1 00:00:14,392 --> 00:00:25,019 You have about 20,000 genes in your DNA. 2 99:59:59,999 --> 99:59:59,999 They encode the molecules that make up your body, 3 99:59:59,999 --> 99:59:59,999 from the keratin in your toenails, to the collagen at the tip of your nose, 4 99:59:59,999 --> 99:59:59,999 to the dopamine surging around inside your brain. 5 99:59:59,999 --> 99:59:59,999 Other species have genes of their own. 6 99:59:59,999 --> 99:59:59,999 A spider has genes for spider silk. 7 99:59:59,999 --> 99:59:59,999 An oak tree has genes for chlorophyll, which turns sunlight into wood. 8 99:59:59,999 --> 99:59:59,999 So where did all those genes come from? 9 99:59:59,999 --> 99:59:59,999 It depends on the gene. 10 99:59:59,999 --> 99:59:59,999 Scientists suspect that life started on Earth about 4 billion years ago. 11 99:59:59,999 --> 99:59:59,999 The early life forms were primitive microbes 12 99:59:59,999 --> 99:59:59,999 with a basic set of genes for the basic tasks required to stay alive. 13 99:59:59,999 --> 99:59:59,999 They passed down those basic genes to their offspring 14 99:59:59,999 --> 99:59:59,999 through billions of generations. 15 99:59:59,999 --> 99:59:59,999 Some of them still do the same jobs in our cells today, like copying DNA. 16 99:59:59,999 --> 99:59:59,999 But none of those microbes had genes for spider silk or dopamine. 17 99:59:59,999 --> 99:59:59,999 There are a lot more genes on Earth today than there were back then. 18 99:59:59,999 --> 99:59:59,999 It turns out that a lot of those extra genes were born from mistakes. 19 99:59:59,999 --> 99:59:59,999 Each time a cell divides, it makes new copies of its DNA. 20 99:59:59,999 --> 99:59:59,999 Sometimes it accidentally copies the same stretch of DNA twice. 21 99:59:59,999 --> 99:59:59,999 In the process, it may make an extra copy of one of its genes. 22 99:59:59,999 --> 99:59:59,999 At first, the extra gene works the same as the original one. 23 99:59:59,999 --> 99:59:59,999 But over the generations, it may pick up new mutations. 24 99:59:59,999 --> 99:59:59,999 Those mutations may change how the new gene works, 25 99:59:59,999 --> 99:59:59,999 and that new gene may duplicate again. 26 99:59:59,999 --> 99:59:59,999 A surprising number of our mutated genes emerged more recently; 27 99:59:59,999 --> 99:59:59,999 Many in just the past few million years. 28 99:59:59,999 --> 99:59:59,999 The youngest evolved after our own species broke off from our cousins, the apes. 29 99:59:59,999 --> 99:59:59,999 While it may take over a million years for a single gene to give rise 30 99:59:59,999 --> 99:59:59,999 to a whole family of genes, 31 99:59:59,999 --> 99:59:59,999 scientists are finding that once the new genes evolve, 32 99:59:59,999 --> 99:59:59,999 they can quickly take on essential functions. 33 99:59:59,999 --> 99:59:59,999 For example, we have hundreds of genes for the proteins in our noses 34 99:59:59,999 --> 99:59:59,999 that grab odor molecules. 35 99:59:59,999 --> 99:59:59,999 The mutations let them grab different molecules, 36 99:59:59,999 --> 99:59:59,999 giving us the power to perceive trillions of different smells. 37 99:59:59,999 --> 99:59:59,999 Sometimes mutations have a bigger effect on new copies of genes. 38 99:59:59,999 --> 99:59:59,999 They may cause a gene to make its protein in a different organ, 39 99:59:59,999 --> 99:59:59,999 or at a different time of life, 40 99:59:59,999 --> 99:59:59,999 or the protein may start doing a different job altogether. 41 99:59:59,999 --> 99:59:59,999 In snakes, for example, there's a gene that makes a protein for killing bacteria. 42 99:59:59,999 --> 99:59:59,999 Long ago, the gene duplicated and the new copy mutated. 43 99:59:59,999 --> 99:59:59,999 That mutation changed the signal in the gene 44 99:59:59,999 --> 99:59:59,999 about where it should make its protein. 45 99:59:59,999 --> 99:59:59,999 Instead of becoming active in the snake's pacreas, 46 99:59:59,999 --> 99:59:59,999 it started making this bacteria-killing protein in the snake's mouth. 47 99:59:59,999 --> 99:59:59,999 So when the snake bit its prey, this enzyme got into the animal's wound. 48 99:59:59,999 --> 99:59:59,999 And when this protein proved to have a harmful effect, 49 99:59:59,999 --> 99:59:59,999 and helped the snake catch more prey, 50 99:59:59,999 --> 99:59:59,999 it became favored, 51 99:59:59,999 --> 99:59:59,999 so now what was a gene in the pancreas makes a venom in the mouth 52 99:59:59,999 --> 99:59:59,999 that kills the snake's prey. 53 99:59:59,999 --> 99:59:59,999 And there are even more incredible ways to make a new gene. 54 99:59:59,999 --> 99:59:59,999 The DNA of animals and plants and other species 55 99:59:59,999 --> 99:59:59,999 contain huge stretches without any protein coding genes. 56 99:59:59,999 --> 99:59:59,999 As far as scientists can tell, its mostly random sequences 57 99:59:59,999 --> 99:59:59,999 of genetic giberish that serve no function. 58 99:59:59,999 --> 99:59:59,999 These stretches of DNA sometimes mutate, just like genes do. 59 99:59:59,999 --> 99:59:59,999 Sometimes those mutations turn the DNA into a place 60 99:59:59,999 --> 99:59:59,999 where a cell cans start reading it. 61 99:59:59,999 --> 99:59:59,999 Suddenly the cell is making a new protein. 62 99:59:59,999 --> 99:59:59,999 At first, the protein may be useless, or even harmful, 63 99:59:59,999 --> 99:59:59,999 but more mutations can change the shape of the protein. 64 99:59:59,999 --> 99:59:59,999 The protein may start doing something useful, 65 99:59:59,999 --> 99:59:59,999 something that makes an organism healthier, stronger, 66 99:59:59,999 --> 99:59:59,999 better able to reproduce. 67 99:59:59,999 --> 99:59:59,999 Scientists have found these new genes at work in many parts of animal bodies. 68 99:59:59,999 --> 99:59:59,999 So our 20,000 genes have many origins, 69 99:59:59,999 --> 99:59:59,999 from the origin of life, to new genes still coming into existence from scratch. 70 99:59:59,999 --> 99:59:59,999 As long as life is here on Earth, it will be making new genes.