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"Turmeric Curcumin Reprogramming
Cancer Cell Death"
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The anticancer effects of the
turmeric pigment curcumin
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extend well beyond it's ability
to block carcinogens.
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The anticancer effects of
curcumin mainly result from
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the multitude of ways it regulates
programmed cell death.
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It's estimated that human body consists
of 10 or so trillion cells,
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that's a million million.
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Almost all of these cells get turned
over within approximately 100 days.
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We're like a new person,
every three months!
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We reinvent ourselves
physically.
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And since we're just
made up of 3 things
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air, water, and food -
those are the only inputs -
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we are what we eat
literally, physically!
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In a sense, our body has to rebuild
itself every three months
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with the building materials we
deliver to it through our stomach.
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Our mouths are like
the access road
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to the continual construction
site to our body.
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Trucks roll in
3 times a day.
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What do we want
them to deliver?
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Some shoddy cheap stuff
we scrounged around for
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or bought at the discount outlets
that's just going to fall apart?
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Or do we want to build
our foundation solid?
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We are each walking
around inside
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the greatest known architectural
structures in the universe!
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Let's not ruin such grand
blueprints by consuming junk.
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Anyway, we only own the biological
real estate we're born with,
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so if need to rebuild every three months,
we also need a wrecking crew.
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If we're replacing 10 trillion
every hundred days,
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that means we have to kill off like
100 billion cells every day, normally.
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Out with the old,
in with the new.
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We do that primarily through
a process called apoptosis,
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pre-programmed
cell death,
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from the Greek "ptosis"
meaning falling,
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and "apo"
meaning away from.
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So it's our cells falling
away from our body.
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For example, we all used to have
webbed fingers and toes, literally.
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Each one of us in the
womb until about 4 months,
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and then the
apoptosis kicks in
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and the cells in the webbing in between kill
themselves off to separate our fingers.
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Some cells in our body overstay
their welcome, though,
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like cancer cells.
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They don't die when
they're supposed to
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by somehow turning off
their suicide genes.
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What can we
do about it?
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Well, one of the ways
curry kills cancer cells,
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is by reprogramming the self-destruct
mechanism back into cancer cells.
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Let me just run through
one of these pathways,
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just to see the complexity.
FAS, is a so-called death receptor,
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which activates the FAS
associated death domain,
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along with death receptor 5,
and death receptor 4.
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FADD then activates caspase-8,
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which ignites the death
machine, and kills the cell.
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Where does curry powder
fit into all this?
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In cancer cells, curcumin,
the pigment in the spice turmeric
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that makes curry
powder yellow,
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upregulates and activates
death receptors,
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as has been demonstrated in
human kidney cancer cells
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as well as skin cancer,
and nose and throat cancer.
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It can also activate the
death machine directly,
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as has been shown in lung
cancer and colon cancer.
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Caspases are so-called
executioner enzymes,
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that when activated, destroy
the cancer cell from within
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by chopping up proteins
left and right,
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kind of a death by
a thousand cuts.
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And that's just
one pathway.
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Here's all the other ways
curcumin can affect apoptosis.
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Here's all the different types of
cancer cells curcumin can kill,
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but it tends to leave
normal cells alone
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for reasons that are
not fully understood.
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Overall, this review showed
that curcumin can kill
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a wide variety of tumor cell types
through diverse mechanisms.
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And it's because curcumin can
affect numerous mechanisms
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of cell death at
the same time,
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it's possible that cancer cells may
not easily develop resistance
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to curcumin-induced
cell death,
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like they do to
most chemotherapy.
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Furthermore, its ability to kill
tumor cells and not normal cells
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makes curcumin an attractive candidate…
for supper?
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Can't make money on some
spice you can buy anywhere.
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An attractive candidate
for drug development.