[Script Info]
Title: 
[Events]
Format: Layer, Start, End, Style, Name, MarginL, MarginR, MarginV, Effect, Text
Dialogue: 0,0:00:00.00,0:00:07.56,Default,,0000,0000,0000,,"Turmeric Curcumin Reprogramming \NCancer Cell Death"
Dialogue: 0,0:00:07.56,0:00:10.70,Default,,0000,0000,0000,,The anticancer effects of the \Nturmeric pigment curcumin
Dialogue: 0,0:00:10.70,0:00:13.92,Default,,0000,0000,0000,,extend well beyond it's ability \Nto block carcinogens.
Dialogue: 0,0:00:13.92,0:00:17.56,Default,,0000,0000,0000,,The anticancer effects of \Ncurcumin mainly result from
Dialogue: 0,0:00:17.56,0:00:22.60,Default,,0000,0000,0000,,the multitude of ways it regulates \Nprogrammed cell death.
Dialogue: 0,0:00:22.60,0:00:26.59,Default,,0000,0000,0000,,It's estimated that human body consists \Nof 10 or so trillion cells,
Dialogue: 0,0:00:26.59,0:00:29.21,Default,,0000,0000,0000,,that's a million million.
Dialogue: 0,0:00:29.21,0:00:34.20,Default,,0000,0000,0000,,Almost all of these cells get turned \Nover within approximately 100 days.
Dialogue: 0,0:00:34.20,0:00:38.08,Default,,0000,0000,0000,,We're like a new person, \Nevery three months!
Dialogue: 0,0:00:38.08,0:00:40.53,Default,,0000,0000,0000,,We reinvent ourselves \Nphysically.
Dialogue: 0,0:00:40.53,0:00:43.82,Default,,0000,0000,0000,,And since we're just \Nmade up of 3 things
Dialogue: 0,0:00:43.82,0:00:47.97,Default,,0000,0000,0000,,air, water, and food - \Nthose are the only inputs -
Dialogue: 0,0:00:47.97,0:00:52.54,Default,,0000,0000,0000,,we are what we eat \Nliterally, physically!
Dialogue: 0,0:00:52.54,0:00:55.57,Default,,0000,0000,0000,,In a sense, our body has to rebuild \Nitself every three months
Dialogue: 0,0:00:55.57,0:01:00.22,Default,,0000,0000,0000,,with the building materials we \Ndeliver to it through our stomach.
Dialogue: 0,0:01:00.22,0:01:02.17,Default,,0000,0000,0000,,Our mouths are like \Nthe access road
Dialogue: 0,0:01:02.17,0:01:05.27,Default,,0000,0000,0000,,to the continual construction \Nsite to our body.
Dialogue: 0,0:01:05.27,0:01:07.40,Default,,0000,0000,0000,,Trucks roll in \N3 times a day.
Dialogue: 0,0:01:07.40,0:01:08.83,Default,,0000,0000,0000,,What do we want \Nthem to deliver?
Dialogue: 0,0:01:08.83,0:01:11.71,Default,,0000,0000,0000,,Some shoddy cheap stuff \Nwe scrounged around for
Dialogue: 0,0:01:11.71,0:01:14.56,Default,,0000,0000,0000,,or bought at the discount outlets \Nthat's just going to fall apart?
Dialogue: 0,0:01:14.56,0:01:17.51,Default,,0000,0000,0000,,Or do we want to build \Nour foundation solid?
Dialogue: 0,0:01:17.51,0:01:19.50,Default,,0000,0000,0000,,We are each walking \Naround inside
Dialogue: 0,0:01:19.50,0:01:23.08,Default,,0000,0000,0000,,the greatest known architectural \Nstructures in the universe!
Dialogue: 0,0:01:23.08,0:01:29.27,Default,,0000,0000,0000,,Let's not ruin such grand \Nblueprints by consuming junk.
Dialogue: 0,0:01:29.27,0:01:33.35,Default,,0000,0000,0000,,Anyway, we only own the biological \Nreal estate we're born with,
Dialogue: 0,0:01:33.35,0:01:37.18,Default,,0000,0000,0000,,so if need to rebuild every three months, \Nwe also need a wrecking crew.
Dialogue: 0,0:01:37.18,0:01:40.18,Default,,0000,0000,0000,,If we're replacing 10 trillion \Nevery hundred days,
Dialogue: 0,0:01:40.19,0:01:44.28,Default,,0000,0000,0000,,that means we have to kill off like \N100 billion cells every day, normally.
Dialogue: 0,0:01:44.29,0:01:46.43,Default,,0000,0000,0000,,Out with the old, \Nin with the new.
Dialogue: 0,0:01:46.43,0:01:50.57,Default,,0000,0000,0000,,We do that primarily through \Na process called apoptosis,
Dialogue: 0,0:01:50.57,0:01:52.49,Default,,0000,0000,0000,,pre-programmed \Ncell death,
Dialogue: 0,0:01:52.50,0:01:54.43,Default,,0000,0000,0000,,from the Greek "ptosis" \Nmeaning falling,
Dialogue: 0,0:01:54.43,0:01:55.79,Default,,0000,0000,0000,,and "apo" \Nmeaning away from.
Dialogue: 0,0:01:55.79,0:01:58.47,Default,,0000,0000,0000,,So it's our cells falling \Naway from our body.
Dialogue: 0,0:01:58.47,0:02:03.29,Default,,0000,0000,0000,,For example, we all used to have \Nwebbed fingers and toes, literally.
Dialogue: 0,0:02:03.30,0:02:06.43,Default,,0000,0000,0000,,Each one of us in the \Nwomb until about 4 months,
Dialogue: 0,0:02:06.44,0:02:07.95,Default,,0000,0000,0000,,and then the \Napoptosis kicks in
Dialogue: 0,0:02:07.96,0:02:14.62,Default,,0000,0000,0000,,and the cells in the webbing in between kill \Nthemselves off to separate our fingers.
Dialogue: 0,0:02:14.62,0:02:17.97,Default,,0000,0000,0000,,Some cells in our body overstay \Ntheir welcome, though,
Dialogue: 0,0:02:17.98,0:02:20.26,Default,,0000,0000,0000,,like cancer cells.
Dialogue: 0,0:02:20.26,0:02:22.35,Default,,0000,0000,0000,,They don't die when \Nthey're supposed to
Dialogue: 0,0:02:22.36,0:02:25.58,Default,,0000,0000,0000,,by somehow turning off \Ntheir suicide genes.
Dialogue: 0,0:02:25.58,0:02:26.77,Default,,0000,0000,0000,,What can we \Ndo about it?
Dialogue: 0,0:02:26.77,0:02:29.46,Default,,0000,0000,0000,,Well, one of the ways \Ncurry kills cancer cells,
Dialogue: 0,0:02:29.46,0:02:33.79,Default,,0000,0000,0000,,is by reprogramming the self-destruct \Nmechanism back into cancer cells.
Dialogue: 0,0:02:33.80,0:02:37.78,Default,,0000,0000,0000,,Let me just run through \None of these pathways,
Dialogue: 0,0:02:37.78,0:02:41.88,Default,,0000,0000,0000,,just to see the complexity.\NFAS, is a so-called death receptor,
Dialogue: 0,0:02:41.88,0:02:45.34,Default,,0000,0000,0000,,which activates the FAS \Nassociated death domain,
Dialogue: 0,0:02:45.35,0:02:48.28,Default,,0000,0000,0000,,along with death receptor 5, \Nand death receptor 4.
Dialogue: 0,0:02:48.28,0:02:51.23,Default,,0000,0000,0000,,FADD then activates caspase-8,
Dialogue: 0,0:02:51.23,0:02:55.30,Default,,0000,0000,0000,,which ignites the death\Nmachine, and kills the cell.
Dialogue: 0,0:02:55.30,0:02:57.67,Default,,0000,0000,0000,,Where does curry powder \Nfit into all this?
Dialogue: 0,0:02:57.67,0:03:00.33,Default,,0000,0000,0000,,In cancer cells, curcumin, \Nthe pigment in the spice turmeric
Dialogue: 0,0:03:00.33,0:03:01.82,Default,,0000,0000,0000,,that makes curry \Npowder yellow,
Dialogue: 0,0:03:01.83,0:03:04.32,Default,,0000,0000,0000,,upregulates and activates \Ndeath receptors,
Dialogue: 0,0:03:04.32,0:03:07.14,Default,,0000,0000,0000,,as has been demonstrated in \Nhuman kidney cancer cells
Dialogue: 0,0:03:07.15,0:03:10.45,Default,,0000,0000,0000,,as well as skin cancer, \Nand nose and throat cancer.
Dialogue: 0,0:03:10.45,0:03:14.19,Default,,0000,0000,0000,,It can also activate the \Ndeath machine directly,
Dialogue: 0,0:03:14.19,0:03:16.90,Default,,0000,0000,0000,,as has been shown in lung \Ncancer and colon cancer.
Dialogue: 0,0:03:16.96,0:03:20.22,Default,,0000,0000,0000,,Caspases are so-called\Nexecutioner enzymes,
Dialogue: 0,0:03:20.23,0:03:23.16,Default,,0000,0000,0000,,that when activated, destroy \Nthe cancer cell from within
Dialogue: 0,0:03:23.16,0:03:24.94,Default,,0000,0000,0000,,by chopping up proteins \Nleft and right,
Dialogue: 0,0:03:24.94,0:03:27.95,Default,,0000,0000,0000,,kind of a death by \Na thousand cuts.
Dialogue: 0,0:03:27.95,0:03:29.78,Default,,0000,0000,0000,,And that's just \None pathway.
Dialogue: 0,0:03:29.79,0:03:33.19,Default,,0000,0000,0000,,Here's all the other ways \Ncurcumin can affect apoptosis.
Dialogue: 0,0:03:33.19,0:03:36.95,Default,,0000,0000,0000,,Here's all the different types of \Ncancer cells curcumin can kill,
Dialogue: 0,0:03:36.95,0:03:40.87,Default,,0000,0000,0000,,but it tends to leave \Nnormal cells alone
Dialogue: 0,0:03:40.87,0:03:42.63,Default,,0000,0000,0000,,for reasons that are \Nnot fully understood.
Dialogue: 0,0:03:42.63,0:03:45.78,Default,,0000,0000,0000,,Overall, this review showed \Nthat curcumin can kill
Dialogue: 0,0:03:45.78,0:03:49.11,Default,,0000,0000,0000,,a wide variety of tumor cell types \Nthrough diverse mechanisms.
Dialogue: 0,0:03:49.11,0:03:52.43,Default,,0000,0000,0000,,And it's because curcumin can \Naffect numerous mechanisms
Dialogue: 0,0:03:52.43,0:03:54.59,Default,,0000,0000,0000,,of cell death at \Nthe same time,
Dialogue: 0,0:03:54.59,0:03:58.31,Default,,0000,0000,0000,,it's possible that cancer cells may \Nnot easily develop resistance
Dialogue: 0,0:03:58.31,0:04:00.19,Default,,0000,0000,0000,,to curcumin-induced \Ncell death,
Dialogue: 0,0:04:00.19,0:04:02.55,Default,,0000,0000,0000,,like they do to \Nmost chemotherapy.
Dialogue: 0,0:04:02.55,0:04:05.39,Default,,0000,0000,0000,,Furthermore, its ability to kill \Ntumor cells and not normal cells
Dialogue: 0,0:04:05.39,0:04:10.10,Default,,0000,0000,0000,,makes curcumin an attractive candidate… \Nfor supper?
Dialogue: 0,0:04:10.10,0:04:12.63,Default,,0000,0000,0000,,Can't make money on some \Nspice you can buy anywhere.
Dialogue: 0,0:04:12.63,0:04:19.80,Default,,0000,0000,0000,,An attractive candidate \Nfor drug development.