I've been spending my summers in the Marine Biological Laboratory in Woods Hole, Massachusetts And there, what I've been doing is essentially renting a boat. What I would like to ask you to do is to come on a boat ride with me tonight. So, we ride off from Eel Pond into the Vineyard South, right off the coast of Martha's Vineyard, equipped with a drone to identify potential spots from which to peer into the Atlantic. Earlier I was going to say into the depths of the Atlantic, but we don't have to go too deep to reach the unknown. Here, barely two miles away, from what is arguably the greatest marine biology lab in the world, we lower a simple plankton net into the water and bring up into the surface things that humanity rarely pays attention to and oftentimes, have never seen before. Here is one of the organisms that we caught in our net, this is a jellyfish. But look closely, living inside this animal is another organism that is very likely entirely new to science. A complete new species. Or how about this other transparent beauty? With a beating heart, asexually growing, on top of its head, progeny that will move on to reproduce sexually. Now let me say that again, this animal is growing asexually, on top of its head, progeny that is going to reproduce sexually in the next generation. A weird jellyfish, not quite, this is an ascidian, this is a group of animals that now we know we share extensive genomic ancestry with, and it is perhaps the closest invertebrate species to our own. Meet your cousin, Thalia democratica I'm pretty sure you didn't save a spot in your last family reunion for Thalia. But, let me tell you, these animals are profoundly related to us in ways we are just beginning to understand. Next time you hear anybody derisively telling you that this type of research is a simple fishing expedition, I hope that you remember the trip that we just took. Today, many biological sciences only see value in studying deeper what we already know, In mapping already discovered continents. But some of us are much more interested in the unknown, we want to discover completely new continents, and gaze at magnificent vistas of ignorance. We crave the experience of being completely baffled by something we have never seen before. And yes, I agree that there's a lot of ego satisfaction in being able to say "Hey, I was the first one to discover that." This is not a self-aggrandizing enterprise because in this type of discovery research, if you don't feel like a complete idiot most of the time, you're just not science-ing hard enough. (Laughter) Every summer, I bring onto the deck of this little boat of ours, more and more things that we know very little about. Very, very, very little about. I would like to tell you tonight, a story about life that rarely gets told in an environment like this. From the vantage point of our 21st biological laboratories, our 21st century biological laboratories, we have began to illuminate many mysteries of life with knowledge. We sensed that after centuries of scientific research, we're beginning to make significant inroads into understanding some of the most fundamental principles of life. Our collective optimism is reflected by the growth of biotechnology across the globe. Striving to utilize scientific knowledge to cure human diseases, things like cancer, aging, degeneretive diseases, these are but some of the undesirables we wish to tame. What I often wonder is, "Why is it that we are having so much trouble trying to solve the problem of cancer? Is it that we're trying to solve the problem of cancer, and not trying to understand life?" Life on this planet shares a common origin. I can summarize 3.5 billion years of the history of life on this planet in a single slide. What you see represented here are all known species, representative of all known species of our planet. in this immensity of life and biodiversity we occupy a rather unremarkable position. Homo sapiens, the last of our kind. And though I don't really want to disparage all the accomplishments of our species, as much as we wish it to be so, and often pretend that it is so, we are not the measure of all things. We are, however, the measurers of many things. We relentlessly quantify, analyze and compare, and some of these are absolutely invaluable and indeed necessary, but this emphasis today, on forcing biological research to specialize, and to produce practical outcomes, is actually restricting our ability to interrogate life, to accept only narrow confines and unsatisfying depths. We are measuring an astonishingly narrow sliver of life, and hoping that those numbers will save all of our lives.