands Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,of workers. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,There was no one there to look\Nat treatment approaches. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,No one to look at the diagnostics. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,No one to figure out what tools\Nshould be used. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,As an example, we could have taken\Nthe blood of survivors, Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,processed it, and put that plasma\Nback in people to protect them. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,But that was never tried. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,So there was a lot that was missing. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,And these things are really \Na global failure. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,The WHO is funded to monitor epidemics, Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,but not to do these things I talked about. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Now in the movies, it's quiet different. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,There's a group of \Nhandsome epidemiologists Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,ready to go, they move in, \Nthey save the day. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,But that's just pure Hollywood. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,The failure to prepare could allow\Nthe next epidemic Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,to be dramatically more devastating\Nthan Ebola. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Let's look at the progression of Ebola\Nover this year. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,About 10,000 people died, \N Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and nearly all were in the three\NWest African countries. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,There's three reasons why\Nit didn't spread more. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,The first is that there was \Na lot of heroic work Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,by the health workers. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,They found the people and they \Nprevented more infections. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,The second is the nature of the virus. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Ebola does not spread through the air. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,And by the time you're contagious,\Nmost people are so sick Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,that they're bedridden. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Third, it didn't get into many urban areas. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,And that was just luck. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,If it had gotten into a lot more\Nurban areas, Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,the case numbers would have \Nbeen much larger. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,So next time, we may not be so lucky. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,You can have a virus where people \Nfeel well enough while they're infectious, Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,they get on a plane or they go to a market. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,The source of the virus could be \Na natural epidemic like Ebola, Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,or it could be bioterrorism. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,And so there are things that would\Nliterally make things \N Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,a thousand times worse. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,In fact, let's look at a model\Nof a virus spread through the air, Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,like the Spanish Flu back in 1918. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,So here's what would happen: Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,it would spread throughout the world\Nvery, very quickly. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,And you can see, over 30 million people\Ndied from that epidemic. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,So this is a seriousl problem. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We should be concerned. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,But in fact, we can build a really good\Nresponse system. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We have the benefits of all the science\Nand technology that we talked about here. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We've got cell phones to get information\Nfrom the public Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and get information out to them. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We have satellite maps where we can see\Nwhere we can see where people are Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and where they're moving. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We have advances in biology\Nthat should dramatically change Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,the turnaround time to look at a pathogen Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and be able to make drugs and vaccines\Nthat fit for that pathogen. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,So we can have tools, but those tools\Nneed to be put into Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,an overall global health system. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,And we need preparedness. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,The best lessons, I think, on how \Nto get prepared Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,are, again, what we do for war. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,For soldiers, we have them full-time,\Nready to go. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We have reserves that can scale us up\Nto large numbers. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,NATO has a mobile unit \Nthat can deploy very rapidly. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,NATO does a lot of war games to check, \N"Are people well trained? Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Do they understand about fuel\Nand logistics Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and the same radio frequencies?" Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,So they are absolutely ready to go. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,So those are the kinds of things\Nwe need to deal with an epidemic. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,What are the key pieces? Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,First, we need strong health systems\Nfor countries. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,That's where mothers can give birth safely, Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,kids can get all their vaccines. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,But, also where we'll see\Nthe outbreak very early on. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We need a medical reserve corps: Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,lots of people who've got the training\Nand background Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,who are ready to go, with the expertise. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,And then we need to pair those\Nmedical people Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,with the military, Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,taking advantage of the military's ability\Nto move fast, do logistics Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,and secure areas. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We need to do simulations: germs games,\Nnot war games, Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,so that we see where the holes are. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,The last time a germ game was done\Nin the United States Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,was back in 2001, and it didn't go so well. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,So far the score is germs: 1, people: 0. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Finally, we need lots of advanced R&D\Nin areas of vaccines and diagnostics. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,There are some big breakthroughs, \Nlike the Adeno-associated virus, Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,that could work very, very quickly. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,Now I don't have an exact budget\Nfor what this would cost,\N Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,but I'm quite sure that it's very modest\Ncompared to the potential harm. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,The World Bank estimates that \Nif we have a worldwide flu epidemic, Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,global wealth would go down\Nby over 3 trillion dollars. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We'd have millions and millions of deaths. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,These investments offer \Nsignificant benefits beyond just Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,being ready for an epidemic. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,The primary healthcare, the R&D,\Nthose things\N Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,would reduce global health equity\Nand make the world more just, Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,as well as more safe. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,So I think this should absolutely\Nbe a priority. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,There's no need to panic. Dialogue: 0,9:59:59.99,9:59:59.99,Default,,0000,0000,0000,,We don't have