[Script Info]
Title: 
[Events]
Format: Layer, Start, End, Style, Name, MarginL, MarginR, MarginV, Effect, Text
Dialogue: 0,0:00:01.41,0:00:05.63,Default,,0000,0000,0000,,It was a Sunday afternoon\Nback in April of this year,
Dialogue: 0,0:00:05.65,0:00:06.98,Default,,0000,0000,0000,,my phone was ringing.
Dialogue: 0,0:00:07.52,0:00:09.48,Default,,0000,0000,0000,,I picked it up,
Dialogue: 0,0:00:09.50,0:00:11.14,Default,,0000,0000,0000,,the voice said,
Dialogue: 0,0:00:11.16,0:00:12.39,Default,,0000,0000,0000,,"It's Rebecca.
Dialogue: 0,0:00:12.85,0:00:16.70,Default,,0000,0000,0000,,I'm just calling to invite you\Nto my funeral."
Dialogue: 0,0:00:18.34,0:00:21.57,Default,,0000,0000,0000,,I said, "Rebecca,\Nwhat are you talking about?"
Dialogue: 0,0:00:21.59,0:00:23.51,Default,,0000,0000,0000,,She said, "Joy,
Dialogue: 0,0:00:23.54,0:00:26.72,Default,,0000,0000,0000,,as my friend, you have to let me go.
Dialogue: 0,0:00:27.24,0:00:28.38,Default,,0000,0000,0000,,It's my time."
Dialogue: 0,0:00:29.85,0:00:32.18,Default,,0000,0000,0000,,The next day, she was dead.
Dialogue: 0,0:00:34.02,0:00:37.18,Default,,0000,0000,0000,,Rebecca was 31 years old when she died.
Dialogue: 0,0:00:37.66,0:00:41.51,Default,,0000,0000,0000,,She had an eight-year struggle\Nwith breast cancer,
Dialogue: 0,0:00:41.53,0:00:43.20,Default,,0000,0000,0000,,it came back three times.
Dialogue: 0,0:00:43.88,0:00:45.54,Default,,0000,0000,0000,,I failed her.
Dialogue: 0,0:00:46.64,0:00:49.04,Default,,0000,0000,0000,,The scientific community failed her.
Dialogue: 0,0:00:49.58,0:00:52.05,Default,,0000,0000,0000,,And the medical community failed her.
Dialogue: 0,0:00:53.25,0:00:55.05,Default,,0000,0000,0000,,And she's not the only one.
Dialogue: 0,0:00:55.67,0:00:57.57,Default,,0000,0000,0000,,Every five seconds,
Dialogue: 0,0:00:57.59,0:01:00.03,Default,,0000,0000,0000,,someone dies of cancer.
Dialogue: 0,0:01:01.37,0:01:05.66,Default,,0000,0000,0000,,Today, we, medical\Nresearchers are committed
Dialogue: 0,0:01:05.68,0:01:08.94,Default,,0000,0000,0000,,to having Rebecca and people like her
Dialogue: 0,0:01:08.97,0:01:11.77,Default,,0000,0000,0000,,be one of the last patients that we fail.
Dialogue: 0,0:01:12.57,0:01:17.05,Default,,0000,0000,0000,,The US government alone\Nhas spent over 100 billion
Dialogue: 0,0:01:17.07,0:01:18.61,Default,,0000,0000,0000,,on cancer research
Dialogue: 0,0:01:18.64,0:01:20.26,Default,,0000,0000,0000,,since the 1970s,
Dialogue: 0,0:01:20.28,0:01:23.88,Default,,0000,0000,0000,,with limited progress\Nin regards to patient survival.
Dialogue: 0,0:01:24.24,0:01:28.04,Default,,0000,0000,0000,,Especially for certain types\Nof very aggressive cancers.
Dialogue: 0,0:01:28.95,0:01:31.16,Default,,0000,0000,0000,,So we need a change, because clearly,
Dialogue: 0,0:01:31.18,0:01:35.19,Default,,0000,0000,0000,,what we've been doing so far\Nhas not been working.
Dialogue: 0,0:01:36.68,0:01:39.97,Default,,0000,0000,0000,,And what we do in medicine\Nis to send out firefighters,
Dialogue: 0,0:01:39.99,0:01:42.26,Default,,0000,0000,0000,,because cancer is like a big fire.
Dialogue: 0,0:01:42.78,0:01:45.58,Default,,0000,0000,0000,,And these firefighters\Nare the cancer drugs.
Dialogue: 0,0:01:46.23,0:01:49.82,Default,,0000,0000,0000,,But we're sending them out\Nwithout a fire truck.
Dialogue: 0,0:01:50.32,0:01:53.48,Default,,0000,0000,0000,,So without transportation,\Nwithout ladders,
Dialogue: 0,0:01:53.51,0:01:55.64,Default,,0000,0000,0000,,and without emergency equipment.
Dialogue: 0,0:01:56.66,0:02:00.87,Default,,0000,0000,0000,,And over 99 percent of these firefighters
Dialogue: 0,0:02:00.90,0:02:02.63,Default,,0000,0000,0000,,never make it to the fire.
Dialogue: 0,0:02:03.55,0:02:06.27,Default,,0000,0000,0000,,Over 99 percent of cancer drugs
Dialogue: 0,0:02:06.29,0:02:08.58,Default,,0000,0000,0000,,never make it to the tumor,
Dialogue: 0,0:02:08.61,0:02:12.84,Default,,0000,0000,0000,,because they lack transportation and tools
Dialogue: 0,0:02:12.86,0:02:16.46,Default,,0000,0000,0000,,to take them to the location\Nthey're aiming for.
Dialogue: 0,0:02:17.100,0:02:22.20,Default,,0000,0000,0000,,Turns out, it really is all about\Nlocation, location, location.
Dialogue: 0,0:02:23.06,0:02:27.30,Default,,0000,0000,0000,,So we need a fire truck\Nto get to the right location.
Dialogue: 0,0:02:28.40,0:02:29.97,Default,,0000,0000,0000,,And I'm here to tell you
Dialogue: 0,0:02:29.100,0:02:32.85,Default,,0000,0000,0000,,that nanoparticles are the fire trucks.
Dialogue: 0,0:02:33.32,0:02:37.40,Default,,0000,0000,0000,,We can load cancer drugs\Ninside nanoparticles
Dialogue: 0,0:02:37.43,0:02:41.08,Default,,0000,0000,0000,,and nanoparticles\Ncan function as the carrier
Dialogue: 0,0:02:41.10,0:02:42.98,Default,,0000,0000,0000,,and necessary equipment
Dialogue: 0,0:02:43.01,0:02:46.58,Default,,0000,0000,0000,,to bring the cancer drugs\Nto the heart of the tumor.
Dialogue: 0,0:02:48.32,0:02:49.82,Default,,0000,0000,0000,,So what are nanoparticles
Dialogue: 0,0:02:49.84,0:02:52.61,Default,,0000,0000,0000,,and what does it really mean\Nto be nano-sized?
Dialogue: 0,0:02:53.66,0:02:57.04,Default,,0000,0000,0000,,Well, there are many different\Ntypes of nanoparticles
Dialogue: 0,0:02:57.06,0:02:58.74,Default,,0000,0000,0000,,made out of various materials,
Dialogue: 0,0:02:58.76,0:03:02.13,Default,,0000,0000,0000,,such as metal-based nanoparticles
Dialogue: 0,0:03:02.16,0:03:04.53,Default,,0000,0000,0000,,or fat-based nanoparticles.
Dialogue: 0,0:03:05.31,0:03:08.88,Default,,0000,0000,0000,,But to really illustrate\Nwhat it means to be nano-sized,
Dialogue: 0,0:03:08.90,0:03:11.66,Default,,0000,0000,0000,,I took one of my hair strands
Dialogue: 0,0:03:11.68,0:03:13.65,Default,,0000,0000,0000,,and placed it under the microscope.
Dialogue: 0,0:03:14.09,0:03:15.56,Default,,0000,0000,0000,,Now, I have very thin hair,
Dialogue: 0,0:03:15.59,0:03:20.63,Default,,0000,0000,0000,,so my hair is approximately\N40,000 nanometers in diameter.
Dialogue: 0,0:03:21.28,0:03:24.27,Default,,0000,0000,0000,,So this means, if we take\N400 of nanoparticles
Dialogue: 0,0:03:24.29,0:03:27.26,Default,,0000,0000,0000,,and we stack them on top of each other,
Dialogue: 0,0:03:27.28,0:03:30.86,Default,,0000,0000,0000,,we get the thickness\Nof a single hair strand.
Dialogue: 0,0:03:31.58,0:03:34.24,Default,,0000,0000,0000,,So I lead a nanoparticle laboratory
Dialogue: 0,0:03:34.27,0:03:37.17,Default,,0000,0000,0000,,to fight cancer and other diseases
Dialogue: 0,0:03:37.20,0:03:39.60,Default,,0000,0000,0000,,at Mayo Clinic here in Jacksonville.
Dialogue: 0,0:03:40.23,0:03:41.39,Default,,0000,0000,0000,,And at Mayo Clinic,
Dialogue: 0,0:03:41.42,0:03:45.12,Default,,0000,0000,0000,,we really have the tools\Nto make a difference for patients,
Dialogue: 0,0:03:45.14,0:03:49.98,Default,,0000,0000,0000,,thanks to the generous donations\Nand grants to fund our research.
Dialogue: 0,0:03:51.57,0:03:55.98,Default,,0000,0000,0000,,And so, how do these nanoparticles\Nmanage to transport cancer drugs
Dialogue: 0,0:03:56.00,0:03:57.16,Default,,0000,0000,0000,,to the tumor?
Dialogue: 0,0:03:57.81,0:04:00.75,Default,,0000,0000,0000,,Well, they have an extensive toolbox.
Dialogue: 0,0:04:01.98,0:04:04.19,Default,,0000,0000,0000,,So cancer drugs without nanoparticles
Dialogue: 0,0:04:04.21,0:04:07.86,Default,,0000,0000,0000,,are quickly washed out of the body\Nthrough the kidneys
Dialogue: 0,0:04:07.88,0:04:09.83,Default,,0000,0000,0000,,because they are so small.
Dialogue: 0,0:04:09.85,0:04:12.15,Default,,0000,0000,0000,,So it's like water going through a sieve.
Dialogue: 0,0:04:12.63,0:04:15.77,Default,,0000,0000,0000,,And so they don't really have time\Nto reach the tumor,
Dialogue: 0,0:04:15.79,0:04:18.02,Default,,0000,0000,0000,,and here we see an illustration of this.
Dialogue: 0,0:04:18.05,0:04:20.25,Default,,0000,0000,0000,,We have the firefighters,\Nthe cancer drugs,
Dialogue: 0,0:04:20.28,0:04:22.39,Default,,0000,0000,0000,,they're circulating in the blood,
Dialogue: 0,0:04:22.41,0:04:24.43,Default,,0000,0000,0000,,but they're quickly washed out of the body
Dialogue: 0,0:04:24.46,0:04:27.59,Default,,0000,0000,0000,,and they don't really end up\Ninside the tumor.
Dialogue: 0,0:04:28.45,0:04:33.08,Default,,0000,0000,0000,,But if we put these cancer drugs\Ninside nanoparticles,
Dialogue: 0,0:04:33.10,0:04:35.19,Default,,0000,0000,0000,,they will not get washed out by the body,
Dialogue: 0,0:04:35.21,0:04:37.53,Default,,0000,0000,0000,,because the nanoparticles are too big.
Dialogue: 0,0:04:37.55,0:04:40.73,Default,,0000,0000,0000,,And they will continue\Nto circulate in the blood,
Dialogue: 0,0:04:40.76,0:04:43.47,Default,,0000,0000,0000,,giving them more time\Nto find the tumor.
Dialogue: 0,0:04:44.25,0:04:46.82,Default,,0000,0000,0000,,And here we see the cancer drugs,\Nthe firefighters,
Dialogue: 0,0:04:46.85,0:04:50.29,Default,,0000,0000,0000,,inside the fire truck, the nanoparticles.
Dialogue: 0,0:04:50.31,0:04:51.99,Default,,0000,0000,0000,,They're circulating in the blood,
Dialogue: 0,0:04:52.01,0:04:53.95,Default,,0000,0000,0000,,they don't get washed out,
Dialogue: 0,0:04:53.97,0:04:57.14,Default,,0000,0000,0000,,and they actually end up\Nreaching the tumor.
Dialogue: 0,0:04:59.48,0:05:01.90,Default,,0000,0000,0000,,And so what other tools\Ndo nanoparticles have?
Dialogue: 0,0:05:02.78,0:05:06.43,Default,,0000,0000,0000,,Well, they can protect cancer drugs\Nfrom getting destroyed
Dialogue: 0,0:05:06.45,0:05:07.60,Default,,0000,0000,0000,,inside the body.
Dialogue: 0,0:05:08.29,0:05:12.05,Default,,0000,0000,0000,,There are certain very important\Nbut sensitive drugs
Dialogue: 0,0:05:12.08,0:05:15.03,Default,,0000,0000,0000,,that are easily degraded\Nby enzymes in the blood.
Dialogue: 0,0:05:15.34,0:05:18.62,Default,,0000,0000,0000,,So unless they have\Nthis nanoparticle protection,
Dialogue: 0,0:05:18.65,0:05:20.93,Default,,0000,0000,0000,,they will not be able to function.
Dialogue: 0,0:05:22.36,0:05:25.36,Default,,0000,0000,0000,,Another nanoparticle tool\Nare the surface extensions
Dialogue: 0,0:05:25.39,0:05:30.51,Default,,0000,0000,0000,,that are like tiny hands\Nwith fingers that grab on to the tumor,
Dialogue: 0,0:05:30.53,0:05:32.12,Default,,0000,0000,0000,,and fit exactly onto it,
Dialogue: 0,0:05:32.14,0:05:34.43,Default,,0000,0000,0000,,so that when the\Nnanoparticles are circulating,
Dialogue: 0,0:05:34.45,0:05:37.01,Default,,0000,0000,0000,,they can attach onto the cancer cells,
Dialogue: 0,0:05:37.03,0:05:40.59,Default,,0000,0000,0000,,buying the cancer drugs\Nmore time to do their job.
Dialogue: 0,0:05:41.89,0:05:44.13,Default,,0000,0000,0000,,And these are just some\Nof the many tools
Dialogue: 0,0:05:44.16,0:05:46.02,Default,,0000,0000,0000,,that nanoparticles can have.
Dialogue: 0,0:05:46.58,0:05:47.76,Default,,0000,0000,0000,,And today,
Dialogue: 0,0:05:47.78,0:05:51.97,Default,,0000,0000,0000,,we have more than 10 clinically\Napproved nanoparticles for cancer
Dialogue: 0,0:05:51.100,0:05:55.16,Default,,0000,0000,0000,,that are given to patients\Nall over the world.
Dialogue: 0,0:05:56.07,0:06:00.36,Default,,0000,0000,0000,,Yet, we have patients\Nlike Rebecca, who die.
Dialogue: 0,0:06:01.36,0:06:05.28,Default,,0000,0000,0000,,So what are the major\Nchallenges and limitations
Dialogue: 0,0:06:05.30,0:06:08.09,Default,,0000,0000,0000,,with currently approved nanoparticles?
Dialogue: 0,0:06:09.50,0:06:12.94,Default,,0000,0000,0000,,Well, a major challenge is the liver,
Dialogue: 0,0:06:12.96,0:06:16.03,Default,,0000,0000,0000,,because the liver is the body's\Nfiltration system,
Dialogue: 0,0:06:16.06,0:06:20.97,Default,,0000,0000,0000,,and the liver recognizes and destroys\Nforeign objects, such as viruses
Dialogue: 0,0:06:20.99,0:06:23.73,Default,,0000,0000,0000,,bacteria and also nanoparticles.
Dialogue: 0,0:06:24.23,0:06:27.58,Default,,0000,0000,0000,,And the immune cells in the liver\Neat the nanoparticles,
Dialogue: 0,0:06:27.60,0:06:30.96,Default,,0000,0000,0000,,preventing them from reaching the tumor.
Dialogue: 0,0:06:33.37,0:06:37.14,Default,,0000,0000,0000,,And here we see an illustration\Nwhere the kidney is no longer a problem,
Dialogue: 0,0:06:37.16,0:06:39.58,Default,,0000,0000,0000,,but these fire trucks, the nanoparticles,
Dialogue: 0,0:06:39.60,0:06:41.27,Default,,0000,0000,0000,,get stuck in the liver,
Dialogue: 0,0:06:41.29,0:06:45.59,Default,,0000,0000,0000,,and actually, less of them\Nend up reaching the tumor.
Dialogue: 0,0:06:47.16,0:06:50.46,Default,,0000,0000,0000,,So a future strategy\Nto improve nanoparticles
Dialogue: 0,0:06:50.49,0:06:54.71,Default,,0000,0000,0000,,is to temporarily disarm\Nthe immune cells in the liver.
Dialogue: 0,0:06:55.40,0:06:57.53,Default,,0000,0000,0000,,So how do we disarm these cells?
Dialogue: 0,0:06:57.88,0:07:01.52,Default,,0000,0000,0000,,Well, we looked at drugs\Nthat were already clinically approved
Dialogue: 0,0:07:01.54,0:07:03.40,Default,,0000,0000,0000,,for other indications
Dialogue: 0,0:07:03.42,0:07:06.20,Default,,0000,0000,0000,,to see if any of them\Ncould stop the immune cells
Dialogue: 0,0:07:06.22,0:07:08.82,Default,,0000,0000,0000,,from eating the nanoparticles.
Dialogue: 0,0:07:09.78,0:07:11.31,Default,,0000,0000,0000,,And unexpectedly,
Dialogue: 0,0:07:11.33,0:07:13.94,Default,,0000,0000,0000,,in one of our preclinical studies,
Dialogue: 0,0:07:13.97,0:07:18.10,Default,,0000,0000,0000,,we found that a 70-year-old malaria drug
Dialogue: 0,0:07:18.13,0:07:20.83,Default,,0000,0000,0000,,was able to stop the immune cells
Dialogue: 0,0:07:20.85,0:07:22.96,Default,,0000,0000,0000,,from internalizing the nanoparticles
Dialogue: 0,0:07:22.98,0:07:25.21,Default,,0000,0000,0000,,so that they could escape the liver
Dialogue: 0,0:07:25.24,0:07:29.20,Default,,0000,0000,0000,,and continue their journey\Nto their goal, the tumor.
Dialogue: 0,0:07:30.54,0:07:33.69,Default,,0000,0000,0000,,And here we see the illustration\Nof blocking the liver.
Dialogue: 0,0:07:33.71,0:07:35.55,Default,,0000,0000,0000,,The nanoparticles don't go there,
Dialogue: 0,0:07:35.57,0:07:38.04,Default,,0000,0000,0000,,and they instead end up in the tumor.
Dialogue: 0,0:07:39.14,0:07:42.03,Default,,0000,0000,0000,,So, sometimes, unexpected connections
Dialogue: 0,0:07:42.05,0:07:43.83,Default,,0000,0000,0000,,are made in science,
Dialogue: 0,0:07:43.86,0:07:46.13,Default,,0000,0000,0000,,that lead to new solutions.
Dialogue: 0,0:07:47.92,0:07:51.63,Default,,0000,0000,0000,,Another strategy\Nfor preventing nanoparticles
Dialogue: 0,0:07:51.65,0:07:54.20,Default,,0000,0000,0000,,from getting stuck in the liver
Dialogue: 0,0:07:54.22,0:07:57.45,Default,,0000,0000,0000,,is to use the body's own nanoparticles.
Dialogue: 0,0:07:57.47,0:07:58.94,Default,,0000,0000,0000,,Yes, surprise, surprise,
Dialogue: 0,0:07:58.97,0:08:02.54,Default,,0000,0000,0000,,you, and you and you, and all of us
Dialogue: 0,0:08:02.57,0:08:05.94,Default,,0000,0000,0000,,have a lot of nanoparticles\Ncirculating in our bodies.
Dialogue: 0,0:08:06.43,0:08:09.07,Default,,0000,0000,0000,,And because they're part of our bodies,
Dialogue: 0,0:08:09.09,0:08:13.02,Default,,0000,0000,0000,,the liver is less likely\Nto label them as foreign.
Dialogue: 0,0:08:14.100,0:08:16.96,Default,,0000,0000,0000,,And these biological nanoparticles
Dialogue: 0,0:08:16.98,0:08:18.71,Default,,0000,0000,0000,,can be found in the saliva,
Dialogue: 0,0:08:18.74,0:08:21.96,Default,,0000,0000,0000,,in the blood, in the urine,\Nin pancreatic juice,
Dialogue: 0,0:08:21.98,0:08:23.98,Default,,0000,0000,0000,,and we can collect them from the body
Dialogue: 0,0:08:23.100,0:08:27.85,Default,,0000,0000,0000,,and use them as fire trucks\Nfor cancer drugs.
Dialogue: 0,0:08:28.86,0:08:30.09,Default,,0000,0000,0000,,And in this case,
Dialogue: 0,0:08:30.12,0:08:33.28,Default,,0000,0000,0000,,the immune cells in the liver\Nare less likely to eat
Dialogue: 0,0:08:33.31,0:08:35.24,Default,,0000,0000,0000,,the biological nanoparticles.
Dialogue: 0,0:08:35.69,0:08:38.62,Default,,0000,0000,0000,,So we're using a Trojan\Nhorse-based concept
Dialogue: 0,0:08:38.64,0:08:40.23,Default,,0000,0000,0000,,to fool the liver.
Dialogue: 0,0:08:40.92,0:08:43.28,Default,,0000,0000,0000,,And here we see\Nthe biological nanoparticles
Dialogue: 0,0:08:43.30,0:08:44.88,Default,,0000,0000,0000,,circulating in the blood,
Dialogue: 0,0:08:44.90,0:08:47.30,Default,,0000,0000,0000,,they don't get recognized by the liver,
Dialogue: 0,0:08:47.32,0:08:49.26,Default,,0000,0000,0000,,and they end up in the tumor.
Dialogue: 0,0:08:50.41,0:08:51.85,Default,,0000,0000,0000,,And in the future,
Dialogue: 0,0:08:51.87,0:08:55.40,Default,,0000,0000,0000,,we want to exploit\Nnature's own nanoparticles
Dialogue: 0,0:08:55.42,0:08:58.36,Default,,0000,0000,0000,,for cancer drug delivery,
Dialogue: 0,0:08:58.39,0:09:01.32,Default,,0000,0000,0000,,to reduce side effects and save lives,
Dialogue: 0,0:09:01.35,0:09:06.27,Default,,0000,0000,0000,,by preventing the cancer drugs\Nfrom being in the wrong location.
Dialogue: 0,0:09:07.76,0:09:09.95,Default,,0000,0000,0000,,However, a major problem has been
Dialogue: 0,0:09:09.98,0:09:14.27,Default,,0000,0000,0000,,how do we isolate these\Nbiological nanoparticles
Dialogue: 0,0:09:14.29,0:09:17.50,Default,,0000,0000,0000,,in large quantities,\Nwithout damaging them?
Dialogue: 0,0:09:18.92,0:09:21.79,Default,,0000,0000,0000,,My lab has developed\Nan efficient method for doing this.
Dialogue: 0,0:09:21.81,0:09:26.25,Default,,0000,0000,0000,,We can process large quantities\Nof liquids from the body
Dialogue: 0,0:09:26.27,0:09:31.06,Default,,0000,0000,0000,,to produce a highly concentrated,\Nhigh-quality formulation
Dialogue: 0,0:09:31.08,0:09:32.95,Default,,0000,0000,0000,,of biological nanoparticles.
Dialogue: 0,0:09:34.14,0:09:38.28,Default,,0000,0000,0000,,And these nanoparticles\Nare not yet in clinical use,
Dialogue: 0,0:09:38.30,0:09:41.32,Default,,0000,0000,0000,,because it takes an average of 12 years
Dialogue: 0,0:09:41.34,0:09:43.78,Default,,0000,0000,0000,,to get something from the lab
Dialogue: 0,0:09:43.80,0:09:45.79,Default,,0000,0000,0000,,to your medicine cabinet.
Dialogue: 0,0:09:48.09,0:09:50.43,Default,,0000,0000,0000,,And this is the type of challenge
Dialogue: 0,0:09:50.46,0:09:55.96,Default,,0000,0000,0000,,that requires team work\Nfrom scientists and physicians,
Dialogue: 0,0:09:55.98,0:09:58.91,Default,,0000,0000,0000,,who dedicate their lives to this battle.
Dialogue: 0,0:10:00.15,0:10:01.58,Default,,0000,0000,0000,,And we keep going
Dialogue: 0,0:10:01.61,0:10:04.76,Default,,0000,0000,0000,,thanks to inspiration from patients.
Dialogue: 0,0:10:05.53,0:10:09.69,Default,,0000,0000,0000,,And I believe that if we keep working\Non these nanomedicines,
Dialogue: 0,0:10:09.72,0:10:13.54,Default,,0000,0000,0000,,we will be able to reduce harm\Nto healthy organs,
Dialogue: 0,0:10:13.56,0:10:15.31,Default,,0000,0000,0000,,improve quality of life,
Dialogue: 0,0:10:15.33,0:10:17.78,Default,,0000,0000,0000,,and save future patients.
Dialogue: 0,0:10:20.36,0:10:22.59,Default,,0000,0000,0000,,I like to imagine
Dialogue: 0,0:10:22.62,0:10:27.74,Default,,0000,0000,0000,,that if these treatments\Nhad been available for Rebecca,
Dialogue: 0,0:10:27.77,0:10:29.76,Default,,0000,0000,0000,,that call from her
Dialogue: 0,0:10:29.78,0:10:32.49,Default,,0000,0000,0000,,could have been an invitation,
Dialogue: 0,0:10:32.52,0:10:34.18,Default,,0000,0000,0000,,not to her funeral,
Dialogue: 0,0:10:34.21,0:10:35.37,Default,,0000,0000,0000,,but her wedding.
Dialogue: 0,0:10:35.40,0:10:36.76,Default,,0000,0000,0000,,Thank you.
Dialogue: 0,0:10:36.78,0:10:40.02,Default,,0000,0000,0000,,(Applause)