1 00:00:06,383 --> 00:00:11,110 You have about 20,000 genes in your DNA. 2 00:00:11,110 --> 00:00:13,950 They encode the molecules that make up your body, 3 00:00:13,958 --> 00:00:17,990 from the keratin in your toenails, to the collagen at the tip of your nose, 4 00:00:17,990 --> 00:00:21,287 to the dopamine surging around inside your brain. 5 00:00:21,287 --> 00:00:23,678 Other species have genes of their own. 6 00:00:23,678 --> 00:00:26,094 A spider has genes for spider silk. 7 00:00:26,094 --> 00:00:30,808 An oak tree has genes for chlorophyll, which turns sunlight into wood. 8 00:00:30,808 --> 00:00:33,332 So where did all those genes come from? 9 00:00:33,332 --> 00:00:35,225 It depends on the gene. 10 00:00:35,225 --> 00:00:40,254 Scientists suspect that life started on Earth about 4 billion years ago. 11 00:00:40,254 --> 00:00:42,741 The early life forms were primitive microbes 12 00:00:42,741 --> 00:00:47,380 with a basic set of genes for the basic tasks required to stay alive. 13 00:00:47,380 --> 00:00:50,175 They passed down those basic genes to their offspring 14 00:00:50,175 --> 00:00:52,321 through billions of generations. 15 00:00:52,321 --> 00:00:57,955 Some of them still do the same jobs in our cells today, like copying DNA. 16 00:00:57,955 --> 00:01:01,942 But none of those microbes had genes for spider silk or dopamine. 17 00:01:01,942 --> 00:01:06,689 There are a lot more genes on Earth today than there were back then. 18 00:01:06,689 --> 00:01:11,468 It turns out that a lot of those extra genes were born from mistakes. 19 00:01:11,468 --> 00:01:15,605 Each time a cell divides, it makes new copies of its DNA. 20 00:01:15,605 --> 00:01:20,167 Sometimes it accidentally copies the same stretch of DNA twice. 21 00:01:20,167 --> 00:01:24,592 In the process, it may make an extra copy of one of its genes. 22 00:01:24,592 --> 00:01:27,818 At first, the extra gene works the same as the original one. 23 00:01:27,818 --> 00:01:32,054 But over the generations, it may pick up new mutations. 24 00:01:32,054 --> 00:01:35,394 Those mutations may change how the new gene works, 25 00:01:35,394 --> 00:01:38,144 and that new gene may duplicate again. 26 00:01:38,144 --> 00:01:41,947 A surprising number of our mutated genes emerged more recently; 27 00:01:41,947 --> 00:01:45,035 many in just the past few million years. 28 00:01:45,035 --> 00:01:50,055 The youngest evolved after our own species broke off from our cousins, the apes. 29 00:01:50,055 --> 00:01:54,148 While it may take over a million years for a single gene to give rise 30 00:01:54,148 --> 00:01:55,905 to a whole family of genes, 31 00:01:55,905 --> 00:01:58,872 scientists are finding that once the new genes evolve, 32 00:01:58,872 --> 00:02:01,695 they can quickly take on essential functions. 33 00:02:01,695 --> 00:02:06,405 For example, we have hundreds of genes for the proteins in our noses 34 00:02:06,405 --> 00:02:08,647 that grab odor molecules. 35 00:02:08,647 --> 00:02:11,298 The mutations let them grab different molecules, 36 00:02:11,298 --> 00:02:14,951 giving us the power to perceive trillions of different smells. 37 00:02:14,951 --> 00:02:19,383 Sometimes mutations have a bigger effect on new copies of genes. 38 00:02:19,383 --> 00:02:22,913 They may cause a gene to make its protein in a different organ, 39 00:02:22,913 --> 00:02:25,446 or at a different time of life, 40 00:02:25,446 --> 00:02:29,175 or the protein may start doing a different job altogether. 41 00:02:29,175 --> 00:02:33,640 In snakes, for example, there's a gene that makes a protein for killing bacteria. 42 00:02:33,640 --> 00:02:38,243 Long ago, the gene duplicated and the new copy mutated. 43 00:02:38,243 --> 00:02:40,957 That mutation changed the signal in the gene 44 00:02:40,957 --> 00:02:43,199 about where it should make its protein. 45 00:02:43,199 --> 00:02:45,800 Instead of becoming active in the snake's pacreas, 46 00:02:45,800 --> 00:02:50,569 it started making this bacteria-killing protein in the snake's mouth. 47 00:02:50,569 --> 00:02:55,048 So when the snake bit its prey, this enzyme got into the animal's wound. 48 00:02:55,048 --> 00:02:57,949 And when this protein proved to have a harmful effect, 49 00:02:57,949 --> 00:03:00,060 and helped the snake catch more prey, 50 00:03:00,060 --> 00:03:01,922 it became favored. 51 00:03:01,922 --> 00:03:05,733 So now what was a gene in the pancreas makes a venom in the mouth 52 00:03:05,733 --> 00:03:07,779 that kills the snake's prey. 53 00:03:07,779 --> 00:03:10,990 And there are even more incredible ways to make a new gene. 54 00:03:10,990 --> 00:03:13,883 The DNA of animals and plants and other species 55 00:03:13,883 --> 00:03:18,197 contain huge stretches without any protein coding genes. 56 00:03:18,197 --> 00:03:22,053 As far as scientists can tell, its mostly random sequences 57 00:03:22,053 --> 00:03:24,676 of genetic gibberish that serve no function. 58 00:03:24,676 --> 00:03:28,704 These stretches of DNA sometimes mutate, just like genes do. 59 00:03:28,704 --> 00:03:31,821 Sometimes those mutations turn the DNA into a place 60 00:03:31,821 --> 00:03:34,307 where a cell can start reading it. 61 00:03:34,307 --> 00:03:36,977 Suddenly the cell is making a new protein. 62 00:03:36,977 --> 00:03:40,515 At first, the protein may be useless, or even harmful, 63 00:03:40,515 --> 00:03:43,913 but more mutations can change the shape of the protein. 64 00:03:43,913 --> 00:03:45,999 The protein may start doing something useful, 65 00:03:45,999 --> 00:03:48,616 something that makes an organism healthier, stronger, 66 00:03:48,616 --> 00:03:50,941 better able to reproduce. 67 00:03:50,941 --> 00:03:55,233 Scientists have found these new genes at work in many parts of animal bodies. 68 00:03:55,233 --> 00:03:58,643 So our 20,000 genes have many origins, 69 00:03:58,643 --> 00:04:03,577 from the origin of life, to new genes still coming into existence from scratch. 70 00:04:03,577 --> 00:04:07,196 As long as life is here on Earth, it will be making new genes.