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Nonsense

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    So both of these mutations are nonsense mutations meaning they
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    both introduce stop codons. But one happens much sooner than the
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    other one does. So it's most likely to be more
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    severe. Think about it for a second. The earlier the mutation,
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    the nonsense mutation that comes in the sequence, the shorter
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    the overall protein's going to be. Which means if this nonsense
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    mutation happens at the very end of the sequence, okay
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    well we're not going to lose very much of our protein.
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    But if it happens way up front, towards the beginning
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    of the sequence, then yeah we're going to lose a lot
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    of the proteins and it's probably going to have a major
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    effect because we're missing far more amino acids. Again while this
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    is a general rule, it is possible that sometimes there's
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    not as big of a difference, because you could imagine there's
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    certain parts of proteins that are more important than others. And
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    so even when you delete big stretches not too much happens.
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    Still, in general, the sooner or the earlier a stop codon happens, a nonsense
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    mutation, the worse effect it's going to
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    have on the function of the overall protein.
Title:
Nonsense
Video Language:
English
Team:
Udacity
Project:
BIO110 - Tales from the Genome
Duration:
01:04
Cogi-Admin edited English subtitles for Nonsense

English subtitles

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