WEBVTT 00:37:46.270 --> 00:37:52.498 Once inside the cervix, the sperm continue on their journey. 00:37:52.498 --> 00:37:55.363 Some remain here, perhaps to provide a back-up 00:37:55.363 --> 00:38:01.622 for those that continue on. 00:38:01.622 --> 00:38:05.588 The rest proceed up through the cavity of the uterus 00:38:05.588 --> 00:38:12.880 in search of the egg. 00:38:16.926 --> 00:38:24.498 Their number is noticeably reduced. 00:38:31.120 --> 00:38:33.498 Here from inside the uterus, 00:38:33.498 --> 00:38:40.558 we see the openings to the two fallopian tubes. 00:38:42.208 --> 00:38:47.590 The sperm swim toward them. 00:38:49.622 --> 00:38:54.498 One leads to the waiting egg. 00:38:54.498 --> 00:38:59.861 The other to an empty tube. 00:39:01.862 --> 00:39:04.588 Only half of the few remaining sperm 00:39:04.588 --> 00:39:10.769 will swim up the tube that holds the egg. 00:39:29.865 --> 00:39:33.268 The tubes are lined with millions of tiny cilia, 00:39:33.268 --> 00:39:35.708 the same cilia which helped draw the egg 00:39:35.708 --> 00:39:40.268 from the ovary toward the uterus at ovulation. 00:39:40.268 --> 00:39:42.529 These cilia sway constantly, 00:39:42.529 --> 00:39:45.498 creating a gentle downward current 00:39:45.498 --> 00:39:52.238 that the sperm must swim against. 00:39:58.620 --> 00:40:01.161 Some sperm get stuck in among the cells 00:40:01.161 --> 00:40:07.329 lining the walls of the tube. 00:40:07.329 --> 00:40:14.738 Others lose their sense of direction. 00:40:18.419 --> 00:40:21.119 During this part of the sperm's journey 00:40:21.119 --> 00:40:24.590 the layer of enzyme inhibitors, at the tips of their heads 00:40:24.590 --> 00:40:28.799 is slowly being worn away. 00:40:28.799 --> 00:40:31.968 The sperm are fully capacitated and able to fertilize 00:40:31.968 --> 00:40:39.329 the egg, if they ever encounter it. 00:40:48.620 --> 00:40:51.391 Of the two hundred million sperm that begin 00:40:51.391 --> 00:40:53.150 this long journey 00:40:53.150 --> 00:41:00.317 only about 50 ever reach the egg. 00:41:02.238 --> 00:41:05.362 The egg is surrounded by 2 layers of the nutritive 00:41:05.362 --> 00:41:07.862 cells which have nourished it on its journey 00:41:07.862 --> 00:41:12.833 in the fallopian tube. 00:41:13.653 --> 00:41:17.298 The sperm immediately release their digestive enzymes 00:41:17.298 --> 00:41:20.921 to break through these protective, nutritive layers 00:41:20.921 --> 00:41:27.088 in order the reach the egg itself. 00:41:27.798 --> 00:41:31.149 At best, only one will eventually enter and 00:41:31.149 --> 00:41:36.738 fertilize the egg. 00:41:39.208 --> 00:41:43.359 The joint force of their exertions starts the egg 00:41:43.359 --> 00:41:51.210 rolling around, like a mysterious, celestial body. 00:42:27.389 --> 00:42:30.468 All the while, the sperm are dissolving their way 00:42:30.468 --> 00:42:37.152 through the egg's outer layers. 00:42:41.214 --> 00:42:44.212 The first sperm to reach the egg's membrane 00:42:44.212 --> 00:42:50.208 is immediately drawn inside. 00:42:50.208 --> 00:42:52.968 This is the tail of the penetrating sperm 00:42:52.968 --> 00:42:55.391 seen from the surface of the egg at enormous 00:42:55.391 --> 00:43:01.921 magnification. 00:43:01.921 --> 00:43:07.891 And this is a picture from inside the egg itself. 00:43:07.891 --> 00:43:16.119 It has been fertilized now for only a fraction of a second. 00:43:16.119 --> 00:43:18.589 Here is the penetrating sperm with a circle 00:43:18.589 --> 00:43:19.394 around it 00:43:19.394 --> 00:43:22.563 from a wider perspective. 00:43:22.563 --> 00:43:26.968 Only this single sperm will be allowed inside the egg. 00:43:26.968 --> 00:43:29.712 A rapid, biochemical change took place in the 00:43:29.712 --> 00:43:31.711 egg's membrane. 00:43:31.711 --> 00:43:37.318 It is now impermeable to all other sperm. 00:43:37.318 --> 00:43:39.833 Once inside the sperm too undergoes a 00:43:39.833 --> 00:43:43.397 dramatic transformation. 00:43:43.397 --> 00:43:47.911 It loses its mid-piece and tail. 00:43:47.911 --> 00:43:54.238 The tailless head spells up almost like rising bread. 00:43:54.238 --> 00:43:56.382 This hole in the sperm head's covering 00:43:56.382 --> 00:43:59.768 is the first indication that it's about to rupture 00:43:59.768 --> 00:44:04.060 and release its precious genetic material. 00:44:04.060 --> 00:44:07.362 Here, the first strand of genes is making its way 00:44:07.362 --> 00:44:12.228 out of the sperm into the egg. 00:44:12.228 --> 00:44:14.968 The genetic material continues to spill out 00:44:14.968 --> 00:44:16.798 from the sperm head. 00:44:16.798 --> 00:44:19.998 Its tightly packed molecules contain the father's 00:44:19.998 --> 00:44:23.219 hereditary message. 00:44:23.219 --> 00:44:25.395 They almost seem to have been dispersed by 00:44:25.395 --> 00:44:31.802 an explosive force. 00:44:31.802 --> 00:44:36.468 This is an extreme close-up of the genetic material itself. 00:44:36.468 --> 00:44:39.240 The magnification on the television screen is over 00:44:39.240 --> 00:44:45.120 half a million times. 00:44:45.120 --> 00:44:47.185 The genetic material of the mother's egg 00:44:47.185 --> 00:44:48.709 and the father's sperm 00:44:48.709 --> 00:44:51.118 combine. 00:44:51.118 --> 00:44:58.740 Two cells have joined to make a single new cell. 00:44:59.153 --> 00:45:06.143 And within 24 hours that new cell begins to divide. 00:45:06.258 --> 00:45:09.028 These early cell divisions of the human embryo 00:45:09.284 --> 00:45:13.074 have never before been filmed. 00:45:15.986 --> 00:45:19.315 The fertilized egg now has 2 nuclei, 00:45:19.315 --> 00:45:24.965 the small indentations at the center of the cell. 00:45:26.076 --> 00:45:30.756 The first division of the egg is beginning. 00:45:37.802 --> 00:45:41.292 Now there are 2 identical cells, 00:45:41.923 --> 00:45:44.353 still within the same nourishing material 00:45:44.406 --> 00:45:46.256 of the original egg. 00:45:46.497 --> 00:45:48.071 No growth has occurred, 00:45:48.071 --> 00:45:52.191 but, rather, a distinction between cells. 00:45:53.397 --> 00:45:55.697 Once it has begun to divide 00:45:55.707 --> 00:45:59.817 the fertilized egg is called a zygote. 00:46:07.834 --> 00:46:12.074 Now there are 4 cells. 00:46:19.351 --> 00:46:22.901 The divisions happen at such an accelerated pace 00:46:22.967 --> 00:46:25.801 that there's little opportunity for the new cells 00:46:25.801 --> 00:46:29.951 to grow before they divide again. 00:46:42.278 --> 00:46:46.558 Now there are 8 cells. 00:46:54.667 --> 00:46:57.910 Each new generation of cells of the zygote is 00:46:57.910 --> 00:47:02.080 smaller than the one before it. 00:47:19.901 --> 00:47:22.397 Another division, 00:47:23.049 --> 00:47:27.229 and another. 00:47:29.514 --> 00:47:32.824 As the zygote divides, it moves along the tube 00:47:33.052 --> 00:47:37.351 toward the uterus. 00:47:39.220 --> 00:47:41.735 Now it has become a dense, compact cluster 00:47:41.735 --> 00:47:46.871 of many cells. 00:47:48.574 --> 00:47:54.826 And after 5 days it is called a blastocyst. 00:47:54.826 --> 00:47:59.205 It is still no bigger than the original egg. 00:47:59.205 --> 00:48:05.717 Its center is filled with liquid. 00:48:08.629 --> 00:48:11.307 Within 10 days of fertilization, 00:48:11.307 --> 00:48:13.492 the blastocyst implants itself firmly 00:48:13.492 --> 00:48:16.018 in the lining of the uterus. 00:48:16.018 --> 00:48:18.007 Already the mother's hormones are directing 00:48:18.007 --> 00:48:19.659 changes in her body 00:48:19.659 --> 00:48:25.023 to prepare it to support the growing embryo. 00:48:25.023 --> 00:48:27.261 Barely visible to the naked eye, 00:48:27.261 --> 00:48:30.629 the embryo will be nourished by the lining of the uterus, 00:48:30.629 --> 00:48:35.483 and then by the placenta. 00:48:35.483 --> 00:48:40.007 After 2 weeks, the embryo is elongated. 00:48:40.007 --> 00:48:48.809 It is barely one tenth of an inch long. 00:48:50.223 --> 00:48:58.402 At the top, what will become its head and brain. 00:49:01.116 --> 00:49:04.131 Below, at the tail, the embryo is firmly attached 00:49:04.131 --> 00:49:09.399 to the placenta, which will nourish it. 00:49:10.446 --> 00:49:13.566 At 4 weeks, the embryo has arm buds and 00:49:13.566 --> 00:49:18.923 is distinctly curled. 00:49:18.923 --> 00:49:25.096 It has the beginning of eyes. 00:49:29.097 --> 00:49:34.870 At 5 weeks, the nose begins to take shape. 00:49:34.870 --> 00:49:38.597 At 6 weeks, leg buds are apparent. 00:49:38.597 --> 00:49:42.668 The embryo is less than half an inch long. 00:49:42.668 --> 00:49:47.007 It floats inside the fluid-filled amniotic sac. 00:49:47.007 --> 00:49:51.905 Its spine is clearly visible. 00:49:51.905 --> 00:50:01.445 At 7 weeks, the embryo is three quarters of an inch long. 00:50:02.128 --> 00:50:04.186 It can move its hands on which there are 00:50:04.186 --> 00:50:10.006 clearly defined fingers. 00:50:14.746 --> 00:50:21.777 Its internal organs are visible. 00:50:23.339 --> 00:50:30.389 The eyelids are formed. 00:50:30.489 --> 00:50:33.155 The skull bones, rich in blood vessels, 00:50:33.155 --> 00:50:35.531 are growing together at an angle at the 00:50:35.531 --> 00:50:40.627 crown of the head. 00:50:40.627 --> 00:50:43.036 At 8 weeks, the fingers of the hand are 00:50:43.036 --> 00:50:45.538 well defined. 00:50:45.538 --> 00:50:56.135 And the toe joints of the feet are clearly visible. 00:50:56.135 --> 00:51:01.372 At about 10 weeks, the embryo is considered a fetus. 00:51:01.372 --> 00:51:04.205 It can move actively. 00:51:04.205 --> 00:51:08.130 There is a suggestion of an ear. 00:51:08.130 --> 00:51:10.445 It is two inches long. 00:51:10.445 --> 00:51:15.837 And it still has the stub of a tail. 00:51:15.837 --> 00:51:21.706 At 11 weeks, it is two and a half inches long. 00:51:21.706 --> 00:51:27.192 At 12 weeks, it is 3 inches long. 00:51:27.192 --> 00:51:30.237 Here-the umbilical cord-connecting the fetus 00:51:30.237 --> 00:51:34.245 to its food supply. 00:51:34.245 --> 00:51:38.475 By 14 weeks, it can bring its hands together. 00:51:38.475 --> 00:51:44.390 And suck its thumb. 00:51:44.390 --> 00:51:47.805 By 15 weeks, the sensory organs are nearly 00:51:47.805 --> 00:51:51.513 completely formed. 00:51:51.513 --> 00:51:57.643 And by 16 weeks, it is actively turning inside the mother. 00:52:05.718 --> 00:52:10.343 This fetus is 18 weeks old. 00:52:10.343 --> 00:52:12.813 It is five and a half inches long. 00:52:12.813 --> 00:52:14.798 And is here shown, 15 times larger than its 00:52:14.798 --> 00:52:22.020 actual size. 00:52:22.796 --> 00:52:25.326 Its mouth and lips are fully formed. 00:52:25.326 --> 00:52:27.388 And it has the strange nasal plugs 00:52:27.388 --> 00:52:31.747 whose purpose is not yet understood. 00:52:31.747 --> 00:52:34.103 The eyes of the fetus are closed, 00:52:34.103 --> 00:52:38.283 but it can see. 00:52:38.835 --> 00:52:42.099 (pulsing sound) 00:52:42.122 --> 00:52:44.587 This sound is made by the fetus as it 00:52:44.673 --> 00:52:47.015 breathes in the amniotic fluid 00:52:47.135 --> 00:52:50.455 in what is known as fetal respiration. 00:52:50.533 --> 00:52:53.893 It brings the fluid in through its mouth, 00:52:53.946 --> 00:52:58.046 and then breathes it out again. 00:53:09.508 --> 00:53:12.886 The umbilical cord is the fetus' link to its 00:53:12.886 --> 00:53:20.297 source of life, the mother. 00:53:20.297 --> 00:53:26.466 Here are the fetus' sex organs. 00:53:27.830 --> 00:53:32.083 All its important physiological systems have developed. 00:53:32.083 --> 00:53:34.751 But it will be at least another 8 weeks before the 00:53:34.751 --> 00:53:37.660 fetus has even a remote chance of surviving 00:53:37.660 --> 00:53:41.706 outside its mother's womb. 00:53:53.266 --> 00:53:55.614 Whatever signals the beginning of birth 00:53:55.614 --> 00:53:57.477 is till a mystery. 00:53:57.477 --> 00:54:00.113 But when the fetus is ready to be born, 00:54:00.113 --> 00:54:03.984 the uterus begins its powerful contractions. 00:54:03.984 --> 00:54:09.175 And the process of birth begins. 00:54:12.536 --> 00:54:13.914 "Pull your legs right in. 00:54:13.914 --> 00:54:16.144 Keep it coming. 00:54:16.144 --> 00:54:19.681 Take another quick breath. 00:54:19.681 --> 00:54:20.481 Hold it. 00:54:20.481 --> 00:54:24.903 Push. 00:54:24.903 --> 00:54:28.210 Don't stop. 00:54:28.210 --> 00:54:30.465 One more. 00:54:30.465 --> 00:54:31.400 Deep breath. 00:54:31.400 --> 00:54:33.526 Push....push. 00:54:33.526 --> 00:54:37.706 That a girl. 00:54:37.706 --> 00:54:43.323 Can you see this baby's head?" 00:54:43.323 --> 00:54:44.915 "Ok, now, stop pushing.' 00:54:51.645 --> 00:54:55.358 "Oh, beautiful job." 00:54:55.358 --> 00:54:56.583 "Here he is... 00:54:56.583 --> 00:54:58.558 suck out his little nose and mouth 00:54:58.558 --> 00:55:01.355 so he can take his nice, clean, first breath. 00:55:06.665 --> 00:55:10.675 Nothing's little about this baby." 00:55:10.675 --> 00:55:16.384 (baby cries) 00:55:16.384 --> 00:55:18.009 "Congratulations!" 00:55:18.009 --> 00:55:21.474 "Another girl!" 00:55:21.474 --> 00:55:34.854 (baby cries) 00:55:34.854 --> 00:55:38.883 "Happy birthday."