[Script Info]
Title: 
[Events]
Format: Layer, Start, End, Style, Name, MarginL, MarginR, MarginV, Effect, Text
Dialogue: 0,0:00:00.00,0:00:02.00,Default,,0000,0000,0000,,Pana cand nu vom face ceva sa o prevenim,
Dialogue: 0,0:00:02.00,0:00:05.00,Default,,0000,0000,0000,,in urmatorii 40 de ani vom avea de-a face cu o epidemie
Dialogue: 0,0:00:05.00,0:00:08.00,Default,,0000,0000,0000,,de boli neurologice la scara mondiala.
Dialogue: 0,0:00:08.00,0:00:12.00,Default,,0000,0000,0000,,O perspectiva optimista.
Dialogue: 0,0:00:12.00,0:00:15.00,Default,,0000,0000,0000,,Pe aceasta harta, fiecare tara care e colorata in albastru
Dialogue: 0,0:00:15.00,0:00:19.00,Default,,0000,0000,0000,,are mai mult de 20% din populatie cu varste de peste 65 de ani.
Dialogue: 0,0:00:19.00,0:00:21.00,Default,,0000,0000,0000,,Aceasta este lumea in care traim.
Dialogue: 0,0:00:21.00,0:00:24.00,Default,,0000,0000,0000,,Si aceasta e lumea in care vor trai copiii vostri.
Dialogue: 0,0:00:25.00,0:00:29.00,Default,,0000,0000,0000,,In ultimii 12000 de ani, distributia varstelor in populatia umana
Dialogue: 0,0:00:29.00,0:00:32.00,Default,,0000,0000,0000,,a aratat ca o piramida, cu cei mai in varsta in varf.
Dialogue: 0,0:00:32.00,0:00:34.00,Default,,0000,0000,0000,,Deja isi pierde aspectul.
Dialogue: 0,0:00:34.00,0:00:38.00,Default,,0000,0000,0000,,In jur de 2050 va fi devenit o coloana si va incepe sa se inverseze.
Dialogue: 0,0:00:38.00,0:00:41.00,Default,,0000,0000,0000,,Iata de ce se intampla acest fenomen.
Dialogue: 0,0:00:41.00,0:00:44.00,Default,,0000,0000,0000,,Dupa 1840, durata medie de viata s-a dublat cel putin,
Dialogue: 0,0:00:44.00,0:00:49.00,Default,,0000,0000,0000,,si continua sa creasca cu o rata de aproximativ 5h pe zi.
Dialogue: 0,0:00:49.00,0:00:52.00,Default,,0000,0000,0000,,Si iata de ce tendinta asta nu este in totalitate un lucru bun:
Dialogue: 0,0:00:52.00,0:00:56.00,Default,,0000,0000,0000,,deoarece peste varsta de 65 de ani, riscul de a dezvolta boala Alzheimer
Dialogue: 0,0:00:56.00,0:01:00.00,Default,,0000,0000,0000,,sau Parkinson creste exponential.
Dialogue: 0,0:01:00.00,0:01:04.00,Default,,0000,0000,0000,,Prin 2050 vor fi aproximativ 32 de milioane de oameni in Statele Unite
Dialogue: 0,0:01:04.00,0:01:07.00,Default,,0000,0000,0000,,cu varste de peste 80 de ani, si daca nu facem ceva,
Dialogue: 0,0:01:07.00,0:01:09.00,Default,,0000,0000,0000,,jumatate dintre ei vor avea boala Alzheimer
Dialogue: 0,0:01:09.00,0:01:12.00,Default,,0000,0000,0000,,iar alte 3 milioane vor avea boala Parkinson.
Dialogue: 0,0:01:12.00,0:01:15.00,Default,,0000,0000,0000,,Chiar in momentul de fata, aceste boli si alte afectiuni neurologice --
Dialogue: 0,0:01:15.00,0:01:18.00,Default,,0000,0000,0000,,pentru care nu avem niciun tratament sau metoda de preventie --
Dialogue: 0,0:01:18.00,0:01:20.00,Default,,0000,0000,0000,,costa aproximativ o treime de trilion de dolari pe an.
Dialogue: 0,0:01:20.00,0:01:24.00,Default,,0000,0000,0000,,Va fi cu mult peste un trilion de dolari in 2050.
Dialogue: 0,0:01:24.00,0:01:26.00,Default,,0000,0000,0000,,Boala Alzheimer incepe cand o proteina
Dialogue: 0,0:01:26.00,0:01:28.00,Default,,0000,0000,0000,,care ar trebui sa fie pliata cumsecade
Dialogue: 0,0:01:28.00,0:01:32.00,Default,,0000,0000,0000,,se pliaza gresit intr-un soi de origami dement.
Dialogue: 0,0:01:32.00,0:01:35.00,Default,,0000,0000,0000,,Deci una dintre abordari este de a crea medicamente
Dialogue: 0,0:01:35.00,0:01:38.00,Default,,0000,0000,0000,,care sa functioneze ca un adeziv molecular,
Dialogue: 0,0:01:38.00,0:01:41.00,Default,,0000,0000,0000,,si sa tina proteina in forma ei justa.
Dialogue: 0,0:01:41.00,0:01:43.00,Default,,0000,0000,0000,,Asta ar trebui sa o impiedice sa formeze ghemuri
Dialogue: 0,0:01:43.00,0:01:47.00,Default,,0000,0000,0000,,care par a fi responsabile de distrugerea unor mari portiuni din creier atunci cand apar.
Dialogue: 0,0:01:47.00,0:01:49.00,Default,,0000,0000,0000,,Este interesant insa ca si alte boli neurologice
Dialogue: 0,0:01:49.00,0:01:52.00,Default,,0000,0000,0000,,care afecteaza parti foarte diferite din creier
Dialogue: 0,0:01:52.00,0:01:55.00,Default,,0000,0000,0000,,prezinta de asemenea ghemuri de proteine pliate gresit,
Dialogue: 0,0:01:55.00,0:01:58.00,Default,,0000,0000,0000,,fapt care sugereaza ca strategia propusa ar putea fi generala,
Dialogue: 0,0:01:58.00,0:02:00.00,Default,,0000,0000,0000,,si sa poate fi folosita in tratarea mai multor boli neurologice.
Dialogue: 0,0:02:00.00,0:02:02.00,Default,,0000,0000,0000,,nu numai a bolii Alzheimer.
Dialogue: 0,0:02:02.00,0:02:05.00,Default,,0000,0000,0000,,Mai exista si o interesanta conexiune cu cancerul aici,
Dialogue: 0,0:02:05.00,0:02:07.00,Default,,0000,0000,0000,,deoarece oamenii cu afectiuni neurologice
Dialogue: 0,0:02:07.00,0:02:10.00,Default,,0000,0000,0000,,au o foarte mica incidenta a cancerelor.
Dialogue: 0,0:02:10.00,0:02:13.00,Default,,0000,0000,0000,,Si iata ca aceasta este o legatura pe care cei mai multi oameni nu o cerceteaza in prezent,
Dialogue: 0,0:02:13.00,0:02:16.00,Default,,0000,0000,0000,,dar de care suntem fascinati.
Dialogue: 0,0:02:16.00,0:02:19.00,Default,,0000,0000,0000,,Mare parte din munca importanta si intregul efort creativ in acest domeniu
Dialogue: 0,0:02:19.00,0:02:22.00,Default,,0000,0000,0000,,sunt finantate de fundatiile filantropice private.
Dialogue: 0,0:02:22.00,0:02:25.00,Default,,0000,0000,0000,,Si inca mai este loc pentru o multime de ajutor privat,
Dialogue: 0,0:02:25.00,0:02:28.00,Default,,0000,0000,0000,,pentru ca ma tem ca guvernul a cam lasat balta acest domeniu.
Dialogue: 0,0:02:28.00,0:02:32.00,Default,,0000,0000,0000,,In timp ce asteptam ca aceste lucruri sa se intample,
Dialogue: 0,0:02:32.00,0:02:34.00,Default,,0000,0000,0000,,iata ce puteti face pentru voi insiva.
Dialogue: 0,0:02:34.00,0:02:36.00,Default,,0000,0000,0000,,Daca vreti sa diminuati riscul pentru boala Parkinson,
Dialogue: 0,0:02:36.00,0:02:41.00,Default,,0000,0000,0000,,cafeina protejeaza intr-o oarecare masura; nimeni nu stie de ce.
Dialogue: 0,0:02:41.00,0:02:44.00,Default,,0000,0000,0000,,Leziunile capului sunt insa daunatoare. Ele pot precipita aparitia bolii Parkinson.
Dialogue: 0,0:02:44.00,0:02:48.00,Default,,0000,0000,0000,,De asemenea gripa aviara nu este o idee prea buna.
Dialogue: 0,0:02:49.00,0:02:52.00,Default,,0000,0000,0000,,Cat despre protectia impotriva bolii Alzheimer,
Dialogue: 0,0:02:52.00,0:02:55.00,Default,,0000,0000,0000,,pare ca uleiul de peste are un efect
Dialogue: 0,0:02:55.00,0:02:58.00,Default,,0000,0000,0000,,de reducere a riscului pentru aceasta boala.
Dialogue: 0,0:02:58.00,0:03:00.00,Default,,0000,0000,0000,,De asemenea ar trebui sa tineti presiunea sangelui in limite decente,
Dialogue: 0,0:03:00.00,0:03:02.00,Default,,0000,0000,0000,,deoarece hipertensiunea cronica
Dialogue: 0,0:03:02.00,0:03:04.00,Default,,0000,0000,0000,,este unicul mare factor de risc in boala Alzheimer.
Dialogue: 0,0:03:04.00,0:03:07.00,Default,,0000,0000,0000,,Tot ea reprezinta cel mai mare factor de risc pentru glaucom,
Dialogue: 0,0:03:07.00,0:03:10.00,Default,,0000,0000,0000,,care este un fel de boala Alzheimer a ochiului.
Dialogue: 0,0:03:10.00,0:03:12.00,Default,,0000,0000,0000,,Si desigur, cand ajungem la efectele cognitive,
Dialogue: 0,0:03:12.00,0:03:14.00,Default,,0000,0000,0000,,principiul "foloseste sau pierde totul" se aplica pe deplin,
Dialogue: 0,0:03:14.00,0:03:16.00,Default,,0000,0000,0000,,si de aceea ar fi bine sa va mentineti stimulati mental.
Dialogue: 0,0:03:16.00,0:03:18.00,Default,,0000,0000,0000,,Dar uite ca acum ma ascultati pe mine.
Dialogue: 0,0:03:18.00,0:03:20.00,Default,,0000,0000,0000,,Deci partea asta o aveti acoperita.
Dialogue: 0,0:03:20.00,0:03:24.00,Default,,0000,0000,0000,,Si inca un lucru la final. Urati celor ca mine multa bafta, da?
Dialogue: 0,0:03:24.00,0:03:26.00,Default,,0000,0000,0000,,Pentru ca ceasul bate pentru noi toti.
Dialogue: 0,0:03:26.00,0:03:29.00,Default,,0000,0000,0000,,Va multumesc.