1 00:00:01,079 --> 00:00:03,291 Chris Anderson. Welcome, Bill Gates. 2 00:00:03,291 --> 00:00:04,688 Bill Gates: Thank you. 3 00:00:04,688 --> 00:00:06,419 CA: All right. It's great to have you here, Bill. 4 00:00:06,419 --> 00:00:08,917 You know, we had a TED conversation 5 00:00:08,917 --> 00:00:10,764 about three months ago about this pandemic, 6 00:00:10,764 --> 00:00:12,805 and back then I think fewer than -- 7 00:00:12,805 --> 00:00:13,821 I think that was the end of March -- 8 00:00:13,821 --> 00:00:16,733 back then, fewer than a thousand people in the US had died, 9 00:00:16,733 --> 00:00:19,515 and fewer than 20,000 worldwide. 10 00:00:19,841 --> 00:00:24,824 I mean, the numbers now are, like, 128,000 dead in the US 11 00:00:24,824 --> 00:00:27,151 and more than half a million worldwide. 12 00:00:27,151 --> 00:00:28,864 in three months. 13 00:00:28,864 --> 00:00:30,045 In three months. 14 00:00:30,045 --> 00:00:35,087 What is your diagnosis of what is possible for the rest of this year? 15 00:00:35,263 --> 00:00:37,198 You look at a lot of models. 16 00:00:37,198 --> 00:00:40,957 What do you think best and worst case scenarios might be? 17 00:00:43,336 --> 00:00:45,782 BG: Well, the range of scenarios, sadly, 18 00:00:45,782 --> 00:00:48,260 is quite large, including that, 19 00:00:48,260 --> 00:00:51,337 as we get into the fall, 20 00:00:51,337 --> 00:00:53,486 we could have death rates 21 00:00:53,486 --> 00:00:57,759 that rival the worst of what we had in the April time period. 22 00:00:58,716 --> 00:01:01,062 If you get a lot of young people infected, 23 00:01:01,062 --> 00:01:04,217 eventually they will infect old people again, 24 00:01:04,217 --> 00:01:06,678 and so you'll get into the nursing homes, 25 99:59:59,999 --> 99:59:59,999 the homeless shelters, 26 99:59:59,999 --> 99:59:59,999 the places where we've had a lot of our deaths. 27 99:59:59,999 --> 99:59:59,999 The innovation track, which probably we will touch on -- 28 99:59:59,999 --> 99:59:59,999 diagnostics, therapeutics, vaccines -- 29 99:59:59,999 --> 99:59:59,999 there's good progress there, 30 99:59:59,999 --> 99:59:59,999 but nothing that would fundamentally alter the fact 31 99:59:59,999 --> 99:59:59,999 that this fall in the United States could be quite bad, 32 99:59:59,999 --> 99:59:59,999 and that's worse than I would have expected a month ago, 33 99:59:59,999 --> 99:59:59,999 the degree to which we're back at high mobility, 34 99:59:59,999 --> 99:59:59,999 not wearing masks, 35 99:59:59,999 --> 99:59:59,999 and now the virus actually has gotten into a lot of cities 36 99:59:59,999 --> 99:59:59,999 that it hadn't been in before 37 99:59:59,999 --> 99:59:59,999 in a significant way, 38 99:59:59,999 --> 99:59:59,999 so it's going to be a challenge. 39 99:59:59,999 --> 99:59:59,999 There's no case where we get much below the current death rate, 40 99:59:59,999 --> 99:59:59,999 which is about 500 deaths a day, 41 99:59:59,999 --> 99:59:59,999 but there's a significant risk we'd go back up 42 99:59:59,999 --> 99:59:59,999 to the even 2,000 a day that we had before, 43 99:59:59,999 --> 99:59:59,999 because we don't have the distancing, 44 99:59:59,999 --> 99:59:59,999 the behavior change, 45 99:59:59,999 --> 99:59:59,999 to the degree that we had in April and May, 46 99:59:59,999 --> 99:59:59,999 and we know this virus is somewhat seasonal, 47 99:59:59,999 --> 99:59:59,999 so that the force of infection, 48 99:59:59,999 --> 99:59:59,999 both through temperature, humidity, more time indoors, 49 99:59:59,999 --> 99:59:59,999 will be worse as we get into the fall. 50 99:59:59,999 --> 99:59:59,999 CA: So there are scenarios where in the US, 51 99:59:59,999 --> 99:59:59,999 like, if you extrapolate those numbers forward, 52 99:59:59,999 --> 99:59:59,999 we end up with, what, 53 99:59:59,999 --> 99:59:59,999 more than a quarter of a million deaths, 54 99:59:59,999 --> 99:59:59,999 perchance, even this year if we're not careful, 55 99:59:59,999 --> 99:59:59,999 and worldwide I guess the death toll could by the end of the year 56 99:59:59,999 --> 99:59:59,999 be well into the millions, with an s. 57 99:59:59,999 --> 99:59:59,999 Is there evidence that the hotter temperatures of the summer 58 99:59:59,999 --> 99:59:59,999 actually have been helping us? 59 99:59:59,999 --> 99:59:59,999 BG: They're not absolutely sure, 60 99:59:59,999 --> 99:59:59,999 but certainly the ?? model definitely wanted to use the season, 61 99:59:59,999 --> 99:59:59,999 including temperature and humidity, 62 99:59:59,999 --> 99:59:59,999 to try and explain why May wasn't worse than it was. 63 99:59:59,999 --> 99:59:59,999 And so as we came out and the mobility numbers got higher, 64 99:59:59,999 --> 99:59:59,999 the models expected more infections and deaths to come out of that, 65 99:59:59,999 --> 99:59:59,999 and the model kept wanting to say, 66 99:59:59,999 --> 99:59:59,999 "But I need to use this seasonality 67 99:59:59,999 --> 99:59:59,999 to match why May wasn't worse, 68 99:59:59,999 --> 99:59:59,999 why June wasn't worse than it was." 69 99:59:59,999 --> 99:59:59,999 And we see in the Southern Hemisphere, 70 99:59:59,999 --> 99:59:59,999 you know, Brazil, 71 99:59:59,999 --> 99:59:59,999 which is the opposite season, 72 99:59:59,999 --> 99:59:59,999 all of South America is having a huge epidemic. 73 99:59:59,999 --> 99:59:59,999 South Africa is having a very fast-growing epidemic. 74 99:59:59,999 --> 99:59:59,999 Fortunately, Australia and New Zealand, 75 99:59:59,999 --> 99:59:59,999 the last countries in the Southern Hemisphere, 76 99:59:59,999 --> 99:59:59,999 are at really tiny case counts, 77 99:59:59,999 --> 99:59:59,999 and so although they have to keep knocking it down, 78 99:59:59,999 --> 99:59:59,999 they're talking about, oh, we have 10 cases, 79 99:59:59,999 --> 99:59:59,999 that's a big deal, let's go get rid of that. 80 99:59:59,999 --> 99:59:59,999 So they're one of these amazing countries 81 99:59:59,999 --> 99:59:59,999 that got the numbers so low 82 99:59:59,999 --> 99:59:59,999 that test, quarantine and trace 83 99:59:59,999 --> 99:59:59,999 is working to get them, 84 99:59:59,999 --> 99:59:59,999 keep them at very near zero. 85 99:59:59,999 --> 99:59:59,999 CA: Aided perhaps a bit by being easier to isolate 86 99:59:59,999 --> 99:59:59,999 and by less density, less population density, 87 99:59:59,999 --> 99:59:59,999 but nonetheless smart policies down there. 88 99:59:59,999 --> 99:59:59,999 BG: Yeah. Everything is so exponential that a little bit of good work 89 99:59:59,999 --> 99:59:59,999 goes a long ways. 90 99:59:59,999 --> 99:59:59,999 It's not a linear game. 91 99:59:59,999 --> 99:59:59,999 Contact tracing, if you have the number of cases we have in the US, 92 99:59:59,999 --> 99:59:59,999 it's super-important to do, 93 99:59:59,999 --> 99:59:59,999 but it won't get you back down to zero. 94 99:59:59,999 --> 99:59:59,999 It'll help you be down, 95 99:59:59,999 --> 99:59:59,999 but it's too overwhelming. 96 99:59:59,999 --> 99:59:59,999 CA: OK, so in May and June in the US, 97 99:59:59,999 --> 99:59:59,999 the numbers were actually slightly better than some of the models predicted, 98 99:59:59,999 --> 99:59:59,999 and it's hypothesized that that might be partly because of the warmer weather. 99 99:59:59,999 --> 99:59:59,999 Now we're seeing, really, would you describe it 100 99:59:59,999 --> 99:59:59,999 as really quite alarming upticks in case rates in the US? 101 99:59:59,999 --> 99:59:59,999 BG: That's right. 102 99:59:59,999 --> 99:59:59,999 In, say, the New York area, 103 99:59:59,999 --> 99:59:59,999 the cases continue to go down somewhat, 104 99:59:59,999 --> 99:59:59,999 but in other parts of the country, 105 99:59:59,999 --> 99:59:59,999 primarily the South right now, 106 99:59:59,999 --> 99:59:59,999 you have increases that are offsetting that, 107 99:59:59,999 --> 99:59:59,999 and you have testing positive rates in young people 108 99:59:59,999 --> 99:59:59,999 that are actually higher 109 99:59:59,999 --> 99:59:59,999 than what we saw even in some of the tougher areas, 110 99:59:59,999 --> 99:59:59,999 and so clearly younger people have come out of mobility 111 99:59:59,999 --> 99:59:59,999 more than older people have increased their mobility, 112 99:59:59,999 --> 99:59:59,999 so the age structure 113 99:59:59,999 --> 99:59:59,999 is right now very young, but because of multigenerational households, 114 99:59:59,999 --> 99:59:59,999 people work in nursing care homes, 115 99:59:59,999 --> 99:59:59,999 unfortunately that will work its way back, 116 99:59:59,999 --> 99:59:59,999 both the time lag and the transmission back up into the elderly, 117 99:59:59,999 --> 99:59:59,999 will start to push the death rate back up, 118 99:59:59,999 --> 99:59:59,999 which it is down, 119 99:59:59,999 --> 99:59:59,999 way down from 2,000 to around 500 right now. 120 99:59:59,999 --> 99:59:59,999 CA: And is that partly because there's a three-week lag 121 99:59:59,999 --> 99:59:59,999 between case numbers and fatality numbers? 122 99:59:59,999 --> 99:59:59,999 And also, perhaps, partly because 123 99:59:59,999 --> 99:59:59,999 there have been some effective interventions 124 99:59:59,999 --> 99:59:59,999 and we're actually seeing the possibility 125 99:59:59,999 --> 99:59:59,999 that the overall fatality rate is actually falling a bit 126 99:59:59,999 --> 99:59:59,999 now that we've gained some extra knowledge? 127 99:59:59,999 --> 99:59:59,999 BG: Yeah, certainly your fatality rate is always lower 128 99:59:59,999 --> 99:59:59,999 when you're not overloaded, 129 99:59:59,999 --> 99:59:59,999 and so Italy when they were overloaded, 130 99:59:59,999 --> 99:59:59,999 Spain, even New York at the start, 131 99:59:59,999 --> 99:59:59,999 certainly China, 132 99:59:59,999 --> 99:59:59,999 there you weren't even able to provide the basics, 133 99:59:59,999 --> 99:59:59,999 the oxygen and things. 134 99:59:59,999 --> 99:59:59,999 A study that our foundation funded in the UK 135 99:59:59,999 --> 99:59:59,999 found the only thing other than remdesivir 136 99:59:59,999 --> 99:59:59,999 that is a proven therapeutic, 137 99:59:59,999 --> 99:59:59,999 which is the dexamethasone, 138 99:59:59,999 --> 99:59:59,999 that for serious patients 139 99:59:59,999 --> 99:59:59,999 is about a 20 percent death reduction, 140 99:59:59,999 --> 99:59:59,999 and there's still quite a pipeline of those things. 141 99:59:59,999 --> 99:59:59,999 You know, hydroxychloroquine never established positive data, 142 99:59:59,999 --> 99:59:59,999 so that's pretty much done. 143 99:59:59,999 --> 99:59:59,999 There's still a few trials ongoing, 144 99:59:59,999 --> 99:59:59,999 but the list of things being tried, 145 99:59:59,999 --> 99:59:59,999 including eventually ?? antibodies, 146 99:59:59,999 --> 99:59:59,999 we will have some additional tools for the fall. 147 99:59:59,999 --> 99:59:59,999 And so when you talk about death rates, 148 99:59:59,999 --> 99:59:59,999 the good news is some innovation we already have 149 99:59:59,999 --> 99:59:59,999 and we will have more 150 99:59:59,999 --> 99:59:59,999 even in the fall. 151 99:59:59,999 --> 99:59:59,999 We should start to have monoclonal antibodies, 152 99:59:59,999 --> 99:59:59,999 which is the single therapeutic that I'm most excited about. 153 99:59:59,999 --> 99:59:59,999 CA: I'll actually ask you to tell me a bit more about that in one sec, 154 99:59:59,999 --> 99:59:59,999 but just putting the pieces together on death rates: 155 99:59:59,999 --> 99:59:59,999 so in a well-functioning health system, 156 99:59:59,999 --> 99:59:59,999 so take the US when places aren't overcrowded, 157 99:59:59,999 --> 99:59:59,999 what do you think 158 99:59:59,999 --> 99:59:59,999 the current fatality numbers are approximately going forward, 159 99:59:59,999 --> 99:59:59,999 like as a percentage of total cases? 160 99:59:59,999 --> 99:59:59,999 Are we below one percent, perhaps? 161 99:59:59,999 --> 99:59:59,999 BG: If you found every case, yes, 162 99:59:59,999 --> 99:59:59,999 you're well below one percent. 163 99:59:59,999 --> 99:59:59,999 People argue, you know, 0.4, 0.5. 164 99:59:59,999 --> 99:59:59,999 By the time you bring in the never symptomatics, 165 99:59:59,999 --> 99:59:59,999 it probably is below 0.5, 166 99:59:59,999 --> 99:59:59,999 and that's good news. 167 99:59:59,999 --> 99:59:59,999 This disease could have been a five percent disease. 168 99:59:59,999 --> 99:59:59,999 The transmission dynamics of this disease 169 99:59:59,999 --> 99:59:59,999 are more difficult than even the experts predicted. 170 99:59:59,999 --> 99:59:59,999 The amount of pre-symptomatic and never symptomatic spread, 171 99:59:59,999 --> 99:59:59,999 and the fact that it's not coughing, 172 99:59:59,999 --> 99:59:59,999 where you would kind of notice, hey, I'm coughing. 173 99:59:59,999 --> 99:59:59,999 Most respiratory diseases make you cough. 174 99:59:59,999 --> 99:59:59,999 This one, in its early stages, it's not coughing, 175 99:59:59,999 --> 99:59:59,999 it's singing, laughing, talking, 176 99:59:59,999 --> 99:59:59,999 actually still particularly for the super-spreaders, 177 99:59:59,999 --> 99:59:59,999 people with very high viral loads, 178 99:59:59,999 --> 99:59:59,999 causes that spread, 179 99:59:59,999 --> 99:59:59,999 and that's pretty novel, 180 99:59:59,999 --> 99:59:59,999 and so even experts have to say, wow, this caught us by surprise. 181 99:59:59,999 --> 99:59:59,999 The amount of asymptomatic spread 182 99:59:59,999 --> 99:59:59,999 and the fact that there's not a coughing element 183 99:59:59,999 --> 99:59:59,999 is not a major piece like the flu or TB. 184 99:59:59,999 --> 99:59:59,999 CA: Yeah, that is devilish cunning 185 99:59:59,999 --> 99:59:59,999 by the virus. 186 99:59:59,999 --> 99:59:59,999 I mean, how much is that non-symptomatic transmission 187 99:59:59,999 --> 99:59:59,999 as a percentage of total transmission? 188 99:59:59,999 --> 99:59:59,999 I've heard numbers it could be as much as half of all transmissions 189 99:59:59,999 --> 99:59:59,999 are basically pre-symptomatic. 190 99:59:59,999 --> 99:59:59,999 BG: Yeah, if you count pre-symptomatics, 191 99:59:59,999 --> 99:59:59,999 then most of the studies show that's like at 40 percent, 192 99:59:59,999 --> 99:59:59,999 and we also have never symptomatics. 193 99:59:59,999 --> 99:59:59,999 The amount of virus you get in your upper respiratory area 194 99:59:59,999 --> 99:59:59,999 is somewhat disconnected. 195 99:59:59,999 --> 99:59:59,999 Some people will have a lot here and very little in their lungs, 196 99:59:59,999 --> 99:59:59,999 and what you get in your lungs 197 99:59:59,999 --> 99:59:59,999 causes the really bad symptoms, 198 99:59:59,999 --> 99:59:59,999 and other organs, 199 99:59:59,999 --> 99:59:59,999 but mostly the lungs, 200 99:59:59,999 --> 99:59:59,999 and so that's when you seek treatment. 201 99:59:59,999 --> 99:59:59,999 And so the worst case in terms of spreading 202 99:59:59,999 --> 99:59:59,999 is somebody who's got a lot in the upper respiratory tract 203 99:59:59,999 --> 99:59:59,999 but almost none in their lungs, 204 99:59:59,999 --> 99:59:59,999 so they're not care-seeking. 205 99:59:59,999 --> 99:59:59,999 CA: Right. 206 99:59:59,999 --> 99:59:59,999 And so if you add in the never symptomatic 207 99:59:59,999 --> 99:59:59,999 to the pre-symptomatic, 208 99:59:59,999 --> 99:59:59,999 do you get above 50 percent of the transmission 209 99:59:59,999 --> 99:59:59,999 is actually from non-symptomatic people? 210 99:59:59,999 --> 99:59:59,999 BG: Yeah, transmission is harder to measure. 211 99:59:59,999 --> 99:59:59,999 You know, we see certain hotspots and things, 212 99:59:59,999 --> 99:59:59,999 but that's a huge question with the vaccine: 213 99:59:59,999 --> 99:59:59,999 will it, besides avoiding you getting sick, 214 99:59:59,999 --> 99:59:59,999 which is what the trial will test, 215 99:59:59,999 --> 99:59:59,999 will it also stop you from being a transmitter? 216 99:59:59,999 --> 99:59:59,999 CA: So that vaccine, 217 99:59:59,999 --> 99:59:59,999 it's such an important question, let's come on to that, 218 99:59:59,999 --> 99:59:59,999 but before we go there, 219 99:59:59,999 --> 99:59:59,999 any other surprises in the last couple months 220 99:59:59,999 --> 99:59:59,999 that we've learned about this virus 221 99:59:59,999 --> 99:59:59,999 that really impact how we should respond to it? 222 99:59:59,999 --> 99:59:59,999 BG: We're still not able to characterize who the super-spreaders are 223 99:59:59,999 --> 99:59:59,999 in terms of what that profile is, 224 99:59:59,999 --> 99:59:59,999 and we may never. 225 99:59:59,999 --> 99:59:59,999 That may just be quite random. 226 99:59:59,999 --> 99:59:59,999 If you could identify them, 227 99:59:59,999 --> 99:59:59,999 they're responsible for the majority of transmission, 228 99:59:59,999 --> 99:59:59,999 a few people who have very high viral loads. 229 99:59:59,999 --> 99:59:59,999 But sadly, we haven't figured that out. 230 99:59:59,999 --> 99:59:59,999 This mode of transmission, 231 99:59:59,999 --> 99:59:59,999 if you're in a room and nobody talks, 232 99:59:59,999 --> 99:59:59,999 there's way less transmission. 233 99:59:59,999 --> 99:59:59,999 That's partly why, although planes can transmit, 234 99:59:59,999 --> 99:59:59,999 it's less than you would expect just in terms of time proximity measures, 235 99:59:59,999 --> 99:59:59,999 because unlike, say, a choir or a restaurant, 236 99:59:59,999 --> 99:59:59,999 you're not exhaling in loud talking 237 99:59:59,999 --> 99:59:59,999 quite as much as in other indoor environments. 238 99:59:59,999 --> 99:59:59,999 CA: What do you think about the ethics of someone who would go on a plane 239 99:59:59,999 --> 99:59:59,999 and refuse to wear a mask? 240 99:59:59,999 --> 99:59:59,999 BG: If they own the plane, that would be fine. 241 99:59:59,999 --> 99:59:59,999 If there's other people on the plane, 242 99:59:59,999 --> 99:59:59,999 that would be endangering those other people. 243 99:59:59,999 --> 99:59:59,999 CA: Early on in the pandemic, 244 99:59:59,999 --> 99:59:59,999 the WHO did not advise that people wear masks. 245 99:59:59,999 --> 99:59:59,999 They were worried about taking them away from frontline medical providers. 246 99:59:59,999 --> 99:59:59,999 In retrospect, was that a terrible mistake that they made? 247 99:59:59,999 --> 99:59:59,999 BG: Yes. 248 99:59:59,999 --> 99:59:59,999 All the experts feel bad 249 99:59:59,999 --> 99:59:59,999 that the value of masks, 250 99:59:59,999 --> 99:59:59,999 which ties back somewhat to the asymptomatics, 251 99:59:59,999 --> 99:59:59,999 if people were very symptomatic, 252 99:59:59,999 --> 99:59:59,999 like in Ebola, 253 99:59:59,999 --> 99:59:59,999 then you know it and you isolate, 254 99:59:59,999 --> 99:59:59,999 and so you don't have a need for a mask-like thing. 255 99:59:59,999 --> 99:59:59,999 The value of masks, 256 99:59:59,999 --> 99:59:59,999 the fact that the medical masks was a different supply chain 257 99:59:59,999 --> 99:59:59,999 than the normal masks, 258 99:59:59,999 --> 99:59:59,999 the fact you could scale up the normal masks so well, 259 99:59:59,999 --> 99:59:59,999 the fact that it would stop that pre-symptomatic, 260 99:59:59,999 --> 99:59:59,999 never symptomatic transmission, 261 99:59:59,999 --> 99:59:59,999 it's a mistake, 262 99:59:59,999 --> 99:59:59,999 but it's not a conspiracy, 263 99:59:59,999 --> 99:59:59,999 it's something that we now know more. 264 99:59:59,999 --> 99:59:59,999 And even now, our error bars on the benefit of masks 265 99:59:59,999 --> 99:59:59,999 are higher than we'd like to admit, 266 99:59:59,999 --> 99:59:59,999 but it's a significant benefit. 267 99:59:59,999 --> 99:59:59,999 CA: All right, I'm going to come in with some questions 268 99:59:59,999 --> 99:59:59,999 from the community. 269 99:59:59,999 --> 99:59:59,999 Let's pull them up there. 270 99:59:59,999 --> 99:59:59,999 Jim Pitofsky: "Do you think reopening efforts in the US have been premature, 271 99:59:59,999 --> 99:59:59,999 and if so how far should the US go to responsibly confront this pandemic?" 272 99:59:59,999 --> 99:59:59,999 BG: Well, the question of how you make tradeoffs 273 99:59:59,999 --> 99:59:59,999 between the benefits, say, of going to school 274 99:59:59,999 --> 99:59:59,999 versus the risk of people getting sick because they go to school, 275 99:59:59,999 --> 99:59:59,999 those are very tough questions 276 99:59:59,999 --> 99:59:59,999 that I don't think any single person 277 99:59:59,999 --> 99:59:59,999 can say, "I will tell you how to make all these tradeoffs." 278 99:59:59,999 --> 99:59:59,999 The understanding of where you have transmission, 279 99:59:59,999 --> 99:59:59,999 and the fact that young people do get infected 280 99:59:59,999 --> 99:59:59,999 and are part of the multi-generational transmission chain, 281 99:59:59,999 --> 99:59:59,999 we should get that out. 282 99:59:59,999 --> 99:59:59,999 If you just look at the health aspect, 283 99:59:59,999 --> 99:59:59,999 we have opened up too liberally. 284 99:59:59,999 --> 99:59:59,999 Now, opening up in terms of mental health 285 99:59:59,999 --> 99:59:59,999 and seeking normal health things 286 99:59:59,999 --> 99:59:59,999 like vaccines and other care, 287 99:59:59,999 --> 99:59:59,999 there are benefits. 288 99:59:59,999 --> 99:59:59,999 I think some of our opening up 289 99:59:59,999 --> 99:59:59,999 has created more risk than benefit. 290 99:59:59,999 --> 99:59:59,999 Opening the bars up as quickly as they did, 291 99:59:59,999 --> 99:59:59,999 is that critical for mental health? 292 99:59:59,999 --> 99:59:59,999 Maybe not. 293 99:59:59,999 --> 99:59:59,999 So I don't think we've been as tasteful about opening up 294 99:59:59,999 --> 99:59:59,999 as I'm sure, as we study it, 295 99:59:59,999 --> 99:59:59,999 that we'll realize some things we shouldn't have opened up as fast, 296 99:59:59,999 --> 99:59:59,999 but then you have something like school, 297 99:59:59,999 --> 99:59:59,999 where even sitting here today, 298 99:59:59,999 --> 99:59:59,999 the exact plan, say, for inner city schools for the fall, 299 99:59:59,999 --> 99:59:59,999 I wouldn't have a black-and-white view 300 99:59:59,999 --> 99:59:59,999 on the relative tradeoffs involved there. 301 99:59:59,999 --> 99:59:59,999 There are huge benefits 302 99:59:59,999 --> 99:59:59,999 to letting those kids go to school, 303 99:59:59,999 --> 99:59:59,999 and how do you weigh the risk? 304 99:59:59,999 --> 99:59:59,999 If you're in a city 305 99:59:59,999 --> 99:59:59,999 without many cases, 306 99:59:59,999 --> 99:59:59,999 I would say probably the benefit is there. 307 99:59:59,999 --> 99:59:59,999 Now that means that you could get surprised. 308 99:59:59,999 --> 99:59:59,999 The cases could show up, and then you'd have to change that, 309 99:59:59,999 --> 99:59:59,999 which is not easy. 310 99:59:59,999 --> 99:59:59,999 But I think around the US there will be places 311 99:59:59,999 --> 99:59:59,999 where that won't be a good tradeoff. 312 99:59:59,999 --> 99:59:59,999 So almost any dimension and inequity, 313 99:59:59,999 --> 99:59:59,999 this disease has made worse: 314 99:59:59,999 --> 99:59:59,999 job type, internet connection, 315 99:59:59,999 --> 99:59:59,999 ability of your school to do online learning. 316 99:59:59,999 --> 99:59:59,999 White collar workers, 317 99:59:59,999 --> 99:59:59,999 people are embarrassed to admit it, 318 99:59:59,999 --> 99:59:59,999 some of them are more productive 319 99:59:59,999 --> 99:59:59,999 and enjoying the flexibility that the at-home thing has created, 320 99:59:59,999 --> 99:59:59,999 and that feels terrible 321 99:59:59,999 --> 99:59:59,999 when you know lots of people are suffering in many ways, 322 99:59:59,999 --> 99:59:59,999 including their kids not going to school. 323 99:59:59,999 --> 99:59:59,999 CA: Indeed. Let's have the next question. 324 99:59:59,999 --> 99:59:59,999 "For us in Rwanda, 325 99:59:59,999 --> 99:59:59,999 early policy interventions have made the difference. 326 99:59:59,999 --> 99:59:59,999 At this point, what policy interventions do you suggest for the US now?" 327 99:59:59,999 --> 99:59:59,999 Bill, I dream of the day where you are appointed 328 99:59:59,999 --> 99:59:59,999 the coronavirus czar 329 99:59:59,999 --> 99:59:59,999 with authority to actually speak to the public. 330 99:59:59,999 --> 99:59:59,999 What would you do? 331 99:59:59,999 --> 99:59:59,999 BG: The innovation tools 332 99:59:59,999 --> 99:59:59,999 are where I and the foundation probably has the most expertise. 333 99:59:59,999 --> 99:59:59,999 Clearly some of the policies on opening up have been too generous, 334 99:59:59,999 --> 99:59:59,999 but I think everybody 335 99:59:59,999 --> 99:59:59,999 could engage in that. 336 99:59:59,999 --> 99:59:59,999 We need leadership 337 99:59:59,999 --> 99:59:59,999 in terms of admitting 338 99:59:59,999 --> 99:59:59,999 that we've still got a huge problem here, 339 99:59:59,999 --> 99:59:59,999 and not turning that into almost a political thing 340 99:59:59,999 --> 99:59:59,999 of, oh, isn't it brilliant what we did. 341 99:59:59,999 --> 99:59:59,999 No, it's not brilliant, 342 99:59:59,999 --> 99:59:59,999 but there's many people, 343 99:59:59,999 --> 99:59:59,999 including the experts, 344 99:59:59,999 --> 99:59:59,999 where there's a lot they didn't understand, 345 99:59:59,999 --> 99:59:59,999 and everybody wishes a week earlier whatever action they took, 346 99:59:59,999 --> 99:59:59,999 they'd taken that a week earlier. 347 99:59:59,999 --> 99:59:59,999 The innovation tools, 348 99:59:59,999 --> 99:59:59,999 that's where the foundation's work 349 99:59:59,999 --> 99:59:59,999 on antibodies, vaccines, 350 99:59:59,999 --> 99:59:59,999 we have deep expertise, 351 99:59:59,999 --> 99:59:59,999 and it's outside of the private sector, 352 99:59:59,999 --> 99:59:59,999 and so we have kind of a neutral ability to work with all the governments 353 99:59:59,999 --> 99:59:59,999 and the companies to pick. 354 99:59:59,999 --> 99:59:59,999 Particularly when you're doing break-even products, 355 99:59:59,999 --> 99:59:59,999 which one should get the resources. 356 99:59:59,999 --> 99:59:59,999 There's no market signal for that. 357 99:59:59,999 --> 99:59:59,999 Experts have to say, OK, this antibody deserves the manufacturing. 358 99:59:59,999 --> 99:59:59,999 This vaccine deserves the manufacturing. 359 99:59:59,999 --> 99:59:59,999 Because, we have very limited manufacturing for both of those things, 360 99:59:59,999 --> 99:59:59,999 and it'll be cross-company, 361 99:59:59,999 --> 99:59:59,999 which never happens in the normal case, 362 99:59:59,999 --> 99:59:59,999 where one company invents it 363 99:59:59,999 --> 99:59:59,999 and then you're using the manufacturing plants 364 99:59:59,999 --> 99:59:59,999 of many companies 365 99:59:59,999 --> 99:59:59,999 to get maximum scale of the best choice. 366 99:59:59,999 --> 99:59:59,999 So I would be coordinating those things, 367 99:59:59,999 --> 99:59:59,999 but we need a leader who keeps us up to date, 368 99:59:59,999 --> 99:59:59,999 is realistic, 369 99:59:59,999 --> 99:59:59,999 and shows us the right behavior, 370 99:59:59,999 --> 99:59:59,999 as well as driving the innovation track. 371 99:59:59,999 --> 99:59:59,999 CA: I mean, you have to yourself be a master diplomat 372 99:59:59,999 --> 99:59:59,999 in how you talk about this stuff. 373 99:59:59,999 --> 99:59:59,999 So I appreciate, almost, the discomfort here, 374 99:59:59,999 --> 99:59:59,999 but you talk regularly with Anthony Fauci, 375 99:59:59,999 --> 99:59:59,999 who is a wise voice on this by most people's opinion. 376 99:59:59,999 --> 99:59:59,999 But to what extent is he just hamstrung? 377 99:59:59,999 --> 99:59:59,999 He's not allowed to play the full role 378 99:59:59,999 --> 99:59:59,999 that he could play in the circumstance. 379 99:59:59,999 --> 99:59:59,999 BG: Dr. Fauci has emerged, 380 99:59:59,999 --> 99:59:59,999 where he was allowed to have some airtime, 381 99:59:59,999 --> 99:59:59,999 and even though he was stating things that are realistic, 382 99:59:59,999 --> 99:59:59,999 his prestige has stuck. 383 99:59:59,999 --> 99:59:59,999 He can speak out in that way. 384 99:59:59,999 --> 99:59:59,999 Typically, the CDC would be the primary voice here. 385 99:59:59,999 --> 99:59:59,999 It's not absolutely necessary, 386 99:59:59,999 --> 99:59:59,999 but in previous health crises, 387 99:59:59,999 --> 99:59:59,999 you let the experts inside the CDC 388 99:59:59,999 --> 99:59:59,999 be that voice. 389 99:59:59,999 --> 99:59:59,999 They're trained to do these things, 390 99:59:59,999 --> 99:59:59,999 and so it is a bit unusual here 391 99:59:59,999 --> 99:59:59,999 how much we've had to rely on Fauci 392 99:59:59,999 --> 99:59:59,999 as opposed to the CDC. 393 99:59:59,999 --> 99:59:59,999 It should be Fauci, who is a brilliant researcher, 394 99:59:59,999 --> 99:59:59,999 so experienced, particularly in vaccines, 395 99:59:59,999 --> 99:59:59,999 in some ways he has become, taking the broad advice 396 99:59:59,999 --> 99:59:59,999 that is the epidemiology advice 397 99:59:59,999 --> 99:59:59,999 and explaining it in the right way, 398 99:59:59,999 --> 99:59:59,999 where he'll admit, 399 99:59:59,999 --> 99:59:59,999 "OK, we may have a rebound here, 400 99:59:59,999 --> 99:59:59,999 and this is why we need to behave that way." 401 99:59:59,999 --> 99:59:59,999 But it's fantastic that his voice has been allowed to come through. 402 99:59:59,999 --> 99:59:59,999 CA: Sometimes. 403 99:59:59,999 --> 99:59:59,999 Let's have the next question. 404 99:59:59,999 --> 99:59:59,999 Nina Gregory: "How are you and your foundation 405 99:59:59,999 --> 99:59:59,999 addressing the ethical questions about which countries 406 99:59:59,999 --> 99:59:59,999 get the vaccine first, 407 99:59:59,999 --> 99:59:59,999 assuming you find one?" 408 99:59:59,999 --> 99:59:59,999 And maybe, Bill, use this as a moment 409 99:59:59,999 --> 99:59:59,999 to just talk about where the quest for the vaccine is 410 99:59:59,999 --> 99:59:59,999 and what are just some of the key things we should all be thinking about 411 99:59:59,999 --> 99:59:59,999 as we track the news on this. 412 99:59:59,999 --> 99:59:59,999 BG: There's three vaccines that are, 413 99:59:59,999 --> 99:59:59,999 if they work, are the earliest: 414 99:59:59,999 --> 99:59:59,999 the Moderna, which unfortunately won't scale very easily, 415 99:59:59,999 --> 99:59:59,999 so if that works, it'll be mostly a US-targeted thing; 416 99:59:59,999 --> 99:59:59,999 then you have the AstraZeneca, which comes from Oxford; 417 99:59:59,999 --> 99:59:59,999 and the Johnson & Johnson. 418 99:59:59,999 --> 99:59:59,999 Those are the three early ones, 419 99:59:59,999 --> 99:59:59,999 and we have animal data 420 99:59:59,999 --> 99:59:59,999 that looks potentially good, 421 99:59:59,999 --> 99:59:59,999 but not definitive, 422 99:59:59,999 --> 99:59:59,999 particularly will it work in the elderly, 423 99:59:59,999 --> 99:59:59,999 and we'll have human data over the next several months. 424 99:59:59,999 --> 99:59:59,999 Those three will be gated by the safety and efficacy trial. 425 99:59:59,999 --> 99:59:59,999 That is, we'll be able to manufacture those, 426 99:59:59,999 --> 99:59:59,999 although not as much as we want. 427 99:59:59,999 --> 99:59:59,999 We'll be able to manufacture those before the end of the year. 428 99:59:59,999 --> 99:59:59,999 Whether the Phase 3 will succeed, 429 99:59:59,999 --> 99:59:59,999 and whether it'll complete before the end of the year, 430 99:59:59,999 --> 99:59:59,999 I wouldn't be that optimistic about. 431 99:59:59,999 --> 99:59:59,999 Phase 3 is where you need to really look at all the safety profile 432 99:59:59,999 --> 99:59:59,999 and efficacy, 433 99:59:59,999 --> 99:59:59,999 but those will get started. 434 99:59:59,999 --> 99:59:59,999 And then there's four or five vaccines 435 99:59:59,999 --> 99:59:59,999 that use different approaches 436 99:59:59,999 --> 99:59:59,999 that are maybe three or four months behind that: 437 99:59:59,999 --> 99:59:59,999 Novavax, Sanofi, Merck. 438 99:59:59,999 --> 99:59:59,999 And so we're funding factory capacity for a lot of these -- 439 99:59:59,999 --> 99:59:59,999 some complex negotiations are taking place right now on this -- 440 99:59:59,999 --> 99:59:59,999 to get factories that will be dedicated to the poorer countries, 441 99:59:59,999 --> 99:59:59,999 what's called low- and middle-income. 442 99:59:59,999 --> 99:59:59,999 And the very scalable constructs 443 99:59:59,999 --> 99:59:59,999 that include AstraZeneca and Johnson & Johnson, 444 99:59:59,999 --> 99:59:59,999 we'll focus on those, 445 99:59:59,999 --> 99:59:59,999 the ones that are inexpensive 446 99:59:59,999 --> 99:59:59,999 and you can build a single factory to make 600 million doses. 447 99:59:59,999 --> 99:59:59,999 So a number of the vaccine constructs 448 99:59:59,999 --> 99:59:59,999 are potential. 449 99:59:59,999 --> 99:59:59,999 I don't see anything before the end of the year. 450 99:59:59,999 --> 99:59:59,999 That's really the best case, 451 99:59:59,999 --> 99:59:59,999 and it's down to a few constructs now, 452 99:59:59,999 --> 99:59:59,999 which typically you have high failure rates. 453 99:59:59,999 --> 99:59:59,999 CA: Bill, is the case 454 99:59:59,999 --> 99:59:59,999 that you and your foundation weren't in the picture here 455 99:59:59,999 --> 99:59:59,999 that market dynamics would likely lead to a situation 456 99:59:59,999 --> 99:59:59,999 where as soon as a promising vaccine candidate emerged, 457 99:59:59,999 --> 99:59:59,999 the richer countries would basically snap up, 458 99:59:59,999 --> 99:59:59,999 gobble up all available initial supply -- 459 99:59:59,999 --> 99:59:59,999 it just takes a while to manufacture these -- 460 99:59:59,999 --> 99:59:59,999 and there would be nothing for the poorer countries, 461 99:59:59,999 --> 99:59:59,999 but that what effectively you're doing, 462 99:59:59,999 --> 99:59:59,999 by giving manufacturing guarantees 463 99:59:59,999 --> 99:59:59,999 and capability to some of these candidates, 464 99:59:59,999 --> 99:59:59,999 you're making it possible that at least some of the early vaccine units 465 99:59:59,999 --> 99:59:59,999 will go to poorer countries? 466 99:59:59,999 --> 99:59:59,999 Is that correct? 467 99:59:59,999 --> 99:59:59,999 BG: Well, it's not just us, but yes, 468 99:59:59,999 --> 99:59:59,999 we're in the central role there 469 99:59:59,999 --> 99:59:59,999 along with a group we created called CEPI, 470 99:59:59,999 --> 99:59:59,999 Coalition for Epidemic Preparedness, 471 99:59:59,999 --> 99:59:59,999 and the European leaders agree with this. 472 99:59:59,999 --> 99:59:59,999 Now we have the expertise to look at each of the constructs 473 99:59:59,999 --> 99:59:59,999 and say, OK, where is there a factory in the world 474 99:59:59,999 --> 99:59:59,999 that has capacity that can build that? 475 99:59:59,999 --> 99:59:59,999 Which one should we put the early money into? 476 99:59:59,999 --> 99:59:59,999 What should the milestones be 477 99:59:59,999 --> 99:59:59,999 where we'll shift the money over to a different one? 478 99:59:59,999 --> 99:59:59,999 Because the kind of private sector people 479 99:59:59,999 --> 99:59:59,999 who really understand that stuff, 480 99:59:59,999 --> 99:59:59,999 some of them work for us, 481 99:59:59,999 --> 99:59:59,999 and we're a trusted party on these things, 482 99:59:59,999 --> 99:59:59,999 we get to coordinate a lot, particularly the manufacturing piece. 483 99:59:59,999 --> 99:59:59,999 Usually, you'd expect the US 484 99:59:59,999 --> 99:59:59,999 to think of this as a global problem and be involved. 485 99:59:59,999 --> 99:59:59,999 So far, no activity on that front has taken place. 486 99:59:59,999 --> 99:59:59,999 I am talking to people in the Congress and the Administration 487 99:59:59,999 --> 99:59:59,999 about when the next relief bill comes along 488 99:59:59,999 --> 99:59:59,999 that maybe one percent of that 489 99:59:59,999 --> 99:59:59,999 could go for the tools 490 99:59:59,999 --> 99:59:59,999 to help the entire world. 491 99:59:59,999 --> 99:59:59,999 And so it's possible, 492 99:59:59,999 --> 99:59:59,999 but it's unfortunate, 493 99:59:59,999 --> 99:59:59,999 and the vacuum here 494 99:59:59,999 --> 99:59:59,999 the world is not that used to 495 99:59:59,999 --> 99:59:59,999 and a lot of people are stepping in, 496 99:59:59,999 --> 99:59:59,999 including our foundation, 497 99:59:59,999 --> 99:59:59,999 to try and have a strategy, 498 99:59:59,999 --> 99:59:59,999 including for the poorer countries 499 99:59:59,999 --> 99:59:59,999 who will suffer a high percentage of the deaths and negative effects, 500 99:59:59,999 --> 99:59:59,999 including their health systems being overwhelmed. 501 99:59:59,999 --> 99:59:59,999 Most of the deaths will be in developing countries, 502 99:59:59,999 --> 99:59:59,999 despite the huge deaths we've seen in Europe and the US. 503 99:59:59,999 --> 99:59:59,999 CA: I mean, I wish I could be a fly on the wall and hearing 504 99:59:59,999 --> 99:59:59,999 you and Melinda talk about this, 505 99:59:59,999 --> 99:59:59,999 because of all of the ethical crimes, let's say, 506 99:59:59,999 --> 99:59:59,999 executed by leaders who should know better, 507 99:59:59,999 --> 99:59:59,999 I mean, it's one thing to not model mask-wearing, 508 99:59:59,999 --> 99:59:59,999 but to not play a role 509 99:59:59,999 --> 99:59:59,999 in helping the world when faced with a common enemy, 510 99:59:59,999 --> 99:59:59,999 respond as one humanity 511 99:59:59,999 --> 99:59:59,999 and instead catalyze a really unseemly scramble between nations 512 99:59:59,999 --> 99:59:59,999 to fight for vaccines, for example. 513 99:59:59,999 --> 99:59:59,999 That just seems that surely history is going to judge that harshly. 514 99:59:59,999 --> 99:59:59,999 That is just sickening. 515 99:59:59,999 --> 99:59:59,999 Isn't it? Am I missing something? 516 99:59:59,999 --> 99:59:59,999 BG: Well, it's not quite as black and white as that. 517 99:59:59,999 --> 99:59:59,999 The US has put more money out 518 99:59:59,999 --> 99:59:59,999 to fund the basic research on these vaccines 519 99:59:59,999 --> 99:59:59,999 than any country by far, 520 99:59:59,999 --> 99:59:59,999 and that research is not restricted. 521 99:59:59,999 --> 99:59:59,999 There's not, like, some royalty that says, "Hey, if you take our money, 522 99:59:59,999 --> 99:59:59,999 you have to pay the US a royalty." 523 99:59:59,999 --> 99:59:59,999 They do, to the degree they fund research, 524 99:59:59,999 --> 99:59:59,999 it's for everybody. 525 99:59:59,999 --> 99:59:59,999 To the degree they fund factories, it's just for the US. 526 99:59:59,999 --> 99:59:59,999 The thing that makes this tough is that in every other global health problem, 527 99:59:59,999 --> 99:59:59,999 the US totally leads smallpox eradication, 528 99:59:59,999 --> 99:59:59,999 the US is totally the leader on polio eradication 529 99:59:59,999 --> 99:59:59,999 with key partners -- CDC, WHO, Rotary, UNICEF, our foundation. 530 99:59:59,999 --> 99:59:59,999 So the world, and on HIV, 531 99:59:59,999 --> 99:59:59,999 what under President Bush's leadership, but it was very bipartisan, 532 99:59:59,999 --> 99:59:59,999 this thing called PEPFAR was unbelievable. 533 99:59:59,999 --> 99:59:59,999 That has saved tens of millions of lives. 534 99:59:59,999 --> 99:59:59,999 And so it's that the world always expected the US 535 99:59:59,999 --> 99:59:59,999 to at least be at the head of the table, 536 99:59:59,999 --> 99:59:59,999 financially, strategy, OK, how do you get these factories for the world, 537 99:59:59,999 --> 99:59:59,999 even if it's just to avoid the infection coming back to the US 538 99:59:59,999 --> 99:59:59,999 or to have the global economy working, 539 99:59:59,999 --> 99:59:59,999 which is good for US jobs 540 99:59:59,999 --> 99:59:59,999 to have demand outside the US. 541 99:59:59,999 --> 99:59:59,999 And so the world is kind of, there's all this uncertainty 542 99:59:59,999 --> 99:59:59,999 about which thing will work, 543 99:59:59,999 --> 99:59:59,999 and there's, OK, who is in charge here? 544 99:59:59,999 --> 99:59:59,999 And so the worst thing, 545 99:59:59,999 --> 99:59:59,999 the withdrawal from WHO, 546 99:59:59,999 --> 99:59:59,999 that is a difficulty 547 99:59:59,999 --> 99:59:59,999 that hopefully will get remedied at some point, 548 99:59:59,999 --> 99:59:59,999 because we need that coordination 549 99:59:59,999 --> 99:59:59,999 through WHO. 550 99:59:59,999 --> 99:59:59,999 CA: Let's take another question. 551 99:59:59,999 --> 99:59:59,999 Ali Kashani: "Are there any particularly successful models 552 99:59:59,999 --> 99:59:59,999 of handling the pandemic that you have seen around the world?" 553 99:59:59,999 --> 99:59:59,999 BG: Well, it's fascinating that, besides early action, 554 99:59:59,999 --> 99:59:59,999 there are definitely things where you take people who have tested positive 555 99:59:59,999 --> 99:59:59,999 and you monitor their ??, 556 99:59:59,999 --> 99:59:59,999 which is a oxygen saturation level in their blood, 557 99:59:59,999 --> 99:59:59,999 which is a very cheap detector, 558 99:59:59,999 --> 99:59:59,999 and then you know to get them to the hospitals fairly early. 559 99:59:59,999 --> 99:59:59,999 Weirdly, patients don't know things are about to get severe. 560 99:59:59,999 --> 99:59:59,999 It's an interesting physiological reason but I won't get into. 561 99:59:59,999 --> 99:59:59,999 And so Germany has a quite a low case fatality rate 562 99:59:59,999 --> 99:59:59,999 that they've done through that type of monitoring. 563 99:59:59,999 --> 99:59:59,999 And then, of course, once you get into facilities, 564 99:59:59,999 --> 99:59:59,999 we've learned that the ventilator actually, although extremely well-meaning, 565 99:59:59,999 --> 99:59:59,999 was actually overused and used in the wrong mode 566 99:59:59,999 --> 99:59:59,999 in those early days. 567 99:59:59,999 --> 99:59:59,999 So the health, the doctors 568 99:59:59,999 --> 99:59:59,999 are way smarter about treatment today. 569 99:59:59,999 --> 99:59:59,999 Most of that I would say is global. 570 99:59:59,999 --> 99:59:59,999 Using this ?? as an early indicator, 571 99:59:59,999 --> 99:59:59,999 that'll probably catch on broadly, 572 99:59:59,999 --> 99:59:59,999 but Germany was a pioneer there. 573 99:59:59,999 --> 99:59:59,999 And now, of course, dexamethasone, 574 99:59:59,999 --> 99:59:59,999 fortunately, it's cheap, it's oral, 575 99:59:59,999 --> 99:59:59,999 we can ramp up manufacture. 576 99:59:59,999 --> 99:59:59,999 That'll go global as well. 577 99:59:59,999 --> 99:59:59,999 CA: Bill, I want to ask you 578 99:59:59,999 --> 99:59:59,999 something about 579 99:59:59,999 --> 99:59:59,999 what it's been like for you personally through this whole process. 580 99:59:59,999 --> 99:59:59,999 Because, weirdly, even though your passion and good intent on this topic 581 99:59:59,999 --> 99:59:59,999 seems completely bloody obvious to anyone who has spent a moment with you, 582 99:59:59,999 --> 99:59:59,999 there are these crazy conspiracy theories out there about you. 583 99:59:59,999 --> 99:59:59,999 I just checked in with a company called Zignal 584 99:59:59,999 --> 99:59:59,999 that monitors social media spaces. 585 99:59:59,999 --> 99:59:59,999 They say that, to date, I think on Facebook alone, 586 99:59:59,999 --> 99:59:59,999 more than four million posts have taken place 587 99:59:59,999 --> 99:59:59,999 that associate you with some kind of conspiracy theory around the virus. 588 99:59:59,999 --> 99:59:59,999 I read that there was a poll that more than 40 percent of Republicans 589 99:59:59,999 --> 99:59:59,999 believe that the vaccine that you would roll out 590 99:59:59,999 --> 99:59:59,999 would somehow plant a microchip in people to track their location. 591 99:59:59,999 --> 99:59:59,999 I mean, I can't even believe that poll number. 592 99:59:59,999 --> 99:59:59,999 And then some people are taking this seriously enough, 593 99:59:59,999 --> 99:59:59,999 and some of them have even been recirculated on Fox News and so forth, 594 99:59:59,999 --> 99:59:59,999 some people are taking this seriously enough 595 99:59:59,999 --> 99:59:59,999 to make really quite horrible threats and so forth. 596 99:59:59,999 --> 99:59:59,999 You seem to do a good job sort of shrugging this off, 597 99:59:59,999 --> 99:59:59,999 but really, like, who else has ever been in this position? 598 99:59:59,999 --> 99:59:59,999 How are you managing this? 599 99:59:59,999 --> 99:59:59,999 What on earth world are we in 600 99:59:59,999 --> 99:59:59,999 that this kind of misinformation can be out there? 601 99:59:59,999 --> 99:59:59,999 What can we do to help correct it? 602 99:59:59,999 --> 99:59:59,999 BG: I'm not sure, 603 99:59:59,999 --> 99:59:59,999 and it's a new thing 604 99:59:59,999 --> 99:59:59,999 that there's conspiracy theories. 605 99:59:59,999 --> 99:59:59,999 I mean, Microsoft had its share of controversy, 606 99:59:59,999 --> 99:59:59,999 but at least that related to the real world, you know? 607 99:59:59,999 --> 99:59:59,999 Did Windows crash more than it should? 608 99:59:59,999 --> 99:59:59,999 We definitely had anti-trust problems. 609 99:59:59,999 --> 99:59:59,999 But at least I knew what that was. 610 99:59:59,999 --> 99:59:59,999 When this emerged, I have to say, 611 99:59:59,999 --> 99:59:59,999 my instinct was to joke about it. 612 99:59:59,999 --> 99:59:59,999 People have said that's really inappropriate, 613 99:59:59,999 --> 99:59:59,999 because this is a very serious thing. 614 99:59:59,999 --> 99:59:59,999 It is going to make people less willing to take a vaccine. 615 99:59:59,999 --> 99:59:59,999 And, of course, once we have that vaccine, 616 99:59:59,999 --> 99:59:59,999 it'll be like masks, 617 99:59:59,999 --> 99:59:59,999 where getting lots of people, 618 99:59:59,999 --> 99:59:59,999 particularly when it's a transmission-blocking vaccine, 619 99:59:59,999 --> 99:59:59,999 there's this huge community benefit 620 99:59:59,999 --> 99:59:59,999 to widespread adoption of that vaccine. 621 99:59:59,999 --> 99:59:59,999 So I am caught a little bit, 622 99:59:59,999 --> 99:59:59,999 unsure of what to say or do, 623 99:59:59,999 --> 99:59:59,999 because the conspiracy piece is a new thing for me, 624 99:59:59,999 --> 99:59:59,999 and what do you say 625 99:59:59,999 --> 99:59:59,999 that doesn't give credence to the thing? 626 99:59:59,999 --> 99:59:59,999 The fact that a Fox News commentator, 627 99:59:59,999 --> 99:59:59,999 Laura Ingraham, was saying this stuff about me microchipping people, 628 99:59:59,999 --> 99:59:59,999 that survey isn't that surprising because that's what they heard 629 99:59:59,999 --> 99:59:59,999 on the TV. 630 99:59:59,999 --> 99:59:59,999 It's wild. 631 99:59:59,999 --> 99:59:59,999 And people are clearly seeking simpler explanations 632 99:59:59,999 --> 99:59:59,999 than going and studying virology. 633 99:59:59,999 --> 99:59:59,999 CA: I mean, 634 99:59:59,999 --> 99:59:59,999 TED is nonpolitical, 635 99:59:59,999 --> 99:59:59,999 but we believe in the truth. 636 99:59:59,999 --> 99:59:59,999 I would say this. 637 99:59:59,999 --> 99:59:59,999 Laura Ingraham, you owe Bill Gates an apology and a retraction. 638 99:59:59,999 --> 99:59:59,999 You do. 639 99:59:59,999 --> 99:59:59,999 And anyone who is watching this 640 99:59:59,999 --> 99:59:59,999 who thinks for a minute 641 99:59:59,999 --> 99:59:59,999 that this man is involved in some kind of conspiracy, 642 99:59:59,999 --> 99:59:59,999 you want your head examined. 643 99:59:59,999 --> 99:59:59,999 You are crazy. 644 99:59:59,999 --> 99:59:59,999 Enough of us know Bill over many years 645 99:59:59,999 --> 99:59:59,999 and have seen the passion and engagement in this to know 646 99:59:59,999 --> 99:59:59,999 that you are crazy. 647 99:59:59,999 --> 99:59:59,999 So get over it, 648 99:59:59,999 --> 99:59:59,999 and let's look at the actual problem of solving this pandemic. 649 99:59:59,999 --> 99:59:59,999 Honestly. 650 99:59:59,999 --> 99:59:59,999 If anyone in the chat here has a suggestion, 651 99:59:59,999 --> 99:59:59,999 a positive suggestion for how you can, 652 99:59:59,999 --> 99:59:59,999 how do you get rid of conspiracies, because they feed on each other. 653 99:59:59,999 --> 99:59:59,999 Now, oh, well I would say that, because I'm part of the conspiracy, 654 99:59:59,999 --> 99:59:59,999 or whatever. 655 99:59:59,999 --> 99:59:59,999 Like, how do we get back to a world where information can be trusted? 656 99:59:59,999 --> 99:59:59,999 We have to do better on it. 657 99:59:59,999 --> 99:59:59,999 Are there any other questions out there from the community? 658 99:59:59,999 --> 99:59:59,999 Aria Bendix from New York City: 659 99:59:59,999 --> 99:59:59,999 "What are your personal recommendations for those who want to reduce 660 99:59:59,999 --> 99:59:59,999 their risk of infection amid an uptick in cases?" 661 99:59:59,999 --> 99:59:59,999 BG: Well, it's great if you have a job 662 99:59:59,999 --> 99:59:59,999 that you can stay at your house 663 99:59:59,999 --> 99:59:59,999 and do it through digital meetings, 664 99:59:59,999 --> 99:59:59,999 and even some of your social activities, 665 99:59:59,999 --> 99:59:59,999 you know, I do video calls with lots of friends. 666 99:59:59,999 --> 99:59:59,999 I have friends in Europe that who knows when I'll see them 667 99:59:59,999 --> 99:59:59,999 but we schedule regular calls to talk. 668 99:59:59,999 --> 99:59:59,999 If you stay fairly isolated, 669 99:59:59,999 --> 99:59:59,999 you don't run much risk, 670 99:59:59,999 --> 99:59:59,999 and it's when you're getting together with lots of other people, 671 99:59:59,999 --> 99:59:59,999 either through work or socialization, 672 99:59:59,999 --> 99:59:59,999 that drives that risk, 673 99:59:59,999 --> 99:59:59,999 and particularly in these communities where you have increased cases, 674 99:59:59,999 --> 99:59:59,999 even though it's not going to be mandated, 675 99:59:59,999 --> 99:59:59,999 hopefully the mobility numbers will show people responding 676 99:59:59,999 --> 99:59:59,999 and minimizing those kind of out of the house contacts. 677 99:59:59,999 --> 99:59:59,999 CA: Bill, I wonder if I could just ask you 678 99:59:59,999 --> 99:59:59,999 just a little bit about philanthropy. 679 99:59:59,999 --> 99:59:59,999 Obviously your foundation has played a huge role in this, 680 99:59:59,999 --> 99:59:59,999 but philanthropy more generally. 681 99:59:59,999 --> 99:59:59,999 You know, you've started this giving pledge movement, 682 99:59:59,999 --> 99:59:59,999 recruited all these billionaires 683 99:59:59,999 --> 99:59:59,999 who have pledged to give away half their net worth 684 99:59:59,999 --> 99:59:59,999 before or after their death. 685 99:59:59,999 --> 99:59:59,999 But it's really hard to do. 686 99:59:59,999 --> 99:59:59,999 It's really hard to give away that much money. 687 99:59:59,999 --> 99:59:59,999 You yourself, I think, 688 99:59:59,999 --> 99:59:59,999 since the giving pledge was started, 689 99:59:59,999 --> 99:59:59,999 what, 10 years ago or something, I'm not sure when, 690 99:59:59,999 --> 99:59:59,999 but your own net worth I think has doubled since that period 691 99:59:59,999 --> 99:59:59,999 despite being the world's leading philanthropist. 692 99:59:59,999 --> 99:59:59,999 Is it just fundamentally hard 693 99:59:59,999 --> 99:59:59,999 to give away money effectively to make the world better? 694 99:59:59,999 --> 99:59:59,999 Or should the world's donors, 695 99:59:59,999 --> 99:59:59,999 and especially the world's really rich donors, 696 99:59:59,999 --> 99:59:59,999 start to almost commit to a schedule, 697 99:59:59,999 --> 99:59:59,999 like, here's a percentage of my net worth each year 698 99:59:59,999 --> 99:59:59,999 that as I get older, 699 99:59:59,999 --> 99:59:59,999 maybe that goes up. 700 99:59:59,999 --> 99:59:59,999 If I'm to take this seriously, 701 99:59:59,999 --> 99:59:59,999 I have to give away, somehow, I've got to find a way 702 99:59:59,999 --> 99:59:59,999 of doing that effectively. 703 99:59:59,999 --> 99:59:59,999 Is that an unfair and crazy question? 704 99:59:59,999 --> 99:59:59,999 BG: Well, it'd be great to up the rate, 705 99:59:59,999 --> 99:59:59,999 and our goal, both as the Gates Foundation or through the giving pledge, 706 99:59:59,999 --> 99:59:59,999 is to help people find causes they connect to. 707 99:59:59,999 --> 99:59:59,999 People give through passion. 708 99:59:59,999 --> 99:59:59,999 Yes, numbers are important, 709 99:59:59,999 --> 99:59:59,999 but there's so many causes out there. 710 99:59:59,999 --> 99:59:59,999 The way you're going to pick is you see somebody who is sick, 711 99:59:59,999 --> 99:59:59,999 you see somebody who is not getting social services. 712 99:59:59,999 --> 99:59:59,999 You see something that helps reduce racism. 713 99:59:59,999 --> 99:59:59,999 And you're very passionate, and so you give to that. 714 99:59:59,999 --> 99:59:59,999 And, of course, 715 99:59:59,999 --> 99:59:59,999 some philanthropic gifts won't work out. 716 99:59:59,999 --> 99:59:59,999 We do need to up the ambition level 717 99:59:59,999 --> 99:59:59,999 of philanthropists. 718 99:59:59,999 --> 99:59:59,999 Now, collaborative philanthropy 719 99:59:59,999 --> 99:59:59,999 that you're helping to facilitate through Audacious, 720 99:59:59,999 --> 99:59:59,999 there's four or five other groups that are getting philanthropists together, 721 99:59:59,999 --> 99:59:59,999 that is fantastic, 722 99:59:59,999 --> 99:59:59,999 because then they learn from each other, 723 99:59:59,999 --> 99:59:59,999 they get confidence from each other, 724 99:59:59,999 --> 99:59:59,999 they feel like, hey, I put in x 725 99:59:59,999 --> 99:59:59,999 and the four other people put money in, 726 99:59:59,999 --> 99:59:59,999 so I'm getting more impact, 727 99:59:59,999 --> 99:59:59,999 and hopefully it can be made for them 728 99:59:59,999 --> 99:59:59,999 even when they find out, 729 99:59:59,999 --> 99:59:59,999 OK, that particular gift didn't work out that well, 730 99:59:59,999 --> 99:59:59,999 but let's keep going. 731 99:59:59,999 --> 99:59:59,999 So philanthropy, yes, 732 99:59:59,999 --> 99:59:59,999 I would like to see the rate go up, 733 99:59:59,999 --> 99:59:59,999 and people who do get going, 734 99:59:59,999 --> 99:59:59,999 it is fun, 735 99:59:59,999 --> 99:59:59,999 it's fulfilling, 736 99:59:59,999 --> 99:59:59,999 you pick which of the family members are partnered in doing it. 737 99:59:59,999 --> 99:59:59,999 In my case, Melinda and I love doing this stuff together, 738 99:59:59,999 --> 99:59:59,999 learning together. 739 99:59:59,999 --> 99:59:59,999 Some families, it will even involve the kids in the activities. 740 99:59:59,999 --> 99:59:59,999 Sometimes the kids are pushing. 741 99:59:59,999 --> 99:59:59,999 When you have lots of money, 742 99:59:59,999 --> 99:59:59,999 you still think of million dollars as a lot of money, 743 99:59:59,999 --> 99:59:59,999 but if you have billions, 744 99:59:59,999 --> 99:59:59,999 you should be giving hundreds of millions. 745 99:59:59,999 --> 99:59:59,999 So it's kind of charming that, in terms of your personal expenditure, 746 99:59:59,999 --> 99:59:59,999 you stay at the level you were at before. 747 99:59:59,999 --> 99:59:59,999 That's societally quite appropriate. 748 99:59:59,999 --> 99:59:59,999 But on your giving, you need to scale up 749 99:59:59,999 --> 99:59:59,999 or else it will be your will, 750 99:59:59,999 --> 99:59:59,999 and you won't get to shape it and enjoy it quite that same way. 751 99:59:59,999 --> 99:59:59,999 And so without, 752 99:59:59,999 --> 99:59:59,999 we don't want to mandate it, 753 99:59:59,999 --> 99:59:59,999 but yes, both you and I want to inspire philanthropists 754 99:59:59,999 --> 99:59:59,999 to see that passion, 755 99:59:59,999 --> 99:59:59,999 to see those opportunities, 756 99:59:59,999 --> 99:59:59,999 significantly faster than in the past, 757 99:59:59,999 --> 99:59:59,999 because whether it's race or disease 758 99:59:59,999 --> 99:59:59,999 or all the other social ills, 759 99:59:59,999 --> 99:59:59,999 the innovation of what philanthropy can go to and do quickly 760 99:59:59,999 --> 99:59:59,999 that, if it works, government can come in behind it and scale it up, 761 99:59:59,999 --> 99:59:59,999 God knows we need solutions, 762 99:59:59,999 --> 99:59:59,999 we need that kind of hope and progress 763 99:59:59,999 --> 99:59:59,999 that expectations are high 764 99:59:59,999 --> 99:59:59,999 that will solve very tough problems. 765 99:59:59,999 --> 99:59:59,999 CA: I mean, most philanthropists, 766 99:59:59,999 --> 99:59:59,999 even the best of them, 767 99:59:59,999 --> 99:59:59,999 find it hard to give away more than about a percent of their net worth every year, 768 99:59:59,999 --> 99:59:59,999 and yet the world's richest often have access 769 99:59:59,999 --> 99:59:59,999 to great investment opportunities. 770 99:59:59,999 --> 99:59:59,999 Many of them are gaining wealth at seven to 10 percent plus per year. 771 99:59:59,999 --> 99:59:59,999 Isn't it the case that to have a real chance 772 99:59:59,999 --> 99:59:59,999 of giving away half your fortune, 773 99:59:59,999 --> 99:59:59,999 at some point you have to plan to give away five, six, seven, eight, 774 99:59:59,999 --> 99:59:59,999 10 percent of your net worth annually? 775 99:59:59,999 --> 99:59:59,999 And that is, isn't that the logic of what should be happening? 776 99:59:59,999 --> 99:59:59,999 BG: Yeah, there are people like Chuck Feeney, 777 99:59:59,999 --> 99:59:59,999 who set a good example 778 99:59:59,999 --> 99:59:59,999 and gave away all of his money. 779 99:59:59,999 --> 99:59:59,999 Even Melinda and I are talking about, 780 99:59:59,999 --> 99:59:59,999 should we up the rate that we give at? 781 99:59:59,999 --> 99:59:59,999 As you say, we've been very lucky on the investment side 782 99:59:59,999 --> 99:59:59,999 through a variety of things. 783 99:59:59,999 --> 99:59:59,999 Tech fortunes in general have done well, 784 99:59:59,999 --> 99:59:59,999 even this year, 785 99:59:59,999 --> 99:59:59,999 which is one of those great contrasts 786 99:59:59,999 --> 99:59:59,999 in what's going on in the world. 787 99:59:59,999 --> 99:59:59,999 And I do think there's an expectation 788 99:59:59,999 --> 99:59:59,999 that we should speed up, 789 99:59:59,999 --> 99:59:59,999 and there's a reason to speed up, 790 99:59:59,999 --> 99:59:59,999 and government is going to miss a lot of needs. 791 99:59:59,999 --> 99:59:59,999 Yes, there's tons of government money out there, 792 99:59:59,999 --> 99:59:59,999 but helping it be spent well, 793 99:59:59,999 --> 99:59:59,999 helping find places it's not stepping up, 794 99:59:59,999 --> 99:59:59,999 and if people are willing to give to the developing world, 795 99:59:59,999 --> 99:59:59,999 they don't have governments 796 99:59:59,999 --> 99:59:59,999 that can print checks for 15 percent of GDP, 797 99:59:59,999 --> 99:59:59,999 and so the suffering there broadly, just the economic stuff alone, 798 99:59:59,999 --> 99:59:59,999 put aside the pandemic, 799 99:59:59,999 --> 99:59:59,999 is tragic. 800 99:59:59,999 --> 99:59:59,999 It's about a five year setback 801 99:59:59,999 --> 99:59:59,999 in terms of these countries moving forward, 802 99:59:59,999 --> 99:59:59,999 and in a few cases it's tough enough that the very stability of the country 803 99:59:59,999 --> 99:59:59,999 is in question. 804 99:59:59,999 --> 99:59:59,999 CA: Well, Bill, 805 99:59:59,999 --> 99:59:59,999 I'm in awe of what you and Melinda have done. 806 99:59:59,999 --> 99:59:59,999 You walk this narrow path 807 99:59:59,999 --> 99:59:59,999 of trying to juggle so many different things, 808 99:59:59,999 --> 99:59:59,999 and the amount of time that you dedicate to the betterment of the world at large, 809 99:59:59,999 --> 99:59:59,999 and definitely the amount of money 810 99:59:59,999 --> 99:59:59,999 and the amount of passion you put into it, 811 99:59:59,999 --> 99:59:59,999 I mean, it's pretty awesome, 812 99:59:59,999 --> 99:59:59,999 and I'm really grateful to you for spending this time with us now. 813 99:59:59,999 --> 99:59:59,999 Thank you so much, 814 99:59:59,999 --> 99:59:59,999 and honestly the rest of this year 815 99:59:59,999 --> 99:59:59,999 your skills and resources are going to be needed more than ever, 816 99:59:59,999 --> 99:59:59,999 so good luck. 817 99:59:59,999 --> 99:59:59,999 BG: Well, thanks. 818 99:59:59,999 --> 99:59:59,999 It's fun work and I'm optimistic, 819 99:59:59,999 --> 99:59:59,999 so thanks, Chris.