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← Enhancers and Silencers

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Showing Revision 1 created 09/27/2013 by Cogi-Admin.

  1. I know we just learned a lot of new terminology,
  2. but hopefully you're able to breeze right through this one.
  3. Now we have three scenarios, a lot of transcription, a
  4. medium amount of transcription, and no transcription. If we need
  5. to match the scenario on the right with the scenario
  6. on the left, so which scenario on the left would
  7. give us, let's say the least amount of transcription. Well,
  8. obviously if our silencer is bound, that silence is transcription.
  9. Enhancer enhances transcription. So if we've silenced our
  10. transcription and we don't have anything to help
  11. enhance, this is probably the scenario which we're
  12. going to have little to no transcription at
  13. all. The scenario above it, however, we have
  14. the enhancer bound and the silencer's unbound. Remember
  15. the proteins mitigate the effects ,of what these
  16. non-coding regions can do. So a bound enhancer is
  17. going to enhance transcription, an unbound silencer won't be
  18. able to silence transcription. And so this is going to be
  19. our most active transcription here, lots of transcription. So
  20. the answer to this one is A. And that leaves
  21. this last scenario, where we don't have a bound
  22. enhancer, we don't have a bound silencer. The promoter is
  23. left to initiate whatever transcription it can on its
  24. own. And so we reach the scenario of some transcription.
  25. It depends entirely on the promoter region itself. But in general, there's
  26. going to be some transcription that happens at the site. But because there's no
  27. enhancer or silencer bound, we're not going to have these extremes show
  28. up, where we have a lot
  29. of transcription happening, or no transcription happening.