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← Could we cure HIV with lasers?

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Showing Revision 12 created 09/09/2020 by Brian Greene.

  1. What do you do when you have a headache?
  2. You swallow an aspirin.
  3. But for this pill to get
    to your head, where the pain is,
  4. it goes through your stomach, intestines
    and various other organs first.
  5. Swallowing pills is the most effective
    and painless way of delivering

  6. any medication in the body.
  7. The downside, though, is that swallowing
    any medication leads to its dilution.
  8. And this is a big problem,
    particularly in HIV patients.
  9. When they take their anti-HIV drugs,
  10. these drugs are good for lowering
    the virus in the blood,
  11. and increasing the CD4 cell counts.
  12. But they are also notorious
    for their adverse side effects,
  13. but mostly bad, because they get diluted
    by the time they get to the blood,
  14. and worse, by the time
    they get to the sites
  15. where it matters most:
    within the HIV viral reservoirs.
  16. These areas in the body --
    such as the lymph nodes,
  17. the nervous system,
    as well as the lungs --
  18. where the virus is sleeping,
  19. and will not readily
    get delivered in the blood
  20. of patients that are under
    consistent anti-HIV drugs therapy.
  21. However, upon discontinuation of therapy,
  22. the virus can awake
    and infect new cells in the blood.
  23. Now, all this is a big problem in treating
    HIV with the current drug treatment,

  24. which is a life-long treatment
    that must be swallowed by patients.
  25. One day, I sat and thought,
  26. "Can we deliver anti-HIV directly
    within its reservoir sites,
  27. without the risk of drug dilution?"
  28. As a laser scientist,
    the answer was just before my eyes:
  29. Lasers, of course.
  30. If they can be used for dentistry,
  31. for diabetic wound-healing and surgery,
  32. they can be used for anything imaginable,
  33. including transporting drugs into cells.
  34. As a matter of fact,
    we are currently using laser pulses

  35. to poke or drill extremely tiny holes,
  36. which open and close almost
    immediately in HIV-infected cells,
  37. in order to deliver drugs within them.
  38. "How is that possible?" you may ask.
  39. Well, we shine a very powerful
    but super-tiny laser beam
  40. onto the membrane of HIV-infected cells
  41. while these cells are immersed
    in liquid containing the drug.
  42. The laser pierces the cell,
    while the cell swallows the drug
  43. in a matter of microseconds.
  44. Before you even know it,
  45. the induced hole
    becomes immediately repaired.
  46. Now, we are currently testing
    this technology in test tubes

  47. or in Petri dishes,
  48. but the goal is to get
    this technology in the human body,
  49. apply it in the human body.
  50. "How is that possible?" you may ask.
  51. Well, the answer is:
    through a three-headed device.
  52. Using the first head, which is our laser,
  53. we will make an incision
    in the site of infection.
  54. Using the second head, which is a camera,
  55. we meander to the site of infection.
  56. Finally, using a third head,
    which is a drug-spreading sprinkler,
  57. we deliver the drugs directly
    at the site of infection,
  58. while the laser is again used
    to poke those cells open.
  59. Well, this might not seem
    like much right now.

  60. But one day, if successful,
    this technology can lead
  61. to complete eradication
    of HIV in the body.
  62. Yes. A cure for HIV.
  63. This is every HIV researcher's dream --
  64. in our case, a cure led by lasers.
  65. Thank you.

  66. (Applause)