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Ukazujem Revíziu 2 vytvorenú 10/16/2017 od DLC.

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    We are on the brink of uncovering
    a hidden world, a world that
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    connects past and future generations
    in ways we never thought possible.
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    What this means is that an environmental
    exposure that your grandmother had
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    could cause a disease in you, even though
    have never been exposed to the toxin,
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    and you are going to pass it on to your
    great-grandkids.
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    These extraordinary discoveries have the
    to effect every aspect of our lives.
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    It's not just the genes, but also the
    environment of the early life
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    of your early ancestors. It's not so much
    you are what you eat, but you are what
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    your mother ate, and maybe you are what
    your grandmother ate. And if you take our
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    data, maybe you are what your grandmother
    or grandfather had.
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    It will change the way we think about our
    relationship with every generation.
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    Makes me feel closer to my children;
    what I experienced in terms of environment
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    will have some type of legacy in my
    children and grandchildren.
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    The science of inheritance is being turned
    on its head.
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    We're changing the view of what
    inheritance is.
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    This small Swedish town may hold
    the evidence to launch a medical
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    revolution. Överkalix lies huddled on the
    edge of the Arctic Circle
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    Inaccessible and remote, it was cutoff
    from the rest of the world for most of
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    its history. Marcus Pembrey has traveled
    here to meet his colleague, Olov Bygren.
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    They believe that the stories lying
    buried in this graveyard may hold the
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    proof to their radical ideas.
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    Here we have multiple generation in
    the same grave.
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    This group of people could really
    contribute to a sea of change in the
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    way we think about inheritance.
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    They have come to this churchyard to
    find grandmothers and granddaughters,
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    grandfathers and grandsons. Connecting
    people who lived almost a hundred years
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    apart, in entirely new ways. Uncovering
    links that confound scientific thinking.
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    Up until now, inheritance was just, just,
    the genes, the DNA sequence. I suspect
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    that we're going to be able to demonstrate
    that the inheritance is more than that.
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    This is a grandson as it were in our
    study...
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    It is the culmination of more than
    twenty years of work, and for the
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    first time Pembrey is confronting the
    magnitude of their discovery.
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    It has really come alive for me, coming
    here, more than I had expected it to.
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    I'm really quite sort of emotional about
    it. Wonderful!
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    Marcus Pembrey is one of a select band of
    scientists, a band that is willing to
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    challenge an orthodoxy. They believe the
    lives of our parents, grandparents, and
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    even our great grandparents can directly
    effect our well-being, despite never
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    experiencing these things ourselves.
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    To many of people, these ideas are
    regarded as scientific heresy.
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    You cannot predict where these important
    will be, the only thing that you can do is
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    follow your instinct.
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    Conventional biology has always believed
    that our genetic inheritance is set in
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    stone at the moment of our conception. At
    that instant, we receive a set of
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    chromosomes from both our mother and our
    father.
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    Within these chromosomes are the genes,
    strips of coded DNA, the basic unit of
    inheritance.
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    After conception, it was presumed assumed that our
    genes were locked away inside every cell
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    of the body, protected untouched from the
    way you live.
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    So what you do in your life may effect you,
    but your genes remain untainted, unchanged
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    for future generations.
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    In classic genetics, your parents and
    grandparents simply pass on their genes,
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    the experiences they accumulated in a
    lifetime are never inherited, lost forever
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    as the genes pass untouched generation
    after generation.
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    The biology of inheritance was a reassuringly
    pure process, or so it seemed.
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    In the early '80's, Marcus Pembrey headed
    the clinical genetic department at
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    Great Ormond Street Hospital for Children.
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    He was frequently treating families with
    unusual genetic conditions.
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    We were constantly coming across families
    which didn't fit the rules, that didn't fit
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    any of the patterns that genetics were
    supposed to fit, so you think of
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    chromosome abnormalities and, uh, you
    check the chromosomes and they are normal.
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    So you then to start imagining as it were,
    you know, what might be underlying this
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    and you are really driven to try and work
    it out because the families really needed
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    some help.
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    The more families he saw, the more the
    rules of inheritance appeared to break
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    down.
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    Diseases and conditions that simply didn't
    fit with the textbook conventions.
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    One condition in particular caught his eye,
    Angelman Syndrome.
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    Named after Harry Angelman, the
    pediatrician who first described Angelman

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    Syndrome, he described them as "happy
    puppy children" because it described some
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    of their apparent features.