1 00:00:00,181 --> 00:00:01,768 [Внутри тимуса] 2 00:00:02,000 --> 00:00:06,333 Наша иммунная система борется с инфекциями и раковыми клетками 3 00:00:06,354 --> 00:00:08,279 с помощью одного из видов лейкоцитов — 4 00:00:08,310 --> 00:00:09,715 Т-клеток, или T-лимфоцитов. 5 00:00:09,932 --> 00:00:13,534 Т-клетки вырабатываются органом, который называется «тимус». 6 00:00:16,572 --> 00:00:21,114 == Далее пока что не переведено == Immature blood cells, made from blood stem cells in the bone marrow, 7 00:00:21,146 --> 00:00:23,819 travel through the blood stream to the thymus. 8 00:00:26,100 --> 00:00:30,248 Inside the thymus over the course of approximately two weeks 9 00:00:30,281 --> 00:00:33,474 a network of different cells impart chemical signals 10 00:00:33,531 --> 00:00:37,310 that affect the fate of the immature T-cells. 11 00:00:37,592 --> 00:00:40,789 They are guided through a process of development, 12 00:00:41,246 --> 00:00:42,778 selection, 13 00:00:43,284 --> 00:00:47,268 and also elimination, to become mature T-cells. 14 00:00:49,100 --> 00:00:53,542 Firstly, the immature T-cells are instructed to develop receptors. 15 00:00:55,147 --> 00:00:57,942 At the next stage, those cells with receptors 16 00:00:58,000 --> 00:01:02,860 that can respond to the type of proteins the ones useful to our immune system 17 00:01:02,914 --> 00:01:06,855 are signaled to survive, the rest are eliminated. 18 00:01:09,189 --> 00:01:12,506 After this stage, some of the developing T-cells 19 00:01:12,526 --> 00:01:16,560 may recognize proteins from the healthy cells of our own body 20 00:01:16,595 --> 00:01:19,887 which can be dangerous and cause auto-immunity, 21 00:01:19,908 --> 00:01:23,341 where they may target those cells and tissues. 22 00:01:24,000 --> 00:01:27,540 In the final stage, these cells are eliminated. 23 00:01:29,478 --> 00:01:32,041 The remaining now-matured T-cells, 24 00:01:32,068 --> 00:01:34,749 which have passed through the selection process, 25 00:01:34,780 --> 00:01:38,536 enter the blood stream and become part of our immune system. 26 00:01:38,787 --> 00:01:42,389 In fact, as little as 1% reach this stage 27 00:01:42,415 --> 00:01:46,860 and are now ready to protect against harmful infection and disease, 28 00:01:46,880 --> 00:01:49,512 but not the healthy cells of our own body. 29 00:01:50,514 --> 00:01:54,295 From a young age, our thymus degenerates -- getting smaller. 30 00:01:54,546 --> 00:01:57,936 Throughout our lives, fewer and fewer T-cells are made, 31 00:01:57,982 --> 00:02:01,981 reducing our protection against new infections and cancer, 32 00:02:02,010 --> 00:02:04,133 especially in old age. 33 00:02:04,635 --> 00:02:06,765 Finding ways to regenerate the thymus 34 00:02:06,795 --> 00:02:10,036 could help to boost the immune system when this happens 35 00:02:10,068 --> 00:02:13,233 and could also lead to treatments for a number of conditions 36 00:02:13,265 --> 00:02:17,009 affecting both the thymus and the immune system.