WEBVTT 00:00:00.000 --> 00:00:02.000 One way to change our genes is to make new ones, 00:00:02.000 --> 00:00:04.000 as Craig Venter has so elegantly shown. 00:00:04.000 --> 00:00:07.000 Another is to change our lifestyles. 00:00:07.000 --> 00:00:11.000 And what we're learning is how powerful and dynamic these changes can be, 00:00:11.000 --> 00:00:14.000 that you don't have to wait very long to see the benefits. 00:00:14.000 --> 00:00:19.000 When you eat healthier, manage stress, exercise and love more, 00:00:19.000 --> 00:00:21.000 your brain actually gets more blood flow and more oxygen. 00:00:21.000 --> 00:00:24.000 But more than that, your brain gets measurably bigger. 00:00:24.000 --> 00:00:26.000 Things that were thought impossible just a few years ago 00:00:26.000 --> 00:00:28.000 can actually be measured now. 00:00:28.000 --> 00:00:31.000 This was figured out by Robin Williams 00:00:31.000 --> 00:00:33.000 a few years before the rest of us. NOTE Paragraph 00:00:33.000 --> 00:00:35.000 Now, there's some things that you can do 00:00:35.000 --> 00:00:38.000 to make your brain grow new brain cells. 00:00:38.000 --> 00:00:40.000 Some of my favorite things, like chocolate and tea, blueberries, 00:00:40.000 --> 00:00:44.000 alcohol in moderation, stress management 00:00:44.000 --> 00:00:46.000 and cannabinoids found in marijuana. 00:00:46.000 --> 00:00:48.000 I'm just the messenger. 00:00:49.000 --> 00:00:52.000 (Laughter) 00:00:52.000 --> 00:00:55.000 What were we just talking about? 00:00:55.000 --> 00:00:57.000 (Laughter) 00:00:57.000 --> 00:00:59.000 And other things that can make it worse, 00:00:59.000 --> 00:01:01.000 that can cause you to lose brain cells. 00:01:01.000 --> 00:01:04.000 The usual suspects, like saturated fat and sugar, 00:01:04.000 --> 00:01:08.000 nicotine, opiates, cocaine, too much alcohol and chronic stress. NOTE Paragraph 00:01:08.000 --> 00:01:11.000 Your skin gets more blood flow when you change your lifestyle, 00:01:11.000 --> 00:01:14.000 so you age less quickly. Your skin doesn't wrinkle as much. 00:01:14.000 --> 00:01:16.000 Your heart gets more blood flow. 00:01:16.000 --> 00:01:18.000 We've shown that you can actually reverse heart disease. 00:01:18.000 --> 00:01:21.000 That these clogged arteries that you see on the upper left, 00:01:21.000 --> 00:01:23.000 after only a year become measurably less clogged. 00:01:23.000 --> 00:01:25.000 And the cardiac PET scan shown on the lower left, 00:01:25.000 --> 00:01:27.000 the blue means no blood flow. 00:01:27.000 --> 00:01:30.000 A year later -- orange and white is maximum blood flow. 00:01:30.000 --> 00:01:33.000 We've shown you may be able to stop and reverse the progression 00:01:33.000 --> 00:01:35.000 of early prostate cancer and, by extension, breast cancer, 00:01:35.000 --> 00:01:37.000 simply by making these changes. 00:01:37.000 --> 00:01:40.000 We've found that tumor growth in vitro was inhibited 00:01:40.000 --> 00:01:42.000 70 percent in the group that made these changes, 00:01:42.000 --> 00:01:45.000 whereas only nine percent in the comparison group. NOTE Paragraph 00:01:45.000 --> 00:01:47.000 These differences were highly significant. 00:01:47.000 --> 00:01:49.000 Even your sexual organs get more blood flow, 00:01:49.000 --> 00:01:51.000 so you increase sexual potency. 00:01:51.000 --> 00:01:53.000 One of the most effective anti-smoking ads was done 00:01:53.000 --> 00:01:55.000 by the Department of Health Services, 00:01:55.000 --> 00:01:57.000 showing that nicotine, which constricts your arteries, 00:01:57.000 --> 00:01:59.000 can cause a heart attack or a stroke, 00:01:59.000 --> 00:02:01.000 but it also causes impotence. 00:02:01.000 --> 00:02:03.000 Half of guys who smoke are impotent. 00:02:03.000 --> 00:02:04.000 How sexy is that? NOTE Paragraph 00:02:04.000 --> 00:02:06.000 Now we're also about to publish a study -- 00:02:06.000 --> 00:02:09.000 the first study showing you can change gene expression in men with prostate cancer. 00:02:09.000 --> 00:02:11.000 This is what's called a heat map -- 00:02:11.000 --> 00:02:14.000 and the different colors -- and along the side, on the right, are different genes. 00:02:14.000 --> 00:02:17.000 And we found that over 500 genes were favorably changed -- 00:02:17.000 --> 00:02:20.000 in effect, turning on the good genes, the disease-preventing genes, 00:02:20.000 --> 00:02:24.000 turning off the disease-promoting genes. NOTE Paragraph 00:02:24.000 --> 00:02:27.000 And so these findings I think are really very powerful, 00:02:27.000 --> 00:02:29.000 giving many people new hope and new choices. 00:02:29.000 --> 00:02:34.000 And companies like Navigenics and DNA Direct and 23andMe, 00:02:34.000 --> 00:02:37.000 that are giving you your genetic profiles, 00:02:37.000 --> 00:02:40.000 are giving some people a sense of, "Gosh, well, what can I do about it?" 00:02:40.000 --> 00:02:43.000 Well, our genes are not our fate, and if we make these changes -- 00:02:43.000 --> 00:02:45.000 they're a predisposition -- but if we make bigger changes 00:02:45.000 --> 00:02:47.000 than we might have made otherwise, 00:02:47.000 --> 00:02:50.000 we can actually change how our genes are expressed. 00:02:50.000 --> 00:02:51.000 Thank you. 00:02:51.000 --> 00:02:53.000 (Applause)