Could we cure HIV with lasers?
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0:01 - 0:03What do you do when you have a headache?
-
0:04 - 0:05You swallow an aspirin.
-
0:06 - 0:11But for this pill to get
to your head, where the pain is, -
0:11 - 0:16it goes through your stomach, intestines
and various other organs first. -
0:17 - 0:22Swallowing pills is the most effective
and painless way of delivering -
0:22 - 0:24any medication in the body.
-
0:25 - 0:30The downside, though, is that swallowing
any medication leads to its dilution. -
0:31 - 0:37And this is a big problem,
particularly in HIV patients. -
0:37 - 0:40When they take their anti-HIV drugs,
-
0:40 - 0:44these drugs are good for lowering
the virus in the blood, -
0:44 - 0:46and increasing the CD4 cell counts.
-
0:47 - 0:51But they are also notorious
for their adverse side effects, -
0:51 - 0:56but mostly bad, because they get diluted
by the time they get to the blood, -
0:57 - 0:59and worse, by the time
they get to the sites -
0:59 - 1:05where it matters most:
within the HIV viral reservoirs. -
1:06 - 1:10These areas in the body --
such as the lymph nodes, -
1:10 - 1:13the nervous system,
as well as the lungs -- -
1:13 - 1:16where the virus is sleeping,
-
1:16 - 1:19and will not readily
get delivered in the blood -
1:19 - 1:24of patients that are under
consistent anti-HIV drugs therapy. -
1:25 - 1:28However, upon discontinuation of therapy,
-
1:28 - 1:32the virus can awake
and infect new cells in the blood. -
1:33 - 1:39Now, all this is a big problem in treating
HIV with the current drug treatment, -
1:39 - 1:43which is a life-long treatment
that must be swallowed by patients. -
1:43 - 1:46One day, I sat and thought,
-
1:46 - 1:52"Can we deliver anti-HIV directly
within its reservoir sites, -
1:52 - 1:54without the risk of drug dilution?"
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1:55 - 1:59As a laser scientist,
the answer was just before my eyes: -
1:59 - 2:01Lasers, of course.
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2:01 - 2:04If they can be used for dentistry,
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2:04 - 2:07for diabetic wound-healing and surgery,
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2:07 - 2:09they can be used for anything imaginable,
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2:09 - 2:13including transporting drugs into cells.
-
2:13 - 2:19As a matter of fact,
we are currently using laser pulses -
2:19 - 2:22to poke or drill extremely tiny holes,
-
2:22 - 2:27which open and close almost
immediately in HIV-infected cells, -
2:27 - 2:30in order to deliver drugs within them.
-
2:30 - 2:32"How is that possible?" you may ask.
-
2:33 - 2:39Well, we shine a very powerful
but super-tiny laser beam -
2:39 - 2:43onto the membrane of HIV-infected cells
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2:43 - 2:47while these cells are immersed
in liquid containing the drug. -
2:48 - 2:53The laser pierces the cell,
while the cell swallows the drug -
2:53 - 2:55in a matter of microseconds.
-
2:55 - 2:57Before you even know it,
-
2:57 - 3:00the induced hole
becomes immediately repaired. -
3:01 - 3:06Now, we are currently testing
this technology in test tubes -
3:06 - 3:07or in Petri dishes,
-
3:07 - 3:12but the goal is to get
this technology in the human body, -
3:12 - 3:13apply it in the human body.
-
3:14 - 3:16"How is that possible?" you may ask.
-
3:16 - 3:21Well, the answer is:
through a three-headed device. -
3:22 - 3:24Using the first head, which is our laser,
-
3:24 - 3:28we will make an incision
in the site of infection. -
3:28 - 3:31Using the second head, which is a camera,
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3:31 - 3:33we meander to the site of infection.
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3:34 - 3:39Finally, using a third head,
which is a drug-spreading sprinkler, -
3:39 - 3:42we deliver the drugs directly
at the site of infection, -
3:42 - 3:46while the laser is again used
to poke those cells open. -
3:47 - 3:50Well, this might not seem
like much right now. -
3:51 - 3:56But one day, if successful,
this technology can lead -
3:56 - 3:59to complete eradication
of HIV in the body. -
3:59 - 4:02Yes. A cure for HIV.
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4:02 - 4:05This is every HIV researcher's dream --
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4:05 - 4:09in our case, a cure led by lasers.
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4:09 - 4:10Thank you.
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4:10 - 4:12(Applause)
- Title:
- Could we cure HIV with lasers?
- Speaker:
- Patience Mthunzi
- Description:
-
Swallowing pills to get medication is a quick, painless and often not entirely effective way of treating disease. A potentially better way? Lasers. In this passionate talk, TED Fellow Patience Mthunzi explains her idea to use lasers to deliver drugs directly to cells infected with HIV. It's early days yet, but could a cure be on the horizon?
- Video Language:
- English
- Team:
- closed TED
- Project:
- TEDTalks
- Duration:
- 04:25
Brian Greene edited English subtitles for Could we cure HIV with lasers? | ||
Krystian Aparta edited English subtitles for Could we cure HIV with lasers? | ||
Cynthia Betubiza edited English subtitles for Could we cure HIV with lasers? | ||
Cynthia Betubiza edited English subtitles for Could we cure HIV with lasers? | ||
Camille Martínez edited English subtitles for Could we cure HIV with lasers? | ||
Krystian Aparta edited English subtitles for Could we cure HIV with lasers? | ||
Camille Martínez approved English subtitles for Could we cure HIV with lasers? | ||
Camille Martínez edited English subtitles for Could we cure HIV with lasers? |